Abstract: Compositions, systems and methods that allow for the detection of the actual physical delivery of a pharmaceutical agent to a body are provided. Embodiments of the compositions include an identifier and an active agent. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.

Abstract: In a first embodiment, electrodes are coupled to a surface at first, second, and third locations, the first location being further from the third location than from the second location. Impedance is measured at distinct frequencies between pairs of the electrodes. As a result, impedance is measured at differing regions below the surface, one region being deeper below the surface than the other region. In a second embodiment, a microfluidic device carries out an analysis. The analysis may be within a flexible patch adhered to a surface, or may be in a solid device implanted in a body of liquid surrounded by tissue. The analysis may involve pumping a fluid or may involve drawing an analyte electrophoretically through a microfluidic channel.

Abstract: A biological sample collection device includes a top cover plate, a bottom portion attached to the top cover plate, the bottom portion comprising a remotely-analyzable biological sample collection portion to collect a biological sample from a body of a subject. The biological sample is to be analyzed at a remote processing facility at a later time. A fastening portion is provided on the bottom portion to affix the remotely-analyzable biological sample collection device to the body of the subject. A real time clock is coupled to the top cover plate and a memory is coupled to the top cover plate and electrically coupled to the real time clock. The remotely-analyzable biological sample collection device may further include a processing unit, at least two electrodes coupled to the processing unit, and a transbody conductive communication module.

Abstract: A re-wearable wireless device includes a reusable component to be secured to a disposable component. The reusable component includes a sensor interface to receive signals from an electrode secured to a living subject and monitors physiological and physical parameters associated with the living subject and a cellular wireless communication circuit. An adhesive base the device includes a first adhesive layer and a second adhesive layer partially covering the first adhesive layer around a perimeter thereof, where the first and second adhesive layers include different adhesives. A method of establishing a link between two wireless devices is also disclosed, where a first wireless device with an insignia representing a communication channel address identification is provided. An image of the insignia is captured with a mobile telephone computing device comprising an image sensor. The captured image is processed to extract the communication channel address identification represented by the insignia.

Abstract: The present invention provides implantable systems that communicate wirelessly with each other using a unique format that enables devices configurations and applications heretofore not possible. Embodiments of the present invention provide communication apparatuses and methods for exchanging information with implantable medical devices. In some embodiments, two implantable devices communicate with each other using quasi-electrostatic signal transmission in a long wavelength/low frequency electromagnetic band, with the patient's body acting as a conductive medium.

Abstract: Pharmaceutical delivery systems for delivering dosages according to the present invention include a carrier component and a cap configured to seal an internal volume of the carrier component, wherein the cap includes a device that produces a unique current signature. Dosages prepared to be delivered according to embodiments of the invention find use in a variety of different applications, including clinical trials.

Abstract: Spatial arrays of electrodes are provided, each array in a region of tissue. The electrodes of an array are connected so that some of the electrodes serve as shield electrodes relative to a pair of electrodes used for pulse stimulation or sensing of electrical activity, or both. The shield electrodes are connected together, defining an electrical node, the node defining a stable potential in predetermined relationship with power supply levels or with reference voltages for sensing circuitry. Multiplexing techniques may be employed so that sensed activity at each of several electrode locations can be communicated to electronics external to the electrode locations.

Abstract: Aspects of the invention include multi-mode communication ingestible event marker devices. Ingestible event marker devices of the invention include an ingestible component comprising a conductive communication module and at least one additional non-conductive communication module. The non-conductive communication module may be integrated with the ingestible component or at least a portion or all of the non-conductive communication module may be associated with a packaging component of the ingestible event marker device. Additional aspects of the invention include systems that include the devices and one or more receivers, as well as methods of using the same.

Abstract: A target authentication device includes an electrode to detect an electrical signal associated with a user of the device. The electrical signal represents an authentication code for the device. An authentication receiver module is coupled to the electrode. The module receives the electrical signal from the electrode and determines whether the electrical signal matches a predetermined criterion to authenticate the identity of the user based on the electrical signal. An authentication module is also disclosed. The authentication module includes one electrode to couple an electrical signal associated with a user to a user of a target authentication device, the electrical signal represents an authentication code for the device. An authentication transmission module is coupled to the electrode. The authentication transmission module transmits the electrical signal from the electrode. A method of authenticating the identity of a user of a target authentication device also is disclosed.

Abstract: System, method, and article to prompt behavior change are provided. Various aspects of the system include health promotion data generated and/or communicated from/to a device; a methodology module associated with software/processor to identify at least one behavior change methodology associated with the health promotion data; and an instruction module associated with a software/processor to initiate the identified at least one behavior change methodology.

Abstract: Low profile antennas for ingestible devices, such as ingestible event markers, are provided. Aspects of the ingestible devices of the invention include low profile signal transmission antennas configured such that they are flexible or degrade after use, allowing the antenna and attached components to pass easily through the body. Embodiments of the low profile antennas are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.

Abstract: The subject matter disclosed herein provides a response to a dose of a substance and/or controls the administration of the dose. In one aspect, there is provided a system. The system may include a processor and at least one memory configured to provide a response determinator. The response determinator may receive therapeutic and wellness data. Moreover, the response determinator may determine a response based on the received therapeutic and wellness data. The response may represent a reaction to a substance integrated with an ingestible event marker. The determined response may be provided to, for example, a therapy controller. Related systems, methods, and articles of manufacture are also described.

Abstract: A system comprising a control device and a wireless energy source electrically coupled to the control device is disclosed. The wireless energy source comprises an energy harvester to receive energy at an input thereof in one form and to convert the energy into a voltage potential difference to energize the control device. Also disclosed, is the system further comprising a partial power source. Also disclosed, is the system further comprising a power source.

Abstract: Pharmaceutical delivery systems for delivering dosages according to the present invention include a carrier component and a cap configured to seal an internal volume of the carrier component, wherein the cap includes a device that produces a unique current signature. Dosages prepared to be delivered according to embodiments of the invention find use in a variety of different applications, including clinical trials.

Abstract: Portable electroviscerography systems are provided. Aspects of the systems include a body-associated receiver and an ingestible identifier unit, both of which are configured to detect visceral electrical signals. The system communicates with an extra-corporeal data processor configured to receive data from the body-associated receiver and generate and electroviscerogram from the received data. Also provided are methods of producing electroviscerograms using systems of the present invention.

Abstract: In a first embodiment, electrodes are coupled to a surface at first, second, and third locations, the first location being further from the third location than from the second location. Impedance is measured at distinct frequencies between pairs of the electrodes. As a result, impedance is measured at differing regions below the surface, one region being deeper below the surface than the other region. In a second embodiment, a microfluidic device carries out an analysis. The analysis may be within a flexible patch adhered to a surface, or may be in a solid device implanted in a body of liquid surrounded by tissue. The analysis may involve pumping a fluid or may involve drawing an analyte electrophoretically through a microfluidic channel.

Abstract: Receivers, which may be external or implantable, are provided. Aspects of receivers of the invention include the presence of one or more of: a high power-low power module; an intermediary module; a power supply module configured to activate and deactivate one or more power supplies to a high power processing block; a serial peripheral interface bus connecting master and slave blocks; and a multi-purpose connector. Receivers of the invention may be configured to receive a conductively transmitted signal. Also provided are systems that include the receivers, as well as methods of using the same. Additionally systems and methods are disclosed for using a receiver for coordinating with dosage delivery systems.

Abstract: Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.

Abstract: The present invention provides implantable systems that communicate wirelessly with each other using a unique format that enables devices configurations and applications heretofore not possible. Embodiments of the present invention provide communication apparatuses and methods for exchanging information with implantable medical devices. In some embodiments, two implantable devices communicate with each other using quasi-electrostatic signal transmission in a long wavelength/low frequency electromagnetic band, with the patient's body acting as a conductive medium.

Abstract: The present invention provides for safe and reliable electronic circuitry that can be employed in ingestible compositions. The ingestible circuitry of the invention includes a solid support; a conductive element; and an electronic component. Each of the support, conductive element and electronic component are fabricated from an ingestible material. The ingestible circuitry finds use in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.