Patents Assigned to Pacira Pharmaceuticals, Inc.
  • Publication number: 20130209548
    Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.
    Type: Application
    Filed: March 6, 2013
    Publication date: August 15, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130195965
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 5, 2013
    Publication date: August 1, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130189349
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 25, 2013
    Applicant: Pacira Pharmaceuticals, Inc.
    Inventor: Pacira Pharmaceuticals, Inc.
  • Publication number: 20130189348
    Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 25, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130189350
    Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.
    Type: Application
    Filed: March 8, 2013
    Publication date: July 25, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: Pacira Pharmaceuticals, Inc.
  • Publication number: 20130183373
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 18, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: Pacira Pharmaceuticals, Inc.
  • Publication number: 20130183371
    Abstract: Disclosed is are formulations comprising a multivesicular liposome and MTX, the administration of which results in a Cmax of MTX between 5% and 50% of the Cmax of an immediate release dosage form of MTX, the duration of which lasts from about 1 to about 30 days. Also disclosed are methods of treating autoimmune diseases and cancer by administering these formulations of MTX.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 18, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130183375
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 8, 2013
    Publication date: July 18, 2013
    Applicant: Pacira Pharmaceuticals, Inc.
    Inventor: Pacira Pharmaceuticals, Inc.
  • Publication number: 20130183374
    Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 18, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130183370
    Abstract: Disclosed is are formulations comprising a multivesicular liposome and MTX, the administration of which results in a Cmax of MTX between 5% and 50% of the Cmax of an immediate release dosage form of MTX, the duration of which lasts from about 1 to about 30 days. Also disclosed are methods of treating autoimmune diseases and cancer by administering these formulations of MTX.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 18, 2013
    Applicant: Pacira Pharmaceuticals, Inc.
    Inventor: Pacira Pharmaceuticals, Inc.
  • Publication number: 20130183372
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 18, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130177635
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 11, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130177634
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 11, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130177633
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 11, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130177636
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 11, 2013
    Applicant: Pacira Pharmaceuticals, Inc.
    Inventor: Pacira Pharmaceuticals, Inc.
  • Publication number: 20130177637
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 11, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130177638
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 11, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20120231070
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Application
    Filed: May 21, 2012
    Publication date: September 13, 2012
    Applicant: PACIRA PHARMACEUTICAL, INC.
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
  • Patent number: 8182835
    Abstract: The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: May 22, 2012
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Sinil Kim, Taehee Kim, Sharad Murdande
  • Publication number: 20120114740
    Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.
    Type: Application
    Filed: October 27, 2011
    Publication date: May 10, 2012
    Applicant: PACIRA PHARMACEUTICALS, INC
    Inventors: Louie Daniel Garcia, Liangjin Zhu, William Joseph Lambert, Gary Patou