Patents Assigned to pe
  • Publication number: 20030166219
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: May 24, 2002
    Publication date: September 4, 2003
    Applicant: PE CORPORATION (NY)
    Inventors: Chunhua Yan, Jane Abu-Threideh, Wei Shao, Gennady Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Publication number: 20030165869
    Abstract: The present invention provides methods and systems for an automated method of identifying allele values from data files derived from processed fluorophore emissions detected during the observation of fluorophore labeled nucleotide probes used in analyzing polymorphic DNA are provided. These methods are used in the rapid and efficient distinguishing of targeted polymorphic DNA sites without control samples.
    Type: Application
    Filed: March 1, 2002
    Publication date: September 4, 2003
    Applicant: PE CORPORATION (NY)
    Inventors: Stephen Glanowski, Jeremy Heil, Emily S. Winn-Deen, Ivy A. McMullen
  • Publication number: 20030166215
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: May 1, 2002
    Publication date: September 4, 2003
    Applicant: PE CORPORATION (NY)
    Inventors: Chunhua Yan, Karen A. Ketchum, Valentina Difrancesco, Ellen M. Beasley
  • Publication number: 20030166185
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Application
    Filed: April 1, 2002
    Publication date: September 4, 2003
    Applicant: PE CORPORATION (NY)
    Inventors: Wei Shao, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Publication number: 20030166187
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Application
    Filed: June 6, 2002
    Publication date: September 4, 2003
    Applicant: PE CORPORATION (NY)
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Publication number: 20030166218
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: May 24, 2002
    Publication date: September 4, 2003
    Applicant: PE CORPORATION (NY)
    Inventors: Ming-Hui Wei, Karl Guegler, Karen A. Ketchum, Gennady Merkulov, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
  • Publication number: 20030166072
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Application
    Filed: May 13, 2002
    Publication date: September 4, 2003
    Applicant: PE CORPORATION (NY)
    Inventors: Jennifer Min Zhong, Chunhua Yan, Ellen M. Beasley
  • Publication number: 20030162278
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
    Type: Application
    Filed: December 18, 2001
    Publication date: August 28, 2003
    Applicant: PE CORPORATION (NY)
    Inventors: Ellen M. Beasley, Chunhua Yan, Valentina Di Francesco
  • Publication number: 20030157679
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: February 8, 2002
    Publication date: August 21, 2003
    Applicant: PE CORPORATION (NY)
    Inventors: Chunhua Yan, Zhaoxi Ke
  • Publication number: 20030148470
    Abstract: Propargylethoxyamino nucleosides are disclosed having the structure 1
    Type: Application
    Filed: July 9, 2002
    Publication date: August 7, 2003
    Applicant: PE Corporation (NY)
    Inventors: Shaheer H. Khan, Steven M. Menchen, Barnett B. Rosenblum
  • Publication number: 20030143723
    Abstract: A thermal cycling device for performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray. The thermal cycling device includes a sample block assembly, an optical detection system, and a sample well tray holder configured to hold the sample well tray. The sample block assembly is adapted for movement between a first position permitting the translation of the sample well tray into alignment with sample block assembly, and a second position, upward relative to the first position, where the sample block assembly contacts the sample well tray. A method of performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray in a thermal cycling device is also provided.
    Type: Application
    Filed: January 30, 2002
    Publication date: July 31, 2003
    Applicant: PE Corporation (NY)
    Inventor: Donald R. Sandell
  • Publication number: 20030129741
    Abstract: The present invention provides, among other things, supports upon which one or more species can be adsorbed, captured, or immobilized for biochemical procedures. In various embodiments, the supports include a plurality of deformable petal-like members that provide binding sites for biochemical species. The invention provides an apparatus and method for the ready insertion of the petal-like members into respective wells of a multi-well microplate (e.g., a standard-format 96- or 384-well plate).
    Type: Application
    Filed: January 4, 2002
    Publication date: July 10, 2003
    Applicant: PE Corporation (NY)
    Inventor: Paul O. Ramstad
  • Publication number: 20030124714
    Abstract: A device for handling PCR microcards, each having an array of sample chambers closed by a transparent material on one side thereof, in relation to a PCR instrument, the device including a carrier having an apertured region with an array of holes corresponding in number and relative location with the array of sample chambers in each of the microcards, and a provision for retaining a microcard on the carrier so that the transparent material faces the apertured region with the reagent sample chambers aligned, respectively, with the holes in the apertured region, and so that the side of the microcard opposite the transparent material is unobstructed at least throughout the array of sample chambers. The device cooperates with the PCR instrument to ensure accurate positioning of the carrier and the microcard retained thereon for real time PCR processing.
    Type: Application
    Filed: November 22, 2002
    Publication date: July 3, 2003
    Applicant: PE Corporation (NY)
    Inventors: Gary L. Bordenkircher, Gary Lim, Jacob Koppel Freudenthal
  • Publication number: 20030082558
    Abstract: The invention provides methods and a kit for primer extension of PNA-DNA chimera from template nucleic acids using polymerases, nucleotide 5′-triphosphates, and primer extension reagents. Structural requirements of the chimera for primer extension include 5 to 15 contiguous PNA monomer units, 3 or more contiguous nucleotides, and a 3′ hydroxyl terminus. The chimera and/or a nucleotide is labelled with fluorescent dyes or other labels. The methods include DINA sequencing, DNA fragment analysis, reverse transcription, mini-sequencing, chromosome labelling, amplification, and single nucleotide polymorphism (SNP) detection.
    Type: Application
    Filed: October 24, 2001
    Publication date: May 1, 2003
    Applicant: PE Corporation (NY)
    Inventors: Michael Egholm, Caifu Chen
  • Publication number: 20030077734
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR peptides and methods of identifying modulators of the GPCR peptides.
    Type: Application
    Filed: July 3, 2002
    Publication date: April 24, 2003
    Applicant: PE CORPORATION (NY)
    Inventors: Jane Ye, Anibal Cravchik, Valentina Di Francesco, Ellen M. Beasley
  • Publication number: 20030077775
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Application
    Filed: October 17, 2001
    Publication date: April 24, 2003
    Applicant: PE CORPORATION (NY)
    Inventors: Chunhua Yan, Ralph Brandenberger, Istvan Ladunga, Karen A. Ketchum
  • Patent number: 6553519
    Abstract: Method and apparatus for detecting signal transfer errors in a digital logic system that might occur in a transfer medium between a source device and a destination device. The method includes sending a first diagnostic signal of one or more bits from the source device through the transfer medium to the destination device; comparing the first diagnostic signal received by the destination device with a second diagnostic signal within the destination device to determine if a signal transfer error has occurred; inverting the first diagnostic signal; sending the inverted first diagnostic signal from the source device through the transfer medium to the destination device; and comparing the inverted first diagnostic signal received by the destination device with the second diagnostic signal to determine if a signal transfer error has occurred. Two embodiments of the invention are disclosed.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: April 22, 2003
    Assignee: Alcatel Internetworking (PE), Inc.
    Inventors: Jeffrey J. Walker, Greg W. Davis, C Stuart Johnson
  • Patent number: 6553000
    Abstract: A switching device for forwarding network traffic to a desired destination on a network, such as a telephone or computer network. The switching device includes multiple ports and uses a lookup table to determine which port to forward network traffic over. The lookup table includes network addresses that are maintained in ascending or descending order. The lookup table also includes network address that differ in length. Fictitious network addresses may also be added to the lookup table to expedite searches in the lookup table. The fictitious network addresses are used in conjunction with a comparison field stored in the lookup table. The comparison field allows network addresses and collapsed network addresses (which represent groups of network addresses) to be stored within the same table. The collapsed network addresses allows for a reduction of overall lookup table size, thereby increasing the speed while reducing the cost of the switching device.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: April 22, 2003
    Assignee: Alcatel Internetworking (PE), Inc.
    Inventors: Jayasenan Sundara Ganesh, Greg W. Davis, Parmajeet Singh, Timothy Scott Michels, James E. Cathey
  • Publication number: 20030072681
    Abstract: The present invention is directed to a system for filling sample chambers with liquid. The system includes a substrate defining the sample chambers and having a fill port, and a network of passageways connecting the sample chambers to the fill port. The system also includes a substrate support to retain the substrate in a fill position and a valve module on the substrate support. The valve module has a fill port seal opening to connect with the fill port of the substrate in the fill position, and a vacuum opening for connection to a source of vacuum. The system further includes a valve body having a liquid outlet port and a vacuum port, and means for operating the valve body so that the liquid outlet port and the vacuum port are alternately in fluid communication with the fill port seal opening.
    Type: Application
    Filed: October 16, 2001
    Publication date: April 17, 2003
    Applicant: PE Corporation (NY)
    Inventors: Jacob K. Freudenthal, Donald R. Sandell
  • Publication number: 20030073108
    Abstract: Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In one embodiment of the invention, a plurality of different-sequence probe pairs are added to a target polynucleotide, where each probe pair includes two polynucleotide probe elements which are complementary in sequence to adjacent portions of a selected one of the target sequences in the target polynucleotide. In each probe pair, one of the probe elements contains a non-polynucleotide polymer chain which imparts a distinctive mobility to the associated probe pair, when the elements in the pair are ligated. The other element in the pair contains a detectable reporter label. After the probe pairs have been allowed to hybridize with the target polynucleotide, the hybridized polynucleotides are treated under conditions effective to ligate the end subunits of target-bound probe elements when their end subunits are base-paired with adjacent target bases.
    Type: Application
    Filed: June 10, 2002
    Publication date: April 17, 2003
    Applicant: PE Corporation (NY)
    Inventors: Paul David Grossman, Steven Fung, Steven Michael Menchen, Sam Lee Woo, Emily Susan Winn-Deen