Abstract: The present invention provides compositions and methods for the treatment or prevention of a neurological disease or disorder of the central nervous system (e.g., a storage disorder, lysosomal storage disorder, neurodegenerative disease, etc.) by reconstitution of brain myeloid cell and microglia upon transplantation of hematopoietic cells enriched in microglia reconstitution potential. The invention also provides compositions and methods for ablating and reconstituting microglia.

Abstract: A laser device comprises a first optical cavity comprising a first gain medium and a second optical cavity comprising a second gain medium. The first gain medium and the second gain medium generate light at respective different ranges of wavelengths. A synchronizer is optically coupled to both the first optical cavity and the second optical cavity and is configured to synchronize and mode-lock light from the first optical cavity and the second optical cavity. The laser device also includes a first optical filter and a second optical filter to filter the light from the first optical cavity and the second optical cavity respectively to output first filtered light pulses at a first predetermined range of wavelengths and second filtered light pulses at a second predetermined range of wavelengths.

Abstract: A method for transmitting electromagnetic signals by a vehicle moving towards a target device including a communication system provided with a radiating system that receives and transmits electromagnetic signals, performs an alignment step with the target device to establish a first communication direction with the target device, communicates with the target device by orienting the radiating system to receive and transmit data along the first communication direction, and performs a subsequent phase for maintaining the alignment with the target device to determine a future position and an orientation of the radiating system with a sensor being operatively connected to an electronic control unit of the vehicle configured to implement control and/or driving assistance functions of the vehicle based on information received from the sensor, and ultimately orientates the electromagnetic signals emitted by the radiating system on the basis of the determined direction of communication.

Abstract: A laser source includes a first laser device configured to generate a first laser beam having a first wavelength, a second laser device configured to generate a second laser beam having a second wavelength, which is different from the first wavelength, and a non-linear crystal configured to receive simultaneously the first and second laser beams and to generate a third laser beam that has a third wavelength, which is larger than each of the first and second wavelengths. The non-linear crystal has a length and a width, and a variable poling period is distributed across the width so that the third wavelength varies within a given wavelength range based on an incident position of the first and second laser beams along the width of the non-linear crystal.

Abstract: Disclosed are methods for assessing the risk that a male subject is affected by prostate cancer and to methods for assessing the risk that such cancer is aggressive, by analysing the gaseous headspace of urine samples with at least three metal oxide semiconductor-based gas sensors, wherein the metal oxide of the first gas sensor is pure or doped SnO2, the metal oxide of the second sensor is pure or doped ZnO and the metal oxides of the third sensor are pure or doped SnO2, pure or doped TiO2 and pure or doped Nb2O5.

Abstract: An abrasive water jet cutting machine including pumping means, which can be fluidically connected to a water source, for the generation of a pressurized water flow; a cutting head, forming a mixing chamber and a focusing nozzle; a dispensing system of powdered abrasive material, including a tank containing powdered abrasive material, a feeding pipe, fluidically connecting the tank to the mixing chamber of the cutting head, a dispenser, which dispenses the powdered abrasive material contained in the tank into the mixing chamber by means of the feeding pipe; wherein the pressurized water flow originating from the pumping means is conveyed into the mixing chamber of the cutting head where the pressure energy of the pressurized water flow is converted into kinetic energy so as to form a water jet; wherein the cutting head mixes, in the mixing chamber, the abrasive material with the water jet forming a water-abrasive material mixture jet, and the cutting head dispenses the water-abrasive material mixture jet by me

Abstract: A differential piezoelectric actuator-system includes an inductor and driver-circuit having switches for transferring energy between first and second actuators and the inductor, and between a voltage-supply node and the inductor. Control circuitry determines whether a next phase in which to operate the driver-circuit is a first charging-phase or a first recovery-phase. The first charging-phase includes operating the switches in: a first sub-phase to transfer energy from the first actuator to the inductor; a second sub-phase to transfer energy from the voltage supply node to the inductor; and a third sub-phase to transfer energy from the inductor to the second actuator. The first recovery-phase includes operating the switches in: a first sub-phase to transfer energy from the first actuator to the inductor; a second sub-phase to transfer energy from the inductor to the second actuator; and a third sub-phase to transfer energy from the inductor to the voltage supply node.

Abstract: A differential piezoelectric actuator-system includes an inductor and driver-circuit having switches for transferring energy between first and second actuators and the inductor, and between a voltage-supply node and the inductor. Control circuitry determines whether a next phase in which to operate the driver-circuit is a first charging-phase or a first recovery-phase. The first charging-phase includes operating the switches in: a first sub-phase to transfer energy from the first actuator to the inductor; a second sub-phase to transfer energy from the voltage supply node to the inductor; and a third sub-phase to transfer energy from the inductor to the second actuator. The first recovery-phase includes operating the switches in: a first sub-phase to transfer energy from the first actuator to the inductor; a second sub-phase to transfer energy from the inductor to the voltage supply node; and a third sub-phase to transfer energy from the inductor to the second actuator.

Abstract: A method for manufacturing a jacquard knitted fabric, including providing an electronic unit for processing digital images; providing a programmable Y-yarn Jacquard knitting machine; obtaining a known digital adversarial image; reducing the image so that the proportions are maintained, the maximum size is reduced to P pixels (P?750) and the minimum size is reduced to p pixels (p?100); halving the height of the image and maintaining the width; posterizing the adversarial image by reducing the colors to C (4?C?Y); generating the operation instructions for the machine, where each color in the image corresponds to a respective yarn and each pixel in the image corresponds to a stitch; selecting C yarns to approximate the colors of the posterized image; feeding the C yarns to the machine; and operating the machine for manufacturing a knitted fabric reproducing the image.

Abstract: The invention relates to an inertial sensor (1) comprising a substrate extending along a drive excitation direction (x) and a detection direction (y) normal to each other, the device plane being perpendicular to a rotation direction (z), a first drive frame (110) and a second drive frame (120), a first sense frame (210), a second sense frame (220), a sense lever (1000) pivotably mounted around a rotation axis (1001), a sensing system comprising a strain gauge (1600) mechanically stressed by the sense lever it is rotating around the rotation axis. The sense lever includes a central portion (1500), a first arm (1100) and a second arm (1200), the central portion having a dimension along the detection direction called central width, the arms having a dimension along the detection direction called arm width, the central width being at least twice greater than the arm width.

Abstract: Disclosed herein is a control system for a projection system, including a first subtractor receiving an input drive signal and a feedback signal and generating a first difference signal therefrom, the feedback signal being indicative of position of a quasi static micromirror of the projection system. A type-2 compensator receives the first difference signal and generates therefrom a first output signal. A derivative based controller receives the feedback signal and generates therefrom a second output signal. A second subtractor receives the first and second output signals and generates a second difference signal therefrom. The second difference signal serves to control a mirror driver of the projection system. A higher order resonance equalization circuit receives a pre-output signal from an analog front end of the projection system that is indicative of position of the quasi static micromirror, and generates the feedback signal therefrom.

Abstract: An optical fibre comprising: an optical waveguide comprising a glass core surrounded by a glass cladding; a coating surrounding said optical waveguide comprising a polymer material comprising a cured polyester obtained by: (a) esterification of a reactant (A) selected from carboxylic acids, triglycerides, and mixtures thereof, having a C16-C24 aliphatic chain comprising at least two conjugated double bonds, with a reactant (B) selected from polyols having at least 3 hydroxyl groups, the polyols being thermally stable up to 300° C.; (b) curing of the 10 so obtained polyester, in the presence of a transition metal salt, the transition metal being selected from Mn, Fe, Co, Cu, and Ni. Preferably, the step of curing is a thermal curing, preferably up to 300° C. The transition metal salt acts as curing accelerator, i.e.

Abstract: A test bench assembly (10) for the simulation of cardiac surgery and/or interventional cardiology operations and/or procedures, comprising a passive heart (12), wherein said passive heart (12) is an explanted or artificial or hybrid heart, said passive heart (12) having at least one pair of cardiac chambers (14, 16; 114, 116) comprising an atrial chamber (14; 114) and a ventricular chamber (16; 116); a reservoir (20), adapted to house the working fluid; a pressure generator (22), adapted to provide said passive heart (12) pumping said working fluid with the pumping function, said pressure generator (22) being fluidically connected both to said ventricular chamber (16) of said passive heart (12) and to said reservoir (20) by means of first fluid connection means; a pressure regulation device (24) which provides the working fluid in input to the atrial chamber (14) with the preload pressure, and the working fluid in output from the ventricular chamber (16) with the afterload pressure, said pressure regulation d

Abstract: A double photodiode electromagnetic radiation sensor device including a substrate, a first integrated photodiode (PD1), a second integrated photodiode (PD2), and more than one metal contact. The substrate may be within a first semiconductor material that defines a first face and a second face. The PD1 may include a first doped region extending to the second face and a “n-” type doping. The PD1 may further include a second doped region extending to the second face having a “p+” type doping. The PD2 may include the first doped region, and a layer in a second semiconductor material placed on the second face in contact with the first doped region defining a third face. The PD2 may yet further include a doped layer in the second semiconductor material having a “p+” type doping and overlapping the third face.

Abstract: A charge detection apparatus may include a radiation sensor having a first electrode and a second electrode for collecting charges of opposite sign and configured to supply to a collecting terminal, connected to the first electrode, a charge signal proportional to an incident radiation. The radiation sensor may define a sensor capacitance associated with the first and the second electrode. The device may also include a charge preamplifier, configured to receive the charge signal and convert it into an electrical output signal, and including an amplifier having a first output terminal. An electrical connection may be included between the first output terminal and the second electrode configured so that the sensor capacitance is in feedback for the amplifier.

Abstract: A cartridge is adapted to house at least one biological sample therein, where the cartridge contains at least two overlapping layers, and the layers include at least one layer of highly hydrophobic, inert, and biocompatible material, with contact angle ?c?90°, hydrophobic layer, and optionally, at least one layer of double-sided adhesive material, where in the absence of the at least one layer of double-sided adhesive material, the overlapping layers are connected together by chemical and/or physical bonding, where each of the overlapping layers has at least one inner hole that is pervious when the layers overlap one another, and the at least one inner hole is closed by the at least one biological sample, where loaded in the cartridge.

Abstract: The present invention relates to covalently cross-linked glycosylated mucin nanoparticles and the use thereof for the delivery and release of active ingredients, markers and/or biomolecules. The subject matter of the invention also relates to covalently cross-linked glycosylated mucin nanoparticles comprising at least one compound selected from an active ingredient, a marker and a biomolecule. The invention further relates to a method for preparing covalently cross-linked glycosylated mucin nanoparticles, optionally comprising at least one compound selected from an active ingredient, a marker and a biomolecule.

Abstract: A device is disclosed for detecting time-resolved optical data, the device comprising a sensor comprising a number of detection elements configured to detect a light signal in a single photon regime, a timing circuit connected to said number of detection elements though a common line, and a control module connected to the sensor, the control module being configured to selectively enable the detection elements of the sensor according to a set of enabling patterns. The timing circuit is configured to measure a time of arrival of an output signal from the detection elements on the common line, the output signal being indicative of the detection of a photon of the light signal by any of the enabled detection elements.

Abstract: An assembly for reshaping a cardiac ventricle in a patient comprising an implantable device for reshaping a ventricle comprising a tether, a non-implantable tool which is detachably connectable to said implantable device and has a proximal portion and a distal portion opposite to said proximal portion; the implantable device further comprises an active anchor adapted to be detachably connected to the distal portion of the tool; the active anchor comprises an abutment portion adapted to abut against a structure of the ventricle; the active anchor of the implantable device comprises an adjustment device adapted to adjust the tensional state of the tether; the distal portion of the tool comprises an adjustment key adapted to cooperate with the adjustment device of the active anchor; the proximal portion of the tool comprises a maneuvering interface which is operatively connectable to said adjustment key for adjusting the tensional state of the tether by acting on the maneuvering interface of the proximal portion

Abstract: A distance measuring device includes a light emission portion for emitting light; a light receiving portion for receiving measurement light that is emitted by the light emission portion and reflected by a measurement object, the light receiving portion comprising a plurality of pixels, each pixel having at least one light receiving portion and outputting a light reception signal that depends on the measurement light incident on the pixel; a discrimination portion for discriminating whether the pixel receives measurement light; a pixel output control portion for selectively outputting the light reception signal of each pixel individually, depending on the determination result of the discrimination portion; and an evaluation portion for receiving the light reception signals output by the pixel output control portion and outputting a distance signal that is indicative of a distance between the measuring device and the measurement object based on these light reception signals.