Patents Assigned to Pari
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Publication number: 20230382991Abstract: An antagonist antibody, or an antigen binding fragment thereof, binds both to human and macaque LILRB1 and/or LILRB2, and has diagnostic and therapeutic uses.Type: ApplicationFiled: October 12, 2021Publication date: November 30, 2023Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE PARIS SACLAY, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Benoit FAVIER, Sixtine COINDRE, Anne WIJKHUISEN, Stéphanie SIMON, Roger LE GRAND, Olivier LAMBOTTE
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Patent number: 11830718Abstract: A spectroscopy device including: an electron source arranged to emit a flux of electrons towards a sample, a pulsed photon source emitting photon pulses towards the sample, at least one spectrometer for receiving a flux of electrons originating from the sample, at least one electron detector; and at least one deflector, between the electron source and the at least one electron detector, synchronized with the pulsed photon source to allow or prevent the passage of electrons emitted by the electron source, towards the electron detector.Type: GrantFiled: March 26, 2020Date of Patent: November 28, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS-SACLAYInventors: Mathieu Kociak, Marcel Tence, Jean-Denis Blazit, Pabitra Das
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Patent number: 11820813Abstract: The present invention relates to a neutralising antibody which is capable of binding to neurotensin with high affinity. The antibody of the present invention neutralises the activity of neurotensin, in particular the oncogenic activities of neurotensin. In particular, the present invention relates to a neutralising antibody which binds to the human neurotensin long fragment, and having a heavy chain variable region which comprises a H-CDR1 region having at least 90% of identity with SEQ ID NO:2, a H-CDR2 region having at least 90% of identify with SEQ ID NO:3 and a H-CDR3 region having at least 90% of identity with SEQ ID NO:4; and a light chain variable region comprising a L-CDR1 region having at least 90% of identity with SEQ ID NO:6, a L-CDR2 having at least 90% of identity with SEQ ID NO:7 and a L-CDR3 region having at least 90% of identity with SEQ ID NO:8. The present invention also provides the use of such antibodies in the treatment of cancer.Type: GrantFiled: August 17, 2020Date of Patent: November 21, 2023Assignees: INSERM (INSITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS DESCARTESInventor: Patricia Forgez
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Patent number: 11821060Abstract: A nickel-based superalloy includes, in atomic percentages, 13% to 21% chromium, 15% to 26% cobalt, 4% to 8% aluminum, 4.5% to 8% titanium, 8% to 18% iron, boron in an atomic percentage less than or equal to 0.5% or no boron, carbon in an atomic percentage less than or equal to 1% or no carbon, at least one additional element selected from molybdenum, tungsten, tantalum and niobium, a total atomic content of the at least one additional element being less than or equal to 1.5% or no such at least one additional element, the remainder being nickel and unavoidable impurities, with a sum of the atomic percentages of aluminum and titanium being comprised between 8.5% and 15%. The novel superalloy composition has a limited density and exhibiting, when hot, good mechanical properties as well as good resistance to oxidation and corrosion.Type: GrantFiled: March 13, 2020Date of Patent: November 21, 2023Assignees: SAFRAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS EST CRETEIL VAL DE MARNEInventors: Pierre Jean Sallot, Clara Desgranges, Anne-Laure Rouffie, Jean-Philippe François Couzinie, Guy Dirras, Ivan Georges Guillot, Jean-Marc Eric Joubert, Mathilde Madeleine Louise Laurent, Loic Perriere, Thomas Philippe Joseph Rieger
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Publication number: 20230365936Abstract: The present disclosure provides methods for generating and/or purifying secretomes, extracellular vesicles, and fractions thereof, from progenitor cells; and provides compositions containing such generated secretomes, extracellular vesicles, and fractions thereof. The present disclosure further provides methods for analyzing activities, and the functionality and potency, of such secretomes, extracellular vesicles, and fractions thereof. The present disclosure also relates to the therapeutic use of secretomes, extracellular vesicles, and fractions thereof. The present disclosure further relates to a good manufacturing practices (GMP)-ready, scalable, culture protocol for the release of clinic-ready secretomes.Type: ApplicationFiled: May 17, 2023Publication date: November 16, 2023Applicants: FUJIFILM Corporation, Assistance Publique - Hôpitaux de ParisInventors: Nisa K. E. RENAULT, Michele L. Hamrick, Chad H. Koonce, Philippe Menasche, Valerie Bellamy, Camille Humbert, Guillaume Churlaud, Jerome Larghero
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Patent number: 11814685Abstract: This invention relates to a method for diagnosing and/or prognosticating HER2-dependent cancer in a subject, comprising a) measuring the amount of one or more miRNA selected from the group consisting of miRNA 429-3p, miRNA 29c-3p, miRNA 29a-3p, miRNA 29b-3p, miRNA 200a-3p, miRNA 200b-3p, miRNA 200c-3p, miRNA 141-3p, miRNA 15a-5p, miRNA 15b-5p, miRNA 16-5p, miRNA 424-5p, miRNA 497-5p, miRNA 615-3p, miRNA 451a-3p and miRNA 542-5p in a sample from the subject; b) comparing the amount of one or more miRNA measured in step a) to a reference value; c) finding a deviation or no deviation of the amount of one or more miRNA measured in step a) from the reference value; and d) attributing said finding of deviation or no deviation to a particular diagnosis and/or prognosis of HER2-dependent cancer in the subject.Type: GrantFiled: October 24, 2018Date of Patent: November 14, 2023Assignees: UNIVERSITÉ PARIS CITÉ, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)Inventors: Sandrine Bourdoulous, Anaïs Domingot, Camille Faure
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Publication number: 20230355902Abstract: A respiratory treatment apparatus configured to provide a flow of breathable gas to a patient, including a breathable air outlet, an outside air inlet, and an pneumatic block module, wherein the pneumatic block module includes: a volute assembly including an inlet air passage, a mount for a blower and an outlet air passage; the blower being mounted in the mount such that an impeller of the blower is in a flow passage connecting the inlet air passage and the outlet air passage; a casing enclosing the volute assembly, wherein air passages within the casing connect air ports on the volute assembly, wherein the inlet air passage of the volute assembly is in fluid communication with the outside air inlet and the outlet air passage of the volute assembly is in fluid communication with the air outlet.Type: ApplicationFiled: July 11, 2023Publication date: November 9, 2023Applicant: ResMed Paris SASInventors: Kenneth Taylor, Simon Robert Cork, Jonathan Huw Thomas, Eva Ng, Benjamin John Leavens, Enrico Brambilla, Frank Van Regteren, Philippe Auguste Chalvignac, Zdzislaw Antoni Ziolkowski, Arthur Kin-Wai Yee, Geoff Crumblin, David Creusot
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Patent number: 11808627Abstract: A photoconductive switch for generating or detecting terahertz radiation (TR) is provided. The photoconductive switch may comprise at least a first and a second pair of electrodes (EV, EH, EGR) on a surface (SS) of a photoconductive substrate, wherein the electrodes of the first pair are separated by a first gap comprising at least a plurality of first rectilinear sections (GV) extending along a first direction (x) and the electrodes of the second pairs are separated by a second gap comprising at least a plurality of second sections (GH) extending along a second direction (y), different from the first direction. The photoconductive switch may further comprise a patterned opaque layer (PML) selectively masking portions of the gaps between the electrodes. Methods and devices for generating and detecting terahertz radiation comprising such photoconductive switches are also provided.Type: GrantFiled: March 28, 2019Date of Patent: November 7, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, ECOLE NORMALE SUPERIEURE DE PARIS, UNIVERSITÉ PARIS CITÉInventors: Kenneth Maussang, Sukhdeep Dhillon, Jerome Tignon
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Patent number: 11797786Abstract: A system for detecting receivers including at least one receiver, a container having a volume for containing the receiver, an antenna suitable for emitting a primary wave in the volume and for receiving a secondary wave emitted by the receiver in the volume in response to reception of the primary wave, and a controller suitable for controlling the emission of the primary wave and for detecting the receiver via the received secondary wave. The system further includes adjustable elements controlled by a control wave, attached to the container and having an impedance that can be modified. Each adjustable element includes a device for recovering energy from the primary wave and/or from the control wave in order to power itself, and a device for receiving the control wave which decodes an adjustment parameter so that the adjustable element controls its impedance.Type: GrantFiled: February 11, 2020Date of Patent: October 24, 2023Assignees: GREENERWAVE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARISInventor: Geoffroy Lerosey
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Publication number: 20230330440Abstract: Devices and methods for reversibly stimulating neuronal cells in a subject. The devices include a module for generating ultrasounds at 4 MHz or more to stimulate neuronal cells expressing mechanosensitive channels with the ultrasounds. The methods include expressing mechanosensitive channels into neuronal cells and exposing the cells to ultrasounds at 4 MHz or more. Also, the use of the methods or devices for visual restoration in a subject.Type: ApplicationFiled: September 9, 2021Publication date: October 19, 2023Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventors: Serge PICAUD, Sara CADONI, José-Alain SAHEL, Mickaël TANTER, Charlie DEMENE
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Publication number: 20230321059Abstract: The present invention relates to a compound selected from mepyramine, prodrugs thereof and pharmaceutically acceptable salts thereof, or a composition comprising such a compound, for use in the topical treatment and prevention of neuropathic pain.Type: ApplicationFiled: September 10, 2021Publication date: October 12, 2023Applicants: Assistance Publique - Hopitaux de Paris, Centre National de la Recherche ScientifiqueInventors: Céline Greco, Patrick Delmas
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Patent number: 11784732Abstract: A wave shaping device which comprises a tunable impedance surface and a controller connected to the surface in order to control its impedance. The shaping device further comprises a transmission module for receiving a pilot signal used to control the impedance of the surface.Type: GrantFiled: January 10, 2022Date of Patent: October 10, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITÉ PARIS CITÉInventors: Mathias Fink, Geoffroy Lerosey, Matthieu Dupre, Nadége Kaina
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Patent number: 11783473Abstract: The invention relates to a method for characterizing, from a volume image, a fibrous structure having a three-dimensional weaving between a plurality of warp yarns extending along a first direction and a plurality of weft yarns extending along a second direction perpendicular to the first one, the method comprising: a first processing of the volume image by filtering along a third direction perpendicular to the first and second directions so as to attenuate the periodic patterns along the third direction, obtaining a two-dimensional image corresponding to an intermediate plane along the third direction of the filtered volume image, a second processing of the two-dimensional image by filtering along the first or second direction so as to attenuate the periodic patterns, obtaining a one-dimensional profile representing the positions of warp or weft columns and corresponding to an intermediate line along the first or second direction.Type: GrantFiled: August 3, 2021Date of Patent: October 10, 2023Assignees: SAFRAN AIRCRAFT ENGINES, SAFRAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQU, ECOLE NORMALE SUPERIEURE PARIS-SACLAYEInventors: Julien Paul Schneider-Die-Gross, Intisar Belhaj Saad, Arturo Mendoza Quispe, Estelle Marie Laure Parra, Stéphane Roux
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Patent number: 11771925Abstract: An implantable ultrasound generating treating device (12) to induce spinal cord or spinal nerves treatment, suitable for implantation in the spinal canal and comprises an elongate support member (22, 32) and an array of several treatment transducers (20) distributed along the elongate support member. The several treatment transducers (20) comprise radial transducers emitting an ultrasound treatment beam oriented radially, wherein the treatment transducers (20) have a resonant frequency comprised between 0.5 and 4 MHz. The device has articulating portions so that the implantable device can adapt its shape to a curved elongation path. Also disclosed is an apparatus including the implantable ultrasound generating treating device and methods comprising inserting the implantable ultrasound generating treating device (12) inside the spinal canal of the spine of the patient.Type: GrantFiled: July 18, 2022Date of Patent: October 3, 2023Assignees: SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE—HÔPITAUX DE PARISInventor: Alexandre Carpentier
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Patent number: 11776526Abstract: Method and system for ultrasonic characterization of a medium Method for ultrasonic characterization of a medium, comprising generating a series of incident ultrasonic waves, generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, determining a focused reflection matrix RFoc(rin, rout, at) of the medium between an input virtual transducer (Win) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay 6t relative to a time instant of the responses of the input virtual transducer (TVin).Type: GrantFiled: September 13, 2021Date of Patent: October 3, 2023Assignees: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de ParisInventors: William Lambert, Thomas Frappart, Alexandre Aubry, Mathias Fink
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Publication number: 20230304065Abstract: The present invention relates to a method for screening compounds for bactericidal activity using thermostable luciferase and based on a real-time bioluminescence measurement. The present invention further relates to a method for determining the sensitivity of a bacterial sample originating from a subject suffering from a bacterial infection to a group of known antibiotics and to a method for assessing the minimum inhibitory concentration (MIC) of a bactericidal compound.Type: ApplicationFiled: August 2, 2021Publication date: September 28, 2023Applicants: Centre National de la Recherche Scientifique (CNRS), Universite Paris-SaclayInventors: Dominique FOURMY, Satoko YOSHIZAWA, Marie EBEYER-MASOTTA, Jean-Luc PERNODET
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Patent number: 11768181Abstract: Method for ultrasonic characterization of a medium, comprising generating a series of incident ultrasonic waves, generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, and determining a focused reflection matrix RFoc(rin, rout, ?t) of the medium between an input virtual transducer (TVin) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay ?t relative to a time instant of the responses of the input virtual transducer (TVin).Type: GrantFiled: September 13, 2021Date of Patent: September 26, 2023Assignees: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de ParisInventors: William Lambert, Alexandre Aubry, Mathias Fink, Thomas Frappart
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Publication number: 20230293586Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.Type: ApplicationFiled: April 6, 2023Publication date: September 21, 2023Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université Paris Cité, Institut National de la Santé et de la Recherche Médicale (INSERM)Inventors: Isabelle ANDRÉ, Marina CAVAZZANA, Kuiying MA, John TCHEN, Tayebeh-Shabi SOHEILI, Ranjita Devi MOIRANGTHEM
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Publication number: 20230294075Abstract: Process for the preparation of a TiO2 photocatalyst/biomass carrier, with TiO2/MxOy nanocrystals, of at least nanometric size and photocatalysis-active at least in visible light, consisting of the following steps: a) preparation and heating of an aqueous solution of hydrochloric acid with a given pH, between 0 and 6, and at a temperature between 20° C. and 60° C.Type: ApplicationFiled: June 30, 2021Publication date: September 21, 2023Applicants: CY CERGY PARIS UNIVERSITÉ, ECOLE NATIONALE SUPERIEURE DE TECHNIQUES AVANCEES, COMMISSARIAT A L' ENERGIE ATOMIQUE AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Nicolas PASTERNAK, Nancy LINDER, Laura-Line RISAL, Johnny DESCHAMPS
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Patent number: 11761928Abstract: Method for ultrasonic characterization of a medium, comprising generating a series of incident ultrasonic waves, generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, and determining a focused reflection matrix RFoc(rin, rout, ?t) of the medium between an input virtual transducer (TVin) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay ?t relative to a time instant of the responses of the input virtual transducer (TVin).Type: GrantFiled: September 13, 2021Date of Patent: September 19, 2023Assignees: Supersonic Imagine, Centre National de la Recherche Scientifique—CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de ParisInventors: William Lambert, Alexandre Aubry, Thomas Frappart, Flavien Bureau, Mathias Fink