Patents Assigned to Proteus Digital Health, Inc.
  • Smart parenteral administration system
    Patent number: 9084566
    Abstract: The invention provides methods and systems for evaluating a fluid transfer event between a parenteral fluid delivery and a patient. The evaluation of the fluid transfer event can be prospective real-time and/or historic, as desired, and take a variety of different formats.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: July 21, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventor: Mark Zdeblick
  • Active signal processing personal health signal receivers
    Patent number: 9083589
    Abstract: The invention provides a receiver associated with a body, e.g., located inside or within close proximity to a body, configured to receive and decode a signal from an in vivo transmitter which located inside the body. Signal receivers of the invention provide for accurate signal decoding of a low-level signal, even in the presence of significant noise, using a small-scale chip, e.g., where the chip consumes very low power. Also provided are systems that include the receivers, as well as methods of using the same.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: July 14, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Lawrence Arne, Kit Yee Au-Yeung, Kenneth C. Crandall, Timothy Robertson
  • Multi-mode communication ingestible event markers and systems, and methods of using the same
    Patent number: 9060708
    Abstract: Aspects of the invention include multi-mode communication ingestible event marker devices. Ingestible event marker devices of the invention include an ingestible component comprising a conductive communication module and at least one additional non-conductive communication module. The non-conductive communication module may be integrated with the ingestible component or at least a portion or all of the non-conductive communication module may be associated with a packaging component of the ingestible event marker device. Additional aspects of the invention include systems that include the devices and one or more receivers, as well as methods of using the same.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: June 23, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Timothy Robertson, Mark Zdeblick
  • Integrated Ingestible Event Marker System with Pharmaceutical Product
    Publication number: 20150112243
    Abstract: A system and method are provided for securing an ingestible electronic device to a pharmaceutical product without damaging the ingestible electronic device. The product includes the ingestible electronic device being placed on the product in accordance with one aspect of the present invention. In accordance with another aspect of the present invention, the ingestible electronic device is placed inside the product. Various embodiments are disclosed in accordance with the present invention for protecting and/or coating of the electronic marker as well as securing the ingestible electronic device onto the product.
    Type: Application
    Filed: May 27, 2014
    Publication date: April 23, 2015
    Applicant: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Robert Duck, Timothy Robertson, Benedict Costello
  • Data gathering system
    Patent number: 9014779
    Abstract: A device for gathering data has first and second electrodes. The first electrode is coupled to a surface of interest, and the second electrode is coupled to “everything else” or “the air”. The first electrode is shielded from the second, and from most sources of parasitic capacitance, by a shield that is driven by an active driver that drives the shield to track, and ideally to match, the instantaneous potential of the electrode. The second electrode is likewise shielded in a similar way from most sources of parasitic capacitance. These shields likewise help to limit the extent to which RFI from the device electronics couples with either of the electrodes. In this way the sensing device achieves a markedly better signal-to-noise ratio at frequency bands of interest.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: April 21, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Mark Zdeblick, James Hutchison, Lawrence Arne
  • Two-wrist data gathering system
    Patent number: 9008761
    Abstract: Sensing is carried out from locations considerably removed from the stomach. Cooperating sensor electronics are placed at each of two wrists of the patient. The potential discomfort and inconvenience of an abdominal patch are reduced or eliminated, and alternative power sources become available.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: April 14, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventor: Mark Zdeblick
  • In-body device with virtual dipole signal amplification
    Patent number: 8961412
    Abstract: Virtual dipole signal amplification for in-body devices, such as implantable and ingestible devices, is provided. Aspects of the in-body deployable antennas of the invention include antennas configured to go from a first configuration to a second configuration following placement in a living body, e.g., via ingestion or implantation. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: February 24, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Benedict James Costello, Timothy L. Robertson, Maria Casillas Holen
  • In-body power source having high surface area electrode
    Patent number: 8956288
    Abstract: Power sources that enable in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body power sources of the invention include a solid support, a first high surface area electrode and a second electrode. Embodiments of the in-power sources are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the power sources of the invention.
    Type: Grant
    Filed: February 14, 2008
    Date of Patent: February 17, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Timothy Robertson, Eric Snyder, Brad Cozad
  • Patient customized therapeutic regimens
    Patent number: 8956287
    Abstract: Methods, systems and compositions that allow for treating a patient according to a patient customized therapeutic regimen are provided. Embodiments of the invention include obtaining dosage administration information from a patient and using the same to tailor a therapeutic regimen for the patient. Embodiments of the invention further include preparing and forwarding to the patient physical pharmaceutical dosages based on the customized therapeutic regimen.
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: February 17, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Mark J. Zdeblick, Andrew Thompson, George M. Savage
  • Pharmaceutical dosages delivery system
    Patent number: 8951234
    Abstract: Pharmaceutical delivery systems for delivering dosages according to the present invention include a carrier component and a cap configured to seal an internal volume of the carrier component, wherein the cap includes a device that produces a unique current signature. Dosages prepared to be delivered according to embodiments of the invention find use in a variety of different applications, including clinical trials.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: February 10, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Gregory Moon, Kityee Au-Yeung, Robert Duck, Maria Casillas Holen
  • Controlled activation ingestible identifier
    Patent number: 8945005
    Abstract: Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a target site of interest. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: February 3, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Timothy Robertson, Olivier Colliou, Mark Zdeblick
  • In-body device having a multi-directional transmitter
    Patent number: 8932221
    Abstract: Multi-directional transmitters for in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body multi-direction transmitters of the invention include signal transmitters configured to transmit an identifying signal in at least two different directions in an x-y plane. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: January 13, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Olivier Colliou, Timothy Robertson, Mark Zdeblick
  • Communication system with remote activation
    Patent number: 8912908
    Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: December 16, 2014
    Assignee: Proteus Digital Health, Inc.
    Inventors: Jeffrey Berkman, Mark Zdeblick, Patricia Johnson, Hooman Hafezi, Jonathan Withrington
  • Active Signal Processing Personal Health Signal Receivers
    Publication number: 20140334575
    Abstract: The invention provides a receiver associated with a body, e.g., located inside or within close proximity to a body, configured to receive and decode a signal from an in vivo transmitter which located inside the body. Signal receivers of the invention provide for accurate signal decoding of a low-level signal, even in the presence of significant noise, using a small-scale chip, e.g., where the chip consumes very low power. Also provided are systems that include the receivers, as well as methods of using the same.
    Type: Application
    Filed: March 6, 2014
    Publication date: November 13, 2014
    Applicant: Proteus Digital Health, Inc.
    Inventors: Lawrence Arne, Kit Yee Au-Yeung, Kenneth C. Crandall, Timothy Robertson
  • System for supply chain management
    Patent number: 8868453
    Abstract: A system for tracking a product from origin to destination is disclosed. The system includes a probe that comprises two plates, a power source and a processor. The power source is controlled by the processor to produce an oscillating output at the plates. Using the oscillating voltage, the probe interrogates a device through capacitive coupling. The device includes a control unit, a memory unit, and first and second materials physically associated with the device for communication using capacitive coupling. Information associated with the device is transferred from the device to the probe through capacitive coupling between the first and second materials and the first and second plates, respectively.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: October 21, 2014
    Assignee: Proteus Digital Health, Inc.
    Inventor: Mark J. Zdeblick
  • In-Body Device with Virtual Dipole Signal Amplification
    Publication number: 20140309504
    Abstract: Virtual dipole signal amplification for in-body devices, such as implantable and ingestible devices, is provided. Aspects of the in-body deployable antennas of the invention include antennas configured to go from a first configuration to a second configuration following placement in a living body, e.g., via ingestion or implantation. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.
    Type: Application
    Filed: January 22, 2014
    Publication date: October 16, 2014
    Applicant: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Benedict Costello, Timothy Robertson, Maria Casillas Holen
  • Ingestible event marker systems
    Patent number: 8858432
    Abstract: Ingestible event marker systems that include an ingestible event marker (i.e., an IEM) and a personal signal receiver are provided. Embodiments of the IEM include an identifier, which may or may not be present in a physiologically acceptable carrier. The identifier is characterized by being activated upon contact with a target internal physiological site of a body, such as digestive tract internal target site. The personal signal receiver is configured to be associated with a physiological location, e.g., inside of or on the body, and to receive a signal the IEM. During use, the IEM broadcasts a signal which is received by the personal signal receiver.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: October 14, 2014
    Assignee: Proteus Digital Health, Inc.
    Inventors: Timothy Robertson, George Savage, Mark Zdeblick, Yashar Behzadi, Benedict Costello, Jeremy Frank, Hooman Hafezi, Tariq Haniff, David O'Reilly
  • Display screen portion having a graphical user interface for patient monitoring
    Patent number: D733727
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: July 7, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Danielle Schulze Cojuangco, Todd Nathan Rinker, Arna Diana Ionescu
  • Display screen portion having a graphical user interface for patient monitoring
    Patent number: D733760
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: July 7, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Danielle Schulze Cojuangco, Todd Nathan Rinker, Arna Diana Ionescu
  • Display screen portion having a graphical user interface for patient monitoring
    Patent number: D733761
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: July 7, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventors: Danielle Schulze Cojuangco, Todd Nathan Rinker, Arna Diana Ionescu