Abstract: The present invention relates to the fields of antibodies, antigen binding fragments and immunodiagnostics. Specifically, the invention relates to a recombinant anti-body or antigen binding fragment for binding thyroid hormone T4 (thyroxine) and halogenated bisphenol A. Also, the present invention relates to an isolated nucleic acid molecule comprising a nucleotide sequence that encodes the recombinant antibody or antigen binding fragment of the present invention, as well as an ex-pression vector and host cell comprising the nucleic acid molecule of the present invention. Still, the present invention relates to a method of producing a recombi-nant antibody or antigen binding fragment for binding T4 thyroid hormone and hal-ogenated bisphenol A, a test kit and an immunoassay comprising the recombinant antibody or antigen binding fragment of the present invention, and a method for determining T4 thyroid hormone and/or halogenated bisphenol A levels in a sam-ple of a subject.

Abstract: A hub carrier is provided having: a central part for carrying a hub for a wheel of a vehicle; an outer frame adapted to connect the hub carrier to a suspension of the vehicle; at least three spokes interposed between the central part and the outer frame, the at least three spokes being rigidly connected to the central part. The at least three spokes have respective end elements connected to the outer frame and provide respective sliding spherical hinges for the at least three spokes. The hub carrier further includes at least three sensors configured for detecting force and/or moment components acting on the hub.

Abstract: A device for the quantification of cellular and non-cellular components in a blood sample including detection electrodes including a first electrode connected with a first input to receive a first signal in input and a second electrode, reference electrodes including a first electrode connected with a second input configured to receive a second signal in input of opposite polarity to the first input signal and a second electrode connected to the second electrode of said detection electrodes, in a common point wherefrom an output signal is picked up, a ferromagnetic concentrator that cooperates with an external magnetic field external to effectuate concentration of said components on said detection electrodes, a substrate configured to house said detection electrodes, reference electrodes, and concentrator; a support configured to collect a blood sample, and a spacer element to confine in the substrate plane the blood sample and to distance said substrate from said support.

Abstract: A distance measuring device includes a light emission portion configured to emit light; a light receiving portion configured to receive measurement light that is emitted by the light emission portion and reflected by the measurement object, the light receiving portion comprising a plurality of pixels configured to output light reception signals that depend on the received measurement light; a plurality of determination portions configured to receive the light reception signals and to determine characteristic values from the received light reception signals, and an evaluation portion that is connected to the plurality of determination portions, the evaluation portion being configured to calculate a distance from the characteristic values determined by the determination portions. Each of the plurality of determination portions is configured to receive the light reception signals only from a plurality of non-adjacent pixels.

Abstract: A method for making an accessory cladding element for use in architecture and design. The method provides preparing an elastically deformable support element, including a first outer surface, in particular a decorated surface, a second outer surface and a plurality of spacer elements placed between the two surfaces. An impermeable and removable layer is applied on the first outer surface to protect at least a part thereof. Then a fluid cement mixture is prepared and introduced into the support element to obtain a cement-based composite structure in a deformable state. The excess fluid cement mixture is removed from the support element. The cement-based composite structure in the deformable state is positioned in a forming device which gives it the desired shape. The composite structure is solidified and after the removable layer is removed.

Abstract: The present invention relates to a polymer comprising repeating units consisting of a substituted pyrrole ring. In particular, the repeating units consist of substituted pyrrole containing polar groups capable of interacting with carbon allotropes such as carbon nanotubes, graphene or nanographites, in order to improve the chemical-physical characteristics of the allotropes mainly by increasing their dispersibility and stability in liquid media and in polymer matrices. The invention also relates to products of addition of these polymers with carbon allotropes in order to obtain easily dispersible macromolecules.

Abstract: A computer implemented lightweight design method including: a preliminary homogenization step for defining a material model related to an adopted manufacturing material; a subsequent optimization step for finding an optimal distribution of material density within the design domain; and a final post-processing step to find the geometry for manufacturing; wherein the preliminary homogenization step is performed for deriving the material model for a 2D/3D version of a porous material provided with circular/spherical holes in a Hexagonal Close-Packed (HCP) arrangement, and the post-processing step comprises computing position and size of the circular/spherical holes.

Abstract: A method for assisting the driving of a vehicle which can be implemented by a relative system including an HMD, and a positioning module mounted on the vehicle. The method can include detecting a vehicle position by the positioning module; determining a position of the HMD by applying a compensation law to the vehicle position, based on the position of the HMD, determining a view volume corresponding to a volume of space comprised in the field of view of the HMD; comparing a set of positions in the view volume with at least one position of interest associated with a stored object of interest , and, if one or more positions of interest are in the view volume, calculating a visualization position of the HMD in which to display an image associated with the object of interest and displaying on the HMD the image in said visualization position.

Abstract: An input is coupled to a cathode of a laser diode having its anode coupled to a high-voltage-supply, with a cascoded current mirror having an input and output branches. The input branch is coupled between the high-voltage-supply and a sense resistor coupled to the input. The output branch is coupled between the high-voltage-supply and an output. A sense resistance is coupled between the output and ground, and includes a diode-coupled transistor coupled to the output and a resistor coupled between the diode-coupled transistor and ground. The input branch generates a current proportional to a voltage across the laser diode, and the output branch generates a mirrored current proportional to the current proportional to the voltage across the laser diode. A voltage proportional to the voltage across the laser diode is generated by the mirrored current flowing through the sense resistance. A comparison circuit compares this voltage to a threshold.

Abstract: Systems, methods, and circuitries are provided for generating a frequency hopping radar signal. In one example, a radar signal modulator include a frequency offset generator, a phase locked loop, and a bandwidth compensation circuitry. The frequency offset generator is configured to generate a sequence of frequency offsets. The bandwidth compensation circuitry is configured to combine a modulation signal and the sequence of frequency offsets to generate a bandwidth compensated signal. The PLL is configured to receive the bandwidth compensated signal and generate a frequency hopping radar signal based on the bandwidth compensated signal.

Abstract: The present invention refers to a brake assist system (1) for cyclist on a bicycle (100) including a braking system (101) having a braking member (105) capable of exerting a braking force (FB) on a front wheel (101) of the bicycle (100) by the effect of a force (Fc) applied by the cyclist on a lever (103). The system (1) includes a sensor (2) for measuring the angular speed (?1) of the front wheel (101) of the bicycle (100); an actuator (3) capable of exerting an actuator force (FA), connectable to said braking system of the bicycle so that the actuator force (FA) opposes the force (Fc) applied by the cyclist on the lever (103), in order to reduce the braking force (FB); and a control module (4) configured for receiving, as an input, the signal representative of the angular speed (?1) of the front wheel (101) and for determining from this a deceleration (?) of the front wheel (101).

Abstract: A method for operating a point laser-scanning microscope includes scanning a sample with a focused illumination laser beam; recording a plurality of images by detecting elements being configurable to an intensity mode, in which the recorded images are intensity images gi,j(n) related to photons collected during an entire dwell time of the illumination beam on an individual position n, or to a time-resolved mode, in which the recorded images are time-resolved images gi,jt(n, t), the collected photons being discriminated based on their arrival times to individual detecting elements; calculating a fingerprint image a by summing the plurality of intensity images gi,j(n) over all positions n; estimating shift matrices sx and sy from the intensity images gi,j(n); reconstructing at least one of a time-resolved object function ft and an intensity object function f; and visualizing at least one of a high-resolution time-resolved image ft˜ and a high-resolution intensity image f˜.

Abstract: Drone (5) which comprises a plurality of propellers (16) driven by motors (17) supported by at least one structure (18) with a winch (8) provided with a drum which can rotate by means of a motor (22) to unwind or wind a suspended cable (6), characterized in that the structure (18) comprises a central seat (19) in which the winch (8) is arranged, so that the center of mass of the drone (5) falls into the drum of the winch (8). The present description also relates to a method of controlling the attitude of the drone (5).

Abstract: It is an object of the present invention a method to introduce compounds inside red blood cells comprising: —providing red blood cells from a subject; —providing one or more compounds to be encapsulated in said red blood cells; —providing a loading device comprising a microporous matrix; —feeding said loading device with a suspension comprising said red blood cells and said one or more compounds; —collecting the red blood cells exiting from said loading device, which are encapsulated red blood cells; characterized in that: —said red blood cells and said one or more compound are in suspension at a pH of between 6.8 and 7.8, preferably of between 7.35 and 7.

Abstract: A level-shifter includes an input node coupled to a laser driver input receiving a trigger signal, the input node receiving a signal indicating generation of a laser drive-pulse. A p-channel transistor has a source coupled to a supply node, a drain coupled to an output node, and a gate coupled to the input node. An n-channel transistor has a drain coupled to the drain of the p-channel transistor, a source coupled to ground, and a gate coupled to the input node. A first switch couples the input node to the output node. Another p-channel transistor has a source coupled to the supply node, a drain coupled to the output node by a second switch, and a gate coupled to the input node. The first switch closes and second switch opens when the signal is low, and the first switch opens and second switch closes when the signal is high.

Abstract: Adducts are described, obtainable from the reaction product of a secondary amine and a diketone, with carbon allotropes in which the carbon is sp2 hybridized, such as graphene, graphite, fullerene, carbon nanotubes and the like, and an inorganic oxide-hy-droxide. A process for preparing said adducts is also described.

Abstract: In accordance with an embodiment, a method of operating a phase locked loop (PLL), the method including: comparing a phase of a reference signal with a phase of a clock signal using a plurality of parallel matched phase detection circuits to provide a plurality of phase detection signals, where each of the plurality of the parallel matched phase detection circuits is configured to have a same phase difference to output characteristic; filtering a sum of the plurality of phase detection signals to form a filtered phase detection signal; and controlling a frequency of an oscillator using the filtered phase detection signal, where the oscillator is configured to provide the clock signal.

Abstract: Compounds have a formula (1) wherein Y and Z are independently O, N, P; R, R1, R2, R3, where present, are independently H. Optionally substituted C1-C12 alkyl, O, or R and R1 and/or R2 and R3 form, together with the atom Y and/or Z to which they are attached, a 3-14 membered ring. The compounds optionally contain one or more additional heteroatoms selected from O, N, and S, optionally substituted. Compositions include such compounds and the medical uses utilize such compounds.

Abstract: Drone (5) which comprises a plurality of propellers (16) driven by motors (17) supported by at least one structure (18), in which a plurality of converters (15) are arranged around the structure (18) to convert electricity to high voltage in low voltage electricity. The present description also relates to a method of controlling the attitude of the drone (5).

Abstract: The present invention concerns an optical fibre comprising: an optical waveguide comprising a glass core surrounded by a glass cladding; a coating surrounding said optical waveguide comprising a cured polymer material comprising a polyester obtained by esterification of: a reactant A selected from an acid, a triglyceride, or a mixture of triglycerides having a C16-C24 aliphatic chain comprising at least two conjugated double bonds; and a polyol made of at least one monomer comprising at least 3 hydroxyl groups, the polyol being thermally stable up to 300° C. (reactant B). The present invention concerns also the above said polyester coating, a method for coating an optical fibre with said polyester coating and a method for obtaining predetermined mechanical properties of a coating for an optical fibre. The cured polymer forming the coating can be prepared by curing the polyester of the invention either thermally or by radiation.