Patents Assigned to Princeton University
-
Publication number: 20230213024Abstract: Disclosed is a miniaturized plasma propulsion device with minimized surface area of the thruster walls exposed to the plasma and, as a result, reduced plasma-surface interactions including a set of segmented electrodes to facilitate the following improvements compared to relevant existing technologies: 1) control of the plasma flow including focusing of the plasma plume 2) increase of the thrust 2) reduction of inefficiencies associated with the electron cross field current, and 3) mitigation of low frequency oscillations. The electrodes affect all these actions when a DC or modulated voltage is applied to one or all of them with the same or different amplitudes, with the same or different frequencies or phases which are all optimized to realize the best performance through changes in the acceleration and/or ionization regions. In addition, the applied voltage to the main electrodes may also be modulated.Type: ApplicationFiled: August 26, 2022Publication date: July 6, 2023Applicant: The Trustees of Princeton UniversityInventors: Jacob Simmonds, Yevgeny Raitses
-
Publication number: 20230212626Abstract: Disclosed is a technique for constructing optogenetic amplifier and inverter circuits utilizing transcriptional activator/repressor pairs, in which expression of the transcriptional activator or repressor, respectively, is controlled by light-controlled transcription factors. This system is demonstrated utilizing the quinic acid regulon system from Neurospora crassa, or Q System, a transcriptional activator/repressor system. This is also demonstrated utilizing the galactose regulon from Saccharomyces cerevisiae, or GAL System. Such optogenetic amplifier circuits enable multi-phase microbial fermentations, in which different light schedules are applied in each phase to dynamically control different metabolic pathways for the production of proteins, fuels or chemicals.Type: ApplicationFiled: December 22, 2022Publication date: July 6, 2023Applicant: The Trustees of Princeton UniversityInventors: Jose L. Avalos, Jared E. Toettcher, Evan M. Zhao, Makoto A. Lalwani
-
Publication number: 20230194702Abstract: Systems and methods are described, and one system includes a three-dimensional (3D) geometric tracker connected to a multiband (MB) inverse synthetic aperture array radar (ISAR), and a classification/alarm logic. The MB ISAR includes spatially distributed radar transmitters (TXs) and receivers (RXs), a TX/RX allocation logic, and a tomographic (TM) image logic. The TX/RX allocation logic is configured to receive 3D tracking data from the 3D geometric tracker, indicating subject 3D position and 3D orientation and, in response, dynamically allocate TXs and RXs to maintain MB illumination of and maintain MB reception of multiple scatter angles from subjects. The TM image processor is configured to construct TM images from the scatter angles, using 3D tracking data, for input to the classification and alarm logic. Optionally, the TX/RX resource allocation logic is configured to receive situation feedback data, for feedback adjusting of allocation of TXs and RXs.Type: ApplicationFiled: April 21, 2021Publication date: June 22, 2023Applicant: The Trustees of Princeton UniversityInventors: Alexei Goun, Herschel RABITZ
-
Publication number: 20230181120Abstract: According to various embodiments, a machine-learning based system for coronavirus detection is disclosed. The system includes one or more processors configured to interact with a plurality of wearable medical sensors (WMSs). The processors are configured to receive physiological data from the WMSs and questionnaire data from a user interface. The processors are further configured to train at least one neural network based on raw physiological data and questionnaire data augmented with synthetic data and subjected to a grow-and-prune paradigm to generate at least one coronavirus inference model. The processors are also configured to output a coronavirus-based decision by inputting the received physiological data and questionnaire data into the generated coronavirus inference model.Type: ApplicationFiled: April 20, 2021Publication date: June 15, 2023Applicant: The Trustees of Princeton UniversityInventors: Shayan HASSANTABAR, Niraj K. JHA
-
Publication number: 20230169241Abstract: Various embodiments comprise systems, methods, mechanisms, apparatus, and improvements thereof providing a machine learning based inverse design method for mm-wave/RF power amplifiers (PAs). Methods according to embodiments provide for efficiently synthesizing power amplifier matching circuit (output matching/output power combiner/backoff efficient output power combiner, interstage matching and input matching/input power divider and phase shifter) for a close to optimum solution in terms of matching bandwidth, efficiency and load modulation, which can exceed the performance limitations of traditional matching network designs.Type: ApplicationFiled: December 1, 2022Publication date: June 1, 2023Applicant: The Trustees of Princeton UniversityInventors: Zheng Liu, Emir All Karahan, Kaushik Sengupta
-
Patent number: 11657523Abstract: The microlens amplitude masks for flying pixel removal in time-of-flight imaging includes systems, devices, methods, and instructions for image depth determination, including receiving an image, adding noise to the image, determining a set of correlation images, each correlation image having a varying phase offset, for each pixel of the image, generating a masked pixel by applying a mask array, and for each masked pixel, determining the depth of the masked pixel to generate a depth map for the image on a per pixel basis.Type: GrantFiled: March 17, 2022Date of Patent: May 23, 2023Assignees: The Trustees of Princeton University, King Abdullah University of Science and TechnologyInventors: Ilya Chugunov, Seung-Hwan Baek, Qiang Fu, Wolfgang Heidrich, Felix Heide
-
Publication number: 20230152664Abstract: Disclosed herein is the detection of dangerous dielectric materials (explosives) and dangerous non-explosive and/or prohibited items. The detection is based on a broad bandwidth nonlinear radar system, driven by a highly stable optical frequency comb. The disclosed approach allows for the spatial resolution of the interrogated object in complex settings. Detection of dangerous materials and non-explosive chemical prohibited items is disclosed.Type: ApplicationFiled: April 22, 2021Publication date: May 18, 2023Applicant: The Trustees of Princeton UniversityInventors: Alexei GOUN, Herschel RABITZ
-
Publication number: 20230143042Abstract: Disclosed herein is a multi-purpose aerosol platform capable of producing and delivery of submicron and nano structured materials for pharmaceutical, biomedical and environmental applications. Depending on the application, active chemical and biological materials may be processed from liquid dispersions into droplets and/or particle formulations. The disclosed system uses moderate gas pressures to atomize liquids into submicron-size droplets that are 10-1000 times smaller in diameter than commercial and research systems. This allows much gentler and rapid droplet-to-particle conversion, applying much smaller physical and chemical stresses on the processed materials than conventional techniques like spray drying, spray coating, spray freeze drying and other technologies. For example, the disclosed system can be used for an ultra-fine nebulization and delivery of viscous therapeutic oils including oils of medical cannabis, for which conventional nebulization systems either fail or became ineffective.Type: ApplicationFiled: April 6, 2021Publication date: May 11, 2023Applicant: The Trustees of Princeton UniversityInventors: Maksym MEZHERICHER, Howard A. STONE
-
Publication number: 20230137975Abstract: According to various embodiments, a power converter circuit is disclosed. The power converter circuit includes at least two vertically stacked printed circuit boards (PCBs) comprising a top PCB and a bottom PCB. The power converter circuit further includes at least one multiphase coupled inductor placed between the top PCB and the bottom PCB. The top PCB is coupled to the bottom PCB via at least one conductive winding of the multiphase coupled inductor. The power converter circuit further includes at least one circuit module placed above the top PCB and at least one power source placed below the bottom PCB. The multiphase coupled inductor is configured to deliver current vertically from the bottom PCB to the top PCB.Type: ApplicationFiled: April 14, 2021Publication date: May 4, 2023Applicants: The Trustees of Princeton University, The Trustees of Dartmouth CollegeInventors: Minjie CHEN, Charles SULLIVAN, Youssef E. ELASSER, Daniel ZHOU, Jaeil BAEK, Yenan CHEN
-
Publication number: 20230126007Abstract: An “inverse” precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described.Type: ApplicationFiled: December 16, 2022Publication date: April 27, 2023Applicant: The Trustees of Princeton UniversityInventors: Robert F. PAGELS, Robert K. PRUD'HOMME
-
Publication number: 20230123785Abstract: Microorganisms are prolific producers of natural products, a group of molecules that make up the majority of drugs approved by the FDA in the past 35 years. After decades of mining, the low-hanging fruit has been picked and so discovery of drug-like molecules from microorganisms has come to a near-halt. The reason for this lack of productivity is that most biosynthetic pathways that give rise to natural products are not active under typical laboratory growth conditions. These so-called ‘cryptic’ or ‘silent’ pathways are a major source of new bioactive molecules and methods that reliably activate them could have a profound impact on drug discovery. Disclosed herein is a rapid genetics-free method for eliciting and detecting cryptic metabolites using an imaging mass spectrometry-based approach. An organism of choice is challenged with elicitors from a small molecule library. The molecules elicited are then imaged by mass spec, which allows for rapid identification of cryptic metabolites.Type: ApplicationFiled: December 1, 2022Publication date: April 20, 2023Applicant: The Trustees of Princeton UniversityInventors: Mohammad R. SEYEDSAYAMDOST, Fei XU, Yihan WU, Leah BUSHIN, Katherine Davis
-
Patent number: 11610984Abstract: Methods, devices, and systems are described for storing and transferring quantum information. An example device may comprise at least one semiconducting layer, one or more conducting layers configured to define at least two quantum states in the at least one semiconducting layer and confine an electron in or more of the at least two quantum states, and a magnetic field source configured to generate an inhomogeneous magnetic field. The inhomogeneous magnetic field may cause a first coupling of an electric charge state of the electron and a spin state of the electron. The device may comprise a resonator configured to confine a photon. An electric-dipole interaction may cause a second coupling of an electric charge state of the electron to an electric field of the photon.Type: GrantFiled: July 29, 2021Date of Patent: March 21, 2023Assignee: The Trustees of Princeton UniversityInventors: Jason Petta, Xiao Mi, David Zajac
-
Publication number: 20230074229Abstract: Various embodiments comprise systems, methods, architectures, mechanisms and apparatus for providing programmable or pre-programmed in-memory computing (IMC) operations via an array of configurable IMC cores interconnected by a configurable on-chip network to support scalable execution and dataflow of an application mapped thereto.Type: ApplicationFiled: February 5, 2021Publication date: March 9, 2023Applicant: The Trustees of Princeton UniversityInventors: Hongyang JIA, Murat OZATAY, Hossein VALAVI, Naveen VERMA
-
Publication number: 20230044467Abstract: Bacterial infections evading the current antibiotic arsenal warrant new treatment options. The mainstay treatment for Clostridium difficile infections involves administration of the broad-spectrum antibiotic vancomycin, which also depletes the gut microbiome and its natural defenses. This leads to recurrent C. difficile infections in 20-30% of patients. Alternative treatment options are limited, triggering a perpetual cycle of relapse and recovery that may eventually lead to death. Keratinicyclin B represents a glycopeptide antibiotic chemotype with a mechanism of action that is selective for Clostridia. When combined, vancomycin (or other glycopeptide antibiotic) and keratinicyclin B interact synergistically to inhibit the growth of C. difficile at concentrations far lower than their respective minimal inhibitory concentrations. Such a combination therapy could allow for targeted colonization clearance at low antibiotic doses, thereby minimizing toxicity and reducing the likelihood of relapse.Type: ApplicationFiled: July 26, 2022Publication date: February 9, 2023Applicant: The Trustees of Princeton UniversityInventors: Mohammad R. Seyedsayamdost, Vasiliki T. Chioti, Katherine M. Davis, Kirklin L. McWhorter
-
Publication number: 20230028572Abstract: Disclosed herein is a simple method for generation of high-throughput aerosols of monodisperse micro-shell particles. To create the aerosol, small nozzles are employed blowing slightly compressed air on a thin liquid film. This allows one to generate bubble aerosols consisting of particles having a thin liquid shell surrounding a gas core, which are suspended in a carrier gas flow or environment. The diameter of the created liquid shells is uniform and scales with the inner diameter of the blowing nozzle, enabling control on the size of the produced monodispersed aerosol and formation of particles between few microns to several hundred of microns in outer diameter. The process throughput is very high, reaching several thousands of particles with liquid micro-shells per second for one blowing nozzle.Type: ApplicationFiled: November 19, 2020Publication date: January 26, 2023Applicant: The Trustees of Princeton UniversityInventors: Maksym MEZHERICHER, Howard A. STONE
-
Patent number: 11557034Abstract: Systems and methods are described for the fully automatic, template-free locating and extracting of a plurality of two-dimensional projections of particles in a micrograph image. A set of reference images is automatically assembled from a micrograph image by analyzing the image data in each of a plurality of partially overlapping windows and identifying a subset of windows with image data satisfying at least one statistic criterion compared to other windows. A normalized cross-correlation is then calculated between the image data in each reference image and the image data in each of a plurality of query image windows. Based on this cross-correlation analysis, a plurality of locations in the micrograph is automatically identified as containing a two-dimensional projection of a different instance of the particle of the first type. The two-dimensional projections identified in the micrograph are then used to determine the three-dimensional structure of the particle.Type: GrantFiled: June 13, 2018Date of Patent: January 17, 2023Assignee: The Trustees of Princeton UniversityInventors: Amit Singer, Ayelet Heimowitz, Joakim Anden, Yuehaw Khoo, Joseph Kileel
-
Patent number: 11549919Abstract: Systems and methods for prediction of state of charge (SOH), state of health (SOC) and other characteristics of batteries using acoustic signals, includes determining acoustic data at two or more states of charge and determining a reduced acoustic data set representative of the acoustic data at the two or more states of charge. The reduced acoustic data set includes time of flight (TOF) shift, total signal amplitude, or other data points related to the states of charge. Machine learning models use at least the reduced acoustic dataset in conjunction with non-acoustic data such as voltage and temperature for predicting the characteristics of any other independent battery.Type: GrantFiled: March 8, 2019Date of Patent: January 10, 2023Assignee: The Trustees of Princeton UniversityInventors: Daniel Artemis Steingart, Shoham Bhadra, Andrew Gaheem Hsieh, Benjamin Hertzberg, Peter James Gjeltema, Clarence Worth Rowley, III, Alexandre S. R. Goy, Jason Wolf Fleischer
-
Publication number: 20220409826Abstract: Systems and methods for automatic intravenous injection in accordance with embodiments of the invention are illustrated. One embodiment includes a method for automatically injecting a needle into a vein. The method includes steps for identifying an injection position using a first set of one or more sensors, positioning an injection mechanism at the identified injection position, and vertically inserting a needle until entry in a vein is detected using a second set of one or more sensors.Type: ApplicationFiled: November 19, 2020Publication date: December 29, 2022Applicants: The Trustees of Princeton University, Invictis Labs, Inc.Inventors: Craig B. Arnold, Miles Cole
-
Publication number: 20220403429Abstract: Microbial consortia exert great influence over the physiology of humans, animals, plants, and ecosystems. However, difficulty in controlling their composition and population dynamics have limited their application in medicine, agriculture, biotechnology, and the environment. The approach disclosed herein provides an effective method to dynamically control population compositions in microbial consortia, which we demonstrate in the context of co-culture fermentations for chemical production. Co-culture fermentations can improve chemical production from complex biosynthetic pathways over monocultures by distributing enzymes across multiple strains, thereby reducing metabolic burden, overcoming endogenous regulatory mechanisms, or exploiting natural traits of different microbial species. However, stabilizing and optimizing microbial sub-populations for maximal chemical production remains a major obstacle in the field.Type: ApplicationFiled: June 21, 2022Publication date: December 22, 2022Applicant: The Trustees of Princeton UniversityInventors: Jose L. Avalos, Makoto A. Lalwani, Mark P. Brynildsen
-
Publication number: 20220403364Abstract: Disclosed is a 3D porous medium and a method of manufacture. The 3D porous medium includes (i) a support structure of transparent hydrogel particles or emulsion droplets, (ii) bacterial nutrient in open volumes between the transparent hydrogel particles, as well as within micropores in the transparent hydrogel particles, and (iii) bacterial cells within the open volumes in the support structure.Type: ApplicationFiled: April 28, 2020Publication date: December 22, 2022Applicant: The Trustees of Princeton UniversityInventors: Sujit Datta, Tapomoy Bhattacharjee