Abstract: Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on a size and type of the tumor to stimulate an immune response against the tumor and other tumors in the subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.

Abstract: Described herein are methods of using inhaled nitric oxide for treating pulmonary hypertension and/or improving oxygen saturation in a patient with a ventilation-perfusion (V/Q) mismatch and/or pulmonary hypertension associated with lung disease.

Abstract: Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one embodiment, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Magnetic nanoparticles are provided having a non-specialized chemical coating facilitating association with a chemical composition by a user before infusion. Systems are provided for delivering a consistent infusion mass of magnetic nanoparticles to a patient.

Abstract: A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. In some embodiments, the controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.

Abstract: Virtual private network (VPN)-related techniques are described. The techniques provide intuitive mechanisms by which a client device more efficiently establishes a VPN connection. In one example, a client device includes a memory, processor(s), and a VPN handler. The VPN handler is configured to monitor actions initiated by one or more applications executable by the programmable processor(s), and determine whether each of the initiated actions requires a VPN connection via which to transmit outbound data traffic corresponding to a respective application of the one or more applications. The VPN handler is further configured to, in response to a detection that at least one initiated action requires the VPN connection via which to transmit the outbound data traffic, automatically establish the VPN connection to couple the client device to an enterprise network, and transmit the outbound data traffic corresponding to the respective application, via the VPN connection.

Abstract: A PEMF web using immersive, flux-guided, micro-coils to direct intense, deeply penetrating, magnetic flux into a subject from each micro-coil capable of pointing in an arbitrary direction. Micro-coils are spooled around iron cores, insulated properly, and soldered to connecting wires, all embedded in a polymeric resin, such as cold-cured silicone resin. Nodes protect, enclose, insulate electrically, and otherwise protect the micro-coils. Connectors between nodes provide mechanical stability against breaking of wires, while permitting folding, bending, buckling, and otherwise deflecting to position the nodes as desired with three degrees of freedom.

Abstract: A policy device grants access to a client device, without authenticating the client device, when the client device provides a session identifier to the policy device that was previously granted to the client device by a second policy device upon authenticating the client device by the second policy device. In one example, a policy device includes a network interface that receives a session identifier from a client device, wherein the policy device comprises an individually administered autonomous policy server, and an authorization module that grants the client device access to a network protected by the policy device based on the session identifier without authenticating the client device by the policy device. In this manner, the client device need not provide authentication information multiple times within a short time span, and the policy device can deallocate resources when a session migrates to a second policy device.

Abstract: A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.

Abstract: An integrated connector module (ICM) is disclosed. In one embodiment, the ICM includes a plurality of shielding components, the plurality of shielding components comprising a port to port shield, an insert to insert shield and a main body shield. The ICM also contains one or more housing components, the one or more housing components comprising a plurality of ports that are arranged so as to be offset from a main signal conditioning portion of the one or more housing components; and an electronics assembly disposed within the one or more housing components. Methods and apparatus for utilizing and manufacturing the aforementioned ICM are also disclosed.

Abstract: A titanium based, ceramic reinforced body formed from an alloy having from about 3 wt. % to about 10 wt. % of zirconium, about 10 wt. % to about 25 wt. % of niobium, from about 0.5 wt. % to about 2 wt. % of silicon, and from about 63 wt. % to about 86.5 wt. % of titanium. The alloy has a hexagonal crystal lattice ? phase of from about 20 vol % to about 70 vol %, and a cubic body centered ? crystal lattice phase of from about 30 vol. % to about 80 vol. %. The body has an ultimate tensile strength of about 950 MPa or more, and a Young's modulus of about 150 GPa or less. A molten substantially uniform admixture of a zirconium, niobium, silicon, and titanium alloy is formed, cast into a shape, and cooled into body. The body may then be formed into a desired shape, for example, a medical implant and optionally annealed.

Abstract: Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on a size and type of the tumor to stimulate an immune response against the tumor and other tumors in the subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.

Abstract: A bubble generator including a container having a side wall and a top wall defining a cavity. An insert is located within the cavity defining a gas path with a trap portion. The gas path being in communication with an exit in the container. The cavity including an opening receiving a gas accumulating within the cavity, the gas path allowing the accumulating gas to escape through the exit once the accumulating gas reaches a predetermined level proximate the trap portion.

Abstract: Systems and methods for communicating downhole signals using a mud pulser. The method includes encoding data collected from a downhole sensor as symbols into electrical pulses received by the mud pulser; transmitting the electrical pulses as pressure pulses through using the mud pulser; converting the pressure pulses into full wave pressure signals; processing the full wave pressure signals to recover the symbols; and decoding the symbols to provide the data.

Abstract: Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.

Abstract: The present invention generally relates to apparatuses for drying heat-sensitive protein compositions. In one aspect, the present invention is directed to a pulse resonator/atomizer for drying heat sensitive protein compositions. The pulse resonator/atomizer comprises: a rotating valve spun by a variable-speed electric motor controlled by a Variable Frequency Drive, plus an atomizer to introduce the heat sensitive protein compositions into the resonating gas stream for drying.

Abstract: A low profile, small size and high performance electronic device for use in, e.g., electronic circuits which provides maximum creepage and/or clearance distances. In one embodiment, the device is configured for a small footprint and utilizes two or more windings that require isolation. The exemplary device includes a self-leaded header made from a unitary construction which comprises a generally a box-like support body having a cavity for mounting a circuit element with primary and secondary windings, the support body having a base and a plurality of leads extending generally horizontally outward from the support body adjacent the base, the support body having one side opening on a side with leads permitting the loading of the inductive device in the cavity, and a routing channel residing on the top of the base, so as to maximize the creepage and clearance distance of the electronic device. Shaped-core and other embodiments are also disclosed.

Abstract: In one example, a mobile device includes a network interface configured to receive data for an application including a set of application permissions describing elements of the mobile device to which the application will have access upon installation of the application, and a processing unit configured to determine a type for the application and, based on an analysis of the set of application permissions and the type for the application, determine whether the application includes malware.

Abstract: A system and method for tracking the remaining length of a material wound on a reel is disclosed. In the system, two sensors deployed relative to the reel (and each other) produce a detection signals when a detection element mounted on the reel is near the respective sensor in an order indicative of forward or reverse reel rotation. The system further includes a processor operably receiving the detection signals to count a total number of forward rotations of the reel, which count is saved in memory. A battery powers the processor, memory, and sensors. The system further includes a transceiver that removably and operably couples between the memory and a calculator that calculates the remaining length of the material wound on the reel based on the total number of forward rotations of the reel. The system may also record the time and location associated with the rotations.

Abstract: In one aspect, methods of treating human papillomavirus (HPV)-associated growths are provided in which nano-pulse stimulation is applied at the site of a cancer. In another aspect, devices and computer systems for delivering nano-pulse stimulation for the treatment of HPV-associated growths are provided.

Abstract: An arc fault sensor disposed on a circuit board proximate to a current carrying trace. The arc fault sensor includes a magnetic flux concentrator (MFC). The MFC includes a first flange and a second flange that are joined by a center post. Each of the first and second flanges have a cross sectional area that is larger than the center post. A sense coil winding is wound around the center post. The arc fault sensor generates an output voltage that is proportional to a rate of change of current in the current carrying conductor. For a given diameter of the sense coil winding, the output voltage is enhanced by the ratio of the cross-sectional areas of the flanges relative to the cross-sectional area of the center post. Methods of manufacturing and utilizing the aforementioned arc fault sensor are also disclosed.