Abstract: In some examples, a method for determining weldable and unweldable portions of a seam comprises receiving a representation of a part including the seam. The method also includes discretizing a representation of the seam into a plurality of waypoints. The method also includes evaluating each waypoint from the plurality of waypoints for feasibility of welding. The method further includes generating a weld path through at least a subset of the plurality of waypoints in accordance with the feasibility of welding.

Abstract: Provided herein are improved delivery systems for oligonucleotides. The delivery systems comprise a liposome that comprises neutral phospholipids and an oligonucleotide that contains both P-ethoxy and phosphodiester backbone linkages, and which targets a BCL2-encoding polynucleotide. Methods of treating patients having cancer with the delivery systems are also provided.

Abstract: Systems and methods for real time feedback and for updating welding instructions for a welding robot in real time is described herein. The data of a workspace that includes a part to be welded can be received via at least one sensor. This data can be transformed into a point cloud data representing a three-dimensional surface of the part. A desired state indicative of a desired position of at least a portion of the welding robot with respect to the part can be identified. An estimated state indicative of an estimated position of at least the portion of the welding robot with respect to the part can be compared to the desired state. The welding instructions can be updated based on the comparison.

Abstract: In some examples, an autonomous robotic welding system comprises a workspace including a part having a seam, a sensor configured to capture multiple images within the workspace, a robot configured to lay weld along the seam, and a controller. The controller is configured to identify the seam on the part in the workspace based on the multiple images, plan a path for the robot to follow when welding the seam, the path including multiple different configurations of the robot, and instruct the robot to weld the seam according to the planned path.

Abstract: Systems and methods for real time feedback and for updating welding instructions for a welding robot in real time is described herein. The data of a workspace that includes a part to be welded can be received via at least one sensor. This data can be transformed into a point cloud data representing a three-dimensional surface of the part. A desired state indicative of a desired position of at least a portion of the welding robot with respect to the part can be identified. An estimated state indicative of an estimated position of at least the portion of the welding robot with respect to the part can be compared to the desired state. The welding instructions can be updated based on the comparison.

Abstract: A universal card reader and mobile device holder may be configured to house a card reader and to selectively secure a mobile device such as a smart phone adjacent to the card reader. Accordingly, the universal card reader and mobile device holder can enable a user to easily interact with the card reader and the mobile device as part of a mobile point-of-sale system.

Abstract: Provided herein are therapeutic oligonucleotides that comprise at least one p-ethoxy backbone linkage but no more than 80% p-ethoxy backbone linkages. Provided herein are improved delivery systems for therapeutic oligonucleotides comprising a liposome that comprises neutral phospholipids and a p-ethoxy oligonucleotide that is entrapped in the liposome.

Abstract: A method of making a heated nitrogenized coffee product and using a process that avoids the negative attributes associated with traditional methods.

Abstract: A device for the capture and adsorption of blood-borne materials of interest comprising a fluidic cartridge with at least one inlet and at least one outlet; a multidirectional fluidic channel between the at least one inlet and the at least one outlet; said multidirectional fluidic channel comprising at least one inner wall; and a substance coating at least a portion of the at least one inner wall of the multidirectional fluidic channel.

Abstract: In some examples, an autonomous robotic welding system comprises a workspace including a part having a seam, a sensor configured to capture multiple images within the workspace, a robot configured to lay weld along the seam, and a controller. The controller is configured to identify the seam on the part in the workspace based on the multiple images, plan a path for the robot to follow when welding the seam, the path including multiple different configurations of the robot, and instruct the robot to weld the seam according to the planned path.

Abstract: A method of manufacture for an improved composition for melt-bonding road marking compound is disclosed. Comprising preparing a PET component from pulverized plastic. Combining the PET component, a pigment component, a filler component, a silica component and a binder component to form a road marking compound. Melting the road marking compound form the melt-bonding road marking compound. Selecting an amount of the PET component to maximize PET in the melt-bonding road marking compound while ensuring the melt-bonding road marking compound remains liquid for application to a road surface.

Abstract: Systems and methods to cut a closing loop to deploy a parachute. The system includes a cutter with a body with a cutter opening that extends through the body and a blade that is movable across the cutter opening. Processing circuitry is configured to signal the cutter to move the blade across the cutter opening. A mount includes a base, a retainer with a channel sized to receive the cutter, and a mount opening that extends through the mount and across the channel. The cutter is configured to fit within the channel with the cutter opening aligned with the mount opening to form a through-opening such that the closing loop extends through the cutter and the mount.

Abstract: Provided herein are methods of treating a cancer in a patient comprising administration of an effective amount of a nuclease-resistant polynucleotide that hybridizes to the translation initiation site of a Grb2 nucleic acid in the patient and either a Bcr-Abl tyrosine kinase inhibitor (e.g., dasatinib) or a cytidine analogue (e.g., decitabine or cytarabine). The cancer may be Ph+ and/or Bcr-Abl positive chronic myelogenous leukemia or acute myeloid leukemia or myelodysplastic syndrome.

Abstract: Presented herein are systems, methods, and apparatus that analyze molecular imprints for detecting cancerous cells. Embodiments of the present disclosure include systems, methods, and apparatus that analyze metabolic imprints of cells for cancer detection. In certain embodiments, the methods/systems comprise extracting thermal and thermodynamic quantities and properties from the molecular imprints. The thermal/thermodynamic quantities and/or further-processed quantities can be mapped on a universal cancer diagnostic scale for disease stratification, thereby providing/determining a normality status of the subject cells.

Abstract: In various examples, a computer-implemented method of generating instructions for a welding robot. The computer-implemented method comprises identifying an expected position of a candidate seam on a part to be welded based on a Computer Aided Design (CAD) model of the part, scanning a workspace containing the part to produce a representation of the part, identifying the candidate seam on the part based on the representation of the part and the expected position of the candidate seam, determining an actual position of the candidate seam, and generating welding instructions for the welding robot based at least in part on the actual position of the candidate seam.

Abstract: Systems and methods for real time feedback and for updating welding instructions for a welding robot in real time is described herein. The data of a workspace that includes a part to be welded can be received via at least one sensor. This data can be transformed into a point cloud data representing a three-dimensional surface of the part. A desired state indicative of a desired position of at least a portion of the welding robot with respect to the part can be identified. An estimated state indicative of an estimated position of at least the portion of the welding robot with respect to the part can be compared to the desired state. The welding instructions can be updated based on the comparison.

Abstract: Some embodiments described herein relate to optical systems and methods for determining the shape and/or size of objects that include projecting a pattern of light onto the object. The pattern of light can be configured such that first-order reflections can be distinguished from second- and/or higher-order reflections, which can be rejected. Thus, even in instances in which the pattern of light is reflected onto the object multiple times, the original, or first-order, reflection can be detected, distinguished, and/or used for laser triangulation. In some embodiments, a pattern of light that does not have reflection and/or rotational symmetry is projected onto the object, such that second-order and/or higher-order reflections can be distinguished from the first-order reflection.

Abstract: This disclosure provides systems, methods, and apparatuses, including computer programs encoded on computer storage media, that provide for optical techniques for manufacturing robots, such as for filtering certain reflections when scanning an object. For example, the techniques may include receiving, from a detector, sensor data based on detected light, the detected light including reflections of light projected by one or more emitters and reflected off of an object. The techniques may further include determining, based on the sensor data, a first-order reflection and a second-order reflection. The techniques may also include determining, based on the first-order reflection and a second-order reflection, a difference, the difference includes a polarity difference, an intensity difference, or a combination thereof. The techniques may include filtering the second-order reflection based on the difference Other aspects and features are also claimed and described.