Patents Assigned to Oxford University Innovation Limited
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Patent number: 10939852Abstract: A method of monitoring changes in oxygen saturation of a subject by analysing a three colour channel video image of the exposed skin of the subject. Within each colour channel a normalised signal obtained by dividing the intensity signal by its mean value, and the normalised signals are averaged across plural regions of interest within the exposed skin area image of the subject. Regions of interest are selected on the basis of the signal-to-noise ratios for the heart rate and breathing rate components. A single representative waveform for each colour channel is obtained by signal averaging and the ratio of the amplitudes of the representative waveforms from two different colour channels, e.g. blue and red, is taken. The changes in the ratio of amplitudes is output as a measure of changes in blood oxygen saturation.Type: GrantFiled: June 2, 2016Date of Patent: March 9, 2021Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Alessandro Guazzi, Mauricio Villarroel Montoya, Lionel Tarassenko
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Patent number: 10934578Abstract: The present invention relates to a method of identifying nucleic acid regions within a nucleic acid sample which interact with one another. In particular, the method relates to a chromatin conformation capture (3C) method which may be used to analyse the interactions between enhancers, silencers, boundary elements and promoters at individual loci at high resolution.Type: GrantFiled: October 24, 2016Date of Patent: March 2, 2021Assignee: Oxford University Innovation LimitedInventors: James R. Hughes, James Davies
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Patent number: 10934635Abstract: There is provided a method of fabricating a trapped vacancy in a crystal lattice of a target comprising: positioning the target in a laser system, the target containing vacancy trapping elements within the crystal lattice; modifying the crystal lattice within the target by using a laser to generate a lattice vacancy; and annealing the target to cause the lattice vacancy to migrate and be captured by a vacancy trapping element to form the trapped vacancy in the crystal lattice.Type: GrantFiled: July 1, 2016Date of Patent: March 2, 2021Assignee: Oxford University Innovation LimitedInventors: Martin James Booth, Patrick Salter, Jason Smith, Yu-Chen Chen
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Patent number: 10928350Abstract: Herein is disclosed a method for detecting a material comprising a thiol group (e.g. homocysteine, cysteine, glutathione) in a sample, the method comprising: •providing an electrode comprising a carbon material; •contacting said electrode with said sample in the presence of catechol or more generally a precursor of ortho-quinone; •performing cyclic or square wave voltammetry to convert catechol to ortho-quinone and wherein said ortho-quinone reacts with the material comprising a thiol group to form an electrochemical reaction product.Type: GrantFiled: March 20, 2015Date of Patent: February 23, 2021Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Patricia Tung Lee, Denise Lowinsohn, Richard Guy Compton
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Patent number: 10928478Abstract: Described herein are methods for monitoring and/or extracting subject motion from multi-channel electrical coupling in imaging of the subject, in particular in magnetic resonance (MR) imaging of the subject.Type: GrantFiled: May 28, 2019Date of Patent: February 23, 2021Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Aaron Hess, Matthew Robson, Sven Jaeschke
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Patent number: 10927013Abstract: The present invention relates to a semiconductor device comprising a semiconducting material, wherein the semiconducting material comprises a compound comprising: (i) one or more first monocations [A]; (ii) one or more second monocations [BI]; (iii) one or more trications [BIII]; and (iv) one or more halide anions [X]. The invention also relates to a process for producing a semiconductor device comprising said semiconducting material. Also described is a compound comprising: (i) one or more first monocations [A]; (ii) one or more second monocations [BI] selected from Cu+, Ag+ and Au+; (iii) one or more trications [BIII]; and (iv) one or more halide anions [X].Type: GrantFiled: August 31, 2016Date of Patent: February 23, 2021Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Henry James Snaith, Amir Abbas Hagighirad, Feliciano Giustino, Marina Filip, George Volonakis
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Patent number: 10914681Abstract: A functional material includes a porous metal-organic framework (MOF) including an organic ligand derived from benzenedicarboxylic acid and a metal ion cluster coordination-bonded with the organic ligand, and a luminescent molecule in pores of the MOF.Type: GrantFiled: July 21, 2017Date of Patent: February 9, 2021Assignees: Samsung Electronics Co., Ltd., OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Ha Jin Kim, In Taek Han, Abhijeet K. Chaudhari, Jin-Chong Tan
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Patent number: 10900081Abstract: The present invention is concerned with prenatal screening and in particular non-invasive prenatal screening, as well as primers, primer sets and kits. In one instance, the invention provides a method of prenatal screening comprising: (a) amplifying a region encompassing the site of a mutation site responsible for the disorder, the amplification being performed on a DNA sample obtained from a pregnant female which comprises both maternal and fetal DNA; (b) sequencing a plurality of products from the amplification and determining whether or not the mutant allele is represented at a different frequency to that expected from the genotype of the pregnant female alone.Type: GrantFiled: March 14, 2014Date of Patent: January 26, 2021Assignee: Oxford University Innovation LimitedInventors: Anna Schuh, Shirley Jane Henderson
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Patent number: 10889622Abstract: The present invention relates to a polypeptide that is capable of promoting the covalent conjugation of two peptide tags or linkers and in particular to a polypeptide comprising: a) an amino acid sequence as set forth in SEQ ID NO: 1; or b) an amino acid sequence with at least 80% sequence identity to a sequence as set forth in SEQ ID NO: 1, wherein said amino acid sequence comprises a glutamic acid at position 61 and one or more of the following: 1) proline at position 66; 2) proline at position 95; 3) glycine at position 96; and 4) valine at position 97, wherein the specified amino acid residues are at positions equivalent to the positions in SEQ ID NO: 1 and wherein said polypeptide is capable of promoting the formation of an isopeptide bond between the lysine residue at position 9 of SEQ ID NO: 2 and the asparagine residue at position 17 of SEQ ID NO: 3.Type: GrantFiled: April 10, 2018Date of Patent: January 12, 2021Assignee: Oxford University Innovation LimitedInventors: Mark Howarth, Can M. Buldun
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Patent number: 10888854Abstract: Catalytic compositions comprising permethylpentalene based metallocene complexes supported on solid methylaluminoxane are disclosed. The compositions are effective catalysts/initiators in the polymerisation of olefins. Also disclosed are uses of the compositions in olefin polymerisation.Type: GrantFiled: October 4, 2016Date of Patent: January 12, 2021Assignee: Oxford University Innovation LimitedInventors: Dermot O'Hare, Jean-Charles Buffet, Zoe Turner, Duncan Fraser
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Patent number: 10889507Abstract: A process for producing a metal oxide powder comprising: providing a precursor solution or dispersion containing a metal complex; spraying the precursor solution on to a heated substrate in the presence of water, thereby depositing material on the substrate; drying the deposited material; and removing the deposited material from the substrate to produce the metal oxide powder.Type: GrantFiled: February 6, 2017Date of Patent: January 12, 2021Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Peter Edwards, Jonathan Dilworth, Vladimir Kuznetsov, Catherine Hayes
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Publication number: 20210000803Abstract: The invention relates to the treatment or control of unipolar depressive disorder by administering a compound of Formula I or a salt thereof to a subject; wherein: E is S or Se; R1 and R2 are optional substituents, and are at each occurrence independently selected from: (1) a halogen, which is preferably selected from F, Cl and Br; (2) C1-C4 alkyl, such as C1-C2 alkyl or C1 alkyl, optionally substituted with one or more halogen atoms, each of which is preferably selected from F, Cl and Br; and (3) C1-C4 alkoxy, such as C1-C2 alkoxy or C1 alkoxy; optionally substituted with one or more halogen atoms, each of which is preferably selected from F, Cl and Br; m is an integer in the range of from 0 to 5; and n is an integer in the range of from 0 to 4.Type: ApplicationFiled: October 26, 2018Publication date: January 7, 2021Applicant: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Trevor SHARP, Philip COWEN, Grant CHURCHILL
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Publication number: 20210000934Abstract: The invention relates to an adjuvant comprising Pattern Recognition Receptor (PRR) agonist molecules linked to polymer chains that are capable of undergoing particle formation in aqueous conditions, or in aqueous conditions in response to external stimuli; and methods of treatment or prevention of disease using such an adjuvant.Type: ApplicationFiled: June 22, 2020Publication date: January 7, 2021Applicants: Oxford University Innovation Limited, The U.S.A., as Represented by the Secretary, Department of Health and Human ServicesInventors: Kerry Fisher, Richard Laga, Geoffrey Lynn, Leonard Seymour, Robert Seder
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Patent number: 10884090Abstract: The present invention relates to methods of assessing or obtaining an indication of the presence of a cognitive disorder by analysing microstructural changes in regions of the brain. The invention particularly relates to methods of assessing or obtaining an indication of the presence of types of dementia, for example Alzheimer's disease, by analysing changes in minicolumns in regions or layers of the cortex of the brain or of the whole brain.Type: GrantFiled: April 7, 2016Date of Patent: January 5, 2021Assignee: Oxford University Innovation LimitedInventors: Steven Chance, Rebecca McKavanagh, Mark Jenkinson, Karla Miller
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Publication number: 20200407785Abstract: The invention relates to a method for sequencing a heteropolymeric target nucleic acid sequence that involves stochastic sensing. The invention also relates to a method for improving a pore for sequencing a target nucleic acid sequence by modifying one or more sites in the pore.Type: ApplicationFiled: April 27, 2020Publication date: December 31, 2020Applicant: Oxford University Innovation LimitedInventors: David Jackson Stoddart, Andrew John Heron, Giovanni Maglia, John Hagan Pryce Bayley
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Patent number: 10877033Abstract: The invention relates to methods of detecting the presence or absence of autoantibodies in an individual and to related methods and kits. In particular, the disclosure concerns measuring from one or more samples from an individual suspected of having a disease with an autoimmune component for binding of one or more autoantibodies to membrane vesicles comprising corresponding one or more antigens.Type: GrantFiled: June 18, 2014Date of Patent: December 29, 2020Assignee: Oxford University Innovation LimitedInventors: Angela Vincent, Patrick Joseph Waters, Alexandru Radu Aricescu
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Patent number: 10873302Abstract: A four-wave mixing transmission line (3) including: an input (15, 17, 19) arranged to receive: a first pump signal (7a) having a first pump frequency; a second pump signal (7b), having a second pump frequency, different to the first pump frequency; and an input signal to be amplified (5); a non-linear medium (3a) having an intrinsic dispersion relationship, the medium (3a) arranged to allow interaction between the input signal (5), the first pump signal (7a) and the second pump signal (7b), such that the input signal (5) is amplified and an idler signal (9) is generated and amplified; and a plurality of dispersion control elements (31, 33, 49), the dispersion control elements (31, 33, 49) arranged to alter the dispersion relationship of the medium (3a) to diverge from the intrinsic dispersion relationship at one or more frequencies, such that the total phase difference between the input signal, (5) the first pump signal (7a), the second pump signal (7b) and the idler signal (9) is kept at zero or substantiallType: GrantFiled: March 3, 2017Date of Patent: December 22, 2020Assignee: Oxford University Innovation LimitedInventor: Boon Kok Tan
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Patent number: 10871612Abstract: A universal interferometer (100) for coupling modes of electromagnetic radiation according to a transformation has N inputs and N outputs for inputting and outputting N modes of electromagnetic radiation into and from the interferometer. Waveguides (101, 102, 103, 104, 105) pass through the interferometer to connect the N inputs to the N outputs and to carry the N modes of electromagnetic radiation. The waveguides provide crossing points between pairs of waveguides and a reconfigurable beam splitter (107) implements a reconfigurable reflectivity and a reconfigurable phase shift at each crossing point. The waveguides and crossing points are arranged such that each of the N modes of electromagnetic radiation is capable of coupling with each of the other modes of electromagnetic radiation at respective reconfigurable beam splitters.Type: GrantFiled: March 11, 2020Date of Patent: December 22, 2020Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: William Clements, Peter Humphreys, Benjamin Metcalf, Steven Kolthammer, Ian Walmsley
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Patent number: 10872682Abstract: A computer assisted method of designing a designed alloy composition comprising a plurality of elements, the method comprising the steps of: populating a multi-dimensional alloy space with a plurality of candidate alloy compositions, the plurality of candidate alloy compositions including for each of the plurality of elements at least three candidate alloy compositions with different amounts of the respective element to each other; performing at least one test on each individual one of the plurality of candidate alloy compositions until each of the individual ones of the plurality of candidate alloy compositions fails a test or has passed all tests; outputting the designed alloy composition based on one or more of the individual ones of the plurality of candidate alloy compositions which have passed all tests, wherein the at least one test includes at least: a phase equilibrium test in which predicted phase equilibrium is determined as a function of elemental composition of the individual one of the pluralityType: GrantFiled: March 23, 2016Date of Patent: December 22, 2020Assignee: Oxford University Innovation LimitedInventors: Roger Reed, Zailing Zhu, David Crudden
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Patent number: 10866295Abstract: The invention provides methods for processing nuclear magnetic resonance (NMR) spectroscopic data to assign resonance peaks in an NMR spectrum of a molecule to atomic nuclei in said molecule, based on graph-theoretical principles. In particular, the methods of the invention may be employed in the assignment of data obtained from methyl-TROSY spectroscopy of proteins.Type: GrantFiled: May 17, 2017Date of Patent: December 15, 2020Assignee: Oxford University Innovation LimitedInventors: Iva Pritisanac, Matteo Thomas Degiacomi, Andrew James Baldwin