Patents Assigned to Pacira Pharmaceuticals, Inc.
  • Patent number: 10398648
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: September 3, 2019
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Ernest George Schutt, Ronald Warren McGuire, Peter Andrew Walters, Kathleen D. A. Los
  • Patent number: 10123974
    Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: November 13, 2018
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Louie Daniel Garcia, Liangjin Zhu, William Joseph Lambert, Gary Patou
  • Patent number: 10045941
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: August 14, 2018
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Ernest George Schutt, Ronald Warren McGuire, Peter Andrew Walters, Kathleen D. A. Los
  • Patent number: 10028911
    Abstract: Disclosed is are formulations comprising a multivesicular liposome and MTX, the administration of which results in a Cmax of MTX between 5% and 50% of the Cmax of an immediate release dosage form of MTX, the duration of which lasts from about 1 to about 30 days. Also disclosed are methods of treating autoimmune diseases and cancer by administering these formulations of MTX.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: July 24, 2018
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Louie Daniel Garcia, Lois Gibson, William Joseph Lambert, Benjamin W. Li, Liangjin Zhu
  • Patent number: 9974744
    Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: May 22, 2018
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Louie Daniel Garcia, Liangjin Zhu, William Joseph Lambert, Gary Patou
  • Patent number: 9808424
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: November 7, 2017
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Ernest George Schutt, Ronald Warren McGuire, Peter Andrew Walters, Kathleen D. A. Los
  • Patent number: 9770414
    Abstract: Disclosed is are formulations comprising a multivesicular liposome and MTX, the administration of which results in a Cmax of MTX between 5% and 50% of the Cmax of an immediate release dosage form of MTX, the duration of which lasts from about 1 to about 30 days. Also disclosed are methods of treating autoimmune diseases and cancer by administering these formulations of MTX.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: September 26, 2017
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Louie Daniel Garcia, Lois Gibson, William Lambert, Benjamin W. Li, Liangjin Zhu
  • Patent number: 9757336
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: September 12, 2017
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Ernest George Schutt, Ronald Warren McGuire, Peter Andrew Walters, Kathleen D. A. Los
  • Patent number: 9737483
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: August 22, 2017
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Ernest George Schutt, Ronald Warren McGuire, Peter Andrew Walters, Kathleen D. A. Los
  • Patent number: 9737482
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: August 22, 2017
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Ernest George Schutt, Ronald Warren McGuire, Peter Andrew Walters, Kathleen D. A. Los
  • Patent number: 9730892
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: August 15, 2017
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Ernest George Schutt, Ronald Warren McGuire, Peter Andrew Walters, Kathleen D. A. Los
  • Patent number: 9724302
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: August 8, 2017
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Ernest George Schutt, Ronald Warren McGuire, Peter Andrew Walters, Kathleen D. A. Los
  • Patent number: 9585838
    Abstract: Multivesicular liposomes are prepared at commercial scales by combining a first w/o emulsion with a second aqueous solution to form a w/o/w emulsion using a static mixer. Solvent is removed from the resulting emulsion to form multivesicular liposome-containing compositions. Further optional process steps include primary filtration and secondary cross-flow filtration. The products produced according to the processes of the invention can be produced through a series of aseptic steps.
    Type: Grant
    Filed: February 25, 2007
    Date of Patent: March 7, 2017
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Hartoun Hartounian, Dagmar Meissner, Clint B. Pepper
  • Patent number: 9205052
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 8, 2015
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
  • Patent number: 9192575
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: November 24, 2015
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
  • Patent number: 8834921
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: September 16, 2014
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
  • Publication number: 20140004173
    Abstract: Multivesicular liposomes are prepared at commercial scales by combining a first w/o emulsion with a second aqueous solution to form a w/o/w emulsion using a static mixer. Solvent is removed from the resulting emulsion to form multivesicular liposome-containing compositions. Further optional process steps include primary filtration and secondary cross-flow filtration. The products produced according to the processes of the invention can be produced through a series of aseptic steps.
    Type: Application
    Filed: March 8, 2013
    Publication date: January 2, 2014
    Applicant: Pacira Pharmaceuticals, Inc.
    Inventor: Pacira Pharmaceuticals, Inc.
  • Publication number: 20130344132
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Application
    Filed: March 15, 2013
    Publication date: December 26, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130306759
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 5, 2013
    Publication date: November 21, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130209547
    Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.
    Type: Application
    Filed: March 6, 2013
    Publication date: August 15, 2013
    Applicant: PACIRA PHARMACEUTICALS INC.
    Inventor: PACIRA PHARMACEUTICALS INC