Abstract: Provided herein are programmable condensate protein systems and nucleic acid constructs encoding the same. The protein system enables modular targeting of proteins of interest. Protein-peptide interaction domains (PPIDs) are incorporated to functionalize engineered condensates with the attributes of the recruited protein, resulting in a modular system that allows for diverse facile and reprogrammable applications, including in enzyme clustering of metabolic pathways. Colocalizing specific metabolic enzymes in these condensates results in functionalized organelles with which can be used to manipulate the output of engineered metabolic pathways for the production of a pharmaceutical precursor.
Abstract: Compositions of matter and devices using those compositions are provided, which can, e.g., impede or restrict the migration of halides from a halide perovskite active layer. The composite material may include n layers of semiconductors, wherein n ? 2. Each layer of semiconductors may contain (i) one or more organic semiconductor layers and one or more inorganic semiconductor layer in contact with the one or more organic semiconductor layers, (ii) one or more composite semiconductor layers, each composite semiconductor layer containing an organic material and inorganic material, or (iii) a combination thereof.
Type:
Application
Filed:
January 12, 2023
Publication date:
September 21, 2023
Applicant:
The Trustees of Princeton University
Inventors:
Barry P. Rand, Ross A. Kerner, James C. Loy
Abstract: Methods and devices for additive production of multi-materials are provided. Various devices may include a plurality of toolheads, each toolhead operably coupled to a different composition and having a kinematic coupling mechanism. The compositions may include a first composition comprising a cement paste or mortar, and a second composition comprising a thermoplastic polymer and/or an elastomeric polymer. The devices may include a moveable tool mount configured to be removably coupled to the kinematic coupling mechanism of each toolhead. A processor may be included that is configured to cause the deposition of the first composition and cause the deposition of the second composition simultaneous with the first composition and/or deposit the second composition after the first composition is deposited. Systems and techniques for toolpath creation may also be provided. In-situ structures may be provided that may include cement paste in contact with a thermoplastic polymer or an elastomeric polymer.
Abstract: The disclosure provides compounds. In certain embodiments, compounds of the disclosure are capable of inhibiting a mammalian SHMT, such as human SMHT1 and/or SHMT2. Compounds of the disclosure have numerous uses.
Type:
Grant
Filed:
April 7, 2020
Date of Patent:
September 19, 2023
Assignee:
The Trustees of Princeton University
Inventors:
Joshua D. Rabinowitz, Hahn Kim, Gregory S. Ducker, Jonathan M. Ghergurovich
Abstract: Subject matter disclosed herein may relate to power converters, and may more particularly relate to multi-stage hybrid power converters, for example.
Type:
Grant
Filed:
December 22, 2020
Date of Patent:
September 19, 2023
Assignees:
The Trustees of Princeton University, pSemi Corporation
Inventors:
Minjie Chen, Yenan Chen, David Giuliano
Abstract: According to various embodiments, a method for encrypting image data for a neural network are disclosed. The method includes mixing the image data with other datapoints to form mixed data; and applying a pixel-wise random mask to the mixed data to form encrypted data. According to various embodiments, a method for encrypting text data for a neural network for natural language processing is disclosed. The method includes encoding each text datapoint via a pretrained text encoder to form encoded datapoints; mixing the encoded datapoints with other encoded datapoints to form mixed data; applying a random mask to the mixed data to form encrypted data; and incorporating the encrypted data into training a classifier of the neural network and fine-tuning the text encoder.
Abstract: Compositions and methods are provided for DNA barcoding of designer mononucleosome and polynucleosome (chromatin array) libraries for use, for example, for the profiling of chromatin readers, writers, erasers, and modulators thereof.
Type:
Grant
Filed:
August 24, 2018
Date of Patent:
September 12, 2023
Assignee:
The Trustees of Princeton University
Inventors:
Tom W. Muir, Uyen T. T. Nguyen, Manuel M. Mueller
Abstract: Provided herein is an isolated fusion protein comprising a light-responsive domain and a heterologous peptide component. Exposure of the fusion protein to light induces a conformational change in the fusion protein that alters an activity of the fusion protein and the activity is a binding activity selected from an in vitro binding activity, an in vivo extracellular binding activity and an in vivo intracellular binding activity. Also provided are methods of using and identifying the fusion proteins.
Type:
Grant
Filed:
June 1, 2020
Date of Patent:
September 5, 2023
Assignee:
The Trustees of Princeton University
Inventors:
Jared Toettcher, Jose Avalos, Maxwell Wilson, Alexander Goglia, Evan M. Zhao, Agnieszka Gil, Cesar Carrasco-Lopez
Abstract: Systems and methods are described, and one method includes illuminating a target-of-interest (TI) with an RF energy configured to effect, over a time duration extending from a first time to a second time, an increase in a temperature of the TI. At a first detection time within the time duration, a first temperature NQR signal spectrum of the TI is detected, and a corresponding first temperature NQR spectrum data set is generates. At a second detection time, subsequent to the first detection time, a second temperature NQR signal spectrum of the TI is detected and corresponding second temperature NQR spectrum data set is output. Based at least in part on the first temperature NQR spectral dataset and the second temperature NQR spectral dataset, the TI is classified between including the SI and not including the SI.
Abstract: Disclosed herein are solar cells with kesterite-based absorbers that hold promise as a low-cost and durable technology to renewably produce electricity using solar energy conversion. The current state-of-the-art (SOA) for such kesterite solar cells is Cu2ZnSn(S,Se)4 and novel materials are required to suppress the formation bandgap-fluctuation- and charge-carrier-recombination-inducing defects and eventually to achieve solar cell efficiencies higher than the SOA. Three important material properties that govern the efficiency of a solar cell are the concentrations of performance-degrading defects, band gap, and chemical stability. Disclosed here is a stable material, specifically Cu2CdGe(S,Se)4, as a new candidate that can exhibit higher defect formation energies than Cu2ZnSnS4 and a nearly optimal bandgap, which can eventually result in higher solar-cell efficiencies in solar energy conversion.
Type:
Application
Filed:
July 19, 2021
Publication date:
August 24, 2023
Applicant:
The Trustees of Princeton University
Inventors:
Emily A. CARTER, Robert B. WEXLER, Sai Gautam GOPALAKRISHNAN
Abstract: A method for controlling the encapsulation efficiency and burst release of water soluble molecules from nanoparticle and microparticle formulations produced by the inverted Flash NanoPrecipitation (iFNP) process and subsequent processing steps is presented. The processing steps and materials used can be adjusted to tune the encapsulation efficiency and burst release of the encapsulated water-soluble material. The encapsulation efficiency of the soluble agent in the particles and the burst release of the soluble agent from the particles can be controlled by: (1) the copolymers used in the assembly or coating process, (2) the degree of crosslinking of the nanoparticle core, (3) the incorporation of small molecule or polymeric additives, and/or (4) the processing and release conditions employed.
Type:
Grant
Filed:
July 19, 2019
Date of Patent:
August 22, 2023
Assignee:
The Trustees of Princeton University
Inventors:
Robert K. Prud'homme, Robert F. Pagels, Chester E. Markwalter
Abstract: Disclosed are dielectric barrier discharge (DBD) devices and methods of use for sterilizing surfaces. The DBD devices generally include one or more first electrodes, one or more second electrodes or chemical reagent layers, and at least one dielectric layer between the one or more first electrodes and the one or more second electrodes or chemical reagent layers. In various configurations, the at least one dielectric layer is either (a) in contact with at least one of the first electrodes or (if present) at least one chemical reagent layer, or (b) is separated from the one or more first electrodes by a first gap and is also separated from the one or more second electrodes or chemical reagent layers by a second gap.
Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for providing programmable or pre-programmed in-memory computing operations.
Abstract: Disclosed are systems and techniques for increasing heat transfer from a substrate to a working fluid. The systems may include a substrate comprising a plurality of grooves or cavities on at least one external surface. The system may also include an infusing liquid filling at least a majority of the plurality of grooves. The system may also include a working fluid configured to flow parallel to the external surface.
Type:
Application
Filed:
February 17, 2023
Publication date:
August 17, 2023
Applicants:
The Trustees of Princeton University, Board of Regents, The University of Texas System, KTH Royal Institute of Technology
Inventors:
Marcus Hultmark, Shervin Bagheri, Johan Sundin, Stefano Leonardi, Umberto Ciri
Abstract: A quantum information processing system comprises a light source, a detector, at least one spatial light modulator and at least one optical lens. The light source is configured to provide a beam of entangled photons. The at least one optical lens is configured to project the resultant beam onto the spatial light modulator, either by direct imaging or by performing a full or partial optical Fourier transform. Said spatial light modulator includes a plurality of discrete pixels and is configured to select one or more of the plurality of discrete pixels to generate a resultant beam from said beam of entangled photons. The resultant beam from said spatial light modulator is projected onto the detector. For optical computation, such as search algorithms, the configuration and projections are repeated to find the optimal solution.
Type:
Grant
Filed:
July 28, 2017
Date of Patent:
August 15, 2023
Assignee:
Trustees of Princeton University
Inventors:
Jason W. Fleischer, Chien-Hung Lu, Xiaohang Sun, Matthew Reichert, Hugo Defienne
Abstract: The invention described herein relates to colloidal particles useful for photoacoustic imaging. The particles comprise a photoacoustic imaging agent with an absorbance maximum or plateau in the range of wavelengths 700-1100 nm. The imaging agent also displays low optical absorbance at some wavelength in the range 700-1100 nm. This combination of high and low optical absorbance enables background subtraction in photoacoustic imaging applications. The imaging agent is an organic compound having low aqueous solubility so that it is stably encapsulated in the hydrophobic core of the particle. The particle is stabilized by a polymeric surface coating, and the polymeric stabilizing layer on the surface of the particle may contain targeting ligands for targeted diagnostics or therapeutic delivery. The particle core may also contain therapeutic agents or other imaging agents.
Type:
Application
Filed:
April 21, 2023
Publication date:
August 10, 2023
Applicant:
The Trustees of Princeton University
Inventors:
Robert K. Prud'homme, Vikram J. Pansare, Shahram Hejazi, Hoang D. Lu, James Bruce Pitner, Jonathan Lindsey
Abstract: Compositions that increase the bioavailability of dihydromyricetin are presented. The bioavailability is increased by methods including formulating dihydromyricetin in nanoparticle form, delivering dihydromyricetin with permeabilizers, and encapsulating dihydromyricetin with an enteric coating.
Type:
Application
Filed:
August 30, 2022
Publication date:
July 6, 2023
Applicants:
The Trustees of Princeton University, Cheers Health, Inc.
Inventors:
Robert K. PRUD'HOMME, Brooks POWELL, Chang TIAN
Abstract: Disclosed herein is a quantitative screen for the assessment of microbiome derived drug metabolism. The disclosed quantitative screen, named MDMQ-Screen, may be employed, inter alia, for assessing the impact of the human gut microbiome on drug metabolism. MDMQ-Screen is used to measure and explain inter-individual variability in drug metabolism. This information is crucial in explaining potential toxic effects of the administered drugs, as well variability in response to therapy between individuals. Inter alia, MDMQ-Screen can be used to assess unexplained variability in drug response and toxicity of already used medications; used in future drug development pipelines to aid in the design and interpretation of clinical trials; and used at bedside to assess the probability of drug response and toxicity and provide recommendations for therapeutic modifications in a personalized medicine manner.