Patents Assigned to Proteus Digital Health, Inc.
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Patent number: 8540632Abstract: Low profile antennas for ingestible devices, such as ingestible event markers, are provided. Aspects of the ingestible devices of the invention include low profile signal transmission antennas configured such that they are flexible or degrade after use, allowing the antenna and attached components to pass easily through the body. Embodiments of the low profile antennas are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.Type: GrantFiled: May 23, 2008Date of Patent: September 24, 2013Assignee: Proteus Digital Health, Inc.Inventors: Timothy L. Robertson, Olivier Colliou, Eric Snyder, Mark J. Zdeblick
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Patent number: 8540664Abstract: The subject matter disclosed herein provides a response to a dose of a substance and/or controls the administration of the dose. In one aspect, there is provided a system. The system may include a processor and at least one memory configured to provide a response determinator. The response determinator may receive therapeutic and wellness data. Moreover, the response determinator may determine a response based on the received therapeutic and wellness data. The response may represent a reaction to a substance integrated with an ingestible event marker. The determined response may be provided to, for example, a therapy controller. Related systems, methods, and articles of manufacture are also described.Type: GrantFiled: March 24, 2010Date of Patent: September 24, 2013Assignee: Proteus Digital Health, Inc.Inventors: Timothy Robertson, Yashar Behzadi
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Patent number: 8542123Abstract: Aspects of the invention include multi-mode communication ingestible event marker devices. Ingestible event marker devices of the invention include an ingestible component comprising a conductive communication module and at least one additional non-conductive communication module. The non-conductive communication module may be integrated with the ingestible component or at least a portion or all of the non-conductive communication module may be associated with a packaging component of the ingestible event marker device. Additional aspects of the invention include systems that include the devices and one or more receivers, as well as methods of using the same.Type: GrantFiled: August 1, 2012Date of Patent: September 24, 2013Assignee: Proteus Digital Health, Inc.Inventors: Timothy Robertson, Mark J. Zdeblick
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Publication number: 20130238647Abstract: Disclosed are an apparatus and system for providing diagnosis information to a requestor. A request module receives information related to a request from the requestor for diagnosis and to facilitate communication to at least one expert resource. A receive module receives at least one response to the request for diagnoses from the at least one expert resource. A select module in communication with the receive module analyzes the at least one response and, based on the analysis, communicates information to at least one predetermined destination. A method is disclosed where a request module receives a request, a receive module receives a plurality of responses to the request and from the plurality of responses, a select module selects a subset of responses and communicates the subset of responses to a predetermined destination.Type: ApplicationFiled: April 19, 2011Publication date: September 12, 2013Applicant: Proteus Digital Health, Inc.Inventor: Andrew Thompson
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Publication number: 20130231188Abstract: The present invention provides receiving devices and method for use with gaming pursuits, including, in one aspect, a plurality of receivers to communicate physiologic data, at least one hub to receive the physiologic data, and a gaming module to receive, directly or indirectly, the physiologic data from the hub.Type: ApplicationFiled: November 1, 2011Publication date: September 5, 2013Applicant: PROTEUS DIGITAL HEALTH, INC.Inventors: Joy Berberich, Mark Zdeblick
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Publication number: 20130223028Abstract: Apparatuses and methods for hybrid housings as well as hybrid housing based implantable medical devices are provided. A hybrid housing comprises a ceramic substrate, a bonding structure formed on the periphery of the ceramic substrate, and a biocompatible metal cap coupled to the ceramic substrate using the bonding structure to form a hermetically sealed enclosure. One or more electronic elements may be formed within the hermetically sealed enclosure, and the electronic elements may be stably associated with the ceramic substrate.Type: ApplicationFiled: July 25, 2011Publication date: August 29, 2013Applicant: PROTEUS DIGITAL HEALTH, INC.Inventors: Lawrence Arne, Marc Jensen, Todd Thompson
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Publication number: 20130217982Abstract: The ingestible event marker data framework provides a uniform, comprehensive framework to enable various functions and utilities related to ingestible event marker data (IEM data). Included are a receiver adapted to be associated with a body of an individual, the receiver configured to receive IEM data; a hub to receive the IEM data; and at least one IEM data system to receive the data from the hub. Among other information, behavioral data and predictive inferences may be provided.Type: ApplicationFiled: March 15, 2013Publication date: August 22, 2013Applicant: PROTEUS DIGITAL HEALTH, INC.Inventor: Proteus Digital Health, Inc.
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Publication number: 20130193950Abstract: The present invention provides for safe and reliable electronic circuitry that can be employed in ingestible compositions. The ingestible circuitry of the invention includes a solid support; a conductive element; and an electronic component. Each of the support, conductive element and electronic component are fabricated from an ingestible material. The ingestible circuitry finds use in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.Type: ApplicationFiled: January 23, 2013Publication date: August 1, 2013Applicant: PROTEUS DIGITAL HEALTH, INC.Inventor: Proteus Digital Health, Inc.
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Patent number: 8480616Abstract: The subject matter disclosed herein provides a response to a dose of a substance and/or controls the administration of the dose. In one aspect, there is provided a system. The system may include a processor and at least one memory configured to provide a response determinator. The response determinator may receive therapeutic and wellness data. Moreover, the response determinator may determine a response based on the received therapeutic and wellness data. The response may represent a reaction to a substance integrated with an ingestible event marker. The determined response may be provided to, for example, a therapy controller. Related systems, methods, and articles of manufacture are also described.Type: GrantFiled: March 24, 2010Date of Patent: July 9, 2013Assignee: Proteus Digital Health, Inc.Inventors: Timothy Robertson, Yashar Behzadi
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Publication number: 20130172690Abstract: An apparatus is disclosed as part of a system for tracking and confirming delivery of a medicinal dose to a user. The apparatus includes a detector. The detector is secured to and communicatively coupled to the user and is capable of detecting a current flow through the user's body. The current flow is produced when the user makes contact with the apparatus. The apparatus includes at least two contact areas connected to a power source where a circuit and, hence, a current path is completed through the user's body as the user makes contact with the apparatus. The current flow is detected by the detector, which is coupled to the user. Also disclosed is an apparatus for tracking and confirming delivery of a medicinal dose to a user where the apparatus includes an acoustic detector. Upon loading the dose into a chamber an acoustic vibration is generated. The vibration is detected and correlated with a current flow that is produced when the user makes contact with the apparatus.Type: ApplicationFiled: April 11, 2011Publication date: July 4, 2013Applicant: PROTEUS DIGITAL HEALTH, INC.Inventors: Lawrence Arne, Benedict Costello, Yuriy Mestman, Timothy Robertson, George Savage, Angela Strand, Todd Thompson, Mark Zdeblick, William McAllister
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Patent number: 8469885Abstract: The present invention provides for safe and reliable electronic circuitry that can be employed in ingestible compositions. The ingestible circuitry of the invention includes a solid support; a conductive element; and an electronic component. Each of the support, conductive element and electronic component are fabricated from an ingestible material. The ingestible circuitry finds use in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.Type: GrantFiled: August 13, 2009Date of Patent: June 25, 2013Assignee: Proteus Digital Health, Inc.Inventors: Hooman Hafezi, Eric Snyder, Benedict Costello
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Patent number: 8473069Abstract: Apparatus and methods enable robust, reliable control for implantable medical devices, including cardiac pacemakers, defibrillators and cardiac resynchronization devices. Integrated circuits in the devices have minimized interfaces, can derive power from the interface signals, and have high voltage and latch-up protection. A device lead has a power generation circuit and a switching circuit using cascaded PMOS transistors for operating with a stable voltage despite fluctuations in the supplied voltage. The lead has control electronics that provide a very low impedance between an electrode and a lead conductor during most of the duration of a pacing pulse, but during a brief initial portion of the pacing pulse, provide a very high impedance to permit charging up a power supply that is local to the control electronics. A method of stabilizing the external impedance and a system for fault detection and fault recovery for an implantable device are also provided.Type: GrantFiled: February 27, 2009Date of Patent: June 25, 2013Assignee: Proteus Digital Health, Inc.Inventors: Yafei Bi, Haifeng Li, Mark Zdeblick, Todd Thompson, Robert Leichner
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Patent number: 8469921Abstract: Receivers, which may be external or implantable, are provided. Aspects of receivers of the invention include the presence of one or more of: a high power-low power module; an intermediary module; a power supply module configured to activate and deactivate one or more power supplies to a high power processing block; a serial peripheral interface bus connecting master and slave blocks; and a multi-purpose connector. Receivers of the invention may be configured to receive a conductively transmitted signal. Also provided are systems that include the receivers, as well as methods of using the same. Additionally systems and methods are disclosed for using a receiver for coordinating with dosage delivery systems.Type: GrantFiled: December 23, 2011Date of Patent: June 25, 2013Assignee: Proteus Digital Health, Inc.Inventors: Timothy Robertson, Fataneh Omidvar, Yashar Behzadi, Lawrence Arne, Kenneth Rowberry, James Hutchison, Robert Leichner, George Savage, Andrew Thompson, Mark Zdeblick, Marc Kreidler, Hooman Hafezi, Robert Duck
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Publication number: 20130144132Abstract: Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.Type: ApplicationFiled: January 31, 2013Publication date: June 6, 2013Applicant: PROTEUS DIGITAL HEALTH, INC.Inventor: PROTEUS DIGITAL HEALTH, INC.
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Publication number: 20130096501Abstract: A method is disclosed for detecting, by a sensing and data acquisition circuit module, at least one parameter associated with an access port. The method includes wiping at least a portion of an access port, allowing the access port to dry for a predetermined amount of time, accessing the access port with an access device, such as a syringe, and detecting at least one parameter associated with the access port by the sensor and acquisition module. An access port is disclosed that includes a sensor and a data acquisition module for sensing, recording, and providing an alert associated with the detection of the at least one parameter associated with the access port.Type: ApplicationFiled: June 20, 2011Publication date: April 18, 2013Applicant: PROTEUS DIGITAL HEALTH, INC.Inventors: Lawrence Arne, Todd Thompson, Mark Zdeblick, Angela Strand, George Savage, Yuriy Mestman, William H. McAllister
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Patent number: 8419638Abstract: Implantable devices for evaluating body-associated fluid transport structures and methods for using the same are provided. In some instances, the implantable devices include an elongated structure with at least one hermetically sealed integrated circuit sensor stably associated therewith and a transmitter. The devices find use in a variety of different applications, including monitoring the function of various types of body-associated fluid transport structures, such as arteriovenous fistulae, vascular grafts, catheters, cerebrospinal fluid shunts, and implantable central venous access devices.Type: GrantFiled: November 18, 2008Date of Patent: April 16, 2013Assignee: Proteus Digital Health, Inc.Inventors: Lawrence W. Arne, Olivier Colliou, Marc Jensen, Mark Zdeblick
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Patent number: 8412347Abstract: A charge pump is provided in the same integrated circuit chip as a control means which permits selectively connecting any of one or more electrodes with conductors along a lead. The charge pump derives about two volts from a one-volt supply, and becomes stable within a few tens of microseconds. The charge pump may be composed of three doublers—the first generating timing signals for the second and third doublers, with the second and third doublers working out of phase with each other.Type: GrantFiled: April 29, 2009Date of Patent: April 2, 2013Assignee: Proteus Digital Health, Inc.Inventor: Mark Zdeblick
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Publication number: 20130073312Abstract: A system and method are disclosed that track a deliverable to a user. The system includes an identifier or tag secured to the deliverable, a computer system for interrogating the identifier, and a personal device in communication with the computer system, wherein the personal device is held by the user at the time the user is administered the deliverable to detect the unique identity associated with the identifier device and confirms delivery of the deliverable to the user. The method includes attaching an identifiable tag that produces a unique signature to the deliverable, interrogating the tag at about the time of delivery to the user, and confirming that the user has been administered the deliverable through detecting the identifiable tag.Type: ApplicationFiled: May 19, 2011Publication date: March 21, 2013Applicant: PROTEUS DIGITAL HEALTH, INC.Inventors: Todd Thompson, Lawrence Arne, Fataneh Omidvar, Yashar Behzadi, Robert Duck, Lorenzo Dicarlo, Gregory Moon
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Publication number: 20130060102Abstract: Sensing is carried out from locations at considerable remove from the stomach. Cooperating sensor electronics are placed at each of two wrists of the patient. The potential discomfort and inconvenience of an abdominal patch are reduced or eliminated. And alternative power sources become available.Type: ApplicationFiled: November 6, 2012Publication date: March 7, 2013Applicant: PROTEUS DIGITAL HEALTH, INC.Inventor: Proteus Digital Health, Inc.
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Patent number: D682846Type: GrantFiled: October 11, 2011Date of Patent: May 21, 2013Assignee: Proteus Digital Health, Inc.Inventors: Danielle Schulze Cojuangco, Todd Nathan Rinker, Arna Diana Ionescu