Patents Assigned to Paratek Pharmaceuticals, Inc.
  • 4-Substituted Tetracyclines and Methods of Use Thereof
    Publication number: 20110077225
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: December 7, 2010
    Publication date: March 31, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Beena Bhatia, Mark Grier, Mark L. Nelson, Jingwen Pan
  • Process for preparing five-membered heterocyclyl tetracycline compounds and methods of use thereof
    Patent number: 7897784
    Abstract: The present invention provides processes for preparing a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein A is a pyrrole, tetrazole or triazole ring.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: March 1, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Bueno, Jose M. Fiandor, Roger Frechette
  • 7-substituted fused ring tetracycline compounds
    Patent number: 7893282
    Abstract: 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: February 22, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Laura Honeyman
  • Methods for Identifying and Using MarR Family Polypeptide Binding Compounds
    Publication number: 20110015375
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: June 18, 2009
    Publication date: January 20, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • 7- and 9- carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
    Patent number: 7858600
    Abstract: Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: December 28, 2010
    Assignees: Paratek Pharmaceuticals, Inc., Trustees of Tufts College
    Inventors: Mark L. Nelson, Stuart B. Levy, Roger Frechette, Todd Bowser, Mohamed Y. Ismail
  • 4-substituted tetracyclines and methods of use thereof
    Patent number: 7858601
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: December 28, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Beena Bhatia, Mark Grier, Mark L. Nelson, Jingwen Pan
  • Substituted polyamines as inhibitors of bacterial efflux pumps
    Patent number: 7829543
    Abstract: Disclosed are methods of treating bacterial infections including those caused by multidrug resistant bacteria using polyamine efflux pump inhibiting compounds, including for example N-benzylated polyazaalkanes, N-benzylated polyaminoalkanes, or mixed N-benzylated poly(aza/amino)alkanes, optionally in combination with other drugs such as antibiotics, as well as pharmaceutical compositions thereof.
    Type: Grant
    Filed: January 7, 2004
    Date of Patent: November 9, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Michael N. Alekshun
  • 3, 10, and 12a substituted tetracycline compounds
    Patent number: 7825105
    Abstract: The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: November 2, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Upul Bandarage, Mohamed Y. Ismail, Mark L. Nelson
  • Substituted tetracycline compounds
    Patent number: 7820641
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: October 26, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Peter Viski, Jackson Chen, Tadeusz Warchol
  • PRODRUGS OF 9-AMINOMETHYL TETRACYCLINE COMPOUNDS
    Publication number: 20100249076
    Abstract: The invention pertains to prodrugs of 9-aminomethyl substituted tetracycline compounds, methods of using the compounds, and pharmaceutical compositions containing them.
    Type: Application
    Filed: June 3, 2010
    Publication date: September 30, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Victor Amoo, Haregewein Assefa, Beena Bhatia, Joel Berniac, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Oak K. Kim, Rachid Mechiche, Kwasi Ohemeng, Jingwen Pan
  • METHODS FOR PREVENTING AND TREATING MICROBIAL INFECTIONS BY MODULATING TRANSCRIPTION FACTORS
    Publication number: 20100227850
    Abstract: The current invention is based, inter alia, on the finding that the transcription factor MarA, and homologues of MarA, e.g., Rob and SoxS, are virulence factors. Accordingly, the invention discloses methods for screening compounds for their ability to modulate these virulence factors. The invention further describes methods for treating and preventing bacterial infections by modulating the expression and/or activity of transcription factors. In addition, the invention provides a method for identifying other virulence factors.
    Type: Application
    Filed: November 24, 2009
    Publication date: September 9, 2010
    Applicant: PARATEK PHARMACEUTICALS, INC.
    Inventors: MICHAEL N. ALEKSHUN, STUART B. LEVY
  • Aromatic a-ring derivatives of tetracycline compounds
    Patent number: 7786099
    Abstract: Aromatized A-ring derivatives of tetracycline compounds are described.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: August 31, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventor: Mark L. Nelson
  • AROMATIC A-RING DERIVATIVES OF TETRACYCLINE COMPOUNDS
    Publication number: 20100204186
    Abstract: Aromatized A-ring derivatives of tetracycline compounds are described.
    Type: Application
    Filed: April 22, 2010
    Publication date: August 12, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventor: Mark L. Nelson
  • 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20100190756
    Abstract: The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: March 18, 2010
    Publication date: July 29, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Upul Bandarage, Jackson Chen, Mohamed Y. Ismail, Mark L. Nelson, Kwasi Ohemeng
  • 7,9-SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20100160263
    Abstract: The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: November 12, 2009
    Publication date: June 24, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Laura McIntyre, Beena Bhatia, Paul Hawkins, Laxma Reddy Nagavelli, Karen Stepleton, Tad Warchol, Paul Sheahan
  • 9-Aminomethyl Substituted Minocycline Compounds
    Publication number: 20100113400
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: May 28, 2009
    Publication date: May 6, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • METHODS FOR SYNTHESIZING AND PURIFYING AMINOALKYL TETRACYCLINE COMPOUNDS
    Publication number: 20100113401
    Abstract: Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 6, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Sean Johnston, Tadeusz Warchol
  • Salts and Polymorphs of a Tetracycline Compound
    Publication number: 20100113399
    Abstract: Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
    Type: Application
    Filed: May 26, 2009
    Publication date: May 6, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Raymond Cvetovich, Tadeusz Warchol
  • 7,9-substituted tetracycline compounds
    Patent number: 7696186
    Abstract: The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: April 13, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Laura McIntyre, Beena Bhatia, Paul Hawkins, Laxma Reddy, Karen Stapleton, Tadeusz Warchol, Paul Sheahan
  • Five-membered heterocyclyl tetracycline compounds and methods of use thereof
    Patent number: 7696358
    Abstract: The present invention describes methods of treating bacterial infections with 7-pyrrolyl tetracycline compounds of formula (I):
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: April 13, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Bueno, Jose M. Fiandor, Roger Frechette