Abstract: Aspects of the invention include multi-mode communication ingestible event marker devices. Ingestible event marker devices of the invention include an ingestible component comprising a conductive communication module and at least one additional non-conductive communication module. The non-conductive communication module may be integrated with the ingestible component or at least a portion or all of the non-conductive communication module may be associated with a packaging component of the ingestible event marker device. Additional aspects of the invention include systems that include the devices and one or more receivers, as well as methods of using the same.

Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.

Abstract: A body associated device comprises a housing, an adhesive layer configured to be applied to a body of a living subject, and at least one standoff located between the housing and the adhesive layer. An electronic module may be located within the housing of the body associated device. A personal communication system comprises a body associated device including an electronic module and further comprises a feedback portion coupled to the housing and to the electronic module. The feedback portion is configured to communicate information between the living subject and the body associated device. An external local node is operative to provide at least one of transmit communications to and receive communications from the body associated device.

Abstract: A system and method are provided for securing an ingestible electronic device to a pharmaceutical product without damaging the ingestible electronic device. The product includes the ingestible electronic device being placed on the product in accordance with one aspect of the present invention. In accordance with another aspect of the present invention, the ingestible electronic device is placed inside the product. Various embodiments are disclosed in accordance with the present invention for protecting and/or coating of the electronic marker as well as securing the ingestible electronic device onto the product.

Abstract: Solid-state thin-film capacitors are provided. Aspects of the solid-state thin-film capacitors include a first electrode layer of a transition metal, a dielectric layer of an oxide of the transition metal, and a second electrode layer of a metal oxide. Also provided are methods of making the solid-state thin-film capacitors, as well as devices that include the same. The capacitor may have one or more cathodic arc produced structures, i.e., structures produced using a cathodic arc deposition process. The structures may be stress-free metallic structures, porous layers and layers displaying crenulations. Aspects of the invention further include methods of producing capacitive structures using chemical vapor deposition and/or by sputter deposition.

Abstract: An ingestible therapy activator system and method are provided. In one aspect, the ingestible therapy activator includes an ingestible device having an effector module to send an effector instruction and a responder module associated with a therapeutic device. The responder module may receive and process the effector instruction, resulting in a response by the therapeutic device. Examples of responses by therapeutic device include activating a therapy, deactivating a therapy, modulating a therapy, and discontinuing a therapy.

Abstract: A method for removing chlorhexidine and/or avobenzone from fabric materials utilizes an acidic detergent composition including phosphoric acid and a surfactant in a flush cycle of a washing machine adapted to perform separate flush, wash, and bleaching cycles. The acidic detergent composition is present in the flush solution in a sufficient quantity to provide a pH less than about 5 and, advantageously, above about 2. The acidic detergent composition is advantageously substantially free of a chlorine-based oxidant.

Abstract: This invention has as its object a method for releasing a product by subjecting a compound of Formula (II?): R?7R?8(HX)C1-C2(YH)R?9R?10 to a chemical oxidation that cleaves the bond C1-C2 to obtain the product. In the compound of Formula (II?): R?7 to R?10, which are identical or different, correspond to a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted functional group; X and Y, which are identical or different, are an oxygen atom, a sulfur atom, or an amine of Formula —NR11R12, wherein R11 is a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, and R12 is not a hydrogen atom. The invention also has as its object a method for releasing a product that comprises, before the chemical oxidation stage, a first step for preparing the compound of Formula (II?). The released product can be a volatile molecule or an active substance or else a specific product.

Abstract: Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.

Abstract: The system of the present invention includes an implantable device that can detect high and low frequency current signature. The implantable device can communicate with a communication device that includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, the communication device is activated.

Abstract: The present invention provides for safe and reliable electronic circuitry that can be employed in ingestible compositions. The ingestible circuitry of the invention includes a solid support; a conductive element; and an electronic component. Each of the support, conductive element and electronic component are fabricated from an ingestible material. The ingestible circuitry finds use in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.

Abstract: The invention provides a receiver associated with a body, e.g., located inside or within close proximity to a body, configured to receive and decode a signal from an in vivo transmitter which located inside the body. Signal receivers of the invention provide for accurate signal decoding of a low-level signal, even in the presence of significant noise, using a small-scale chip, e.g., where the chip consumes very low power. Also provided are systems that include the receivers, as well as methods of using the same.

Abstract: A multiplexed medical carrier provides for sensing one or more patient parameters and/or delivering energy via separately identifiable effectors. The carrier includes a body and at least two electrical conductors coupled with at least two effectors. Effectors may be any combination of sensors, actuators or both. Sensors may measure such parameters as pressure, oxygen content, volume, conductivity, fluid flow rate, or any other chemical or physical parameters. Actuators may be used, for example, to pace a heart, stimulate muscle or neural tissue, broadcast ultrasonic energy, emit light, heat or other forms of radiation, or deliver any form of energy or substance. A method for collecting medical data from a patient includes interrogating a network of multiplexed sensors residing on parallel conductors in the patient, including addressing a first addressable sensor in the network to obtain data and addressing a second addressable sensor in the network to obtain data.

Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

Abstract: Compositions, systems and methods that allow for the detection of the actual physical delivery of a pharmaceutical agent to a body are provided. Embodiments of the compositions include an identifier and an active agent. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.

Abstract: A biological sample collection device includes a top cover plate, a bottom portion attached to the top cover plate, the bottom portion comprising a remotely-analyzable biological sample collection portion to collect a biological sample from a body of a subject. The biological sample is to be analyzed at a remote processing facility at a later time. A fastening portion is provided on the bottom portion to affix the remotely-analyzable biological sample collection device to the body of the subject. A real time clock is coupled to the top cover plate and a memory is coupled to the top cover plate and electrically coupled to the real time clock. The remotely-analyzable biological sample collection device may further include a processing unit, at least two electrodes coupled to the processing unit, and a transbody conductive communication module.

Abstract: In a first embodiment, electrodes are coupled to a surface at first, second, and third locations, the first location being further from the third location than from the second location. Impedance is measured at distinct frequencies between pairs of the electrodes. As a result, impedance is measured at differing regions below the surface, one region being deeper below the surface than the other region. In a second embodiment, a microfluidic device carries out an analysis. The analysis may be within a flexible patch adhered to a surface, or may be in a solid device implanted in a body of liquid surrounded by tissue. The analysis may involve pumping a fluid or may involve drawing an analyte electrophoretically through a microfluidic channel.

Abstract: The present invention provides implantable systems that communicate wirelessly with each other using a unique format that enables devices configurations and applications heretofore not possible. Embodiments of the present invention provide communication apparatuses and methods for exchanging information with implantable medical devices. In some embodiments, two implantable devices communicate with each other using quasi-electrostatic signal transmission in a long wavelength/low frequency electromagnetic band, with the patient's body acting as a conductive medium.

Abstract: A re-wearable wireless device includes a reusable component to be secured to a disposable component. The reusable component includes a sensor interface to receive signals from an electrode secured to a living subject and monitors physiological and physical parameters associated with the living subject and a cellular wireless communication circuit. An adhesive base the device includes a first adhesive layer and a second adhesive layer partially covering the first adhesive layer around a perimeter thereof, where the first and second adhesive layers include different adhesives. A method of establishing a link between two wireless devices is also disclosed, where a first wireless device with an insignia representing a communication channel address identification is provided. An image of the insignia is captured with a mobile telephone computing device comprising an image sensor. The captured image is processed to extract the communication channel address identification represented by the insignia.

Abstract: Pharmaceutical delivery systems for delivering dosages according to the present invention include a carrier component and a cap configured to seal an internal volume of the carrier component, wherein the cap includes a device that produces a unique current signature. Dosages prepared to be delivered according to embodiments of the invention find use in a variety of different applications, including clinical trials.