Patents Assigned to Pulse
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Patent number: 10219715Abstract: A biocompatible, implantable electrode for electrically active medical devices. The implantable medical electrode has a surface geometry which optimizes the electrical performance of the electrode, while mitigating the undesirable effects associated with prior art porous surfaces. The electrode has an optimized surface topography for improved electrical performance. Such a electrode is suitable for devices which may be permanently implanted in the human body as stimulation electrodes, such as pacemakers, or as sensors of medical conditions. Such is achieved by the application of ultrafast high energy pulses to the surface of a solid, monolithic electrode material for the purpose of increasing the surface area and thereby decreasing its after-potential polarization. In addition, the electrode material comprises a biocompatible metal having a minimal or eliminated amount of metal oxides which are detrimental to electrode performance.Type: GrantFiled: June 17, 2015Date of Patent: March 5, 2019Assignee: Pulse Technologies, Inc.Inventor: Andrew E. Fisk
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Patent number: 10197477Abstract: An analysis cartridge the includes a main body portion and a filter assembly. The main body portion includes an upper portion that defines an upper chamber and a lower portion that defines a fluid chamber. The filter assembly is movable along a filter assembly path between a first position and a second position. The filter assembly has an opening defined therethrough. In the first position, the opening partially defines the upper chamber and in the second position the opening partially defines the fluid chamber.Type: GrantFiled: January 17, 2017Date of Patent: February 5, 2019Assignee: Pulse Health LLCInventors: Martin Krauss, Maura Mahon, Andrew King, Steve Cooper, James Ingle, Gerald Thomas, David Barsic, Neal Andrews, Brian Young, Juven Lara, Charles Noll
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Patent number: 10194220Abstract: Antenna apparatus that utilizes a utility line in order to improve performance of the antenna apparatus. In one embodiment, a smart meter that utilizes the aforementioned antenna apparatus is disclosed. The smart meter includes a utility meter housing configured to house a smart metering module, the utility meter housing enclosing: a wireless reporting portion comprising a helical coil radiator, the helical coil radiator being coupled to an RF transmission path, the RF transmission path configured to couple the helical coil radiator to an RF transceiver integrated circuit; an enclosure configured to house the RF transceiver integrated circuit, the enclosure further comprising a distribution portion comprising one or more meter sensing electronics; and a utility line port, the utility line port configured to position a utility line adjacent and parallel with the helical coil radiator.Type: GrantFiled: January 5, 2017Date of Patent: January 29, 2019Assignee: Pulse Finland OYInventors: Heikki Korva, Kimmo Koskiniemi
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Publication number: 20190022141Abstract: Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on a size and type of the tumor to stimulate an immune response against the tumor and other tumors in the subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.Type: ApplicationFiled: September 26, 2018Publication date: January 24, 2019Applicant: Pulse Biosciences, Inc.Inventors: Richard Lee Nuccitelli, Pamela S. Nuccitelli, Joanne Lum, Kaying Lui, Brian G. Athos, Mark P. Kreis, Zachary R. Mallon, Jon Berridge
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Publication number: 20190021811Abstract: This disclosure relates to an in vivo treatment of tissue, for example, a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 1 nanosecond. Surface of a tissue surrounding the skin lesion may be marked to guide the device to deliver the electric pulses at substantially precise locations on the lesion surface. This treatment may prevent at least growth of the lesion.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Applicant: Pulse Biosciences, Inc.Inventors: Cesar Escobar Blanco, Elena Tovkan Forster, Stefani Reiko Takahashi
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Patent number: 10159734Abstract: Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.Type: GrantFiled: May 20, 2016Date of Patent: December 25, 2018Assignee: Pulse Therapeutics, Inc.Inventor: Francis M. Creighton
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Publication number: 20180353916Abstract: Non-clogging airlift pumps and associated systems and methods employing said pumps. The airlift pumps generally include an enclosed air tank within which is located a hollow cylinder having an open top and a closed bottom wall. A gas (e.g., air) line passes into the air tank for supplying gas thereto. A suction port is located in the bottom wall of the cylinder, and a substantially vertically-oriented discharge pipe passes through a top wall of the air tank such that an intake end of the discharge pipe resides within the cylinder. Multiple airlift pumps may be used in conjunction in a given application.Type: ApplicationFiled: June 28, 2018Publication date: December 13, 2018Applicant: Pulsed Burst Systems, LLCInventor: Masao Kondo
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Patent number: 10137152Abstract: A subject is inoculated from a disease by exposing a biopsy of a tumor or other abnormal growth to a nanosecond pulsed electric field (nsPEF). A sufficient treatment can be confirmed by detecting calreticulin on the tumor cell membranes, which indicates apoptosis occurring in the tumor cells. Treated tumor cells from the biopsy are then reintroduced into the subject. The calreticulin-exhibiting tumor cells activate the subject's immune system against the tumor, and any other like tumors in the body, and effectively vaccinates the subject against the disease. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. The immune response may be measured at a later time. Specific electrical characteristics of the nsPEF treatments can be based on the type and/or strength of the tumor.Type: GrantFiled: January 17, 2018Date of Patent: November 27, 2018Assignee: Pulse Biosciences, Inc.Inventors: Richard Lee Nuccitelli, Pamela S. Nuccitelli, Joanne Lum, Kaying Lui, Brian G. Athos, Mark P. Kreis, Zachary R. Mallon, Jon Berridge
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Patent number: 10142292Abstract: An integrated, multi-service network client for cellular mobile devices is described. The multi-service client includes a VPN handler having an interface programmed to exchange the network packets with the security manager for application of the security service, wherein the VPN handler is configurable to operate in one of an enterprise mode and in a non-enterprise mode, wherein in the enterprise mode the VPN handler establishes a VPN connection with a remote VPN security device and provides encryption services to securely tunnel the network packets between the cellular mobile device and the remote VPN security device, and wherein in the non-enterprise mode the VPN handler directs the network packets to the security manager without application of the encryption services and communicates the network packets to a packet-based network without tunneling the packets.Type: GrantFiled: December 14, 2010Date of Patent: November 27, 2018Assignee: Pulse Secure LLCInventors: Yin Wei, Subramanian Iyer, Richard Campagna, James Wood
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Publication number: 20180318004Abstract: Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.Type: ApplicationFiled: July 19, 2018Publication date: November 8, 2018Applicant: Pulse Biosciences, Inc.Inventors: Richard Lee Nuccitelli, Jon Casey Berridge, Zachary Mallon, Mark Kreis, Brian Athos, Pamela Nuccitelli
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Patent number: 10116644Abstract: This disclosure describes techniques for verifying the identity of a user with a network access control (NAC) device in response to receiving a security assertion request for the user. To verify the identity of a user, an NAC device may, in response to receiving a security assertion request from a user agent executing on a client device, cause the user agent to redirect a session verification request to an NAC client executing on the client device. The NAC client may detect the session verification request, and provide information indicative of a valid network access session for the user to the NAC device. The NAC device may verify the identity of the user based on the information indicative of the valid network access session. In this way, an NAC device may verify the identity of a user without requiring the user to re-authenticate with the NAC device.Type: GrantFiled: August 2, 2017Date of Patent: October 30, 2018Assignee: Pulse Secure, LLCInventors: Ankur Agrawal, Chandrasekaran Rajagopalan
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Patent number: 10090590Abstract: Apparatus and methods for enhanced antenna port isolation are disclosed. In one embodiment, a spatially compact patch antenna apparatus is disclosed. A plurality of walls are incorporated into the antenna assembly's bottom cover. The walls are located under the radiating element located on a top cover of the antenna assembly. The walls are in one implementation oriented orthogonally with respect to one another, and are placed adjacent to respective antenna feeds. The walls are then at least partly metallized using, for example, a laser direct structuring (LDS) process, and are further connected to a ground plane of an external substrate. By incorporating the metallized wall structures on the existing plastic structure of the bottom cover, isolation between the antenna ports is improved without requiring installation of additional components, use of slots in the ground plane, or increased physical separation (i.e., distance). Manufacturing cost and consistency are also advantageously improved.Type: GrantFiled: September 25, 2014Date of Patent: October 2, 2018Assignee: Pulse Finland OyInventors: Kimmo Koskiniemi, Kimmo Honkanen, Jouni Liflander
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Patent number: 10079088Abstract: A low profile, small size and high performance electronic device for use in, e.g., electronic circuits which provides maximum creepage and/or clearance distances. In one embodiment, the device is configured for a small footprint and utilizes two or more windings that require isolation. The exemplary device includes a self-leaded header made from a unitary construction which comprises a generally a box-like support body having a cavity for mounting a circuit element with primary and secondary windings, the support body having a base and a plurality of leads extending generally horizontally outward from the support body adjacent the base, the support body having one side opening on a side with leads permitting the loading of the inductive device in the cavity, and a routing channel residing on the top of the base, so as to maximize the creepage and clearance distance of the electronic device. Shaped-core and other embodiments are also disclosed.Type: GrantFiled: May 8, 2017Date of Patent: September 18, 2018Assignee: Pulse Electronics, Inc.Inventor: James Douglas Lint
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Patent number: 10079428Abstract: Antenna apparatus and methods of use and tuning. In one exemplary embodiment, the solution of the present disclosure is particularly adapted for small form-factor, metal-encased applications that utilize satellite wireless links (e.g., GPS), and uses an electromagnetic (e.g., capacitive) feeding method that includes one or more separate feed elements that are not galvanically connected to a radiating element of the antenna. In addition, certain implementations of the antenna apparatus offer the capability to carry more than one operating band for the antenna.Type: GrantFiled: March 11, 2013Date of Patent: September 18, 2018Assignee: Pulse Finland OYInventors: Pertti Nissinen, Kimmo Koskiniemi, Prasadh Ramachandran
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Patent number: 10075432Abstract: A device may include an authentication server and a server. The authentication server may receive a first form of a password from a client device in accordance with an authentication protocol, and authenticate the client device based on a comparison of the first form to a value derived from a second form of the password stored in a password database, where the comparison fails when the first form is not comparable to a value derived from the second form. The server may establish a secure connection to the client, receive a plain-text password from the client device over the secure connection, authenticate the client device by comparing a value derived from the plain-text password with a value derived from the second form, and update the password database with a third form of the password that permits the authentication server to successfully authenticate the client device when the authentication server receives the first form.Type: GrantFiled: July 13, 2016Date of Patent: September 11, 2018Assignee: Pulse Secure, LLCInventors: Andy Tsang, Roger A. Chickering, Clifford E. Kahn, Jeffrey C. Venable, Sr.
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Patent number: 10069209Abstract: Capacitively coupled antenna apparatus and methods of operating and adaptively tuning the same. In one embodiment, the insertion loss component in “beside the hand/head” use scenarios is significantly reduced or eliminated such that the antenna experiences only absorptive losses (which generally cannot be avoided), and a very small insertion loss by the host device radio frequency tuner. The exemplary antenna apparatus may be configured for multi-band operation, and also has a very small form factor (e.g., 3 mm ground clearance only at the bottom of the PCB, 4 mm height in one implementation), thereby allowing for use in spatially compact host devices such as slim-line smartphones, tablets, and the like. The adaptive antenna arrangement (using capacitive feed) can be tuned such that the tuner is used in free space, and the user's hand/head tunes the antenna to the band of interest while in use.Type: GrantFiled: March 11, 2013Date of Patent: September 4, 2018Assignee: Pulse Finland OYInventors: Prasadh Ramachandran, Petteri Annamaa
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Publication number: 20180243558Abstract: A pulse generation system is disclosed. The pulse generation system includes a controller, an output terminal, and a plurality of pulse generator circuits. The controller is configured to cause a driving signal pulse to be transmitted to any selected one or more of the pulse generator circuits, and to cause the driving signal pulse to not be transmitted to any selected one or more other pulse generator circuits. Each of the pulse generator circuits is configured to generate an output voltage pulse at the output terminal in response to the driving signal pulse being transmitted thereto.Type: ApplicationFiled: February 28, 2017Publication date: August 30, 2018Applicant: Pulse Biosciences, Inc.Inventors: Brian G. Athos, Shu Xiao, David J. Danitz, Mark P. Kreis, Darrin R. Uecker
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Patent number: 10057239Abstract: A policy device grants access to a client device, without authenticating the client device, when the client device provides a session identifier to the policy device that was previously granted to the client device by a second policy device upon authenticating the client device by the second policy device. In one example, a policy device includes a network interface that receives a session identifier from a client device, wherein the policy device comprises an individually administered autonomous policy server, and an authorization module that grants the client device access to a network protected by the policy device based on the session identifier without authenticating the client device by the policy device. In this manner, the client device need not provide authentication information multiple times within a short time span, and the policy device can deallocate resources when a session migrates to a second policy device.Type: GrantFiled: December 31, 2009Date of Patent: August 21, 2018Assignee: Pulse Secure, LLCInventor: Roger A. Chickering
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Patent number: 10029008Abstract: A system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator is provided. In one embodiment, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.Type: GrantFiled: May 16, 2016Date of Patent: July 24, 2018Assignee: Pulse Therapeutics, Inc.Inventor: Francis M. Creighton
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Publication number: 20180153937Abstract: A subject is inoculated from a disease by exposing a biopsy of a tumor or other abnormal growth to a nanosecond pulsed electric field (nsPEF). A sufficient treatment can be confirmed by detecting calreticulin on the tumor cell membranes, which indicates apoptosis occurring in the tumor cells. Treated tumor cells from the biopsy are then reintroduced into the subject. The calreticulin-exhibiting tumor cells activate the subject's immune system against the tumor, and any other like tumors in the body, and effectively vaccinates the subject against the disease. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. The immune response may be measured at a later time. Specific electrical characteristics of the nsPEF treatments can be based on the type and/or strength of the tumor.Type: ApplicationFiled: January 17, 2018Publication date: June 7, 2018Applicant: Pulse Biosciences, Inc.Inventors: Richard Lee Nuccitelli, Pamela S. Nuccitelli, Joanne Lum, Kaying Lui, Brian G. Athos, Mark P. Kreis, Zachary R. Mallon, Jon Berridge