Patents Assigned to Paratek Pharmaceuticals, Inc.
  • Substituted tetracycline compounds for treatment of inflammatory skin disorders
    Publication number: 20130345179
    Abstract: Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.
    Type: Application
    Filed: August 19, 2013
    Publication date: December 26, 2013
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Haregewein Assefa, Beena Bhatia, Michael P. Draper, Laura Honeyman, Oak K. Kim, Dennis P. Molnar
  • METHODS OF USING (4S,4AS,5AR,12AS)-4-DIMETHYLAMINO-3,10,12,12A-TETRAHYDROXY-7-[(METHOXY(METHYL)AMINO)-METHYL]-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-NAPHTHACENE-2-CARBOXYLIC ACID AMIDE
    Publication number: 20130302442
    Abstract: A method of treating a bacterial infection, e.g., a bacterial infection with methicillin resistant Staphylococcus aureus, Helicobacter pylori, Chlamydia trachomatis, or Chlamydia pneumonia, comprising administering to a subject (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide or a pharmaceutically acceptable salt thereof is disclosed. More specifically, a method of treating a bacterial infection comprising administering to a subject crystalline mono hydrochloride salt, crystalline mono mesylate salt or crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed.
    Type: Application
    Filed: May 14, 2013
    Publication date: November 14, 2013
    Applicants: Paratek Pharmaceuticals, Inc., Warmer Chilcott Company, LLC
    Inventors: Catherine Coulter, Sean M. Johnston, Farzaneh Seyedi, Tina M. deVries
  • Substituted tetracycline compounds for treatment of inflammatory skin disorders
    Patent number: 8513223
    Abstract: Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: August 20, 2013
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Haregewein Assefa, Beena Bhatia, Michael P. Draper, Laura Honeyman, Oak Kim, Dennis P. Molnar
  • 7-substituted tetracycline compounds
    Patent number: 8492365
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: July 23, 2013
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
  • 3, 10, and 12a substituted tetracycline compounds
    Patent number: 8481513
    Abstract: The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: July 9, 2013
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Upul Bandarage, Jackson Chen, Mohamed Y. Ismail, Mark L. Nelson, Kwasi Ohemeng
  • 11a, 12-derivatives of tetracycline compounds
    Patent number: 8470804
    Abstract: 11a,12-dehydrotetracycline compounds are described.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: June 25, 2013
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Mohamed Y. Ismail, Mark L. Nelson, Faye Seyedi
  • Substituted tetracycline compounds
    Patent number: 8466132
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: June 18, 2013
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Paul Abato, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Mohamed Y. Ismail, Mark L. Nelson, Kwasi Ohemeng, Jingwen Pan
  • Substituted tetracycline compounds for treatment of infections
    Patent number: 8440646
    Abstract: Methods and compositions for the treatment of Bacillus anthracis infections are described.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: May 14, 2013
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, S. Ken Tanaka
  • Transcription factor modulating compounds and methods of use thereof
    Patent number: 8436031
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: May 7, 2013
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventor: Oak K. Kim
  • Substituted Tetracycline Compounds
    Publication number: 20130102779
    Abstract: The present invention pertains to tetracycline compounds of formula (VIIa): R5*, R5*?, R7r*, and R9m* are defined herein. These tetracycline compounds can be used to treat tetracycline compound-responsive states, such as multiple sclerosis and rheumatoid arthritis.
    Type: Application
    Filed: November 27, 2012
    Publication date: April 25, 2013
    Applicant: PARATEK PHARMACEUTICALS, INC.
    Inventor: Paratek Pharmaceuticals, Inc.
  • Methods for treating spinal muscular atrophy using tetracycline compounds
    Patent number: 8399437
    Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: March 19, 2013
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Todd Bowser, Michael P. Draper, Stuart B. Levy, Mark L. Nelson
  • Salts and polymorphs of 9-(2,2-dimethylpropyl-aminomethyl) minocycline
    Patent number: 8383610
    Abstract: Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: February 26, 2013
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Raymond Cvetovich, Tadeusz Warchol
  • CRYSTALLINE SALTS OF (4S,4AS,5AR,12AS)-4-DIMETHYLAMINO-3,10,12,12A-TETRAHYDROXY-7-[(METHOXY(METHYL)AMINO)-METHYL]-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-NAPHTHACENE-2-CARBOXYLIC ACID AMIDE AND METHODS OF USING THE SAME
    Publication number: 20130012480
    Abstract: A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide are also disclosed having improved stability. A pharmaceutical composition containing the crystalline salts and methods of treating inflammatory skin disorders and bacterial infections comprising administering the crystalline salts are also disclosed.
    Type: Application
    Filed: May 14, 2012
    Publication date: January 10, 2013
    Applicants: PARATEK PHARMACEUTICALS, INC., WARNER CHILCOTT COMPANY, LLC
    Inventors: Catherine Coulter, Sean M. Johnston, Farzaneh Seyedi
  • Substituted tetracycline compounds
    Patent number: 8318706
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: November 27, 2012
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Oak Kim, Haregewein Assefa, Laura Honeyman
  • 9-SUBSTITUTED MINOCYCLINE COMPOUNDS
    Publication number: 20120283201
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: July 12, 2012
    Publication date: November 8, 2012
    Applicants: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhalie, Atul K. Verma, Laura Honeyman, Tadeusz Warchol, David Messersmith
  • 7-pyrazolyl tetracycline compounds and methods of use thereof
    Patent number: 8304445
    Abstract: The present invention provides compounds of Formula (I) and related methods and formulations: wherein: A represents a pyrazole ring optionally substituted by one or more R groups.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: November 6, 2012
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Bueno, Jose M. Fiandor, Roger Frechette
  • 7-iodo tetracyclines and related methods
    Patent number: 8288570
    Abstract: 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: October 16, 2012
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Laura Honeyman
  • Methods of Using Substituted Tetracycline Compounds to Modulate RNA
    Publication number: 20120245130
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Application
    Filed: March 21, 2012
    Publication date: September 27, 2012
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael Draper, Mark L. Nelson, Graham Jones
  • 9-substituted minocycline compounds
    Patent number: 8258120
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: September 4, 2012
    Assignees: Paratek Pharmaceuticals, Inc., Trustees of Tufts College
    Inventors: Mark L. Nelson, Mohamed Y. Ismail, Laura Honeyman
  • METHODS FOR IDENTIFYING AND USING MarR FAMILY POLYPEPTIDE BINDING COMPOUNDS
    Publication number: 20120209003
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: September 9, 2011
    Publication date: August 16, 2012
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette