Abstract: An in vitro assay for inducing extracellular trap (ET) formation, including contacting immune cells, in in vitro culture or within a biological sample, with immobilized human polyvalent immunoglobulins; and to uses thereof, in particular in an in vitro method for screening a drug for its ability to modulate ET formation, in an in vitro method for assessing the susceptibility of a subject to ET formation, in an in vitro method for predicting the response of a subject to a modulator of ET formation, and in in vitro method for monitoring the response of a subject to an immunomodulator.

Abstract: The present invention relates to compounds of formula (I); for use as peripheral NMDA receptor antagonists.

Abstract: A method for manufacturing a superconducting LC-type resonator of the type including at least one high-resistivity substrate on which are printed an inductive meander, a first so-called lower electrode and a second so-called upper electrode arranged opposite the first so as to form together a capacitor connected in parallel with the inductive meander, as well as inductive coupling means dedicated to the resonator, in which a sacrificial aluminium layer is deposited between the first and second electrodes. Also disclosed is the superconducting LC-type resonator thus obtained and the use of such a resonator for detecting the noise of a millimetre photon.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of obesity. In particular, the present invention relates to a method of treating obesity in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an indoleamine 2-3 dioxygenase (IDO) inhibitor.

Abstract: The use of recombinant AAV vectors expressing a molecule of interest in a method for treating diseases or conditions affecting the nervous system in a subject in need thereof, or in a method for increasing or inducing expression of the molecule of interest in the nervous system of a subject.

Abstract: An apparatus having an implantable ultrasound generating treating device to induce brain disorder treatment, suitable for implantation in or under the skull bone of a patient, includes several ultrasound generating transducers, which are connectable by a common electrical connection circuit to a generator, and wherein the ultrasound generating transducers each have one or several operating frequencies. The transducers include the group of transducers having several transducers driven by a same electrical drive signal, and connected to the generator system by a common electrical connection circuit, where the electric drive signal serves both as power signal and as a control signal for operating selectively, within said group, at least one or the other of a first transducer or sub-group of transducers, and of a second transducer or sub-group of transducers. The apparatus is also used to treat brain disorders.

Abstract: A device for supplying an ultrasonic transducer including a power interface configured to provide an analog power signal, called supply signal, to the ultrasonic transducer, and further including a delta-sigma modulator configured to produce a delta-sigma modulator of a sinusoidal signal, called drive signal, and provide a digital signal, called control signal, to control said power interface. Also an ultrasonic device powered by such a supply device, an ultrasonic head including such ultrasonic devices and an ultrasonic system including such an ultrasonic head.

Abstract: The present invention relates to an in vitro method of culturing a segmented filamentous bacterium strain, comprising co-culturing said segmented filamentous bacterium strain with a eukaryotic host cell, wherein the culture is performed at an O2 level inferior to 5% in a rich tissue culture liquid medium containing bacterial medium components including iron. The present invention also relates to methods for genetically modifying a segmented filamentous bacterium strain comprising a step a culturing the strain in vitro.

Abstract: The present invention concerns a thermosensitive polymeric hydrogel comprising at least one thermosensitive copolymer, one aqueous solution, and a mucoadhesive excipient, wherein said thermosensitive polymeric hydrogel further comprises at least one immunostimulatory adjuvant and/or at least one cytokine and/or at least one chemokine and/or atleast one heat shockprotein. Another object of the invention is a thermosensitive polymeric hydrogel according to the invention for use in the treatment of tumors or metastasis in a subject having a cancer, preferably a metastatic cancer.

Abstract: The present invention relates to compounds simultaneously having thermally activated delayed fluorescence (TADF), circularly polarised luminescence (CPL) and aggregation-induced emission enhancement (AIEE) properties. The invention also relates to the use of such compounds as a photocatalyst or as a dopant, in particular in the emitting layers of light-emitting diodes (OLEDs), as well as light-emitting devices or light-emitting diodes (OLEDs) comprising such compounds.

Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.

Abstract: The invention is in the field of therapy of antibody deficiencies. Inventors demonstrate for the first time in both controls and IgA-deficient patients, systemic anti-microbiota IgG responses correlate with reduced inflammation suggesting that systemic IgG responses contribute to the gut microbiota confinement. Furthermore, SIgAd-associated inflammation is inversely correlated with systemic anti-commensal IgG responses, which may thus serve as a second line of defense. Altogether, these data suggest that systemic IgG and intestinal IgA cooperate in different body compartments to limit systemic pro-inflammatory pathways. As selective IgA deficient patients harbour elevated seric anti-commensal IgG levels, these findings suggest that in selective IgA deficiency, microbiota confinement is obtained at the price of a strong inflammatory response.

Abstract: An apparatus for simulating an atonic uterine body after childbirth includes a one-piece part, which includes: a flexible body having the shape of an atonic uterine body after childbirth, the flexible body is bendable by hand so that the flexible body reproduces a haptic behavior of an atonic uterine body after childbirth; and a rigid neck extending the flexible body, the rigid neck surrounding an opening of the part, the rigid neck having a rigidity greater than a rigidity of the flexible body. The part defines an outer surface and an inner surface. The inner surface defines an inner cavity of the part, wherein the inner cavity opens out into the outer surface so as to define the opening.

Abstract: A method for the preparation of an electrode comprising a substrate made of an aluminium based material, vertically aligned carbon nanotubes and an electrically conductive polymer matrix, the method comprising the following successive steps: (a) synthesising, on a substrate made of an aluminium based material, a carpet of vertically aligned carbon nanotubes according to the technique of CVD (Chemical Vapour Deposition) at a temperature less than or equal to 650° C.; (b) electrochemically depositing the polymer matrix on the carbon nanotubes from an electrolyte solution including at least one precursor monomer of the matrix, at least one ionic liquid and at least one protic or aprotic solvent. Further disclosed is the prepared electrode and a device for storing and returning electricity such as a supercapacitor comprising the electrode.

Abstract: An aerosol generator for generating an aerosol from a fluid, comprising: a vibratable membrane having a first side for being in contact with the fluid and an opposite second side, the membrane having a plurality of through holes penetrating the membrane in an extension direction from the first side to the second side, whereby the fluid passes the through holes from the first side to the second side when the membrane is vibrated for generating the aerosol at the second side, each through hole having along its extension direction a smallest diameter, a larger diameter that is larger than the smallest diameter and defined by that diameter that is closest to triple, preferably twice said smallest diameter, each through hole having a nozzle portion defined by that continuous portion of the through hole in the extension direction comprising the smallest diameter of the through hole and bordered by the larger diameter of the through hole, wherein the ratio of the total length of each through hole in the extension di

Abstract: The invention relates to a method for characterizing, from a volume image, a fibrous structure having a three-dimensional weaving between a plurality of warp yarns extending along a first direction and a plurality of weft yarns extending along a second direction perpendicular to the first one, the method comprising: a first processing (E10) of the volume image by filtering along a third direction perpendicular to the first and second directions so as to attenuate the periodic patterns along the third direction, obtaining (E20) a two-dimensional image corresponding to an intermediate plane along the third direction of the filtered volume image, a second processing (E31, E41) of the two-dimensional image by filtering along the first or second direction so as to attenuate the periodic patterns, obtaining (E32, E33) a one-dimensional profile representing the positions of warp or weft columns and corresponding to an intermediate line along the first or second direction of the filtered two-dimensional image, and co

Abstract: The invention relates to a method of processing data representative of a person’s binocular motricity, the method comprising the following steps: stimulating the binocular motricity of a person by means of a binocular motricity stimulation device (21) configured to specifically stimulate saccades, vergences or a combination of both or of a reading test (22); physical stimuli in 3D real space seen with both eyes naturally (without artifices); acquiring the movement of the right eye (RE) and the left eye (LE) of a person (P) during said stimulation and, if applicable, a stimulation signal from the binocular motor stimulation device; the method comprising the following steps implemented in a processing unit (3); determination from the movement of the left eye (LE) and the right eye (RE), of an effective trajectory (Tr1) of the eyes in response to each stimulation, an effective trajectory corresponding to a saccade and/or a vergence movement of the eyes.