Patents Assigned to pe
  • Head up display system
    Patent number: 6445506
    Abstract: A head-up display system (10) incorporates a combiner (16) which is movable to a stowed (i.e., out-of-use) position by rotation about an axis (C) in or parallel to the plane of image projection.
    Type: Grant
    Filed: January 17, 2001
    Date of Patent: September 3, 2002
    Assignee: Pilkington PE Limited
    Inventor: Lee Vernon Eccles
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Publication number: 20020119548
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: April 1, 2002
    Publication date: August 29, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Chunhua Yan, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Apparatus and method for spotting a substrate
    Patent number: 6440217
    Abstract: The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongate fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: August 27, 2002
    Assignee: PE Corporation (NY)
    Inventors: Charles S. Vann, Zbigniew Bryning
  • Isolated human phosphodiesterase proteins, nucleic acid molecules encoding human phosphodiesterase proteins, and uses thereof
    Publication number: 20020115179
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phosphodiesterase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phosphodiesterase peptides, and methods of identifying modulators of the phosphodiesterase peptides.
    Type: Application
    Filed: March 12, 2002
    Publication date: August 22, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Ming-Hui Wei, Xin Wang, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
    Publication number: 20020115186
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Application
    Filed: February 1, 2002
    Publication date: August 22, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Marion Webster, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6437110
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: August 20, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ellen M. Beasley, Wei Shao, Karen A. Ketchum, Valentina Di Francesco
  • Isolated nucleic acid molecules encoding human protease proteins, and uses thereof
    Patent number: 6436689
    Abstract: The present invention provides amino acid sequence of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identify orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: August 20, 2002
    Assignee: PE Corporation (NY)
    Inventors: Karl Guegler, Marion Webster, Chunhua Yan, Wei Shao, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Matrix storage and dispensing system
    Patent number: 6432719
    Abstract: The present invention provides a system and process providing variable access to, as well as quick and accurate dispensing of, numerous selected reagents from a mass storage arrangement. According to one embodiment, an array of reagent dispensers is supported over a movable platform assembly. The platform assembly aligns a designated receiving receptacle under a selected dispenser of the array so that a respective reagent can be dispensed therein. Advantageously, the apparatus and process can be carried out under the control of a programmed computer.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: August 13, 2002
    Assignee: PE Corporation (NY)
    Inventors: Charles S. Vann, David M. Cox
  • Binary probe and clamp composition and methods for a target hybridization detection
    Patent number: 6432642
    Abstract: Binary probe and clamp compositions conduct methods for target hybridization detection. Where the probe is a substrate for exonuclease cleavage, the composition provides quantitation and detection of PCR products, by real-time and end-point measurements. Where the probe is an amplification primer, the composition provides an improved method for labelling and detection of PCR products. Probes and clamps may be labelled with fluorescent dyes, quenchers, hybridization-stabilizing moieties, chemiluminescent dyes, and affinity ligands. Clamps may be nucleic acid analogs, such as 2-aminoethylglycine PNA.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: August 13, 2002
    Assignee: PE Corporation (NY)
    Inventors: Kenneth J. Livak, Michael Egholm, Michael W. Hunkapiller
  • Fluorescent nucleobase conjugates having anionic linkers
    Publication number: 20020102590
    Abstract: Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.
    Type: Application
    Filed: October 11, 2001
    Publication date: August 1, 2002
    Applicant: PE Corporation (NY)
    Inventors: Meng Taing, Shaheer H. Khan, Steven M. Menchen, Barnett B. Rosenblum
  • Capillary electrophoresis method and apparatus for reducing peak broadening associated with the establishment of an electtric field
    Publication number: 20020100689
    Abstract: Methods for reducing peak broadening associated with the establishment of a run field in a capillary electrophoresis process, and apparatus useful for carrying out such methods, are described. Such methods include defining a maximum ramp rate to be used during an initial electric field ramp, defining a minimum period over which the run field is established, and/or maintaining a temperature of a separation medium to within certain ranges during the initial electric field ramp. In addition, methods for determining a ramp rate effective for reducing peak broadening are disclosed.
    Type: Application
    Filed: February 13, 2002
    Publication date: August 1, 2002
    Applicant: PE Corporation (NY)
    Inventors: Ben F. Johnson, Eric S. Nordman
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6426206
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: July 30, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • PCR plate cover and maintaining device
    Patent number: 6426215
    Abstract: A cover for a PCR plate having multiple wells including a rigid sheet, and a resiliently compliable sheet cooperating with one side of the substantially rigid sheet to a press a sealing sheet against the surface of the PCR plate to maintain a seal in the wells. The cover further includes at least one retaining device attached to the rigid sheet to engage with the PCR plate and retain the substantially rigid sheet and the resiliently compliable sheet in a condition to press the sealing sheet against the surface of the PCR plate. Also disclosed is an assembly that includes a PCR plate and a cover that is designed to prevent sample loss.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: July 30, 2002
    Assignee: PE Corporation (NY)
    Inventor: Donald R. Sandell
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6423521
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: July 23, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ishwar Chandramouliswaran, Karl Guegler, Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Dual field-of-view objects system for the infrared
    Patent number: 6424460
    Abstract: A dual field-of-view objective system (40) which is inexpensive, has high transmission and is essentially achromatized and athermalized. The system (40) uses a silicon front lens A and all lens elements have positive temperature/refractive index change coefficient.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: July 23, 2002
    Assignee: Pilkington PE Limited
    Inventor: Anthony John Kirkham
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Patent number: 6420150
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: July 16, 2002
    Assignee: PE Corporation (NY)
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6416990
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: July 9, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ming-Hui Wei, Karl Guegler, Karen A. Ketchum, Gennady V. Merkulov, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
  • Apparatus and method for spotting a substrate
    Patent number: 6413586
    Abstract: The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongate fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: July 2, 2002
    Assignee: PE Corporation (NY)
    Inventors: Charles S. Vann, Zbigniew Bryning
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6413756
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: July 2, 2002
    Assignee: PE Corporation (NY)
    Inventors: Chunhua Yan, Jane Abu-Threideh, Wei Shao, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6410294
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: June 25, 2002
    Assignee: PE Corporation (NY)
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley