Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target entities bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target entities from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target entities bound to magnetic beads on the surface of the plate. In a further feature, the microfluidic detection system is configured to pass target molecules through the plate to be bound to a functionalized surface of the lower chamber.

Abstract: Oligomerization catalyst and method for oligomerization using the catalyst. The catalyst comprises a single Zn(II) or Ga(III) metal ion center directly bonded to a support through a shared oxygen atom, the catalyst having at least one M-O bond which forms an active site for oligomerization. The method includes reacting one or more C2 to C12 olefins with the oligomerization catalyst at a temperature of about 200° C. or higher to provide an oligomer product comprising C4 to C26 olefins.

Abstract: Oligomerization catalyst and method for oligomerization using the catalyst. The catalyst comprises a single Zn(II) or Ga(III) metal ion center directly bonded to a support through a shared oxygen atom, the catalyst having at least one M-O bond which forms an active site for oligomerization. The method includes reacting one or more C2 to C12 olefins with the oligomerization catalyst at a temperature of about 200° C. or higher to provide an oligomer product comprising C4 to C26 olefins.

Abstract: A composition comprising an active agent that inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) is provided. With the composition, food intake can be suppressed, and/or body weight can be reduced, and/or metabolic disorders can be prevented and/or treated.

Abstract: A textile-based sensing system is disclosed that includes a textile substrate formed from interlaced semiconducting textile fibers and metal fibers. Intersections between the semiconducting textile fibers and the metal fibers define a plurality of non-ohmic junctions configured to generate electrical signals in response to mechanical stimuli applied to the textile substrate. The plurality of non-ohmic junctions collectively form a distributed textile sensor matrix. One or more processing devices receive electrical signals generated by the textile sensor matrix and process the signals using a trained model configured to compensate for variability arising from non-conformal contact between the textile substrate and a user. Based on analysis of spatiotemporal patterns in the electrical signals, the trained model classifies at least one of a user interaction or an object interaction. The classification is used to interface with an electromechanical system to cause interaction-dependent control.

Abstract: A method for pathogen detection is also disclosed which includes (i) operating a micropump forcing a first fluid hosting a pathogen-selective antibody from a source to a destination, defining a target, via a microfluidic channel, (ii) operating the micropump to thereby force a second fluid potentially hosting the selective pathogen from the source to the destination, obtaining a signal from the destination indicating a mass change; (iii) comparing the mass change to a predetermined threshold to indicate conditional presence of the pathogen and concentration of the pathogen, (iv) operating the micropump forcing a third fluid hosting a pathogen-selective photoluminescent label from the source to the destination, (v) activating a light excitation subsystem, (vi) capturing images from the target; and (vii) analyzing the images to determine presence of the label thus double-confirming a) presence of the pathogen, and b) concentration of the pathogen.

Abstract: A method of optimizing a network-based quantum computer includes coupling a plurality of contacts with a network of transport channels. The plurality of contacts includes at least one read-out contact and at least one electrostatic control contact, and each channel of the network of transport channels is coupled with a read-out contact and an electrostatic control contact. The at least one electrostatic control contact is operable to control an electric charge within the network of transport channels. The method further includes initiating an optimization algorithm coupled with the plurality of contacts to generate an optimal contact setting configuration for the plurality of contacts coupled with the network of transport channels. Additionally, the method includes adjusting the plurality of contacts according to optimal the contact setting configuration.

Abstract: A state of battery testing system is disclosed which includes a charger, a load to be coupled across the battery's positive and negative terminals, a processer adapted to apply a predetermined voltage pulse across the battery's positive and negative terminals, apply the load to the battery, measure and log current through the load as Iexp, and establish a model based on establishing an initial estimation of state of the battery (?0), and establishing a modeled state of battery (?i) based on a plurality of internal parameters of the battery. The model is adapted to output a model current through the load, inputting ?0 and the plurality of internal parameters of the model to thereby generate Imodel, generate an objective function (ƒ) based on a comparison of Imodel and Iexp, and iteratively optimize ?i, and output ?optimal based on the iterations.

Abstract: The vibration attenuation system includes a load bearing layer, a non-load bearing layer, and a rigid beam connector. The load bearing layer has a first density and a first stiffness. The non-load bearing layer has a second density and a second stiffness. The second density is lower than the first density. The rigid beam connector has a third density and a third stiffness. The rigid beam connector couples the load bearing layer to the non-load bearing layer. The coupling of the non-load bearing layer to the load bearing layer is enabled through the use of the rigid beam connector which provides a nonlocal connection to transfer energy from the load bearing layer to the non-load bearing layer.

Abstract: The invention generally relates to methods of coupling a carbon containing moiety to an amine containing moiety.

Abstract: Caninized antibodies and antigen binding fragments thereof are provided that bind programmed death ligand 1 in a canine subject. Methods of treating cancer in a canine subject using the caninized antibodies and/or antigen binding fragments are also provided, as are methods for predicting and modeling anti-cancer activity of a test compound in a subject.

Abstract: A system is provided for analyzing volatile compounds from a liquid sample using proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS). The system includes a PTR-TOF-MS device, a pressurized zero-air supply, and a sample container defining a headspace above a liquid sample. A purge valve selectively introduces zero air into the headspace, and a sample valve selectively delivers headspace gas to the mass spectrometer. In a purge mode, zero air flows through the headspace and into the PTR-TOF-MS device. In an equilibrium mode, both valves restrict flow to fluidly isolate the headspace, allowing volatile compounds to reach static gas-liquid equilibrium. In a sampling mode, headspace gas is delivered to the PTR-TOF-MS device for a defined sampling duration.

Abstract: A method for correcting colors in a captured image, which includes receiving a ground truth color chart having a plurality of reference color patches, capturing an image based on a first color domain from a scene or sample of interest juxtaposed with the ground truth color chart, obtaining ground truth color values associated with each of the reference color patches in a second color domain, generating a scene or sample-specific dataset using the plurality of color values of the reference color patches in the ground truth color chart in the first and second color domains as the input and output, training a neural network of color correction with the dataset, and applying the trained neural network to convert portion of the scene or sample of interest outside the ground truth color chart in the first color domain to thereby generate an output image based on the second color domain.

Abstract: A method of generating a ground truth color chart including color patches for biological imaging and colorimetric bioassays is disclosed which includes using a mathematical relationship associated with a tissue of interest expressing a relationship between intensity as a function of wavelength, the received mathematical relationship having a plurality of parameters, synthesizing a plurality of synthesized spectra based on the mathematical relationship, converting each of the plurality of synthesized spectra to a predetermined color space under a predetermined illuminant, thereby generating a digital tissue-specific gamut, identifying a plurality of digital gamut points within the digital tissue-specific gamut based on a predetermined criterion, and printing a tissue-specific gamut based on the digital tissue-specific gamut thus establishing a ground truth color chart having a plurality of color patches, whereby each of the plurality of digital gamut points corresponds to an associated printed color patch usin

Abstract: An artificial photoreceptors (APR) includes a nano-dielectric core, a plurality of optical dipoles each optical dipole attached to the surface of the nano-dielectric core, and each optical dipole includes a first nano-particle configured to generate a positive voltage when receiving a light pulse having a predetermined wavelength, and a second nano-particle configured to generate a negative voltage when receiving a light pulse having the predetermined wavelength, wherein i) a plurality of a first set of the first and second nano-particles of the plurality of optical dipoles cancel each other's voltages such that a plurality of APRs only generate voltages at locations corresponding to edge-detected signals representing edges of an object; or ii) a plurality of a second set of the first and second nano-particles of the plurality of optical dipoles generate positive and negative voltages to sequentially generate responses for biological receptors.

Abstract: Systems and techniques can prevent reflux induced laryngospasm and the pathologies resulting therefrom, including (but not limited to) sudden death in epilepsy (SUDEP) and sudden infant death syndrome (SIDS).

Abstract: A system may receive a package previously irradiated for sterilization. The package may have a sensor comprising a reference tag and sensing tag at least partially coated with a material comprising poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) and Polyurethan (PU). The system may scan the sensing tag and the reference tag. The system may determine, based on radio frequency (RF) signals reflected from the sensing tag and reference tag, the sensor is exposed to radiation. The system may output a quality measure indicative of the sensor being exposed to radiation.

Abstract: The carbon capture system includes a wind turbine, a direct-air capture (DAC) system, and a processor. The wind turbine has a first location and/or a first position. The processor is communicatively coupled to the DAC system. The processor is configured to input a wind turbine wake from the wind turbine and/or incident carbon dioxide profile, execute an algorithm to determine a wind velocity and/or a concentration of the carbon dioxide in the wind turbine wake, and output a second location and/or a second position of the DAC system. The second location and/or the second position of the DAC system is optimized to enhance the quantity of carbon dioxide captured from to the wind turbine.

Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.

Abstract: Near-infrared (NIR) perovskite light-emitting diodes (PeLEDs) and methods of formation are described. To form the PELEDs, perovskite precursors are dissolved using a mixture of N,N-dimethylformamide (DMF) and N-methylpyrrolidone (NMP) to form perovskite crystals. The perovskite crystals are modified using a small-bandgap organic cation of 2-(5-(7-(3-ethylthiophen-2-yl)-5,6-difluorobenzo[c][1,2,5]thiadiazol-4-yl)thiophen-2-yl)ethan-1-aminium iodide (TeFBTT) to form a two- or three-dimensional (2D/3D) perovskite heterostructure in a (TeFBTT)2PbI4 thin film. The (TeFBTT)2PbI4 thin film is then used to form the NIR PeLED.