Patents Assigned to pe
  • ISOLATED HUMAN UDP-GLYCOSYLTRANSFERASE PROTEINS
    Publication number: 20020182692
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Application
    Filed: February 1, 2002
    Publication date: December 5, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Marion Webster, Ming-Hui Wei, Valentina Difrancesco, Ellen M. Beasley
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Publication number: 20020182681
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.
    Type: Application
    Filed: July 22, 2002
    Publication date: December 5, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Trevor Woodage, Ming-Hui Wei, Chinnappa Kodira, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
    Patent number: 6489456
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: December 3, 2002
    Assignee: PE Corporation (NY)
    Inventors: Steven I. Ladunga, Maureen E. Higgins
  • Isolated human NADPH oxidase, nucleic acid molecules encoding said proteins, and uses thereof
    Patent number: 6489149
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: December 3, 2002
    Assignee: PE Corporation (NY)
    Inventors: Wei Shao, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6489153
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: December 3, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ming-Hui Wei, Karen A. Ketchum, Ellen M. Beasley, Valentina DiFrancesco
  • Apparatus and method for spotting a substrate
    Publication number: 20020174831
    Abstract: The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongate fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.
    Type: Application
    Filed: July 30, 2002
    Publication date: November 28, 2002
    Applicant: PE Corporation (NY)
    Inventors: Zbigniew T. Bryning, Charles S. Vann
  • Methods and reagents for combined PCR amplification and hybridization probing
    Patent number: 6485903
    Abstract: An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease activity of a polymerase and the 3′→5′ extension of by a polymerase. The invention also includes methods for performing combined PCR amplification and hybridization probing, one such method including the steps of contacting a target nucleic acid sequence with PCR reagents and an oligonucleotide probe as described above, and subjecting these reagents to thermal cycling. One preferred refinement of the above method further includes the addition of a strand displacer to facilitate amplification.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: November 26, 2002
    Assignee: PE Corporation (NY)
    Inventor: Paul E. Mayrand
  • Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
    Publication number: 20020173459
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Application
    Filed: May 18, 2001
    Publication date: November 21, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Chunhua Yan, Erika A. Lindquist, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
    Patent number: 6482936
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: November 19, 2002
    Assignee: PE Corporation (NY)
    Inventors: Song Hu, Karen A. Ketchum, Fangcheng Gong, Istvan I. Ladunga, Maureen E. Higgins, Ralph Brandenberger
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6482624
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: November 19, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ming-Hui Wei, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof
    Publication number: 20020169289
    Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.
    Type: Application
    Filed: April 9, 2002
    Publication date: November 14, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Chunhua Yan, Karen A. Ketchum, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Publication number: 20020168741
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: December 6, 2001
    Publication date: November 14, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Weiniu Gan, Jane Ye, Valentina DI Francesco, Ellen M. Beasley
  • Isolated human phosphatase proteins, nucleic acid molecules encoding human phosphatase proteins, and uses thereof
    Patent number: 6479270
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phosphatase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phosphatase peptides, and methods of identifying modulators of the phosphatase peptides.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: November 12, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ming-Hui Wei, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Multiple-labelled oligonucleotides synthesized on solid-supports
    Publication number: 20020165389
    Abstract: Methods and compositions to label oligonucleotides and analogs directly on a solid-support having the structure 1
    Type: Application
    Filed: November 7, 2001
    Publication date: November 7, 2002
    Applicant: PE Corporation (NY)
    Inventors: Ravi S. Vinayak, Linda G. Lee, Khairuzzaman B. Mullah, Barnett B. Rosenblum
  • Isolated human enzyme, nucleic acid molecules encoding human enzyme, and uses thereof
    Publication number: 20020164733
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Application
    Filed: September 21, 2001
    Publication date: November 7, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Ming-Hui Wei, Chunhua Yan, Valentina DiFrancesco, Ellen M. Beasley
  • Isolated human dehydrogenases, nucleic acid molecules encoding these human dehydrogenases, and uses thereof
    Publication number: 20020160481
    Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the dehydrogenase polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the dehydrogenase polypeptides, and methods of identifying modulators of the dehydrogenase polypeptides.
    Type: Application
    Filed: April 9, 2002
    Publication date: October 31, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Fangcheng Gong, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
    Publication number: 20020155572
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
    Type: Application
    Filed: March 14, 2002
    Publication date: October 24, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Computer network switch with parallel access shared memory architecture
    Patent number: 6470021
    Abstract: A packet switch includes a multiple of bidirectional ports that are each connected by dedicated signal paths to a multiple of memory subsystems that in turn are connected to shared memory within the switch. The signal path from each port carries a fragment of a data stream between the port and each memory subsystem. The ports send and receive data stream fragments in parallel from the memory subsystems. This parallel action reduces the bandwidth required of a memory subsystem by dividing the port's data stream among the multiple memory subsystems. In storing data for forwarding to another port, each memory subsystem selects on a time division basis in parallel the data stream fragments from the same port and stores them in memory. In retrieving data from memory for a port, each memory subsystem selects on a time division basis in parallel the same port to receive the data stream fragments read from memory.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: October 22, 2002
    Assignee: Alcatel Internetworking (PE), Inc.
    Inventors: Bernard N. Daines, Greg W. Davis, Thomas J. Hammond, David K. Couch, Christopher A. Schalick
  • Apparatus and method for spotting a substrate
    Patent number: 6467700
    Abstract: The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube adapted to contain the liquid. An elongate fiber is disposed within the tube for axial movement therein between raised and lowered positions. Upon shifting or oscillating the fiber between its raised and lowered positions, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of micro-arrays having a great number of individual spots.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: October 22, 2002
    Assignee: PE Corporation (NY)
    Inventors: Charles S. Vann, Zbigniew Bryning
  • PNA-DNA chimeric probe arrays and methods of use
    Patent number: 6469151
    Abstract: The invention provides methods, kits, and compositions for ligation of PNA-DNA chimeric probes and oligonucleotides when they are hybridized adjacently to template nucleic acids using ligases and ligation reagents. Structural requirements of the chimeras for ligation include 5 to 15 contiguous PNA monomer units, 2 or more contiguous nucleotides, and a 3′ hydroxyl or 5′ hydroxyl terminus. The chimera and/or oligonucleotide may be labelled with fluorescent dyes or other labels. The methods include, for example, oligonucleotide-ligation assays (OLA) and single nucleotide polymorphism detection.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: October 22, 2002
    Assignee: PE Corporation
    Inventors: Michael Egholm, Caifu Chen