Patents Assigned to Pfizer
  • Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-Yl]-N-(2-hydroxyethyl)-4-methylbenzamide
    Patent number: 8324230
    Abstract: Crystalline forms of the p38 kinase inhibitor 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide is provided. Also provided are combinations and pharmaceutical compositions comprising the crystalline forms, and methods for the prophylaxis and/or treatment of a p38 kinase-mediated condition comprising administering to a subject a therapeutically effective amount of the crystalline forms.
    Type: Grant
    Filed: October 3, 2005
    Date of Patent: December 4, 2012
    Assignee: Pfizer Inc.
    Inventor: Jon G. Selbo
  • Monocarbams
    Patent number: 8324198
    Abstract: The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, R5, and R6 as defined herein. The invention also relates to pharmaceutical compositions and methods of treating bacterial infections using compounds of formula (I).
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: December 4, 2012
    Assignee: Pfizer Inc.
    Inventors: Steven Joseph Brickner, Mark Edward Flanagan, Manjinder Singh Lall
  • SALTS AND POLYMORPHS OF 8-FLUORO-2--1,3,4,5-TETRAHYDRO-6H-AZEPINO[5,4,3-CD]INDOL-6-ONE
    Publication number: 20120302550
    Abstract: The present invention relates to novel polymorphic forms of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a mammalian disease condition mediated by poly(ADP-ribose) polymerase activity including the disease condition such as cancer.
    Type: Application
    Filed: February 10, 2011
    Publication date: November 29, 2012
    Applicant: Pfizer Inc.
    Inventors: Patricia Ann Basford, Anthony Michael Campeta, Adam Gillmore, Matthew Cameron Jones, Eleftherios Kougoulos, Suman Luthra, Robert Walton
  • IMIDAZOPYRIDINONES
    Publication number: 20120302598
    Abstract: The invention relates to imidazopyridinones, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. By activating TLRs, it should be possible to induce or stimulate immune cells to mount an immune response. In particular, the TLR7 has been implicated in viral infections (such as HCV or HBV), cancers and tumours, and T2 Helper cell (TH2) mediated diseases, and hence TLR7 agonists are potentially useful in the treatment of such diseases. We have now found a series of imidazopyridinones which are agonists of TLR7. According, there is provided a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is 3- to 8-membered saturated heterocyclic group wherein one ring member is O; and R2 is phenyl or pyridinyl, each optionally substituted by C1-C6alkyl.
    Type: Application
    Filed: November 22, 2011
    Publication date: November 29, 2012
    Applicant: PFIZER LIMITED
    Inventors: Peter H. Jones, David Cameron Pryde, Thien Duc Tran
  • DISPENSING DEVICE
    Publication number: 20120298107
    Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.
    Type: Application
    Filed: July 27, 2012
    Publication date: November 29, 2012
    Applicant: PFIZER LIMITED
    Inventors: Peter John Houzego, John Kelshaw Conway, Martin Douglas Pearl, Andrew Mark Bryant
  • Pyrazolospiroketone acetyl-CoA carboxylase inhibitors
    Patent number: 8318762
    Abstract: The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of acetyl-CoA carboxylase enzyme(s) in an animal.
    Type: Grant
    Filed: May 18, 2009
    Date of Patent: November 27, 2012
    Assignee: Pfizer Inc.
    Inventors: Jeffrey W. Corbett, Richard Elliott, Kevin Freeman-Cook, David A. Griffith, Dennis P. Phillion
  • IGE CH3 Peptide Vaccine
    Publication number: 20120294848
    Abstract: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
    Type: Application
    Filed: August 1, 2012
    Publication date: November 22, 2012
    Applicant: PFIZER VACCINES LLC
    Inventors: Alan Daniel Brown, Brian Robert Champion, Clare Christy, David Paul Gervais, Lyn Howard Jones, Anne Maria Kristina Kjerrstrom, David Cameron Pryde, Lee Richard Roberts, David Michael Wyatt
  • DEVICE FOR DISPENSING A PLURALITY OF UNITARY DOSES OF DRY POWDER, AND INHALER COMPRISING SUCH DEVICE
    Publication number: 20120291782
    Abstract: Device for dispensing a plurality of unitary doses (2) of dry powder, comprising at least one support comprising conduits each defining a flow path for an airstream carrying one of the unitary dose (2), the support having first (26) and second (27) members secured to one another so that a first conduit portion (29) of the first member faces a second conduit portions (43) of the second member to define one of the conduits, and a first separation portion (30) of the first member faces a second separation portions (45) of the second member, the support comprising a plurality of barrier-forming elements (31, 46) each arranged between corresponding first (30) and second (45) separation portions to prevent dry powder from passing from one of the conduits to one of the adjacent conduits.
    Type: Application
    Filed: January 6, 2011
    Publication date: November 22, 2012
    Applicant: PFIZER LIMITED
    Inventors: Nicholas John Bowman, Declan Reilly
  • Toluene sulfonic acid salt of a therapeutic compound and pharmaceutical compositions thereof
    Patent number: 8314139
    Abstract: The present invention is directed to the tosylate salt of trans-N-ethyl-3- fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)-phenyl]-cyclobutanecarboxamide (1): to solvates (e.g., hydrates) thereof, to polymorphs thereof, to pharmaceutical compositions thereof and to a method of treating depression, mood disorders, schizophrenia, anxiety disorders, cognitive disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper- and hypo-motility and acidic secretion of the gastro-intestinal tract comprising administering a therapeutically effective amount thereof.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: November 20, 2012
    Assignee: Pfizer Inc.
    Inventors: Todd W Butler, Travis T Wager
  • Pyrrolo[2,3-d]pyrimidine derivatives: their intermediates and synthesis
    Patent number: 8309716
    Abstract: This invention relates to methods and intermediates useful for the synthesis of pyrrolo[2,3-d]pyrimidine compounds. Specifically novel synthetic methods and intermediates for the synthesis of 3-{(3R,4R)-4-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino}-piperidin-1-yl)-3-oxo-propionitrile and its corresponding citrate salt are disclosed.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: November 13, 2012
    Assignee: Pfizer Inc.
    Inventors: Sally Gut Ruggeri, Joel M Hawkins, Teresa M Makowski, Jennifer L Rutherford, Frank J Urban
  • Anti-Diabetic Compounds
    Publication number: 20120282279
    Abstract: The present invention provides a FGF21 molecule covalently attached to the combining site of an antibody via a linker, wherein the linker is covalently attached to the side chain of a linking residue within FGF21. Various uses of the compounds are provided, including methods to prevent or treat diabetes or diabetes-related conditions.
    Type: Application
    Filed: November 4, 2011
    Publication date: November 8, 2012
    Applicants: COVX TECHNOLOGIES IRELAND LIMITED, PFIZER INC
    Inventors: Tapan Kanti Das, Tamara Shafer Hodge, Tetsuya Ishino, Nancy Jane Levin, Moorthy Sitharamaiah Suriyanarayana Palanki, Erin Kristan Parsons, Bernard Norman Violand
  • A METHOD FOR DETECTING A MALFUNCTIONING EGG PICKER
    Publication number: 20120279908
    Abstract: Methods and apparatus are provided that automatically determine whether or not eggs designated for removal from an egg carrier have been removed by an egg removal apparatus. Light is emitted along a path above and across an egg carrier as an egg picker moves to pick up an egg. The length of time that the light path is blocked when the egg picker is moved is measured and used to determine whether or not the egg has been removed from the carrier. Another apparatus and method is provided for detecting a malfunctioning egg picker. A detection device detects a number of eggs in the egg carrier. A control device monitors the egg picker and the detection device. The control device calculates the number of eggs in the egg carrier for determining when the number of eggs varies a predetermined amount from an egg count number for the egg carrier.
    Type: Application
    Filed: July 17, 2012
    Publication date: November 8, 2012
    Applicant: Pfizer Inc.
    Inventor: John H. Hebrank
  • NOVEL CEPHALOSPORINS USEFUL AS ANTIBACTERIAL AGENTS
    Publication number: 20120283237
    Abstract: The present invention provides novel cephalosporin derivatives of formula I, their analogues, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
    Type: Application
    Filed: April 30, 2012
    Publication date: November 8, 2012
    Applicant: PFIZER INC.
    Inventors: Brian A. Duclos, Edmund L. Ellsworth, Richard A. Ewin, Paul D. Johnson, Timothy A. Johnson, Graham M. Kyne, Susan M. K. Sheehan, Rajendran Vairagoundar
  • Immunostimulatory nucleic acids
    Patent number: 8304396
    Abstract: The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: November 6, 2012
    Assignees: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH, Pfizer Inc.
    Inventors: Arthur M. Krieg, Ulrike Samulowitz, Jörg Vollmer, Eugen Uhlmann, Marion Jurk, Grayson B. Lipford, Robert Rankin
  • Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids
    Patent number: 8304252
    Abstract: The present invention is directed to a regio-and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S)-3 cyano-5-methylhexanoic acid, which is a useful intermediate in the synthesis of (S)-3(aminomethyl)-5-methylhexanoic acid (pregabalin). Pregabalin can be used for treating certain cerebral diseases, for example, in the treatment and prevention of seizure disorders, pain, and psychotic disorders.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: November 6, 2012
    Assignee: Pfizer Inc.
    Inventors: Michael P. Burns, Justin K. Weaver, John Wing Wong
  • KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANE
    Publication number: 20120276599
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
    Type: Application
    Filed: June 15, 2012
    Publication date: November 1, 2012
    Applicants: PFIZER, INC., CODEXIS, INC.
    Inventors: Jack Liang, Stephane J. Jenne, Emily Mundorff, Rama Voladri, James Lalonde, Gjalt W. Huisman
  • Methods of treating inflammatory pain
    Patent number: 8298536
    Abstract: Methods of Treating Inflammatory Pain The invention relates to an anti-CGRP antibody for use in the prevention and/or treatment of inflammatory pain and/or symptoms of inflammatory pain, and to a method of treating and/or preventing inflammatory pain and/or symptoms of inflammatory pain using an anti-CGRP antibody.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: October 30, 2012
    Assignee: Pfizer Limited
    Inventors: Laura Corradini, Ian Machin, Kristian Todd Poulsen, David Louis Shelton, Joerg Zeller
  • IgE CH3 peptide vaccine
    Patent number: 8298547
    Abstract: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
    Type: Grant
    Filed: December 9, 2009
    Date of Patent: October 30, 2012
    Assignee: Pfizer Vaccines, LLC
    Inventors: Alan Daniel Brown, Brian Robert Champion, Clare Christy, David Paul Gervais, Lyn Howard Jones, Anne Maria Kristina Kjerrstrom, David Cameron Pryde, Lee Richard Roberts, David Michael Wyatt
  • SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS
    Publication number: 20120270893
    Abstract: The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; wherein G is R1, R2 and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.
    Type: Application
    Filed: April 21, 2012
    Publication date: October 25, 2012
    Applicant: PFIZER INC.
    Inventors: Robert Lee Dow, David James Edmonds, David Andrew Griffith, James Alfred Southers, JR.
  • Structural arrangement for an in ovo injection device
    Patent number: D670064
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: October 30, 2012
    Assignee: Pfizer Inc.
    Inventors: Paul Archie Steen, Michael Glenn Schnupper, Daniel Scott Rees