Patents Assigned to Politecnico di Milano
  • Publication number: 20210318239
    Abstract: A device is disclosed for detecting time-resolved optical data, the device comprising a sensor comprising a number of detection elements configured to detect a light signal in a single photon regime, a timing circuit connected to said number of detection elements though a common line, and a control module connected to the sensor, the control module being configured to selectively enable the detection elements of the sensor according to a set of enabling patterns. The timing circuit is configured to measure a time of arrival of an output signal from the detection elements on the common line, the output signal being indicative of the detection of a photon of the light signal by any of the enabled detection elements.
    Type: Application
    Filed: July 22, 2019
    Publication date: October 14, 2021
    Applicants: POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE - CNR, UNIVERSITY COLLEGE LONDON
    Inventors: Cosimo D'ANDREA, Gianluca VALENTINI, Andrea FARINA, Simon ARRIDGE
  • Patent number: 11125632
    Abstract: Piezoresistive detection resonant device comprising a substrate, a mobile par configured to move with respect the substrate, suspension elements suspending the mobile part to the substrate, a piezoresistive detection device to detect the motions of the mobile part, said piezoresistive detection device comprising at least one strain gauge, wherein the piezoresistive detection resonant device also comprises a folded spring with at least two spring arms, connected to the mobile part and configured to be deformed by the motion of the mobile part, the at least one gauge being suspended between the substrate and the folded spring in such manner that the deformation of the gauge is reduced compared to the motion of the mobile part.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: September 21, 2021
    Assignees: Commissariat a L'Energie Atomique et aux Energies Alternatives, POLITECNICO DI MILANO
    Inventors: Patrice Rey, Guillaume Jourdan, Philippe Robert, Giacomo Langfelder, Antonio F Longoni, Stefano Dellea
  • Patent number: 11111469
    Abstract: A device for cell culture comprising: a main body (11); said main body (11) comprises a plurality of circular portions (21-23); said device comprises a plurality of caps (51-53); each of said plurality of caps (51-53) comprises a base structure (58) having a circular hole (57), housing an upper slide (54) and an elastomeric layer (56) secured to said slide (54); said elastomeric layer (56) has a rectangular hole (59); said plurality of caps (51-53) being adapted to cooperate with said plurality of circular portions (21-23); each of said plurality of circular portions (21-23) each comprise an inlet hole (64-66) and an outlet hole (67-69) aligned with the long side of said rectangular hole (59), to perfuse the culture chamber (12-14) located in said rectangular hole (59) of said elastomeric layer (56).
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: September 7, 2021
    Assignee: POLITECNICO DI MILANO
    Inventors: Manuela Teresa Raimondi, Matteo Lagana
  • Patent number: 11110605
    Abstract: A method for controlling the motion of one or more collaborative robots is described, the collaborative robots being mounted on a fixed or movable base, equipped with one or more terminal members, and with a motion controller, the method including the following iterative steps: —determining the position coordinates of the robots, and the position coordinates of one or more human operators collaborating with the robot; —determining a set of productivity indices associated with relative directions of motion of the terminal member of the robot, the productivity indices being indicative of the speed at which the robot can move in each of the directions without having to slow down or stop because of the presence of the operator; —supplying the controller of the robot with the data of the set of productivity indices associated with the relative directions of motion of the terminal member of the robot, so that the controller can determine the directions of motion of the terminal member of the robot based on the high
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: September 7, 2021
    Assignee: Politecnico Di Milano
    Inventors: Andrea Maria Zanchettin, Paolo Rocco
  • Publication number: 20210254275
    Abstract: The present invention relates to a process for coating fibers containing polar moieties with an adduct between a sp2 hybridized carbon allotrope and a pyrrole derivative, and the coated fibers thus obtained. The present invention further relates to composite materials comprising said coated fibers and the process for the production thereof.
    Type: Application
    Filed: May 7, 2019
    Publication date: August 19, 2021
    Applicant: POLITECNICO DI MILANO
    Inventors: Maurizio Stefano GALIMBERTI, Vincenzina BARBERA
  • Publication number: 20210230270
    Abstract: The present invention relates to the fields of antibodies, antigen binding fragments and immunodiagnostics. Specifically, the invention relates to a recombinant anti-body or antigen binding fragment for binding thyroid hormone T4 (thyroxine) and halogenated bisphenol A. Also, the present invention relates to an isolated nucleic acid molecule comprising a nucleotide sequence that encodes the recombinant antibody or antigen binding fragment of the present invention, as well as an ex-pression vector and host cell comprising the nucleic acid molecule of the present invention. Still, the present invention relates to a method of producing a recombi-nant antibody or antigen binding fragment for binding T4 thyroid hormone and hal-ogenated bisphenol A, a test kit and an immunoassay comprising the recombinant antibody or antigen binding fragment of the present invention, and a method for determining T4 thyroid hormone and/or halogenated bisphenol A levels in a sam-ple of a subject.
    Type: Application
    Filed: May 28, 2019
    Publication date: July 29, 2021
    Applicants: Teknologian tutkimuskeskus VTT Oy, Politecnico di Milano
    Inventors: Tarja NEVANEN, Henri AROLA, Antti TULLILA, Juha ROUVINEN, Tarja PARKKINEN, Pierangelo METRANGOLO
  • Patent number: 11057022
    Abstract: A monostable circuit includes a delay cell with a reference generator generating a reference current based upon a PVT invariant resistance and a threshold voltage, and a delay block with an output capacitor and an output circuit altering an amount of charge stored on the output capacitor as a function of the reference current, in response to an input signal. An inverter has an input coupled to the output circuit. A logic circuit logically combines output of the inverter and the input signal to generate a monostable trigger pulse. The output circuit includes a current source sourcing the reference current to the output capacitor in response to a first logic state of an input signal, and a current sink sinking current from the output capacitor to discharge the output capacitor, in response to a second logic state of the input signal.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: July 6, 2021
    Assignees: STMicroelectronics S.r.l., Politecnico Di Milano
    Inventors: Marco Zamprogno, Alireza Tajfar
  • Patent number: 11051714
    Abstract: A wearable device for continuous monitoring of the respiratory rate of a patient, using a first inertial sensor positioned on the abdomen, a second inertial sensor positioned on the thorax, and a third inertial sensor being positioned on a part of the body not subject to respiratory movements, fixed with respect to the torso. Each inertial sensor includes a microprocessor connected to a transmitter configured for processing the signals and supplying a signal represented by a quaternion that describes the orientation of the inertial sensors with respect to the Earth's reference system. A receiver is configured for receiving the abdominal quaternion of the first inertial sensor, the thoracic quaternion of the second inertial sensor, and the reference quaternion of the third inertial sensor and sending them to a control center configured for calculating the respiratory rate from the signals represented by a filtered abdominal quaternion and a filtered thoracic quaternion.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: July 6, 2021
    Assignee: POLITECNICO DI MILANO
    Inventors: Andrea Aliverti, Ambra Cesareo
  • Publication number: 20210189353
    Abstract: The present invention refers to Amadoriase enzyme protein variants having de-glycating activity and improved thermostability compared to the wild type Amadoriase. The present invention refers also to the use of the thermostabilized Amadoriase as deglycating agent, preferably in the food industry. Moreover, the present invention refers to the use of the thermostabilized Amadoriase as diagnostic and/or therapeutic tools. Preferably, the Amadoriase enzyme protein variants of the invention can be used for determining the level of glycated haemoglobin in a biological sample and therefore for monitoring diabetes.
    Type: Application
    Filed: June 21, 2018
    Publication date: June 24, 2021
    Applicants: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, POLITECNICO DI MILANO
    Inventors: Alfonso Gautieri, Emilio Parisini, Federica Rigoldi, Stefano Donini, Alberto Redaelli
  • Publication number: 20210188682
    Abstract: A device for sludge treatment comprises a supporting frame of an external casing defining a treatment chamber provided with one inlet opening of the sludge to be treated; one discharge opening of the treated sludge; at least one auger element housed within the treatment chamber, and adapted to move the sludge to be treated along a direction of advancement; and filtration means located internally to the treatment chamber and surrounding the auger element; at least one anodic element associated with the auger element, and application means for applying a potential difference between the anodic element and the filtration means, generating an electric field adapted to interact with the sludge to be treated to produce an electro-osmotic process.
    Type: Application
    Filed: October 26, 2018
    Publication date: June 24, 2021
    Applicants: X2 SOLUTIONS S.R.L., POLITECNICO DI MILANO
    Inventors: Vittorio BOSI, Emanuele DE RISIO, Roberto CANZIANI, Gonzalo GARCÌA FUENTES, Simone VISIGALLI, Giuseppe DI FLORIO
  • Patent number: 11041069
    Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (?-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: June 22, 2021
    Assignees: Massachusetts Institute of Technology, Politecnico di Milano
    Inventors: Umberto Capasso Palmiero, James C. Kaczmarek, Daniel Griffith Anderson, Davide Moscatelli
  • Publication number: 20210179821
    Abstract: The present invention relates to a vulcanizable elastomeric composition comprising a secondary accelerator that may be used in combination with sulphenamide alone, completely avoiding the use of a guanidine. Moreover, said accelerator promotes dispersion of the silica in the compound and migrates with difficulty in the elastomeric composition itself. The invention also relates to the use of a vulcanization accelerator for said elastomeric composition, to the associated vulcanization process and to a tyre comprising same.
    Type: Application
    Filed: December 23, 2016
    Publication date: June 17, 2021
    Applicants: Pirelli Tyre S.p.A., POLITECNICO DI MILANO
    Inventors: Maurizio Stefano GALIMBERTI, Roberto SEBASTIANO, Vincenzina BARBERA, Valeria CIPOLLETTI, Gabriella LEONARDI, Shuquan SUN, Luigia ROSSIELLO
  • Publication number: 20210181022
    Abstract: A Fourier-transform hyperspectral imaging system may include an optical imaging system configured to produce an image of an object, and an adjustable birefringent common-path interferometer module comprising a movable birefringent element and configured to produce interfering replicas of an input radiation which are delayed from each other by a phase delay adjustable by the moving birefringent element. The interferometer module may be configured to produce collinear replicas for entering optical rays parallel to said optical axis. The hyperspectral imaging system further comprises a two-dimensional light detector configured to receive the replicas and provide digital images of the object depending on said adjustable phase delay. The system also includes an analysis device configured to perform a Fourier Transform of the digital images to obtain a hyperspectral representation of the object.
    Type: Application
    Filed: July 25, 2019
    Publication date: June 17, 2021
    Applicants: POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Cristian Angelo MANZONI, Giulio CERULLO, Dario POLLI, Antonio PERRI, Fabrizio PREDA, Gianluca VALENTINI, Andrea BASSI
  • Patent number: 11031152
    Abstract: A flame-retardant electric cable has a core including at least one electric conductor, an electrically insulating coating and an outermost layer made from a substantially thermoplastic, low smoke zero halogen flame-retardant polymer composition. The composition includes a polymeric base made of at least one polyethylene homopolymer or copolymer having a density of 0.94 g/cm3 at most. The composition further includes 60-64% by weight of a metal hydroxide, at least 2% by weight of an ammonium coated montmorillonite having average particle dimensions of from 5 to 20 ?m, and a polysiloxane.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: June 8, 2021
    Assignees: Prysmian S.p.A., Politecnico di Milano
    Inventors: Franco Galletti, Elena Roda, Giuseppe Merigo, Sergio Gutierrez
  • Patent number: 11027045
    Abstract: The present invention relates to a supermatrix of synthetic niches comprising at least two matrices of niches wherein each matrix comprises n×m niches and wherein the distance (d) between a matrix and the other is greater than zero and wherein in each matrix every synthetic niche has one or more walls in common with the others synthetic niches of the matrix. A support for the culture of cells that includes at least one supermatrix and the use of said supermatrix or support for the in vitro culture of cells, in particular stem cells, or for the in vivo implant in a subject in order to promote tissue or organ regeneration through cell repopulation are also within the scope of the present invention.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: June 8, 2021
    Assignees: POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE, FONDAZIONE CARIPLO
    Inventors: Manuela Teresa Raimondi, Giulio Cerullo, Roberto Osellame, Andrea Remuzzi
  • Publication number: 20210137766
    Abstract: A device for the controlled assistance of the grip, including a first element, which can be worn on one hand, and which includes a pair of ferromagnetic plates. The device also includes a second element which includes a ferromagnetic core whose opposite poles are each connected to one of the two ferromagnetic plates. The device further includes a power supply unit connected to an excitation coil wound around the ferromagnetic core. A control unit controls the voltage supplied by the power supply unit to the ends of the coil, so as to adjust the magnetic field generated to the ferromagnetic plates.
    Type: Application
    Filed: March 13, 2018
    Publication date: May 13, 2021
    Applicant: POLITECNICO DI MILANO
    Inventors: Alessandra Laura Giulia PEDROCCHI, Giovanni Maria FOGLIA
  • Publication number: 20210123808
    Abstract: A measurement system of photoluminescence properties of a sample, comprises a radiation source module configured to generate a first radiation, an excitation optical path coupled to the radiation source module, a support structured to support a sample to be optically coupled to excitation optical path and adapted to provide a photoluminescence radiation, and collection path coupled to the sample and configured to propagate the photoluminescence radiation. The system also includes an analysis device configured to receive the photoluminescence radiation and provide data/information on photoluminescence properties of sample. At least one path between the excitation path and the collection path comprises a respective adjustable birefringent common-path interferometer module configured to produce first and second radiations adapted to interfere with each other.
    Type: Application
    Filed: March 19, 2018
    Publication date: April 29, 2021
    Applicant: Politecnico di Milano
    Inventors: Dario POLLI, Giulio CERULLO, Fabrizio PREDA, Antonio PERRI, Jürgen HAUER
  • Publication number: 20210094875
    Abstract: An optical fibre comprising: an optical waveguide comprising a glass core surrounded by a glass cladding; a coating surrounding said optical waveguide comprising a polymer material comprising a cured polyester obtained by: (a) esterification of a reactant (A) selected from carboxylic acids, triglycerides, and mixtures thereof, having a C16-C24 aliphatic chain comprising at least two conjugated double bonds, with a reactant (B) selected from polyols having at least 3 hydroxyl groups, the polyols being thermally stable up to 300° C.; (b) curing of the 10 so obtained polyester, in the presence of a transition metal salt, the transition metal being selected from Mn, Fe, Co, Cu, and Ni. Preferably, the step of curing is a thermal curing, preferably up to 300° C. The transition metal salt acts as curing accelerator, i.e.
    Type: Application
    Filed: January 19, 2018
    Publication date: April 1, 2021
    Applicants: Prysmian S.P.A., Politecnico Di Milano
    Inventors: Lidia TERRUZZI, Pamela DE MARTINO, Attilio CITTERIO, Massimo GOLA
  • Patent number: 10961492
    Abstract: A microfluidic device for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs that includes a culture chamber may include: a confinement apparatus configured to define at least one compartment configured to contain a cellular matrix and at least one compartment configured to contain a culture medium, the confinement apparatus being hydrophobic and pervious to the culture medium; and/or at least one counter element. The confinement apparatus and at least one counter element may be reciprocally mobile between resting and compression positions of the cellular matrix. A method for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs at a microscale may include: controlled compression of a cellular matrix for a predetermined period of time. The cellular matrix may be delimited by a confinement apparatus that is pervious to a culture medium.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 30, 2021
    Assignees: POLITECNICO DI MILANO, FONDAZIONE CARIPLO
    Inventors: Alberto Redaelli, Marco Rasponi, Paola Occhetta
  • Publication number: 20210086182
    Abstract: A device for the quantification of cellular and non-cellular components in a blood sample including detection electrodes including a first electrode connected with a first input to receive a first signal in input and a second electrode, reference electrodes including a first electrode connected with a second input configured to receive a second signal in input of opposite polarity to the first input signal and a second electrode connected to the second electrode of said detection electrodes, in a common point wherefrom an output signal is picked up, a ferromagnetic concentrator that cooperates with an external magnetic field external to effectuate concentration of said components on said detection electrodes, a substrate configured to house said detection electrodes, reference electrodes, and concentrator; a support configured to collect a blood sample, and a spacer element to confine in the substrate plane the blood sample and to distance said substrate from said support.
    Type: Application
    Filed: July 17, 2018
    Publication date: March 25, 2021
    Applicant: Politecnico di Milano
    Inventors: Riccardo BERTACCO, Daniela PETTI, Giorgio FERRARI, Edoardo ALBISETTI, Marco GIACOMETTI