Patents Assigned to PTC
  • Augmented reality system
    Patent number: 10922893
    Abstract: An example augmented reality system includes: obtaining information about an instance of a device; recognizing the instance of the device based on the information; selecting a digital twin for the instance of the device, with the digital twin being unique to the instance of the device; and generating augmented reality content based on the digital twin and an actual graphic of the instance of the device.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: February 16, 2021
    Assignee: PTC Inc.
    Inventors: Vladimir Parfenov, Kevin Elliott Jordan, Steven Thomas Dertien, Moshe Jacob Baum, Andre Gosselin, Stephen Prideaux-Ghee, James E. Heppelman
  • Device and method for propagating plants
    Patent number: 10918033
    Abstract: A method and a device for propagating plants, by way of which the risk of contamination can be minimized and the costs of the production of plants can be reduced. This is achieved in that the plants to be propagated are automatically grasped by a first gripper and separated, the individual plants, hanging on the first gripper, are systematically cut into multiple clones and the individual clones are automatically transported away by a second gripper for further processing.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: February 16, 2021
    Assignee: RoBoTec PTC GmbH
    Inventors: Friederike von Rundstedt, Stephan von Rundstedt
  • Gene therapy for AADC deficiency
    Patent number: 10898585
    Abstract: The present invention is directed to compositions and methods for treating aromatic L-amino acid decarboxylase (AADC) deficiency. This invention includes a method of treating AADC deficiency in a pediatric subject, comprising the steps of: (a) providing a pharmaceutical formulation comprising an rAAV2-hAADC vector, (b) stereotactically delivering the pharmaceutical formulation to at least one target site in the brain of the subject in a dose of an amount at least about 1.8×1011 vg; wherein delivering the pharmaceutical formulation to the brain is optionally by frameless stereotaxy, and optionally wherein the dose is an amount of at least about 2.4×1011 vg and in some embodiments wherein the pharmaceutical formulation comprises a rAAV2-hAADC vector concentration of about 5.7×1011 vg/mL.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: January 26, 2021
    Assignees: PTC THERAPEUTICS .INC., NATIONAL TAIWAN UNIVERSTY
    Inventors: Mark Pykett, Richard Thorn, Wuh-Liang (“Paul”) Hwu
  • Compounds for treating spinal muscular atrophy
    Patent number: 10882868
    Abstract: The present invention provides compounds of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: January 5, 2021
    Assignees: Hoffmann-La Roche Inc., PTC Theranentics. Inc.
    Inventors: Hasane Ratni, Luke Green, Marla L. Weetall, Nikolai A. Naryshkin
  • Methods for treating Huntington's disease
    Patent number: 10881658
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: January 5, 2021
    Assignee: PTC Therapeutics, Inc.
    Inventors: Suresh Babu, Anuradha Bhattacharyya, Seongwoo Hwang, Minakshi Jani, Young-choon Moon, Nadiya Sydorenko
  • Methods for treating Huntington's disease
    Patent number: 10874672
    Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
    Type: Grant
    Filed: December 11, 2016
    Date of Patent: December 29, 2020
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Suresh Babu, Anuradha Bhattacharyya, Seongwoo Hwang, Minakshi Jani, Young-choon Moon, Nadiya Sydorenko
  • Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
    Patent number: 10849885
    Abstract: The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases associated with nonsense mutations. In particular, the invention relates to specific doses and dosing regimens for the use of 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid in mammals having diseases associated with nonsense mutations.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: December 1, 2020
    Assignee: PTC Therapeutics, Inc.
    Inventors: Samit Hirawat, Langdon Miller
  • Compounds for treating spinal muscular atrophy
    Patent number: 10851101
    Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: December 1, 2020
    Assignees: PTC Therapeutics, Inc., F. Hoffman-La Roche AG
    Inventors: Hongyan Qi, Soongyu Choi, Amal Dakka, Gary Mitchell Karp, Jana Narasimhan, Nikolai Naryshkin, Anthony A. Turpoff, Marla L. Weetall, Ellen Welch, Matthew G. Woll, Tianle Yang, Nanjing Zhang, Xiaoyan Zhang, Xin Zhao, Luke Green, Emmanuel Pinard, Hasane Ratni
  • METHODS FOR MODIFYING RNA SPLICING
    Publication number: 20200370043
    Abstract: Described herein is an intronic recognition element for splicing modifier (iREMS) that can be recognized by a small en molecule splicing modifier compound of Formula (I) provided herein or a form thereof, wherein W, X, A and B are as defined herein. In one aspect, methods for modifying RNA splicing to modulate the amount of a product of a gene, wherein a precursor RNA transcript transcribed from the gene that contains an intronic REMS is modified utilizing a splicing modifier compound of Formula (I), are described herein. In another aspect, methods for modifying RNA splicing to modulate the amount of an RNA transcript or protein product encoded by a gene, wherein a precursor RNA transcript transcribed from the gene is modified to comprise an intronic REMS utilizing a splicing modifier compound of Formula (I), are described herein.
    Type: Application
    Filed: June 13, 2018
    Publication date: November 26, 2020
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Anuradha BHATTACHARYYA, Amal DAKKA, Kerstin EFFENBERGER, Vijayalakshmi GABBETA, Minakshi B. JANI, Wencheng LI, Nikolai NARYSHKIN, Christopher TROTTA, Kari WIEDINGER
  • NUTRIENT MEDIUM FOR AUTOMATED CULTIVATION OF PLANTS
    Publication number: 20200344960
    Abstract: A nutrient medium for the cultivation of plants, containing (a) 3 g/l to 18 g/l agar and (b) 0.5 g/l to 3 g/l carrageenan, as well as plant plugs which contain such a nutrient medium, a method for the production of the plant plugs, and a method for the automated or semi-automated cultivation of plants using the plant plugs.
    Type: Application
    Filed: January 10, 2019
    Publication date: November 5, 2020
    Applicant: RoBoTEC PTC GmbH
    Inventor: Friederike Von Rundstedt
  • Polymorphic and amorphous forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide
    Patent number: 10751302
    Abstract: Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: August 25, 2020
    Assignee: PTC Therapeutics, Inc.
    Inventors: Paul Mollard, Peter Giannousis, Shazad Suchit, Mahmoud Mirmehrabi
  • Displaying content in an augmented reality system
    Patent number: 10755480
    Abstract: An example method is performed by a computing system, and includes: obtaining an image of an object captured by a device during relative motion between the object and the device; determining a location of the device relative to the object during image capture based on one or more attributes of the object in the image; mapping a three-dimensional (3D) graphical model representing the object to the object in the image based, at least in part, on the location of the device, where the 3D graphical model includes information about the object; receiving a selection of a part of the object; and outputting, for rendering on a user interface, at least some information from the 3D graphical model based on the part selected.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: August 25, 2020
    Assignee: PTC INC.
    Inventors: Stephen Prideaux-Ghee, Andre Gosselin, Neil Potter, Orit Itzhar
  • Methods for enriching alpha-tocotrienol from mixed tocol compositions
    Patent number: 10745371
    Abstract: Provided herein are methods for making an alpha-tocotrienol enriched tocol mixture, such as from a plant or plant-derived material. Also provided herein are simulated moving bed purification methods for tocotrienol compounds such as alpha tocotrienol.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: August 18, 2020
    Assignee: PTC Therapeutics, Inc.
    Inventors: Peter Giannousis, Paul Mollard, Noah M. Benjamin, Jeffrey D. Butler, Olivier Dapremont, James B. Falabella
  • Treatment of pervasive developmental disorders with redox-active therapeutics
    Patent number: 10736857
    Abstract: Methods of treating or suppressing pervasive developmental disorders (PDDs) including; autistic disorder, Asperger's syndrome, childhood disintegrative disorder (CDD), Rett's disorder, and PDD-not otherwise specified (PDD-NOS) or attention deficit/hyperactivity disorder (ADHD) comprising administering to a subject in need thereof a therapeutically effective amount of one or more compounds as disclosed herein.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: August 11, 2020
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Guy M. Miller, Viktoria Kheifets
  • 2-substituted amino-naphth (1,2-d) imidazol-5-one compounds or pharmaceutically acceptable salts thereof
    Patent number: 10738014
    Abstract: Provided herein are therapeutic and/or prophylactic compounds for mitochondrial or oxidative stress diseases such as cancer, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, Machado-Joseph disease, spinocerebellar ataxia, Huntington disease, Parkinson disease, Alzheimer disease, myocardial infarction, cerebral infarction, diseases related to aging, diabetes, alcoholic liver injury, chronic obstructive pulmonary disease, mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), and the like, wherein the compound is represented by formula (1), or reduced forms thereof, or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: August 11, 2020
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Hiroyuki Kitano, Kazuto Mori
  • Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
    Patent number: 10703701
    Abstract: Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are tocopherol quinone derivatives. Further disclosed are compounds, compositions, and methods for treatment of, or prophylaxis against, radiation exposure.
    Type: Grant
    Filed: December 17, 2016
    Date of Patent: July 7, 2020
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Andrew W. Hinman, Steven J. Richards
  • Scripting of soap commands
    Patent number: 10708346
    Abstract: A computer-implemented method processes a simple object access protocol (SOAP) command. The method includes interpreting an XML script to perform a function contained in the XML script, the XML script containing the SOAP command, parsing the SOAP command from the XML script, and passing the SOAP command to a SOAP interpreter for execution.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: July 7, 2020
    Assignee: PTC Inc.
    Inventor: James R. Hansen
  • Second touch zoom control
    Patent number: 10698601
    Abstract: A second touch zoom solution allows maintaining selection control, and movement of a selection point, during zoom operations not possible through traditional pinch-zoom. A first finger touch to a touch screen establishes a hot spot, selection, or one-finger gesture. Before the first finger is lifted from the touch screen, a second finger is placed on the screen and serves as a zoom control. Dragging the second finger away from the first zooms in; toward the first zooms out. Dragging the first finger does not affect the zoom, even if the motion changes the difference between the two fingers. When the second finger is lifted, the zoom level stays where it is. When the first finger is lifted, the zoom returns to the zoom level before the gesture began.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: June 30, 2020
    Assignee: PTC Inc.
    Inventor: Michael S. Morton
  • Multi-user cloud parametric feature-based 3D CAD system with branch and merge
    Patent number: 10691844
    Abstract: Disclosed is a parametric feature-based 3D CAD system that allows multiple users to simultaneously edit a parametric feature-based 3D CAD model consisting of 3D parts and assemblies of those parts (3D Model). Several CAD users, each using their own computer, phone, or tablet, can edit the same 3D Model at the same time. Editing may be separate and simultaneous—there is no need for users to worry about locking, checking out, or otherwise restricting each other's access to 3D Models. As a result, users see each other's changes occur in real-time, and may also identify what aspects other users are actively modifying through visible Collaboration Cues.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: June 23, 2020
    Assignee: PTC Inc.
    Inventors: Michael R. Lauer, Ilya Baran, Nicholas J. Eyre, Louis V. Gallo, III
  • Methods for modulating the amount of RNA transcripts
    Patent number: 10688099
    Abstract: Described herein are methods for modulating the amount of a gene product and compounds for use in such methods. More particularly, described herein are methods for modulating the amount of an RNA transcript or protein product as the result of gene expression and compounds for use in such methods.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: June 23, 2020
    Assignee: PTC Therapeutics, Inc.
    Inventor: Nikolai Naryshkin