Patents Assigned to Paul Scherrer Institut
  • Publication number: 20190240360
    Abstract: A gastrin analogue shows high uptake in CCK-2 receptor positive tumors and simultaneously a very low accumulation in the kidneys. This is achieved by a mini-gastrin analogue PP-F11 having the formula: PP-F11-X-DGlu-DGlu-DGlu-DGlu-DGlu-DGlu-Ala-Tyr-Gly-Trp-Y-Asp-Phe-NH2, wherein Y is an amino acid replacing methionine and X is a chemical group attached to the peptide for diagnostic and/or therapeutic intervention at CCK-2 receptor relevant diseases. Very suitable compounds with respect to a high tumor to kidney ratio are mini-gastrin analogues with six D-glutamic acids or six glutamines. These compounds still possess a methionine which can be oxidized easily which is a disadvantage for clinical application under GMP due to the forms which may occur. The elimination of the methionine leads to a lower affinity to oxidation which in general favors the tumor-kidney-ratio. Ideally, the methionine is replaced by norleucine.
    Type: Application
    Filed: October 11, 2018
    Publication date: August 8, 2019
    Applicant: Paul Scherrer Institut
    Inventors: Martin Behe, Roger SCHIBLI
  • Patent number: 10357578
    Abstract: The radionuclide 43Sc is produced at commercially significant yields and at specific activities and radionuclidic purities which are suitable for use in radiodiagnostic agents including imaging agents. In a method, a solid target having an isotopically enriched target layer prepared on an inert substrate is positioned in a specially configured target holder and irradiated with a charged-particle beam of protons or deuterons. The beam is generated using an accelerator such as a biomedical cyclotron at energies ranging from 3 to about 22 MeV. The method includes the use of three different nuclear reactions: a) irradiation of enriched 43Ca targets with protons to generate the radionuclide 43Scin the nuclear reaction 43Ca (p,n)43Sc, b) irradiation of enriched 42Ca targets with deuterons to generate the radionuclide 43Sc in the nuclear reaction 42Ca(d,n)43Sc, and c) irradiation of enriched 46Ti targets with protons to generate the radionuclide 43Sc in the nuclear reaction 46Ti (p,a)43Sc.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: July 23, 2019
    Assignee: Paul Scherrer Institut
    Inventors: Andreas Tuerler, Nicholas Van Der Meulen, Maruta Bunka
  • Patent number: 10356342
    Abstract: An X ray detector with single photon measurement capabilities includes a layer of photosensitive material and an N×M array of photo-detector diodes in the layer of photosensitive material. The photo-detector diodes have a bias potential interface and a diode output interface. An N×M array of high gain, low noise readout unit cells are assigned to the photo-detector diodes. Each readout unit cell has an input interface connecting the diode output interface to a high-gain charge-to-voltage amplifier with integration capacitors. The high-gain charge-to-voltage amplifier can switch between different gains. A comparator and a digital block monitors the charge of the integration capacitance and switches the gain depending from the monitored charge of the integration capacitance. The pixel detector provides the possibility of in pixel intermediate evaluation of an automatic gain switching circuit state to increase the dynamic range of the detector in case of quasi continuous incoming particle flux.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: July 16, 2019
    Assignee: Paul Scherrer Institut
    Inventors: Dominic Greiffenberg, Aldo Mozzanica, Xintian Shi, Bernd Schmitt
  • Publication number: 20190184201
    Abstract: A system for particle beam therapy has an adjustable gantry for beam delivery to a patient site. The gantry has a beam coupling section, a first beam bending section with beam deflection and/or focusing magnets. A beam transport section receiving the particle beam from the first beam bending section and guiding the particle beam to a second beam bending section. The beam exits at a window of a beam nozzle. A patient table/chair is rotatable in the horizontal plane or in a plane being parallel to the horizontal plane and optionally being adjustable vertically. The gantry is supported by a tilting mechanism allowing the gantry to be tilted vertically by an angle ?1?[?90°; +90°]. A rotation mechanism is disposed in a way that the second beam bending section and the beam nozzle are rotatable by an angle ?2?[?180°; +180°] around a direction given by the angle ?1.
    Type: Application
    Filed: June 20, 2017
    Publication date: June 20, 2019
    Applicant: Paul Scherrer Institut
    Inventors: JACOBUS MAARTEN SCHIPPERS, ALEXANDER GERBERSHAGEN
  • Patent number: 10319576
    Abstract: A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel. A laser beam (41) enters the sample chamber (21) through a lateral window (16) and impinges on a surface (24) of a sample (23) to ablate material from the sample. The sample may be positioned in such a distance from the flow channel that the laser-generated aerosol mass distribution has its center within the flow channel. This leads to short aerosol washout times. The laser ablation cell is particularly well suited for aerosol generation in inductively coupled plasma mass spectrometry (ICPMS), including imaging applications.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: June 11, 2019
    Assignees: ETH ZÜRICH, PAUL SCHERRER INSTITUT
    Inventors: Detlef Günther, Daniel Grolimund, Hao Wang
  • Patent number: 10201066
    Abstract: A compact light source based on electron beam accelerator technology includes a storage ring, a booster ring, a linear accelerator and an undulator for providing light having the characteristics for actinic mask inspection at 13.5 nm. The booster ring and the storage ring are located at different levels in a concentric top view arrangement in order to keep the required floor space small and to reduce interference effects. Quasi-continuous injection by enhanced top-up injection leads to high intensity stability and combats lifetime reductions due to elastic beam gas scattering and Touschek scattering. Injection into the storage ring and extraction from the booster ring are performed diagonal in the plane which is defined by the parallel straight section orbits of the booster ring and the storage ring. For the top-up injection from the booster ring into the storage ring two antisymmetrically arranged Lambertson septa are used.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: February 5, 2019
    Assignee: Paul Scherrer Institut
    Inventors: Yasin Ekinci, Leonid Rivkin, Albin Wrulich, Andreas Streun
  • Patent number: 10130724
    Abstract: A gastrin analog shows high uptake in CCK-2 receptor positive tumors and simultaneously a very low accumulation in the kidneys. This is achieved by a mini-gastrin analog PP-F11 having the formula: PP-F11-X-DGlu-DGlu-DGlu-DGlu-DGlu-DGlu-Ala-Tyr-Gly-Trp-Y-Asp-Phe-NH2, wherein Y is an amino acid replacing methionine and X is a chemical group attached to the peptide for diagnostic and/or therapeutic intervention at CCK-2 receptor relevant diseases. Very suitable compounds with respect to a high tumor to kidney ratio are mini-gastrin analogs with six D-glutamic acids or six glutamines. These compounds still possess a methionine which can be oxidized easily which is a disadvantage for clinical application under GMP due to the forms which may occur. The elimination of the methionine leads to a lower affinity to oxidation which in general favors the tumor-kidney-ratio. Ideally, the methionine is replaced by norleucine.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: November 20, 2018
    Assignee: Paul Scherrer Institut
    Inventors: Martin Behe, Roger Schibli
  • Patent number: 10132799
    Abstract: Provided is a method for the functionalization of immunoglobulins through the use of transglutaminase, including methods for screening functionalized antibodies for characteristics of interest, antibody compositions comprising a plurality of functionalized antibodies, and functionalized antibodies with rodent constant regions.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: November 20, 2018
    Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUT
    Inventors: Christian Belmant, Delphine Bregeon, Patrick Dennler, Eliane Fischer, François Romagne, Roger Schibli, Laurent Gauthier
  • Patent number: 10042270
    Abstract: A reflective sample, such as a mask, is imaged in an optics system. A radiation source emits a light beam with relatively low coherence. A first focusing element focuses the beam before a mirror reflects the focused beam towards the sample at an incidence angle of between 2 and 25° A pinhole aperture plate upstream of the sample has a first aperture to focus and cut-off the beam diameter to form a more monochromatic beam. The sample is displaced by a mechanism in a direction perpendicular to the normal vector of the sample surface while it reflects the light beam. The reflected beam passes a second aperture in the pinhole aperture plate next to the first aperture on its way to a pixel detector. The second aperture limits the diameter of the reflected beam, thereby adjusting the diameter of the light beam before it reaches the pixel detector.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: August 7, 2018
    Assignee: Paul Scherrer Institut
    Inventors: Yasin Ekinci, Sangsul Lee
  • Patent number: 10036010
    Abstract: The present application relates to methods for the functionalization of antibodies using transglutaminase, in particular antibodies lacking Fc regions. Also disclosed herein are peptide tags for transglutaminase, linking reagents, functionalized antibodies, multi-specific antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: July 31, 2018
    Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUT
    Inventors: Eliane Fischer, François Romagne, Patrick Dennler
  • Patent number: 9922811
    Abstract: A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel. A laser beam (41) enters the sample chamber (21) through a lateral window (16) and impinges on a surface (24) of a sample (23) to ablate material from the sample. The sample may be positioned in such a distance from the flow channel that the laser-generated aerosol mass distribution has its center within the flow channel. This leads to short aerosol washout times. The laser ablation as cell is particularly well suited for aerosol generation in inductively coupled plasma mass spectrometry (ICPMS), including imaging applications.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: March 20, 2018
    Assignees: ETH ZURICH, PAUL SCHERRER INSTITUT
    Inventors: Detlef Gunther, Daniel Grolimund, Hao Wang
  • Patent number: 9916655
    Abstract: The latest progresses in breast imaging using differential phase contrast techniques pose the question of how to fuse multiple information sources, yielded by absorption, differential phase, and scattering signals, into a single, informative image for clinical diagnosis. It is proposed to use an image fusion scheme based on a multiple-resolution framework. The three signals are first transformed into multiple bands presenting information at different frequencies and then a two-step processing follows: (1) intra-band processing enhances the local signal-to-noise ratio using a novel noise estimation method and context modeling; and (2) inter-band processing weights each band by considering their characteristics and contributions, and suppressing the global noise level. The fused image, looking similar to a conventional mammogram but with significantly enhanced detail features, is reconstructed by inverse transform.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: March 13, 2018
    Assignee: Paul Scherrer Institut
    Inventors: Marco Stampanoni, Zhentian Wang
  • Patent number: 9915708
    Abstract: An assembly of Hall sensors provides the following: the three averaged values for the magnetic field components are assigned to the same point in space, at the center of the Hall sensor assembly. This allows for the instantaneous measurement of the full field vector. With the appropriate electrical connections of the Hall elements from opposing surfaces of each pair, undesired planar Hall effect is practically cancelled out.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: March 13, 2018
    Assignee: Paul Scherrer Institut
    Inventors: Stephane Sanfilippo, Vjeran Vrankovic, Christina Wouters
  • Patent number: 9764038
    Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: September 19, 2017
    Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUT
    Inventors: Patrick Dennler, Delphine Bregeon, Laurent Gauthier, François Romagné, Christian Belmant, Eliane Fischer, Roger Schibli
  • Patent number: 9717803
    Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: August 1, 2017
    Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUT
    Inventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Eliane Fischer, Laurent Gauthier, Francois Romagné, Roger Schibli
  • Patent number: 9700275
    Abstract: A quantitative radiographic method uses X-ray imaging. The method uses a ratio of the absorption signal and the (small-angle) scattering signal (or vice-versa) of the object as a signature for the materials. The ratio image (dubbed R image) is independent from the thickness of the object in a wide sense, and therefore can be used to discriminate materials in a radiographic approach. This can be applied to imaging systems, which can record these two signals from the underlying object (for instance, an X-ray grating interferometer). Possible applications could be in material science, non-destructive testing and medical imaging. Specifically, the method can be used to estimate a volumetric breast density. The use of the R image and the corresponding algorithm are also presented hereafter.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: July 11, 2017
    Assignee: PAUL SCHERRER INSTITUT
    Inventors: Marco Stampanoni, Zhentian Wang
  • Patent number: 9632189
    Abstract: An energy-sensitive imaging detector for fast-neutrons includes energy-selective radiator foil stacks converting neutrons into recoil protons. The foils are separated by gas-filled gaps and formed of two interconnected layers: a hydrogen-rich layer such as a polyethylene layer for neutron-to-proton conversion, and a metal foil layer, such as an aluminum layer, defining a proton energy cut-off and limiting a proton emission angle. Energetic recoil protons emerging from the radiator foil release electrons in surrounding gas in the gaps. An electric field efficiently drifts the electrons through the gaps. An electron detector with position sensitive readout, based on Micro-Pattern Gaseous Detector technologies (such as THick Gaseous Electron Multipliers—THGEM) or other measures provides electron amplification in gas. The charge detector has a dedicated imaging data-acquisition system detecting the drifted electrons thereby sensing the position of the original impinging neutrons.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: April 25, 2017
    Assignee: Paul Scherrer Institut
    Inventors: Marco Cortesi, Volker Dagendorf, Horst-Michael Prasser, Robert Zboray
  • Patent number: 9496124
    Abstract: A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel. A laser beam (41) enters the sample chamber (21) through a lateral window (16) and impinges on a surface (24) of a sample (23) to ablate material from the sample. The sample may be positioned in such a distance from the flow channel that the laser-generated aerosol mass distribution has its center within the flow channel. This leads to short aerosol washout times. The laser ablation cell is particularly well suited for aerosol generation in inductively coupled plasma mass spectrometry (ICPMS), including imaging applications.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: November 15, 2016
    Assignees: ETH ZURICH, PAUL SCHERRER INSTITUT
    Inventors: Detlef Günther, Daniel Grolimund, Hao Wang
  • Patent number: 9439615
    Abstract: A non-invasive method distinguishes between two types of micro-calcification by x-ray imaging in mammography. Two major types of micro-calcifications are found and confirmed by histopathology and they are correlated to benign and malignant breast lesions. Distinguishing between them non-invasively will significantly improve early breast cancer diagnosis. This is based on the fact that these two types of micro-calcifications show opposite absorption and small-angle scattering signals in x-ray imaging. The imaging system, which can record these two signals of the breast tissue simultaneously for instance, an x-ray grating interferometer, can be used to uniquely determine the micro-calcification type. This is expected to be used in mammography to improve early breast cancer diagnosis, increase diagnosis accuracy and decrease the biopsy rate.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: September 13, 2016
    Assignee: Paul Scherrer Institut
    Inventors: Marco Stampanoni, Zhentian Wang
  • Patent number: 9427478
    Abstract: The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: August 30, 2016
    Assignees: Innate Pharma, Paul Scherrer Institut
    Inventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Laurent Gauthier, François Romagne, Eliane Fischer, Roger Schibli