Patents Assigned to Purdue Research Foundation
  • Publication number: 20240082246
    Abstract: A combination of active agents for the treatment of Lowe Syndrome (LS) comprising a RhoA inhibitor and a mTOR inhibitor; a pharmaceutical composition comprising the combination and a pharmaceutically acceptable carrier; a combination of pharmaceutical compositions in which one composition comprises a RhoA inhibitor and the other composition comprises a mTOR inhibitor; and a method of treating a patient for LS.
    Type: Application
    Filed: November 14, 2023
    Publication date: March 14, 2024
    Applicant: Purdue Research Foundation
    Inventor: Ruben Claudio Aguilar
  • Publication number: 20240083877
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Application
    Filed: April 26, 2023
    Publication date: March 14, 2024
    Applicant: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel Patrick Flaherty, Jatinder Kaur
  • Patent number: 11926093
    Abstract: Methods of embedding a heating circuit in an article fabricated by additive manufacturing. The methods describe techniques such as co-extruding a wire, capable of being heated, along with print material in additive manufacturing of the article, and placing a pre-shaped wire capable of being heated between adjacent layers of the article. A third method includes dispensing a wire, capable of being heated, during the additive manufacturing of the article, and compacting the wire into the printed material. An apparatus for embedding a heating circuit in an article fabricated by additive manufacturing. The apparatus contains a wire dispenser, a cutter to control the length of the wire dispensed, and a compactor capable of embedding the wire capable of being heated into the printed material. An article made by additive manufacturing is disclosed. The article contains at least one heating element embedded in the article during the additive manufacturing process.
    Type: Grant
    Filed: January 10, 2021
    Date of Patent: March 12, 2024
    Assignee: Purdue Research Foundation
    Inventors: Eduardo Barocio, Robert Byron Pipes, Bastian Brenken, Anthony Jordan Favaloro, Nicholas Mario DeNardo
  • Patent number: 11925696
    Abstract: The present disclosure relates to compositions and methods of carbonic anhydrase IX inhibitors. The present disclosure also relates to targeting conjugates of carbonic anhydrase IX inhibitors. The present disclosure also relates to the use of targeting conjugates of carbonic anhydrase IX inhibitors in SPECT imaging methods.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: March 12, 2024
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Pengcheng Lu
  • Patent number: 11926803
    Abstract: A solid-state lubricant composition is disclosed. The solid-lubricant contains graphene, an oxide of a metal, and one or more polymeric binders. A method of making a solid-state lubricant coating on various substrates is disclosed. The method includes the steps of making a homogeneous slurry comprising powder of an oxide of a metal, graphene, and a polymeric binder with organic volatile solvent; coating a substrate with the homogeneous slurry with desired thicknesses; and drying the slurry on the substrate naturally or applying additional heat, resulting in a solid lubricant coating on the substrate. Substrates with coated solid composite lubricant show wear reduction and lower coefficient of friction compared with uncoated substrates.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: March 12, 2024
    Assignee: Purdue Research Foundation
    Inventors: Vilas Ganpat Pol, Farshid Sadeghi, Abdullah Alazemi, Arthur D. Dysart
  • Patent number: 11927170
    Abstract: A hydrokinetic turbine system for harvesting energy from riverine and tidal sources, including a first floating dock, a marine hydrokinetic turbine mounted on the first floating dock, and a second floating dock. The system further includes a winch assembly mounted on the second floating dock and operationally connected to the first floating dock and a linkage assembly operationally connected to the first floating dock and to the second floating dock. The linkage assembly may be actuated to pull the first floating dock into contact with the second floating dock. The linkage assembly may be actuated to distance the first floating dock from the second floating dock, and the winch assembly may be energized to orient the first floating dock into a position wherein the marine hydrokinetic turbine is above the first floating dock and wherein the winch assembly may be energized to orient the first floating dock into a position wherein the marine hydrokinetic turbine is below the first floating dock.
    Type: Grant
    Filed: January 10, 2022
    Date of Patent: March 12, 2024
    Assignee: Purdue Research Foundation
    Inventors: Jun Chen, Haiyan H. Zhang, Charles Greg Jensen
  • Patent number: 11929141
    Abstract: Sparsity-aware reconfiguration compute-in-memory (CIM) static random access memory (SRAM) systems are disclosed. In one aspect, a reconfigurable precision succession approximation register (SAR) analog-to-digital converter (ADC) that has the ability to form (n+m) bit precision using n-bit and m-bit sub-ADCs is provided. By controlling which sub-ADCs are used based on data sparsity, precision may be maintained as needed while providing a more energy efficient design.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: March 12, 2024
    Assignee: Purdue Research Foundation
    Inventors: Kaushik Roy, Amogh Agrawal, Mustafa Fayez Ahmed Ali, Indranil Chakraborty, Aayush Ankit, Utkarsh Saxena
  • Patent number: 11918661
    Abstract: The present disclosure relates to a novel nano-droplet composition comprising a fluorocarbon core and a polymeric shell, and the method of using and making the novel nano-droplet composition. The fluorocarbon core and the polymeric shell of the novel nano-droplet form a micelle with a size range of 10-1000 nm. The fluorocarbon core comprises at least one fluorocarbon compound with a formula of CnF2n+2 and n is 5-10. The fluorocarbon compound is substantial in liquid form. And the nano-droplet composition has a temperature profile such that the nano-droplet composition has a temperature range of 20-60° C. throughout a temperature modulation process, and has a temperature of about 37° C. prior to administration to a human, animal, biological cell, or tissue subject.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: March 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Pavlos P Vlachos, Anastasiia Vasiukhina, Luis Solorio
  • Patent number: 11919941
    Abstract: Soluble, self-assembling collagens derived from tissues are extensively characterized such that one can predict and customize the final collagen-fibril matrix with respect to fibril microstructure (i.e., fibril density, interfibril branching), viscoelasticity and proteolytic degradability. As shown herein these matrices template and direct the deposition of mesoporous silica at the level of individual collagen fibrils. The fibril density, silicic acid concentration, and time of exposure to silicifying solution were varied and the resulting hybrid materials were analyzed by scanning electron microscopy, energy-dispersive x-ray spectroscopy, and rheology. Microstructural properties of the collagen-fibril template are preserved in the silica surface of hybrid materials.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: March 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Jenna Leigh Rickus, Sherry L. Voytik-Harbin, Jennifer L. K. Rich
  • Patent number: 11919207
    Abstract: A wearable accessory capable of communicating data to actuators or from sensors is disclosed. The wearable accessory includes a conductor wire disposed in a moldable medium according to a predetermined pattern, the moldable medium being an electrically insulating material, the conductor wire terminating at an input and an output.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: March 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Babak Ziaie, Rahim Rahimi
  • Patent number: 11918513
    Abstract: Drainage devices have a self-clearing capability for reducing obstructions and a controllable flow restriction capability for controlling drainage flow, and microactuators for providing such capabilities. Such a microactuator includes a frame and an appendage anchored to the frame such that the frame supports the appendage, the frame at least partially surrounds the appendage, and the appendage is disposed in an opening or window defined by the frame. The appendage includes a platform and at least one beam that anchors the platform to the frame to enable the appendage to deflect out of a plane defined by the frame. The platform may include a ferromagnetic material that enables the appendage to deflect in response to an applied magnetic field.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: March 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Hyowon Lee, Simon John, Hyunsu Park
  • Patent number: 11922100
    Abstract: A method for generating an energy usage profile for a software program executed in a computing device includes generating a call trace of an executed system call, identifying a first power consumption and duration of a first power state due to the first system call using a model, identifying a second power consumption and duration of a second power state based on the model, and generating an energy usage profile for the software program. The energy usage profile includes energy consumption of the computing device for the system call based on the first power consumption level multiplied by the first duration and the second power consumption level multiplied by the second duration associated an identifier for the call trace.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: March 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Yu Charlie Hu, Abhinav Pathak
  • Patent number: 11925118
    Abstract: A method of inactivating harmful microorganisms of a filtration medium including pathogenic bacteria and viruses is disclosed which includes placing a predetermined quantity of a hybridized fluorescent silk on to a filtration medium, applying light for a predetermined amount of time to the placed quantity of the hybridized fluorescent silk, and passing a fluid through the medium, wherein the fluid is one of substantially air or substantially water, wherein the hybridized fluorescent silk is one of KillerRed, SuperNova, KillerOrange, Dronpa, TurboGFP, mCherry, or any combination thereof.
    Type: Grant
    Filed: March 25, 2022
    Date of Patent: March 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Jung Woo Leem, Seung Ho Choi, Young L. Kim
  • Patent number: 11925117
    Abstract: A method of disinfection of a surface of a subject of harmful microorganisms including pathogenic bacteria and viruses upon visible light irradiation using a hybridized fluorescent silk is provided. The method includes placing a predetermined quantity of the hybridized fluorescent silk i) directly on to a skin surface of a subject; or ii) on a medium and then placing the medium on the skin surface of the subject. The method further includes applying light in the visible spectrum for a predetermined amount of time to the placed quantity of hybridized fluorescent silk, wherein the hybridized fluorescent silk is one of KillerRed, SuperNova, KillerOrange, Dronpa, TurboGFP, mCherry, or any combination thereof.
    Type: Grant
    Filed: March 25, 2022
    Date of Patent: March 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Jung Woo Leem, Seung Ho Choi, Young L. Kim
  • Publication number: 20240066022
    Abstract: The present application generally relates to a method to treat a patient with a bacterial infection caused by Clostridium difficile. Particularly the method compromises the step of administering a therapeutically effective amount of diiodohydroxyquinoline, with or without one or more anti-infective agents, to the patient in need of relief from said infection. Methods of uses and composition matters are within the scope of this disclosure.
    Type: Application
    Filed: November 6, 2023
    Publication date: February 29, 2024
    Applicant: Purdue Research Foundation
    Inventors: Mohamed Seleem, Nader Abutaleb
  • Publication number: 20240065270
    Abstract: The present application relates to a method of weed control for a crop field using a synergistic effect of two herbicides cellulosin and isoxaben. A composition matter together with said method comprising cellulosin and isoxaben is within the scope of the present invention.
    Type: Application
    Filed: November 6, 2023
    Publication date: February 29, 2024
    Applicant: Purdue Research Foundation
    Inventor: Chunhua Zhang
  • Publication number: 20240069321
    Abstract: An apparatus for large-scale dynamic imaging of a sample is described. The apparatus includes an optical detector, a light guide, a dichroic beam splitter, and a light source. The light guide includes a first portion and a second portion. The second defines a tapered shape such that a first diameter defined by a distal end of the second portion is smaller than a second diameter defined by a proximal end of the second portion. The dichroic beam splitter is positioned between the first portion and the second portion of the light guide. The light source is configured to direct a light beam through an external surface of the dichroic beam splitter. The dichroic beam splitter is configured to direct the light beam toward the second open end of the light guide and transfer the return emitted signal through the light guide to the optical detector.
    Type: Application
    Filed: August 30, 2023
    Publication date: February 29, 2024
    Applicant: Purdue Research Foundation
    Inventor: Meng Cui
  • Patent number: 11913924
    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
    Type: Grant
    Filed: March 30, 2023
    Date of Patent: February 27, 2024
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang
  • Patent number: 11915585
    Abstract: A method of generating an output movement layout for a traffic intersection is disclosed which includes receiving intersection geographical data, establishing a center point for the intersection, receiving vehicle global positioning system (GPS) data, establishing a radius of interest for the intersection based on the received vehicle GPS data, establishing entry and exit headings for each vehicle based on the GPS data, generating an angular cluster chart based on the entry and exit headings of each vehicle, and generating an output movement layout for the intersection based on the generated angular cluster chart. Further, a method for green time reallocation at traffic signals is disclosed that is based on the congestion experienced by vehicles identified as following specific movements.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: February 27, 2024
    Assignee: Purdue Research Foundation
    Inventors: Enrique Daniel Saldivar Carranza, Haoxiang Howell Li, Darcy Bullock
  • Patent number: 11912655
    Abstract: Processes and systems for upgrading natural gas liquids. At least a portion of the natural gas liquid components in a shale gas stream can be dehydrogenated to their corresponding olefin derivatives prior to separating any methane from the liquids. Further processing subsequent to dehydrogenation could include various separations, oligomerizing olefins produced in the dehydrogenation step, recovering desired products, etc. The order of the processing steps subsequent to dehydrogenation could be adjusted in various cases.
    Type: Grant
    Filed: May 18, 2022
    Date of Patent: February 27, 2024
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Rakesh Agrawal, Yiru Li