Patents Assigned to Paratek Pharmaceuticals, Inc.
  • 7-pyrollyl 9-aminoacyl tetracycline compounds and methods of use thereof
    Patent number: 8211937
    Abstract: A compound of formula (I): wherein: A represents an aromatic 5 membered heterocycle, optionally containing, in addition to the nitrogen atom indicated in formula (I), one to three additional nitrogen atoms.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: July 3, 2012
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Fiandor, Roger Frechette
  • Methods of using substituted tetracycline compounds to modulate RNA
    Patent number: 8173624
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: May 8, 2012
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael Draper, Mark L. Nelson, Graham Jones
  • 11a, 12-Derivatives of Tetracycline Compounds
    Publication number: 20120101070
    Abstract: 11a,12-dehydrotetracycline compounds are described.
    Type: Application
    Filed: December 29, 2011
    Publication date: April 26, 2012
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Mohamed Y. Ismail, Mark L. Nelson, Faye Seyedi
  • SubstitutedTetracycline Compounds for the Treatment of Malaria
    Publication number: 20120101071
    Abstract: This invention provides a method for treating or preventing malaria in a subject. The method includes administering to the subject an effective amount of a substituted tetracycline compound, such that malaria is treated or prevented. In one aspect, the invention relates to pharmaceutical compositions which include an effective amount of a tetracycline compound to treat malaria in a subject and a pharmaceutically acceptable carrier. The substituted tetracycline compounds of the invention can be used to in combination with one or more anti-malarial compounds or can be used to treat or prevent malaria which is resistant to one or more other anti-malarial compounds.
    Type: Application
    Filed: December 28, 2011
    Publication date: April 26, 2012
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael DRAPER, Mark L. NELSON
  • 9-aminoacyl tetracycline compounds and methods of use thereof
    Patent number: 8101591
    Abstract: A compound of formula (I):
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: January 24, 2012
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Carmen Garcia-Luzon, Juan Carlos Cuevas, Jose M. Fiandor, Araceli Mallo, Mark L. Nelson, Roger Frechette
  • 11a, 12-derivatives of tetracycline compounds
    Patent number: 8088755
    Abstract: 11a,12-dehydrotetracycline compounds are described.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: January 3, 2012
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Mohamed Y. Ismail, Mark L. Nelson, Faye Seyedi
  • Substituted tetracycline compounds for the treatment of malaria
    Patent number: 8088820
    Abstract: This invention provides a method for treating or preventing malaria in a subject. The method includes administering to the subject an effective amount of a substituted tetracycline compound, such that malaria is treated or prevented. In one aspect, the invention relates to pharmaceutical compositions which include an effective amount of a tetracycline compound to treat malaria in a subject and a pharmaceutically acceptable carrier. The substituted tetracycline compounds of the invention can be used to in combination with one or more anti-malarial compounds or can be used to treat or prevent malaria which is resistant to one or more other anti-malarial compounds.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: January 3, 2012
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael Draper, Mark L. Nelson
  • Transcription factor modulating compounds and methods of use thereof
    Publication number: 20110306611
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Application
    Filed: August 3, 2009
    Publication date: December 15, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Victor Amoo, Oak K. Kim, Atul K. Verma
  • 9-substituted minocycline compounds
    Patent number: 8048867
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: November 1, 2011
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhatia, Atul K. Verma, Laura McIntyre, Tadeusz Warchol, David Messersmith
  • 7-N-Substituted Phenyl Tetracycline Compounds
    Publication number: 20110257421
    Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Application
    Filed: June 30, 2011
    Publication date: October 20, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Darrell J. Koza
  • Methods for identifying and using MarR family polypeptide binding compounds
    Patent number: 8039221
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: October 18, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • Substituted Tetracycline Compounds as Synergistic Antifungal Agents
    Publication number: 20110245501
    Abstract: The present invention relates to substituted tetracycline compounds and related methods for increasing the antifungal activity of an antifungal agent. The methods include administering to a subject an effective amount of a substituted tetracycline compound in combination with an antifungal agent such that the subject is treated for the fungal associated disorder.
    Type: Application
    Filed: June 14, 2011
    Publication date: October 6, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael Draper, Mark L. Nelson
  • TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20110230523
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Application
    Filed: August 6, 2009
    Publication date: September 22, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. LEVY, Michael N. ALEKSHUN, Brent L. PODLOGAR, Kwasi OHEMENG, Atul K. VERMA, Tadeusz WARCHOL, Beena BHATIA, Todd BOWSER, Mark GRIER
  • SUBSTITUTED POLYAMINES AS INHIBITORS OF BACTERIAL EFFLUX PUMPS
    Publication number: 20110218168
    Abstract: Disclosed are methods of treating bacterial infections including those caused by multidrug resistant bacteria using polyamine efflux pump inhibiting compounds, including for example N-benzylated polyazaalkanes, N-benzylated polyaminoalkanes, or mixed N-benzylated poly(aza/amino)alkanes, optionally in combination with other drugs such as antibiotics, as well as pharmaceutical compositions thereof.
    Type: Application
    Filed: September 29, 2010
    Publication date: September 8, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Michael N. Alekshun
  • 7-Iodo Tetracyclines and Related Methods
    Publication number: 20110207951
    Abstract: 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described.
    Type: Application
    Filed: February 18, 2011
    Publication date: August 25, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Laura Honeyman
  • Methods for Treating Spinal Muscular Atrophy Using Tetracycline Compounds
    Publication number: 20110207706
    Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
    Type: Application
    Filed: May 3, 2011
    Publication date: August 25, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Todd Bowser, Michael Draper, Stuart B. Levy, Mark L. Nelson
  • 7-Pyrazolyl Tetracycline Compounds and Methods of Use Thereof
    Publication number: 20110160165
    Abstract: The present invention provides compounds of Formula (I) and related methods and formulations: wherein: A represents a pyrazole ring optionally substituted by one or more R groups.
    Type: Application
    Filed: March 1, 2011
    Publication date: June 30, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Bueno, Jose M. Fiandor, Roger Frechette
  • Substituted tetracycline compounds as synergistic antifungal agents
    Patent number: 7960366
    Abstract: Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.
    Type: Grant
    Filed: September 16, 2004
    Date of Patent: June 14, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael Draper, Mark L. Nelson
  • Methods for treating spinal muscular atrophy using tetracycline compounds
    Patent number: 7935687
    Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: May 3, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Todd Bowser, Michael Draper, Stuart B. Levy, Mark L. Nelson
  • 7-And 9-Carbamate, Urea, Thiourea, Thiocarbamate, And Heteroaryl-Amino Substituted Tetracycline Compounds
    Publication number: 20110092467
    Abstract: Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.
    Type: Application
    Filed: December 22, 2010
    Publication date: April 21, 2011
    Applicants: Paratek Pharmaceuticals, Inc., Trustees of Tufts College
    Inventors: Mark L. Nelson, Stuart B. Levy, Roger Frechette, Todd Bowser, Mohamed Y. Ismail