Abstract: A low profile, small size and high performance electronic device for use in, e.g., electronic circuits which provides maximum creepage and/or clearance distances. In one embodiment, the device is configured for a small footprint and utilizes two or more windings that require isolation. The exemplary device includes a self-leaded header made from a unitary construction which comprises a generally a box-like support body having a cavity for mounting a circuit element with primary and secondary windings, the support body having a base and a plurality of leads extending generally horizontally outward from the support body adjacent the base, the support body having one side opening on a side with leads permitting the loading of the inductive device in the cavity, and a routing channel residing on the top of the base, so as to maximize the creepage and clearance distance of the electronic device. Shaped-core and other embodiments are also disclosed.

Abstract: A system and method for tracking the remaining length of a material wound on a reel is disclosed. In the system, two sensors deployed relative to the reel (and each other) produce a detection signals when a detection element mounted on the reel is near the respective sensor in an order indicative of forward or reverse reel rotation. The system further includes a processor operably receiving the detection signals to count a total number of forward rotations of the reel, which count is saved in memory. A battery powers the processor, memory, and sensors. The system further includes a transceiver that removably and operably couples between the memory and a calculator that calculates the remaining length of the material wound on the reel based on the total number of forward rotations of the reel. The system may also record the time and location associated with the rotations.

Abstract: In one example, a mobile device includes a network interface configured to receive data for an application including a set of application permissions describing elements of the mobile device to which the application will have access upon installation of the application, and a processing unit configured to determine a type for the application and, based on an analysis of the set of application permissions and the type for the application, determine whether the application includes malware.

Abstract: Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.

Abstract: In one aspect, methods of treating human papillomavirus (HPV)-associated growths are provided in which nano-pulse stimulation is applied at the site of a cancer. In another aspect, devices and computer systems for delivering nano-pulse stimulation for the treatment of HPV-associated growths are provided.

Abstract: An arc fault sensor disposed on a circuit board proximate to a current carrying trace. The arc fault sensor includes a magnetic flux concentrator (MFC). The MFC includes a first flange and a second flange that are joined by a center post. Each of the first and second flanges have a cross sectional area that is larger than the center post. A sense coil winding is wound around the center post. The arc fault sensor generates an output voltage that is proportional to a rate of change of current in the current carrying conductor. For a given diameter of the sense coil winding, the output voltage is enhanced by the ratio of the cross-sectional areas of the flanges relative to the cross-sectional area of the center post. Methods of manufacturing and utilizing the aforementioned arc fault sensor are also disclosed.

Abstract: The pulse applicator includes a first arm, including a first electrode, a second arm, including a second electrode, and a spacer. The first arm, the spacer, and the second arm are movably connected, and define a gap between the first arm and the second arm. The first electrode, the gap, and the second electrode are selectively alignable, and the first electrode and the second electrode are configured to deliver an electrical field across the gap in response to an electrical pulse received across the first and second electrodes.

Abstract: A low cost, low profile, small size and high performance inductive device for use in electronic circuits. In one exemplary embodiment, the device includes a ferrite core comprising a step gap, a winding disposed on the core, and a magnetic powder and epoxy mixture packed in to create a cubic-shaped inductor optimized for electrical and magnetic performance. Additionally, the incorporation of the magnetic powder and epoxy mixture around the step gap eliminates fringing magnetic fields during device operation thereby minimizing adverse electromagnetic inference on adjacently disposed electronic components. The geometry and placement of the step gaps can be varied in order to optimize performance parameters associated with the underlying inductive device. Methods of manufacture and use for the inductive device are also disclosed.

Abstract: A biocompatible, implantable electrode for electrically active medical devices. The implantable medical electrode has a surface geometry which optimizes the electrical performance of the electrode, while mitigating the undesirable effects associated with prior art porous surfaces. The electrode has an optimized surface topography for improved electrical performance. Such a electrode is suitable for devices which may be permanently implanted in the human body as stimulation electrodes, such as pacemakers, or as sensors of medical conditions. Such is achieved by the application of ultrafast high energy pulses to the surface of a solid, monolithic electrode material for the purpose of increasing the surface area and thereby decreasing its after-potential polarization. In addition, the electrode material comprises a biocompatible metal having a minimal or eliminated amount of metal oxides which are detrimental to electrode performance.

Abstract: Directional antenna apparatus and methods of utilizing the same. In one embodiment, the directional antenna apparatus includes a chip component disposed on a ground plane. The chip component includes a conductive layer disposed upon a ceramic substrate. The conductive layer of the chip component is connected to electronic circuitry via one or more feed structures and one or more ground structures. The chip component and the ground plane are disposed atop a reflector component in a substantially orthogonal orientation. By spacing the ground plane from the reflector component by a set amount, the directional nature of the directional antenna apparatus may be configured.

Abstract: An analysis cartridge the includes a main body portion and a filter assembly. The main body portion includes an upper portion that defines an upper chamber and a lower portion that defines a fluid chamber. The filter assembly is movable along a filter assembly path between a first position and a second position. The filter assembly has an opening defined therethrough. In the first position, the opening partially defines the upper chamber and in the second position the opening partially defines the fluid chamber.

Abstract: Data files are supplied to a plurality of requesting stations (102 to 106) by accessing serving devices (109 to 116). A plurality of requests are received for one or more data files at a traffic management system (101) from requesting stations via an external network (107). A specific server is selected at the traffic management system and a request is issued to the selected server over a local network for the requested file. The requested file is accepted at the traffic management system from the selected server over the local network and the requested file is sent from the traffic management system to the requesting station over external network. The response of selected servers is monitored (302) when responding to issued requests thereby generating monitored responses. The monitored responses are compared (303) against an operational criterion to identify sub-standard operations.

Abstract: Antenna apparatus that utilizes a utility line in order to improve performance of the antenna apparatus. In one embodiment, a smart meter that utilizes the aforementioned antenna apparatus is disclosed. The smart meter includes a utility meter housing configured to house a smart metering module, the utility meter housing enclosing: a wireless reporting portion comprising a helical coil radiator, the helical coil radiator being coupled to an RF transmission path, the RF transmission path configured to couple the helical coil radiator to an RF transceiver integrated circuit; an enclosure configured to house the RF transceiver integrated circuit, the enclosure further comprising a distribution portion comprising one or more meter sensing electronics; and a utility line port, the utility line port configured to position a utility line adjacent and parallel with the helical coil radiator.

Abstract: This disclosure relates to an in vivo treatment of tissue, for example, a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 1 nanosecond. Surface of a tissue surrounding the skin lesion may be marked to guide the device to deliver the electric pulses at substantially precise locations on the lesion surface. This treatment may prevent at least growth of the lesion.

Abstract: Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on a size and type of the tumor to stimulate an immune response against the tumor and other tumors in the subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.

Abstract: Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.

Abstract: A method for computing fractional flow reserve (FFR), comprising: receiving geometrical parameters of a blood vessel segment comprising a proximal end and a distal end, the geometrical parameters comprising a first geometrical parameter, a second geometrical parameter and a third geometrical parameter; and with the proximal end as a reference point, deriving a reference lumen diameter function and a geometrical parameter difference function based on the geometrical parameters and the distance from the position along the segment of blood vessel to the reference point. Derivatives of the geometrical parameter difference function are calculated in multiple scales. A maximum mean blood flow velocity of the segment is obtained, and FFR is computed as a ratio of a second blood flow pressure at the first location of the blood vessel to a first blood flow pressure at the proximal end of the segment based on the multiple scales of derivative difference functions and the maximum mean blood flow velocity.

Abstract: A subject is inoculated from a disease by exposing a biopsy of a tumor or other abnormal growth to a nanosecond pulsed electric field (nsPEF). A sufficient treatment can be confirmed by detecting calreticulin on the tumor cell membranes, which indicates apoptosis occurring in the tumor cells. Treated tumor cells from the biopsy are then reintroduced into the subject. The calreticulin-exhibiting tumor cells activate the subject's immune system against the tumor, and any other like tumors in the body, and effectively vaccinates the subject against the disease. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. The immune response may be measured at a later time. Specific electrical characteristics of the nsPEF treatments can be based on the type and/or strength of the tumor.

Abstract: An integrated, multi-service network client for cellular mobile devices is described. The multi-service client includes a VPN handler having an interface programmed to exchange the network packets with the security manager for application of the security service, wherein the VPN handler is configurable to operate in one of an enterprise mode and in a non-enterprise mode, wherein in the enterprise mode the VPN handler establishes a VPN connection with a remote VPN security device and provides encryption services to securely tunnel the network packets between the cellular mobile device and the remote VPN security device, and wherein in the non-enterprise mode the VPN handler directs the network packets to the security manager without application of the encryption services and communicates the network packets to a packet-based network without tunneling the packets.

Abstract: Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.