Abstract: Provided herein are methods for making an alpha-tocotrienol enriched tocol mixture, such as from a plant or plant-derived material. Also provided herein are simulated moving bed purification methods for tocotrienol compounds such as alpha tocotrienol.

Abstract: A method for the computer-aided training of an artificial neural network (ANN) for recognizing structural features on objects, by means of which method identified structural features on objects are recognizable rapidly and reliable. That is achieved by virtue of the fact that a convolutional neural network (CNN) having a multiplicity of neurons is used for the training of an ANN for feature recognition on objects. Said network comprises a multiplicity of convolutional and/or pooling layers for the extraction of information from images of individual objects. In this case, the images of the objects are respectively scaled or scaled up and/or down from layer to layer. During the scaling of the images information about the structural features of the objects is maintained, specifically independently of the scaling of the images.

Abstract: A method for predicting variables of interest related to a system includes collecting one or more sensor streams over a time period from sensors in the system and generating one or more anomaly streams for the time period based on the sensor streams. Values for variables of interest for the time period are determined based on the sensor streams and the anomaly streams. Next, a time-series predictive algorithm is applied to the (i) the sensor streams, (ii) the anomaly streams, and (iii) the values for the variables of interest to generate a model for predicting new values for the variables of interest. The model may then be used to predict values for the variables of interest at a time within a new time period based on one or more new sensor streams.

Abstract: The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases associated with nonsense mutations. In particular, the invention relates to specific doses and dosing regimens for the use of 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid in mammals having diseases associated with nonsense mutations.

Abstract: A method of use for Cpd 1 as an inhibitor of dihydroorotate dehydrogenase (DHODH) function in treating or ameliorating a hematological cancer in a subject in need thereof comprising, administering an effective amount of Cpd 1 to the subject, having the structure: or a form or pharmaceutical composition thereof.

Abstract: An example augmented reality system includes: obtaining information about an instance of a device; recognizing the instance of the device based on the information; selecting a digital twin for the instance of the device, with the digital twin being unique to the instance of the device; and generating augmented reality content based on the digital twin and an actual graphic of the instance of the device.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: A method and a device for propagating plants, by which the propagation rate or growth rate of the plants can be increased. This is achieved in that at least one plant is recorded at least in regions by an image recognition device and plant-specific features of the at least one plant are recognized by a control unit on the basis of the items of information obtained by the image recognition device. In dependence on the recognized features, at least one component of the plant is then automatically severed from the plant by a cutting means for propagation. A type and/or physical properties of the cutting means to increase a propagation rate of the plants are selected in accordance with the recognized plant-specific features of the plant.

Abstract: The present description relates to a method or use of a compound for treating or ameliorating HD (Huntington's Disease) in a subject in need thereof comprising administering to the subject an effective amount of a compound of Formula (I): or a form thereof, wherein R1, R2, Ra, Rb and Rc are as defined herein. In particular, the present description relates to a method of use of a compound of Formula (I) or a form or composition thereof for treating or ameliorating HD in a subject in need thereof comprising, administering an effective amount of the compound or a form or composition thereof to the subject.

Abstract: Provided herein are therapeutic and/or prophylactic compounds for mitochondrial or oxidative stress diseases such as cancer, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, Machado-Joseph disease, spinocerebellar ataxia, Huntington disease, Parkinson disease, Alzheimer disease, myocardial infarction, cerebral infarction, diseases related to aging, diabetes, alcoholic liver injury, chronic obstructive pulmonary disease, mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), and the like, wherein the compound is represented by formula (1), or reduced forms thereof, or pharmaceutically acceptable salts thereof.

Abstract: The present description relates to a method or use of a compound for treating or ameliorating HD (Huntington's Disease) in a subject in need thereof comprising administering to the subject an effective amount of a compound of Formula (I): or a form thereof, wherein w1, w2, w3, w4, w5, w6 and w7 are as defined herein. In particular, the present description relates to a method of use of a compound of Formula (I) or a form or composition thereof for treating or ameliorating HD in a subject in need thereof comprising, administering an effective amount of the compound or a form or composition thereof to the subject.

Abstract: An alternatively spliced intronic sequence is disclosed, the splicing of which can be induced in the presence of a small molecule, as described herein.

Abstract: The present description relates to a tablet formulation of 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-5-fluoro-3-(piperidin-4-yl)benzo[e][1,2,4]triazine, a compound for use in treating Huntington's disease, and a method of making the same.

Abstract: The present description relates to compounds of formula (I) useful for improving pre-mRNA splicing in a cell. In particular, another aspect described herein relates to substituted pyrrolo[2,3-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof and methods of use for treating or ameliorating familial dysautonomia.

Abstract: The present description relates' to compounds of formula (I) useful for improving pre-mRNA splicing in a cell. In particular, another aspect of the present description relates to substituted thieno[3,2-b]pyridine compounds, forms, and pharmaceutical compositions thereof and methods of use for treating or ameliorating familial dysautonomia.

Abstract: The invention discloses novel processes for production, enrichment and/or isolation of alpha-tocotrienol from source material comprising at least one non-alpha-tocotrienol, such as natural extracts comprising mixed tocotrienols.

Abstract: Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.

Abstract: A method allows transferring references from vertices, edges, and faces of a solid or surface model to an edited model, by finding correspondences between vertices, edges, faces, and bodies of the models. The method begins by quickly finding matching bodies and aligning them, considering factors such as size, complexity, and the location of its vertices, edges, and faces. For every pair of matched bodies, it then matches exactly coincident vertices, edges, and faces. Of the remaining unmatched topology, it matches edges and faces in the new model that overlap those of the old model considerably. It uses near-neighbor structures to speed up the search for correspondences by eliminating old-new pairs of vertices, edges, and faces that do not overlap. Finally, it iteratively matches unmatched vertices, edges, and faces whose adjacent vertices, edges, and faces are in exact correspondence between the old and new models.

Abstract: Disclosed is a parametric feature-based 3D CAD system that allows multiple users to simultaneously edit a parametric feature-based 3D CAD model consisting of 3D parts and assemblies of those parts (3D Model). Several CAD users, each using their own computer, phone, or tablet, can edit the same 3D Model at the same time. Editing may be separate and simultaneous—there is no need for users to worry about locking, checking out, or otherwise restricting each other's access to 3D Models. As a result, users see each other's changes occur in real-time, and may also identify what aspects other users are actively modifying through visible Collaboration Cues.

Abstract: Provided herein are methods for making an alpha-tocotrienol enriched tocol mixture, such as from a plant or plant-derived material. Also provided herein are simulated moving bed purification methods for tocotrienol compounds such as alpha tocotrienol.