Abstract: A method includes periodically sending a polling call to an enterprise system outside the firewall at a first polling rate during normal operating conditions, monitoring for a fault condition, periodically sending polling calls to the device outside the firewall at a second polling rate when a fault condition is detected, the second polling rate being higher than the first polling rate. The second polling rate is used as result of a fault condition. The method also includes sending a problem report with the polling calls when the fault condition is detected.

Abstract: The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.

Abstract: Methods and systems herein enables communication between connected devices and a federation of servers in a distributed computing system. The federation of servers allows a given connected device to freely move within the system such that the connected device does not need any knowledge of its own location or any routing details about nodes within the federation. The edge and intermediate servers employ a non-network addressable identifier associated with the device to establish a binding path from the platform server to the device. In another aspect, the intermediate servers operate as stateless servers and do not maintain or track the states of communication that relay therethrough. Rather, the intermediate servers inject the state information to each inbound message and employ routing rules in directing the injected information back to its source.

Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

Abstract: A system and method of a communication device including a port configured to receive a plurality of binary data streams having a binary header and a binary body. The device includes a memory storing a first message structure description of the binary header and the binary body, and a second message structure description of a metadata construct of the message. The device includes a processor configured to parse a received binary data stream using the first message structure description to determine the binary header and the binary body. The processor parses the binary body using the second message structure description to determine the one or more groups of description values forming the metadata construct. The processor uses a portion of the determined description values of the metadata construct to determine the one or more groups of data values of the message construct.

Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

Abstract: The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.

Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.

Abstract: A computer-implemented method processes a simple object access protocol (SOAP) command. The method includes interpreting an XML script to perform a function contained in the XML script, the XML script containing the SOAP command, parsing the SOAP command from the XML script, and passing the SOAP command to a SOAP interpreter for execution.

Abstract: A method, non-transitory computer readable medium and data management computing apparatus comprising searching across a plurality of different heterogeneous data indexes based on portions of one or more search keywords in response to a received request. A result set for each of the plurality of different heterogeneous data indexes is obtained based on the searching. Further, one or more facets to each of the obtained results sets are added. Furthermore, a plurality of visualization techniques are automatically identified for each of the obtained results sets based on the facets in each of the obtained result sets and a model entity type associated with each of the plurality of different heterogeneous data indexes. Finally, each of the obtained results sets with the added facets and the identified one of the plurality of visualization techniques is provided.

Abstract: This technology generates a plurality of instances of things each including a dynamically generated interface structure and services associated with and properties of the corresponding one of the things. The services associated with and the properties of one of the plurality of instances of things for a selected one of the plurality of instances of things are retrieved and provided. A service definition for a selected one of the services is retrieved and provided based on the retrieved and provided services associated with and properties for the selected one of the plurality of instances of things. A requested consumption call for the selected one of the services is executed based on the retrieved service definition. A defined result set for the executed consumption call is provided in the dynamically generated interface structure associated with the requested one of the plurality of instances of things.

Abstract: A system and method for abstracting communication protocol using self-describing messages. The method includes providing a first communication protocol having control codes and binary messages having a self-describing schema of a data object model. The method includes providing a second communication protocol where instances of the second communication protocol are associatively mapped to the instances of the first communication protocol. The method includes receiving a message in the second communication protocol. The method includes classifying the message as being either a control message or a data message and translating it to a second message where upon the message has been classified as a control message, the processor maps the control message to one or more control codes and where upon the message has been classified as a data message, the processor maps the data message to a corresponding binary message having the self-describing schema.

Abstract: The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases associated with nonsense mutations. In particular, the invention relates to specific doses and dosing regimens for the use of 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid in mammals having diseases associated with nonsense mutations.

Abstract: Provided herein are novel solid state forms of tapentadol salts, process for their preparation, pharmaceutical compositions, and method of treating thereof. The tapentadol salts include an L-(?)-camphorsulfonate salt, a dibenzoyl-(L)-tartrate salt, a dibenzoyl-(D)-tartrate salt, a malate salt, a maleate salt, or a salicylate salt.

Abstract: The present invention relates to methods for identifying compounds that modulate untranslated region-dependent expression of a target gene. The invention particularly relates to using untranslated regions of a target gene or fragments thereof linked to a reporter gene to identify compounds that modulate untranslated region-dependent expression of a target gene. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.

Abstract: A method to dynamically group devices based on device information, which is associated with a system for monitoring the device information that communicates information between a device and an enterprise. Information is collected from a device information source to obtain an actual status of a device. The actual status of the device is compared to a stored status of the device. The stored status is stored on a server of the enterprise. The enterprise determines if the actual status has been changed from the stored status. When a change is detected, the method performs at least one of the acts of automatically disassociating the device from a group that reflects the stored status and automatically associating the device with a new group to reflect the actual status.

Abstract: A method manages configurations of devices in a system that communicates information between a device and an enterprise. The method includes building a defined configuration for a device type. The defined configuration includes a set of value requirements. An actual configuration having values associated with the device is compared to the defined configurations. The actual configuration and defined configuration are stored in a database of the enterprise. The method also includes determining, in the enterprise, if the values of actual configuration match the corresponding value requirements of the defined configurations. The method runs business logic associated with the device based on a result from the step of determining if the values of the actual configuration match the corresponding values of the defined configurations. The matched configurations are stored for subsequent use.

Abstract: The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases associated with nonsense mutations. In particular, the invention relates to specific doses and dosing regimens for the use of 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid in mammals having diseases associated with nonsense mutations.

Abstract: The invention relates to the fields of screening assays, compounds, and methods for altering gene expression and protein levels. In particular, the invention includes assays to screen for agents capable of modulating gene expression in a UTR-dependent manner and agents capable of modulating gene expression.

Abstract: A system and method for developing real-time web-service objects. The method includes providing a client-side application running on a connected device. The client-side application executes Webpage definition files having a composite Web-service objects, including a first and second composite Web-service objects where each of the object has been associatively linked to a data service from a data source. The method includes receiving, during runtime of the client-side application, a first updated data content from the data source. The method includes caching the first updated data content in memory and, upon receiving a second updated data content, retrieving the first updated data content from memory and updating the composite Web-service objects of the Webpage definition files using the first and second update data contents.