Abstract: This invention generally relates to a device for preparing and transferring a monolayer or thin film. In particular this present invention is a device for preparing and transferring a monolayer or thin film to a substrate using an improved version of the Langmuir-Schaefer technique, which incorporates in situ thermal control, for instance to heat the supporting substrate before and/or during the transfer process.

Abstract: Systems, kits, and methods for detecting and quantifying proteomic activity using DNA-encoded probes are provided, where the proteomic activity may be enzymatic activity or ligand binding affinity. Such systems and methods encode quantitative proteomic activity information into DNA sequence populations and utilize DNA-linked substrates or ligands as activity probes. The systems, kits, and methods that are directed to detecting ligand affinity further include crosslinking steps to ensure the integrity of the DNA-linked ligands during purification and washing. Signal detection involves the chemical manipulation of a probe population downstream of sample exposure and application of purifying, selective pressure for desired products. Selection-induced changes in DNA abundance between the initial pool and the purified pool indicate sample activity.

Abstract: A method of selectively broadcasting a message to a client by a server without knowing the client's internet protocol (IP) address includes receiving video feeds of an area of interest from one or more cameras, performing target recognition and tracking on one or more targets, including position of the one or more targets, extracting target-specific context parameters from the one or more recognized and tracked targets, encoding the target-specific context parameters into a header, thereby generating a context address for the one or more targets, appending the context address to a message for the one or more targets from a predetermined set of messages based on the position of the one or more targets, thereby generating one or more packets of information, and broadcasting the one or more packets wirelessly to one or more client mobile devices each associated with the one or more targets.

Abstract: The invention provides siRNA compositions that specifically downregulates expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD).

Abstract: Three-dimensional (3D) printed fluoropolymer-based energetic compositions are made using 3D printing methods. The 3D printed fluoropolymer-based energetic compositions comprise a fluoropolymer and a reactive metal or metal oxide. The total weight percentage of the fluoropolymer and the reactive metal or metal oxide is 70-100% of the 3D printed fluoropolymer-based energetic composition, and the weight percentage of the reactive metal or metal oxide is 5-85 wt % of the total weight of the 3D printed fluoropolymer-based energetic material. The 3D printed fluoropolymer-based energetic material has a thickness of at least 200 ?m.

Abstract: The present disclosure relates to boron carbide (B4C) composite material and the method of making and using the boron carbide (B4C) composite.

Abstract: Various embodiments relate to a compound of the formula (I) and (II), wherein X, X1, X2, X3, and R1-R4 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and/or (II) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I) and/or (II), or a pharmaceutical composition comprising compounds of the formula (I) and/or (II), to a patient in need thereof.

Abstract: A method includes identifying a plurality of local tracklets from a plurality of targets, creating a plurality of global tracklets from the plurality of local tracklets, wherein each global tracklet comprises a set of local tracklet of the plurality of local tracklets, wherein the set of local tracklet corresponds to a target of the plurality of targets; extracting motion features of the target from the each global tracklet of the plurality of global tracklets, wherein the motion features of each target of the plurality of targets from each global tracklet of the plurality of global tracklets are distinguishable from the motion features of remaining targets of the plurality of targets from remaining global tracklets; transforming the motion features into an address code by using a hashing process; and transmitting a plurality of address codes and a transformation parameter of the hashing process to a communication device.

Abstract: This invention generally relates to methods useful for measuring heart rate, respiration conditions, and oxygen saturation and a wearable device that incorporate those methods with a computerized system supporting data collection, analysis, readout and sharing. Particularly this present invention relates to a wearable device, such as a wristwatch or ring, for real time measuring heart rate, respiration conditions, and oxygen saturation.

Abstract: A system architecture encoded on a non-transitory computer readable medium, the system architecture includes a first protocol. The first protocol is configured to receive a plurality of outputs from an ICS used in controlling an industrial system. The first protocol is configured to receive a plurality of inputs from a physical module. The physical module includes at least one of a component, a sensor, or the ICS. Additionally, the system architecture includes a second protocol, wherein the second protocol is configured to validate the plurality of inputs from the first protocol. Moreover, the system architectures includes a third protocol, wherein the third protocol is configured to validate the plurality of outputs from the first protocol. Further, the system architecture includes a fourth protocol, wherein the fourth protocol is configured to manage the ICS based on the second protocol and the third protocol.

Abstract: The present disclosure relates to a novel portable apparatus suitable for providing an optimized amount of refrigerant to a refrigeration system, and to methods of using the novel portable apparatus.

Abstract: The present disclosure provides to a novel two-target method for measuring the concentration of dust clouds, and an apparatus system that uses the novel two-target method. Cornstarch, corn dust, and saw dust are tested with the apparatus system with the method. This method used the light extinction coefficient of a dust cloud between two targets using a digital camera. This extinction coefficient is linearly related to the concentration of the dust, and the mass extinction coefficient is the key value for this measurement method. The mass extinction efficiency (K) depend greatly on the physical and chemical properties of the dust particles.

Abstract: Oligomerization catalyst and method for oligomerization using the catalyst. The catalyst comprises a single Zn(II) or Ga(III) metal ion center directly bonded to a support through a shared oxygen atom, the catalyst having at least one M-O bond which forms an active site for oligomerization. The method includes reacting one or more C2 to C12 olefins with the oligomerization catalyst at a temperature of about 200° C. or higher to provide an oligomer product comprising C4 to C26 olefins.

Abstract: An in silico screening method generated compounds that are against laminin receptor 37LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.

Abstract: A controlled variable delivery external gear machine (VD-EGM). The VD-EGM includes a housing, an inlet, a drive gear, a driven gear, the drive gear configured to engage the driven gear in an angular mesh zone, an outlet, a first slider comprising a first longitudinal portion connected to a second longitudinal portion such that longitudinal forces applied to the first and second longitudinal portions substantially cancel each other thereby requiring between about 0 N to about 20 N to longitudinally moving the first slider, selective positioning of the first slider configured to vary net operational volumes of fluid communication between the inlet and the outlet, for a given rotational speed of the drive gear, and a first drive mechanism coupled to the first slider and configured to cause the first slider to slide in a longitudinal direction.

Abstract: An electronic memory array includes a plurality of memory domains, a current controller, and a selector device. Each memory domain includes a plurality of bit cells. The current controller includes a current controller output electrically connectable to said plurality of memory domains and is configured to control a bit cell current. The selector device is electrically connected to the current controller and the plurality of memory domains. The selector device is configured to selectively electrically connect the current controller output to only a select one of said memory domains, such that the current controller controls only the bit cell current of the bit cells of the select memory domain.

Abstract: The present disclosure generally relates to layer-wise agglomerated controlled release granular urea composition and methods of making and using the layer-wise agglomerated controlled release granular urea composition. In a particular composition, the water-soluble plant nutrient comprises urea, the binding material for the core comprises corn starch, the hydrogel for the coating layer comprises corn starch hydrogel, the core has a thickness of 2.5-3.5 mm and a closed porosity of 0.05-3%, and the coating layer has a thickness of 1.35-1.5 mm and a closed porosity of 0.1-5%.

Abstract: The present disclosure relates to novel ?-opioid receptor agonists, and the method of making and using the novel ?-opioid receptor agonists. The novel ?-opioid receptor agonists are selective ?-opioid receptor agonists that have substantially no beta-arrestin 2 recruitment or low beta-arrestin 2 recruitment. The novel ?-opioid receptor agonists may be used for the treatment for alcohol use disorders and other co-occurring psychiatric disorders.

Abstract: A reference imaging system including a planar reference piece. The reference imaging system further includes a three-axis gantry for positioning the planar reference piece at a plurality of points in a 3D coordinate system. Additionally, the reference imaging system includes a yaw actuator for adjusting the yaw angle of the object. Furthermore, the reference imaging system includes a pitch actuator for adjusting the pitch of the object. Moreover, the reference imaging system includes a computer processing unit for controlling the 3D position, pitch and yaw of the planar reference piece.

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) possesses array of strategies to evade antibiotics through mutational inactivation, hiding inside host immune cells or concealing inside the biofilm in a sessile form. We report a drug-free approach to eradicate MRSA through blue-light bleaching of staphyloxanthin (STX), an anti-oxidative carotenoid residing inside the cell membrane of S. aureus. The photobleaching process, uncovered through a transient absorption imaging study and quantitated by mass spectrometry, decomposes STX and sensitizes MRSA to reactive oxygen species attack. Consequently, photobleaching using low-level blue light exhibits high-level synergy when combined with low-concentration of hydrogen peroxide. Antimicrobial effectiveness of this synergistic therapy is validated in MRSA culture, MRSA-infected macrophage cells, biofilm, and a mouse wound infection model. Collectively, these findings highlight broad applications of STX photobleaching for MRSA-infected diseases.