Patents Assigned to PTC
  • Substituted pyrimidine Bmi-1 inhibitors
    Patent number: 10370371
    Abstract: Amine substituted pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: August 6, 2019
    Assignee: PTC Therapeutics, Inc.
    Inventors: Wu Du, Ramil Baiazitov, Chang-Sun Lee, Young-Choon Moon, Steven D. Paget, Hongyu Ren, Nadiya Sydorenko, Richard Gerald Wilde
  • Systems and methods for developing and using real-time data applications
    Patent number: 10338896
    Abstract: Methods and systems herein employ graphical elements as a coding basis within a development platform to develop Web applications that access and aggregate real-time data of connected devices. The development platform includes testing and development functions to simplify the development of mashup web applications. In one aspect, the platform causes updates of the client-side applications, and the real-time data to be received at each test device with a save action of the development workspace. In another aspect, the platform inserts code to enable caching operations at the client-side applications, based on associative linking of the graphical objects during development. In another aspect, the platform employs multiple-level hierarchical real-time data to enable the client-side applications to maintain client-side cursors of the last presentation state of the data upon an update of the applications.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: July 2, 2019
    Assignee: PTC Inc.
    Inventors: Philip J. Huber, Lawrence Fan, Samuel T. Malapas, Brandon Hahr, Rick Bullotta
  • Maintaining independent states for multiple web browser instances
    Patent number: 10326818
    Abstract: A method includes receiving a request for a target Web page, the request containing a session identifier (ID) associated with an instance of a Web browser, and determining if the session ID is new or existing. If the session ID is new, the method includes creating a window session object, and initializing the window session object with data defining a state of the instance of the Web browser. If the session ID is existing, the method includes accessing a stored window session object using the session ID, the stored window session object containing data defining a state of the instance of the Web browser, generating the target Web page based on the data, and providing the target Web page to the Web browser.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: June 18, 2019
    Assignee: PTC Inc.
    Inventors: Matthew Harvey, Jared MacDonald, Andre Beskrowni, Joshua Spiewak
  • Systems and methods using binary dynamic rest messages
    Patent number: 10313410
    Abstract: A system and method of a communication device including a port configured to receive a plurality of binary data streams having a binary header and a binary body. The device includes a memory storing a first message structure description of the binary header and the binary body, and a second message structure description of a metadata construct of the message. The device includes a processor configured to parse a received binary data stream using the first message structure description to determine the binary header and the binary body. The processor parses the binary body using the second message structure description to determine the one or more groups of description values forming the metadata construct. The processor uses a portion of the determined description values of the metadata construct to determine the one or more groups of data values of the message construct.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: June 4, 2019
    Assignee: PTC Inc.
    Inventors: Rick Bullotta, John Canosa, Bob Deremer, Mike Mahoney
  • Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid for the treatment of disease
    Patent number: 10300047
    Abstract: The present invention relates to crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, pharmaceutical compositions and dosage forms comprising the crystalline forms, methods of making the crystalline forms and methods for their use for the treatment, prevention or management of diseases ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: May 28, 2019
    Assignee: PTC Therapeutics, Inc.
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Young-Choon Moon
  • Compositions for an orally active 1,2,4-oxadiazole for the treatment of disease
    Patent number: 10285980
    Abstract: The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases associated with nonsense mutations. In particular, the invention relates to specific doses and dosing regimens for the use of 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid in mammals having diseases associated with nonsense mutations.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: May 14, 2019
    Assignee: PTC Therapeutics, Inc.
    Inventors: Samit Hirawat, Langdon Miller
  • Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid
    Patent number: 10233161
    Abstract: Provided herein are pharmaceutical compositions, which comprise a 1,2,4-oxadiazole benzoic acid or a pharmaceutically acceptable salt thereof. Further provided herein are certain pharmaceutically acceptable salts of a 1,2,4-oxadiazole benzoic acid and methods for making the same. Further provided herein are methods of treating or preventing a disease associated with a nonsense mutation or a premature stop codon, comprising administering such pharmaceutical compositions or pharmaceutically acceptable salts to a patient having a disease associated with a nonsense mutation or a premature stop codon.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: March 19, 2019
    Assignee: PTC Therapeutics, Inc.
    Inventors: Marla L. Weetall, Ellen Welch, Mandar V. Dali, James Takasugi
  • System and method for dynamically grouping devices based on present device conditions
    Patent number: 10212055
    Abstract: A method to dynamically group devices based on device information, which is associated with a system for monitoring the device information that communicates information between a device and an enterprise. Information is collected from a device information source to obtain an actual status of a device. The actual status of the device is compared to a stored status of the device. The stored status is stored on a server of the enterprise. The enterprise determines if the actual status has been changed from the stored status. When a change is detected, the method performs at least one of the acts of automatically disassociating the device from a group that reflects the stored status and automatically associating the device with a new group to reflect the actual status.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: February 19, 2019
    Assignee: PTC Inc.
    Inventors: David Patrick Hart, John Louis Taylor
  • Methods for modulating the amount of RNA transcripts
    Patent number: 10195202
    Abstract: Described herein are methods for modulating the amount of a gene product and compounds for use in such methods. More particularly, described herein are methods for modulating the amount of an RNA transcript or protein product as the result of gene expression and compounds for use in such methods.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: February 5, 2019
    Assignee: PTC Therapeutics, Inc.
    Inventor: Nikolai Naryshkin
  • Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation supression therapy
    Patent number: 10172836
    Abstract: The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases associated with nonsense mutations. In particular, the invention relates to specific doses and dosing regimens for the use of 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid in mammals having diseases associated with nonsense mutations.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: January 8, 2019
    Assignee: PTC Therapeutics, Inc.
    Inventors: Samit Hirawat, Langdon Miller
  • Automated methodology for inductive bias selection and adaptive ensemble choice to optimize predictive power
    Patent number: 10157349
    Abstract: A computer-implemented method of automating inductive bias selection includes a computer receiving a plurality of examples, each example providing a plurality of feature-value pairs. The computer constructs an inductive bias dataset which correlates each respective example in the plurality of examples with numerical indications of training quality. The numerical indications of training quality for each respective example are generated by creating a plurality of models, with each model corresponding to a distinct set of inductive biases. The training quality for each respective model is evaluated when applied to the respective example. The computer uses the inductive bias dataset to select a plurality of inductive biases for application to one or more new datasets.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: December 18, 2018
    Assignee: PTC Inc.
    Inventors: Ryan Todd Caplan, Bruce F. Katz, Joseph John Pizonka
  • METHODS FOR TREATING EPILEPSY
    Publication number: 20180333397
    Abstract: Provided herein are methods of treating, preventing, ameliorating or managing a nonsense mutation mediated epileptic disease, comprising administering a 1,2,4-oxadiazole benzoic acid to a patient having a nonsense mutation mediated epileptic disease. In particular, provided herein are methods of treating, preventing, ameliorating or managing a CDKL5 and/or SCN1A (Dravet syndrome) nonsense mutation mediated epileptic disease.
    Type: Application
    Filed: October 28, 2016
    Publication date: November 22, 2018
    Applicant: PTC Therapeutics, Inc.
    Inventors: Ellen Welch, Yuki Tomizawa, Priya Vazirani
  • Compositions of 1,2,4-oxadiazole benzoic acid compounds and methods for their use
    Patent number: 10071081
    Abstract: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: September 11, 2018
    Assignee: PTC Therapeutics, Inc.
    Inventors: Gary Mitchell Karp, Seongwoo Hwang, Guangming Chen, Neil Gregory Almstead, Young-Choon Moon
  • Retrieving data from a server
    Patent number: 10069937
    Abstract: A system includes a server and a controller embedded in a device. Both the server and the embedded controller are capable of communicating over a computer network. The embedded controller sends a command to the server over the computer network that identifies an instance of the device. In response, the server identifies the instance of the device based on the command, retrieves data that is specific to the instance of the device, and sends the data to the embedded controller over the computer network.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: September 4, 2018
    Assignee: PTC Inc.
    Inventor: James R. Hansen
  • Establishing a virtual tunnel between two computers
    Patent number: 10069939
    Abstract: A system transfers data via a communication session between a client application and a server application, where the client application runs on a first network and the server application runs on a second network. The system includes a proxy having a socket to the client application. The proxy converts data between a local protocol run on the first network to a non-local protocol. An agent creates a socket to the server application. The agent converts data between a local protocol run on the second network and the non-local protocol. A server is in communication with the proxy and the agent. The server contains a message queue dedicated to the communication session. The message queue stores data transmitted during the communication session.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: September 4, 2018
    Assignee: PTC Inc.
    Inventor: Felix Shedrinsky
  • Compositions for an orally active 1,2,4-oxadiazole for the treatment of disease
    Patent number: 10034863
    Abstract: The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases associated with nonsense mutations. In particular, the invention relates to specific doses and dosing regimens for the use of 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid in mammals having diseases associated with nonsense mutations.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: July 31, 2018
    Assignee: PTC Therapeutics, Inc.
    Inventors: Samit Hirawat, Langdon Miller
  • Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid for the treatment of disease
    Patent number: 10028939
    Abstract: The present invention relates to crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, pharmaceutical compositions and dosage forms comprising the crystalline forms, methods of making the crystalline forms and methods for their use for the treatment, prevention or management of diseases ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: July 24, 2018
    Assignee: PTC Therapeutics, Inc.
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Young-Choon Moon
  • System and method of establishing permission for multi-tenancy storage using organization matrices
    Patent number: 10025942
    Abstract: A system and method of establishing permissions for multi-tenancy storage using an organization matrices is provided. The method includes a computing application for setting permissions for accessing data entries of a multi-tenant database, the data entries storing data associated with a number of computing devices where the multi-tenant database is accessible by two or more tenants and/or sub-tenants. The method includes displaying via a graphical user interface that displays the one or more tenants in a single workspace where the tenants are displayed in a hierarchical structure. The method includes receiving a permission commands to establish the permissions for a tenant and causing the permissions to be set.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: July 17, 2018
    Assignee: PTC Inc.
    Inventors: John Schaefer, Rick Bullotta
  • Methods for integrating semantic search, query, and analysis and devices thereof
    Patent number: 10025880
    Abstract: A method, non-transitory computer readable medium and data management computing apparatus comprising searching across a plurality of different heterogeneous data indexes based on portions of one or more search keywords in response to a received request. A result set for each of the plurality of different heterogeneous data indexes is obtained based on the searching. Further, one or more facets to each of the obtained results sets are added. Furthermore, a plurality of visualization techniques are automatically identified for each of the obtained results sets based on the facets in each of the obtained result sets and a model entity type associated with each of the plurality of different heterogeneous data indexes. Finally, each of the obtained results sets with the added facets and the identified one of the plurality of visualization techniques is provided.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: July 17, 2018
    Assignee: PTC Inc.
    Inventors: Rick Bullotta, John Schaefer
  • Scoring a population of examples using a model
    Patent number: 10019542
    Abstract: A computer-implemented method for scoring an example with causal information includes a computer system receiving an indication of a goal and applying a predictive model to the example to yield an output score with respect to the goal. The computer system produces causal score for each feature-value pair in the example, each causal score indicating of a relative extent to which the feature-value pair is responsible for influencing the output score. Then, the computer system presents the output score and the causal score for each feature-value pair in the example.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: July 10, 2018
    Assignee: PTC Inc.
    Inventors: Ryan Todd Caplan, Bruce F. Katz, Joseph John Pizonka