Abstract: A microelectromechanical (MEMS) gas sensor operating based on Knudsen thermal force is disclosed. The sensor includes a substrate, at least one stationary assembly that is fixedly coupled to the substrate, and at least one moveable assembly that is positioned above the substrate which is biased to move substantially according to a main axis and juxtaposed with the at least one stationary assembly.

Abstract: Compositions comprising collagen and insulin-producing cells are provided. Processes for making such a collagen and insulin-producing cell compositions are also provided. Methods for controlling, or lowering blood glucose levels and treating metabolic disorders in mammals, including type 1 diabetes, with such compositions are further provided. Methods to prolong insulin-producing cell viability and function in vitro or during transport are also provided.

Abstract: The present disclosure relates to a novel pupilometer and method of using the pupilometer to record and analyze direct and consensual reflex of pupils to identify brain lesion locations of a patient with brain injuries.

Abstract: Provided in one example herein is an aqueous ink composition, including: pigment particles having at least one metal oxide; an aqueous medium; and a cationic double-chain surfactant consisting a quaternary ammonium salt. Methods of making and using the ink composition are also provided.

Abstract: The present disclosure relates to novel ?-opioid receptor agonists, and the method of making and using the novel ?-opioid receptor agonists. The novel ?-opioid receptor agonists are selective ?-opioid receptor agonists that have substantially no beta-arrestin 2 recruitment or low beta-arrestin 2 recruitment. The novel ?-opioid receptor agonists may be used for the treatment for alcohol use disorders and other co-occurring psychiatric disorders.

Abstract: A light emitting diode (LED) including a first contact. The LED further includes a first semiconductor layer over the first contact. The first semiconductor layer comprises hexagonal Boron Nitride. Additionally, the LED includes a second semiconductor layer over the first semiconductor layer. The second semiconductor layer comprises at least one hexagonal Boron Nitride quantum well and at least one hexagonal Boron Nitride quantum barrier. Moreover, the LED includes a third semiconductor layer over the second semiconductor layer. The third semiconductor layer comprises hexagonal Boron Nitride. Further, the LED includes a second contact over the third semiconductor layer.

Abstract: The present application relates to a method for inhibiting exocytosis of a plant, fungi or a mammalian cells, in particular to inhibition of Exo70 proteins involved in exocytosis using a compound analogue of Endosidin2 (ES2). A composition matter comprising said compounds and methods of use are within the scope of the present invention.

Abstract: A postural sway analysis system is disclosed. The system includes a camera worn by an individual, a processing unit coupled to the camera, a floor marker placed on a floor near the shoes or feet of the individual. The camera is configured to acquire images of the floor marker, which has a known size or diameter, while the individual is standing. The processing unit is configured to capture an initial calibration image of the floor marker using the camera while an individual is standing still to determine the distance between the camera and the floor marker. The processing unit is further configured to capture subsequent time-varying images of the floor marker while the individual is standing (and swaying). Furthermore, the processing unit is configured to compare the calibration images to the subsequent time-varying images to determine a postural sway of the individual.

Abstract: Sensors and methods are provided that include a diamond material containing a nitrogen vacancy center, the diamond material being configured to be exposed to an environment comprising one or more gases, an optical light source configured to excite the nitrogen vacancy center of the diamond material with an optical light beam produced therefrom, a detector configured to detect a signal originating from the diamond material in response to the optical light beam exciting the nitrogen vacancy center, and the capability of analyzing the signal to identify a specific gas in the environment. Also included are levitated spin-optomechanical systems capable of elevating in a vacuum a diamond material containing a nitrogen vacancy center, applying microwave radiation to the diamond material for controlling and flipping the electron spin of the nitrogen vacancy center, and monitoring electron spin of the nitrogen vacancy center.

Abstract: The present disclosure relates to novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide, and methods to make and use the novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide.

Abstract: Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes various embodiments of the present invention.

Abstract: An ultra-thin planar device is used for arbitrary waveform formation on a micrometer scale, regardless of the incident light's polarization. Patterned perforations are made in a 30 nm-thick metal film, creating discrete phase shifts and forming a desired wavefront of cross-polarized, scattered light. The signal-to-noise ratio of these devices is at least one order of magnitude higher than current metallic nano-antenna designs. The focal length of a lens built on such principle can also be adjusted by changing the wavelength of the incident light. All proposed embodiments can be embedded, for example, on a chip or at the end of an optical fiber.

Abstract: This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

Abstract: Methods and systems suitable for fabricating multi-layer elastic electronic devices, and elastic electronic devices formed thereby. A method of fabricating an elastomer-based electronic device includes printing a first liquid material and then a second liquid material on a fabric substrate that comprises fibers. The first and second liquid materials are sequentially printed with a three-dimensional printer that directly prints the first liquid material onto the fabric substrate so that the first liquid material wicks through some of the fibers of the fabric substrate and forms a solid matrix of an elastomer-based composite that comprises the matrix and the fabric substrate, after which the three-dimensional printer directly prints the second liquid material on the elastomer-based composite to form a film thereon. The elastomer-based composite and film are electrical components of the elastomer-based electronic device.

Abstract: A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a miro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample.

Abstract: The present disclosure generally relates to 3D-architected soft machines with topologically encoded actuation, and methods of making and using the 3D-architected soft machines.

Abstract: The present disclosure provides solid collagen constructs and tissue compositions, wherein a polymerizable collagen solution or suspension is extruded in the presence or absence of cells to formed an aligned architecture comprising solid collagen constructs such as those made with fibrillar collagen. Methods of using and of manufacturing solid collagen constructs and tissue compositions, where the component collagen is solid fibrillar collagen and cells are preferentially aligned, are also provided.

Abstract: The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions.

Abstract: A single volume soft sensor capable of sensing real-time continuous contact and stretching. A low-cost and an easy method to fabricate such piezoresistive elastomer-based soft sensors for instant interactions is also provided. An electrical impedance tomography (EIT) technique is employed to estimate changes of resistance distribution on the sensor caused by fingertip contact. To compensate for the rebound elasticity of the elastomer and achieve real-time contact sensing, an adaptive baseline update for EIT is utilized. The baseline updates are triggered by fingertip contact and movement detections.

Abstract: The present disclosure generally relates to layer-wise agglomerated controlled release granular urea composition and methods of making and using the layer-wise agglomerated controlled release granular urea composition. In a particular composition, the water-soluble plant nutrient comprises urea, the binding material for the core comprises corn starch, the hydrogel for the coating layer comprises corn starch hydrogel, the core has a thickness of 2.5-3.5 mm and a closed porosity of 0.05-3%, and the coating layer has a thickness of 1.35-1.5 mm and a closed porosity of 0.1-5%.