Abstract: Vegetation cutting apparatuses may include a wheeled apparatus frame. A cutting assembly may be carried by the wheeled apparatus frame. The cutting assembly may include an elongated chain support member having a chain support member edge. An elongated debris removal slot may extend into the chain support member from the chain support member edge. A cutting chain may be configured to traverse the chain support member edge of the chain support member. An engine may drivingly engage the cutting chain.

Abstract: A training aid for use in developing putting mechanics is disclosed. The aid comprises a base that is placed on a practice putting surface. The base includes a guide rail shaped to describe two superimposed arcs that define the optimal 3-dimensional path for a putting stroke. The training aid includes a practice putter that has a notch in the base of the putter head that fits over the guide rail. The notch causes the putter head follow the path defined by the guide rail. Deviation from the optimal path results in friction between the notch and guide rail, which in turn provides tactile feedback to the user that they are off the optimal path. The device also includes features that allow for optimal placement of the golf ball relative to the intended line of the putt and marking to assist in gauging the distance the golf ball will travel.

Abstract: Provided herein, in some embodiments, are methods and composition for controlling Mycobacterium avium subspecies paratuberculosis (MAP) infection and contamination.

Abstract: In some aspects, the described systems and methods provide for a method for predicting tissue characteristics for a pathology image. A statistical model trained on multiple annotated pathology images is used. Each of the training pathology images includes an annotation describing tissue characteristics for one or more portions of the image. The method includes accessing a pathology image for predicting tissue characteristics. A trained statistical model is retrieved from a storage device. A set of patches is defined from the pathology image. Each of the patches in the set includes a subset of pixels from the corresponding pathology image. The set of patches is processed using the trained statistical model to predict respective annotations for each patch in the set. The predicted annotations are stored on the storage device.

Abstract: A device to orient a riser of a parachute. The device can include a twist body that is includes a slot through which the riser passes. The slot includes a twist to change the orientation of the riser from a relatively high-profile orientation to a relatively low-profile orientation. The device can also include a link to connect the riser to the suspension lines on the canopy.

Abstract: Provided herein are improved delivery systems for oligonucleotides, said delivery system comprising a liposome that comprises neutral phospholipids and a P-ethoxy oligonucleotide, which targets a STAT3-encoding polynucleotide. Methods of treating patients with said delivery systems are also provided.

Abstract: The present application provides a novel drug screening platform designed to identify drugs that favorably modulate cellular bioenergetics in the human brain of a zebrafish which has been modified by altering a teleost gene that corresponds to a human gene associated with a brain dysfunction disorder (such as epilepsy). The drug screening platform are also useful for determining a mutation in a human gene associated with a brain dysfunction disorder that is associated with a human individual responsive to the treatment of a compound. Also provided are modified teleosts useful for the methods described herein.

Abstract: A device to orient a riser of a parachute. The device can include a twist body that is includes a slot through which the riser passes. The slot includes a twist to change the orientation of the riser from a relatively high-profile orientation to a relatively low-profile orientation. The device can also include a link to connect the riser to the suspension lines on the canopy.

Abstract: A system and method of capturing and rendering stereoscopic panoramic content is provided. The system may capture information from a virtual scene to generate a stereoscopic panorama in the form of a stereoscopic cube map. Using the pre-captured cube map, the system may render stereoscopic images during gameplay, image viewing, and/or playback of a three dimensional video. The system may capture camera distance information during capture for use in distortion reduction during image rendering and playback. The system may implement additional distortion reduction measures. Further, the system may use the capture camera distance information to write to depth buffers corresponding to rendered images for use when introducing dynamic gameplay elements into the scene. Additionally, the system may use realistic camera models to simulate human anatomy and reduce distortions associated with simplistic camera models.

Abstract: Provided herein are methods of treating a cancer in a patient comprising administration of an effective amount of a nuclease-resistant polynucleotide that hybridizes to the translation initiation site of a Grb2 nucleic acid in the patient and either a Bcr-Abl tyrosine kinase inhibitor (e.g., dasatinib) or a cytidine analogue (e.g., decitabine or cytarabine). The cancer may be Ph+ and/or Bcr-Abl positive chronic myelogenous leukemia or acute myeloid leukemia or myelodysplastic syndrome.

Abstract: Provided herein are therapeutic oligonucleotides that comprise at least one p-ethoxy backbone linkage but no more than 80% p-ethoxy backbone linkages. Provided herein are improved delivery systems for therapeutic oligonucleotides comprising a liposome that comprises neutral phospholipids and a p-ethoxy oligonucleotide that is entrapped in the liposome.

Abstract: Disclosed is a microneedling device and a method for the microneedling of human or animal tissue. The method comprises the following steps; (a) providing a microneedling device having an electrically conductive microneedle and an electrically conducting nosepiece assembly spaced apart from the electrically conductive microneedle and acting as a counter electrode; (b) placing the electrically conductive microneedle and nosepiece assembly into contact with the tissue to be microneedled; (c) measuring the electrical impedance between the microneedle tip and the nosepiece or the current through the microneedle motor; (d) commencing insertion of the microneedle and moving the microneedle toward the tissue surface; (e) starting a step counter when the impedance reduces or the microneedle motor current increases; (f) incrementing the step counter with every step of the vertical drive motor until the step count reaches the prespecified value thereby controlling the depth of the hole microneedled.

Abstract: Methods are disclosed for educating a patient about a medical condition. A healthcare provider (HCP) may collect information about a medical condition of the patient and may transmit the information to a server. The HCP may also take one or more specimens, such as hard or soft tissue, and send them to a medical laboratory. The medical laboratory may retrieve the information from the server, create a medical report based on the information and the one or more specimens, and transmit the medical report to the server. The HCP may retrieve the medical report from the server and deliver it to the patient. Based on the medical report, the HCP or the medical laboratory may recommend one or more educational videos for the patient to view which may educate the patient on the medical condition.

Abstract: The invention is directed to a method of generating and measuring transiently evoked otoacoustic emissions (TEOAE) acoustic signals generated in the cochlea using a scheme of stimulating both inner ears simultaneously, left ear alone, and right ears alone with at least two different first and second averaging buffers per ear in a switching scheme with automated detection of contralateral suppression of TEOAE via statistical analysis of the differences of suppressed and unsuppressed responses.

Abstract: Some embodiments described herein relate to optical systems and methods for determining the shape and/or size of objects that include projecting a pattern of light onto the object. The pattern of light can be configured such that first-order reflections can be distinguished from second- and/or higher-order reflections, which can be rejected. Thus, even in instances in which the pattern of light is reflected onto the object multiple times, the original, or first-order, reflection can be detected, distinguished, and/or used for laser triangulation. In some embodiments, a pattern of light that does not have reflection and/or rotational symmetry is projected onto the object, such that second-order and/or higher-order reflections can be distinguished from the first-order reflection.

Abstract: An equipment mounting assembly, such as a skid plate, for mounting and supporting motion picture production and other similar equipment without fasteners. The equipment mounting assembly can comprise a fixture mount having a mounting terminus defining a coupling interface; a mount support base having an upper surface; and a retention system operable to selectively and releasably secure the fixture mount about the mount support base. The retention system can comprise a position keep system, such that the fixture mount can be movable about the mount support base once secured within the retention system.

Abstract: Systems and methods to provide a response to advertising determine and/or obtain a commercial good that is related to an advertisement presented to a user, and further determine and/or obtain a commercial source for that commercial good. Information regarding the particular commercial good and/or the corresponding commercial source is presented to the user, for example using a graphical user interface. The user may subsequently be able to buy the commercial good from the commercial source.

Abstract: Provided herein are therapeutic oligonucleotides that comprise at least one p-ethoxy backbone linkage but no more than 80% p-ethoxy backbone linkages. Provided herein are improved delivery systems for therapeutic oligonucleotides comprising a liposome that comprises neutral phospholipids and a p-ethoxy oligonucleotide that is entrapped in the liposome.

Abstract: Provided herein are methods of treating cancer or an autoimmune disease comprising administering a liposome that comprises neutral phospholipids and a P-ethoxy oligonucleotide that targets a IGF-1R-encoding polynucleotide.