Abstract: A system for applying thermal therapy includes a portable housing and at least one conduit supportable in proximity to body tissue, the conduit having an inlet end and outlet end. The housing supports at least one thermoelectric module, a power storage unit, a pump, a fluid inlet and a fluid outlet. The fluid inlet and fluid outlet are to the inlet and outlet of the conduit. The pump is operably connected to pump fluid from the fluid inlet to the fluid outlet. The at least one thermoelectric module is coupled to generate a thermal change in fluid disposed between the fluid inlet and the fluid outlet. The power storage unit is operably coupled to provide operating power to the pump and the at least one thermoelectric module.

Abstract: The invention generally relates to methods, reagents, and substrates for detecting target analytes.

Abstract: A method of temperature self-calibrating ion-selective electrodes (ISEs) is disclosed which includes calibrating at least two ISEs against a reference electrode (RE) in a calibration solution with a predetermined concentration as the temperature of the calibration solution varies according to a known schedule, wherein the calibration of the at least two ISEs includes determining calibration parameters of each of the at least two ISEs with respect to the RE, placing the at least two calibrated ISEs and the RE into a field solution for determining one or more field parameters of the field solution, measuring voltage across a first of the at least two calibrated ISEs and the RE (Vi), measuring voltage across a second of the at least two calibrated ISEs and the RE (Vi+1), determining Vi?Vi+1, and determining the one or more field parameters.

Abstract: A nail coil remediation apparatus includes a roller assembly, a rotary holding shaft, and a nail channel assembly. The roller assembly includes sequentially aligned stages, at least one stage interfacing with at least one motor that powers the roller assembly. The stages include an aligning stage that includes a first roller and a helical gear member having multiple teeth, and a straightening stage including a second roller. The rotary holding shaft is configured to support the nail coil and selectively transfer the nail coil to and from the roller assembly. The nail channel assembly includes a slot configured to receive the nail coil from rotary holding shaft and selectively transfer the nail coil through the roller assembly.

Abstract: A Composition of matter defined by the general formula of M1M2M3M4M5M6M7M8M9X3, wherein: X is Carbon; and M1, M2, M3, M4, M5, M6, M7, M8 and M9 each represent a different transition metal selected from the group consisting of Ti, Ta, Sc, Cr, Zr, Hf, Mo, and Nb.

Abstract: An alloy comprising 92 at % aluminum, 2 at % titanium, 2 at % iron, 2 at % cobalt, and 2 at % nickel. A method of making an alloy is disclosed. The method contains the steps of providing particles of desired composition, utilizing a selective leaser melting (SLM) apparatus producing a first layer of the particles on a substrate and melting and solidifying a first group selected areas of the layer of particles, wherein the melting and the solidification results in an alloy of desired composition, containing intermetallic lamellae and has thickness equal to thickness of the first layer. The process is repeated to produce an object of specified thickness and shape containing the melted and solidified areas.

Abstract: Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy.

Abstract: Pneumatic soft actuators, and methods and machines capable of modifying their performance and mechanical characteristics. Such a pneumatic soft actuator can be used to connect mechanical components and include an inflatable pouch formed by an airtight, flexible, non-stretchable membrane. The inflatable pouch has oppositely-disposed ends adapted to couple to the mechanical components, and has two lateral edges in which symmetrical folds are formed and define end geometries at the ends of the inflatable pouch. Inflation and deflation of the inflatable pouch increases and decreases, respectively, a distance between the ends of the inflatable pouch to induce relative motion between the mechanical components coupled to the ends of the inflatable pouch.

Abstract: Processes for incorporating phase change materials (PCM) into porous construction elements, composite construction elements produced thereby, and structures constructed therefrom. Such a process includes heating a PCM to a temperature at or above a melting temperature thereof to liquify the PCM and yield a liquid PCM, fully immersing a porous construction element in the liquid PCM, and infiltrating the liquid PCM into porosity of the construction element while the construction element and liquid PCM are at a subatmospheric pressure level and at a temperature sufficient to maintain the PCM in a liquid state to yield a composite construction element in which the porosity of the construction element has been at least partially filled with the PCM. Such a composite construction element is preferably capable of increasing the thermal inertia of a building envelope constructed therefrom with little or no detrimental effects on properties of the construction elements.

Abstract: Polynucleotides, constructs/vectors, host cells, polypeptides, and methods of producing phenylalanine in a prokaryotic host, such as for subsequent isolation.

Abstract: A system and method for implicit user authentication using data from multiple wearable devices is disclosed. Two or more wearable devices associated with a user collect physiological and activity-related data, which is transmitted to an authentication platform that computes and selects influential features for model development. The platform generates device-level and aggregated models using machine learning classifiers to verify user identity based on the collected data. If model confidence score falls below a defined threshold, an explicit authentication step is initiated. The disclosed approach enhances security and usability by enabling continuous, burden-free authentication in Internet of Things (IoT) environments.

Abstract: A system and method for wireless positioning incorporates positioning neural network that utilizes low-dimensional features in mobile settings. The low-dimensional features are, in particular, a minimum description feature set that comprises a predetermined number of largest power measurements and their temporal positions. For robust performance against various channel conditions, the predetermined feature size is adaptively selected by jointly optimizing over the expected amount of information and classification capability, quantified through information-theoretic measures.

Abstract: Disclosed herein is a small molecule targeted drug conjugate for anti-influenza chemotherapy and immunotherapy. The disclosed drug conjugate may form an adaptor to recruit additional CAR T cells or other immune cells for precise elimination of influenza virus-infected cells in a subject. Concurrently administered antibodies or pre-existing immunity in influenza-virus infected subject works well with the targeted conjugate to eliminate virus infected cells, saving valuable time for rescuing late stage patients.

Abstract: Methods of polymerizing a diene to produce a polydiene, the method comprising (i) melting a diene to produce a neat liquid; and (ii) irradiating the melted polydiene with ultraviolet (UV) light to produce a polymer; wherein the melting and irradiating are performed substantially in the absence of solvent or catalyst.

Abstract: One or more systems, devices, computer program products and/or computer-implemented methods of use provided herein relate to image enhancement using a generative adversarial network (GAN). The computer-implemented system can comprise a memory that can store computer-executable components. The computer-implemented system can further comprise a processor that can execute the computer-executable components stored in the memory, wherein the computer-executable components can comprise a training component that can train a discriminator of the GAN to score a texture of a CT image, wherein the texture can be derived from a difference of two conditionally independent estimates produced by a generator of the GAN by respectively processing two independent noisy samples of images.

Abstract: Systems, methods and media for calibrating structured light camera systems are provided. In some examples, a system comprises: a light source; a first camera comprising: a first image sensor; and a first lens; a second camera comprising: a second image sensor; and a second lens; and a processor programmed to: receive, from the first and second image sensors, first images of a predetermined first pattern presented on a flat panel display; calibrate the first and second cameras using the first images and features of the predetermined first pattern; cause the light source to emit a series of second patterns toward a scene including a flat surface; receive, from image sensors, second images of the series of second patterns; and calibrate the light source using the second images and features of the series of second patterns.

Abstract: Cyclic peptides that are inhibitors of a pathogenic free-living amoeba (e.g., Balamuthia mandrillaris, Naegleria fowleri, and Acanthamoeba castellanii), compositions comprising the same, and their use for inhibiting infections or diseases caused by the pathogenic free-living amoeba.

Abstract: A method for generating electromagnetic waves, includes coupling a transmission line to a direct current (DC) voltage source, the transmission line includes a first conductor, a second conductor and a composite disposed between the first conductor and the second conductor, the composite includes non-linear inclusions comprising one or more of non-linear dielectric and non-linear magnetic inclusions mixed in a matrix material, The DC voltage source has a ground that is coupled to second conductor of the transmission line, the first conductor, the second conductor, and the composite form a capacitor, charging the capacitor in the transmission line by the DC voltage source, generating an electromagnetic wave that generates a microwave burst when quickly discharging the charged capacitor, the capacitor is quickly discharged by a switch disposed after the transmission line that is configured to short the first conductor to the second conductor, thereby eliminating a need for a pulse generator.

Abstract: The present disclosure provides for novel compositions and pharmaceutical formulations of bacteriophage suitable for stable storage and effective therapeutic treatment of a patient.

Abstract: Disclosed are methods for the doubling of a plant cell's chromosome by applying an electromagnetic field and methods for obtaining a doubled-haploid plant cell. In some embodiments, the plant cell is selected from the group comprising maize, rice, tomato, and tobacco. Also disclosed is an apparatus for applying an electromagnetic field to a plant cell.