Patents Assigned to Oxford University Innovation Limited
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Patent number: 11313842Abstract: A method for separating ionic species from an analyte solution to form a fractionated sample, the method comprising contacting the analyte solution with an ion-exchanger that is selectively permeable to ionic species of either a positive or negative charge, contacting an opposing side of the ion-exchanger with a draw solution, wherein the draw solution comprises adsorber particles dispersed in a liquid carrier, establishing a concentration gradient across the ion-exchanger to allow at least some ionic species from the analyte solution to permeate through the ion-exchanger to the draw solution, adsorbing ionic species that permeate from the analyte solution onto the adsorber particles, separating adsorber particles having the ionic species adsorbed thereto from at least part of the draw solution, and eluting the ionic species from the separated adsorber particles to form a fractionated analyte sample comprising eluted ionic species.Type: GrantFiled: June 12, 2018Date of Patent: April 26, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventor: Imad Ahmed
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Patent number: 11311509Abstract: The subject disclosure provides compositions for reducing serum cholesterol and/or triglyceride levels in subjects. These compositions can comprise racemic ?-hydroxybutyrate or D-?-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic ?-hydroxybutyrate or D-?-hydroxybutyrate, esters of D-?-hydroxybutyrate, oligomers of D-?-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol or R-1,3 butandiol alone and can be, optionally, administered in conjunction with a low fat diet to a subject.Type: GrantFiled: November 29, 2018Date of Patent: April 26, 2022Assignees: OXFORD UNIVERSITY INNOVATION LIMITED, Government of the USA, as represented by the Secretary, Department of Health and Human ServicesInventors: Kieran Clarke, Richard Lewis Veech
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Patent number: 11304903Abstract: The invention provides a compartmentalised gel matrix comprising one or more compartments, wherein each compartment comprises a volume of hydrophobic medium and one or more aqueous droplets therein. The invention further provides a pharmaceutical formulation comprising a compartmentalised gel matrix according to the invention, a synthetic cell comprising a compartmentalised gel matrix according to the invention and a synthetic tissue comprising a compartmentalised gel matrix according to the invention.Type: GrantFiled: March 27, 2018Date of Patent: April 19, 2022Assignees: Oxford University Innovation Limited, Katholieke Universiteit LeuvenInventors: John Hagan Pryce Bayley, Kunwar Tanuj Sapra, Giovanni Maglia, Mariam Mohamed Abdelsattar Bayoumi
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Patent number: 11306325Abstract: The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their uses in medicine. In particular, the present invention provides an adenoviral vector comprising the genome of an adenovirus other than AdHu5 and AdY25, wherein the genome of the adenovirus has been modified such that the vector lacks the native E4 locus of the adenovirus and comprises heterologous E4Orf1, E4Orf2 and E4Orf3 coding regions from AdY25.Type: GrantFiled: June 23, 2017Date of Patent: April 19, 2022Assignee: Oxford University Innovation LimitedInventors: Sarah C. Gilbert, Adrian V S Hill, Matthew G. Cottingham, Matthew Dicks, Susan J. Morris, Alexander Douglas
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Patent number: 11302833Abstract: The invention provides an optoelectronic device comprising a porous material, which porous material comprises a semiconductor comprising a perovskite. The porous material may comprise a porous perovskite. Thus, the porous material may be a perovskite material which is itself porous. Additionally or alternatively, the porous material may comprise a porous dielectric scaffold material, such as alumina, and a coating disposed on a surface thereof, which coating comprises the semiconductor comprising the perovskite. Thus, in some embodiments the porosity arises from the dielectric scaffold rather than from the perovskite itself. The porous material is usually infiltrated by a charge transporting material such as a hole conductor, a liquid electrolyte, or an electron conductor. The invention further provides the use of the porous material as a semiconductor in an optoelectronic device. Further provided is the use of the porous material as a photosensitizing, semiconducting material in an optoelectronic device.Type: GrantFiled: August 8, 2018Date of Patent: April 12, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Henry Snaith, Michael Lee
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Patent number: 11282973Abstract: The present invention relates to a semiconductor device comprising a semiconducting material, wherein the semiconducting material comprises a halometallate compound comprising: (a) cesium; (b) palladium; and (c) one or more halide anions [X]. The invention also relates to a layer comprising the semiconducting material. The invention further relates to a process for producing a halometallate compound of formula (IV): [A]2[MIV][X]6, which process uses a H[X] and a compound comprising a sulfoxide group.Type: GrantFiled: April 20, 2018Date of Patent: March 22, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Nobuya Sakai, Amir Abbas Haghighirad, Henry James Snaith
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Patent number: 11282511Abstract: A computer implemented method for automatic speech analysis comprising setting a target phrase, the target phrase comprising a target phoneme, the target phoneme having corresponding target values of a set of phonological features associated therewith, wherein each target value is one of: an indication that the phonological feature should be present, an indication that the phonological feature should be absent, or an indication that the presence of the phonological feature is not specified, receiving a speech signal, wherein the speech signal comprises a user's attempt to say the target phrase, analysing the speech signal to determine the phonological features present within a portion of the speech signal corresponding to the target phoneme and assigning a probability to each of the set of phonological features, comparing the probability assigned to each phonological feature based on the speech signal to the expected target value of that phonological feature within the phrase, determining a deviation from theType: GrantFiled: April 17, 2018Date of Patent: March 22, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Vipul Arora, Aditi Lahiri, Henning Reetz
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Patent number: 11276734Abstract: The invention provides an optoelectronic device comprising: (i) a porous dielectric scaffold material; and (ii) a semiconductor having a band gap of less than or equal to 3.0 eV, in contact with the scaffold material. Typically the semiconductor, which may be a perovskite, is disposed on the surface of the porous dielectric scaffold material, so that it is supported on the surfaces of pores within the scaffold. In one embodiment, the optoelectronic device is an optoelectronic device which comprises a photoactive layer, wherein the photo-active layer comprises: (a) said porous dielectric scaffold material; (b) said semiconductor; and (c) a charge transporting material. The invention further provides the use, as a photoactive material in an optoelectronic device, of: (i) a porous dielectric scaffold material; and (ii) a semi-conductor having a band gap of less than or equal to 3.0 eV, in contact with the scaffold material.Type: GrantFiled: July 1, 2019Date of Patent: March 15, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Henry Snaith, Michael Lee
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Patent number: 11258024Abstract: The invention provides an optoelectronic device comprising a mixed-anion perovskite, wherein the mixed-anion perovskite comprises two or more different anions selected from halide anions and chalcogenide anions. The invention further provides a mixed-halide perovskite of the formula (I) [A][B][X]3 wherein: [A] is at least one organic cation; [B] is at least one divalent metal cation; and [X] is said two or more different halide anions. In another aspect, the invention provides the use of a mixed-anion perovskite as a sensitizer in an optoelectronic device, wherein the mixed-anion perovskite comprises two or more different anions selected from halide anions and chalcogenide anions. The invention also provides a photosensitizing material for an optoelectronic device comprising a mixed-anion perovskite wherein the mixed-anion perovskite comprises two or more different anions selected from halide anions and chalcogenide anions.Type: GrantFiled: November 28, 2017Date of Patent: February 22, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Henry Snaith, Michael Lee, Takuro Murakami
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Patent number: 11249153Abstract: Apparatus for generating spin waves comprising a body (102) of magnetic material and an elastic wave generator (120), wherein the body (102) has a surface (108) and the elastic wave generator (120) is arranged to transmit elastic waves so that they propagate through the body (102) towards the surface (108) and are reflected at the surface to form a standing elastic wave in the body (102), thereby generating spin waves.Type: GrantFiled: November 14, 2017Date of Patent: February 15, 2022Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: John Francis Gregg, Tsz Cheong Fung, Burkard Hillebrands
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Publication number: 20220041662Abstract: The present invention relates to peptides, in particular cell penetrating peptides, of 40 amino acid residues or less comprising at least one directly glycosylated amino residue and one or more arginine rich arm domains, and to conjugates of such cell penetrating peptides with a therapeutic molecule. The present invention further relates to the use of the peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders of the central nervous system.Type: ApplicationFiled: April 23, 2021Publication date: February 10, 2022Applicants: Oxford University Innovation Limited, United Kingdom Research and InnovationInventors: Matthew Wood, Suzan Hammond, Melissa Bowerman, Michael Gait, Frank Adendroth, Graham McClorey
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Publication number: 20220023387Abstract: The subject invention provides a method of preventing or treating a condition associated with a defect in, or damage to, an organ in a subject with, or at risk for, such defect or damage to such organ which comprises administering to the subject a therapeutically effective amount of the fully reduced (all thiol) form of HMGB1 or a biologically active truncated form of HMGB1, so as to prevent or treat such condition. The subject invention also provides a method of improving regeneration of blood in a subject comprising administering a therapeutically effective amount of the fully reduced (all thiol) form of HMGB1 or a biologically active truncated form of HMGB1, effective to improve regeneration of blood.Type: ApplicationFiled: April 9, 2019Publication date: January 27, 2022Applicant: Oxford University Innovation LimitedInventors: Jagdeep Nanchahal, Ana Isabel Espirito Santo, Geoffrey Lee, James Chan, Nicole Horwood, Marc Feldmann
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Patent number: 11230715Abstract: The present invention relates to exosomes, loaded with genetic material and methods of producing them and to the use of such exosomes for delivering genetic material in vivo, in particular the use of such exosomes in methods of gene therapy or gene silencing.Type: GrantFiled: April 24, 2020Date of Patent: January 25, 2022Assignee: Oxford University Innovation LimitedInventors: Yiqi Seow, Lydia Alvarez, Matthew Wood
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Patent number: 11230722Abstract: Novel compounds and compositions containing (R)-3-hydroxybutyrate derivatives are disclosed. The compounds and compositions can be used as nutritional supplements to increase physical performance and as therapeutics to ameliorate symptoms of medical conditions, particularly neurological conditions, such as Alzheimer's and similar conditions. Novel methods for making R-3-hydroxybutyrate derivatives also are disclosed. Exemplary methods employ a supercritical solvent, such as supercritical carbon dioxide, and employ a lipase catalyzed esterification or transesterification reaction to produce the (R)-3-hydroxybutyrate derivatives.Type: GrantFiled: March 7, 2018Date of Patent: January 25, 2022Assignees: Oxford University Innovation Limited, U.S. Dept. Of Health and Human Services, (DHHS), U.S. GovernmentInventors: Richard Lewis Veech, Michael Todd King, Kieran Clarke
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Patent number: 11213797Abstract: The invention relates to an apparatus for producing a droplet assembly, which apparatus comprises a droplet generator. A process for producing a droplet assembly, using an apparatus comprising a droplet generator is also described. The invention also relates to droplet assemblies comprising a plurality of droplets. Various uses of the droplet assemblies are also described.Type: GrantFiled: December 6, 2013Date of Patent: January 4, 2022Assignee: Oxford University Innovation LimitedInventors: John Hagan Pryce Bayley, Gabriel Villar, Alexander D. Graham
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Patent number: 11198901Abstract: The present invention relates to a method for forming nano-gaps in graphene. The method may include applying a voltage across a region of graphene such that a nano-gap which extends across the entire width of the graphene is formed, wherein the region across which the voltage is applied may include a point which is the narrowest in the region.Type: GrantFiled: June 23, 2015Date of Patent: December 14, 2021Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: George Andrew Davidson Briggs, Jan Andries Mol
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Patent number: 11197920Abstract: The present invention relates to particles, particularly virus-like particles (VLPs), comprising fusion polypeptides comprising selected repeat units derived from the repeating regions of Type I and Type II circumsporozoite proteins (CSP) of Plasmodium vivax (Pv), together with an amino acid sequence derived from the C-terminal PvCSP sequence. In some embodiments, the fusion polypeptide additionally comprises an amino acid sequence derived from the N-terminal PvCSP sequence and/or a surface antigen polypeptide derived from Hepatitis B virus (HBV-S). The invention also relates to nucleotide sequences coding for such fusion polypeptides, vectors and plasmids comprising such nucleotide sequences, and host cells comprising such vectors and plasmids. The invention additionally relates to compositions, particularly vaccine compositions, comprising the fusion polypeptides or VLPs for use as vaccines for the prevention of malaria.Type: GrantFiled: May 18, 2017Date of Patent: December 14, 2021Assignee: Oxford University Innovation LimitedInventor: Arturo Reyes-Sandoval
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Patent number: 11179456Abstract: The invention relates to a nucleic acid encoding a polypeptide comprising a plurality of conserved peptide sequences, or variants thereof, wherein the conserved sequences are conserved across one or more HPV genotypes 16, 18, 31, 52, 53, and 58; and wherein the polypeptide comprises a conserved peptide sequence of each of the HPV proteins E1, E2, E4, E5, E6, and E7; and associated vaccines, viral vectors, treatment and prophylaxis.Type: GrantFiled: August 16, 2018Date of Patent: November 23, 2021Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Lucy Dorrell, Joshua Blight, Arturo Reyes-Sandoval
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Patent number: 11169366Abstract: A compact microscope including an enclosure, a support element, a primary optical support element located within the enclosure and supported by the support element, at least one vibration isolating mount between the support element and the primary optical support element, an illumination section, an objective lens system, a sample stage mounted on the primary optical support element, an illumination optical system to direct an illumination light beam from the illumination section to the sample stage, and a return optical system to receive returned light from sample stage and transmit returned light to a detection apparatus, wherein the illumination optical system and return optical system are mounted on the primary optical support element.Type: GrantFiled: May 7, 2019Date of Patent: November 9, 2021Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Achillefs Kapanidis, Bo Jing, Robert Crawford
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Patent number: 11161862Abstract: This invention relates to compounds that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.Type: GrantFiled: April 20, 2018Date of Patent: November 2, 2021Assignee: Oxford University Innovation LimitedInventors: Tim Sparey, Andrew Ratcliffe, Edward Cochrane, Brett Stevenson, David Hallett, Franz Lagasse, Gilbert Lassalle, Alexandre Froidbise