Abstract: This present patent application relates to a method for controlling a targeted gene expression with an environmental trigger useful for manufacturing a natural product or an analogue thereof biologically. In particular, the present invention discloses an expression system comprises a gene expressing for a fusion protein of elastin-like polypeptides (ELPs) and a transcription factor, wherein a targeted gene expression is regulated by the phase change of the fusion protein initiated by an environmental trigger, including changes of temperature, pH value, ionic strength or a combination thereof. The method, the expression system and their products are within the scope of this invention.

Abstract: A method executed by a processing system of an edge router deployed in a content distribution network includes receiving a request from an endpoint device for a first file, determining that a portion of the first file is not stored in a cache of the edge router, determining that the cache is at a capacity threshold, selecting a second file to evict from the cache, wherein the second file is one of a plurality of files stored in the cache, wherein each file of the plurality of files is scheduled to be evicted from the cache when a threshold period of time has passed since a last request for the each file was received by the edge router, and wherein the threshold period of time associated with the second file is scheduled to expire soonest among all of the plurality of files, and evicting the second file from the cache.

Abstract: A nanodevice provides for electric-field control of magnon-QSD interactions. The nanodevice includes a ferroelectric substrate, a ferromagnetic material disposed over the ferroelectric substrate, and a nanodiamond including an ensemble of nitrogen-vacancy (NV) spins, each NV magnetically interfacing with the ferromagnetic material. An electric field is measured by applying a voltage across the ferroelectric substrate and the ferromagnetic material, changing a magnon excitation spectrum of the ferromagnetic material with respect to an electron spin resonance frequency of the ensemble of NV spins, and measuring a relaxation rate of the ensemble of NV spins.

Abstract: The invention generally relates to systems and methods for precursor and neutral loss scan in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to excite a precursor ion and eject a product ion in the single ion trap.

Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.

Abstract: The present invention relates to series of compounds as an inhibitor targeting Proliferating Cell Nuclear Antigen (PCNA). Pharmaceutical compositions of those compounds and methods of using them in the treatment of cancer are within the scope of this disclosure.

Abstract: The present disclosure relates to compositions comprising a plurality of live Lactococcus lactic bacteria and one or more compounds selected from ?-tocotrienol (?TE), ?-tocotrienol (?TE), and/or ?TE-13?-carboxychromanol (?TE-13?-COOH, abbr. ?TE-13?), and to the method for treating colitis and/or preventing colon cancer live with the novel compositions.

Abstract: The present invention generally relates to a composition matter useful for diagnosis and treatment of Alzheimer's disease comprising A-L-F or a pharmaceutically acceptable salt thereof, wherein A is beta-amyloid peptide or a fragment thereof, L is an optional linker and F is a pH-responsive fluorophore, dye, or a therapeutic agent. Composition matters, methods of use as well as a kit for diagnosis and/or treatment of Alzheimer's disease are within the scope of this disclosure.

Abstract: Systems and methods that involve distributing water droplets onto a media, particular but nonlimiting examples of which include systems and methods for exchanging heat between process water and air in an evaporative cooling system that includes media with a plurality of individual elements each having a surface. The surfaces of at least some of the individual elements individually have a static electrical charge, and the static electrical charges are different among the surfaces of the individual elements.

Abstract: A non-transitory computer-readable medium encoded with a computer-readable program which, when executed by a first processor, will cause a computer to execute a method of authenticating a user, the method including training a plurality of models. The method additionally includes sending, by a computer, an acoustic signal. Further, the method includes receiving, by the computer, a reflected acoustic signal, wherein the reflected acoustic signal comprises information about a signature. Moreover, the method includes receiving, by the computer, motion data about the information about the signature. The method additionally includes comparing the information about the signature to a model to generate a score. Additionally, the method includes deciding, based on the score, if the information about the signature is within a predetermined tolerance level.

Abstract: Processes and systems for upgrading natural gas liquids. At least a portion of the natural gas liquid components in a shale gas stream can be dehydrogenated to their corresponding olefin derivatives prior to separating any methane from the liquids. Further processing subsequent to dehydrogenation could include various separations, oligomerizing olefins produced in the dehydrogenation step, recovering desired products, etc. The order of the processing steps subsequent to dehydrogenation could be adjusted in various cases.

Abstract: An acoustic shield for protecting a vibrational sensitive device includes a first unit cell and a second unit cell. The first unit cell includes a first locally resonant unit. The first locally resonant unit controls a first phase gradient and the first unit cell includes a first surface. The second unit cell includes a second surface proximate to the first surface. The second unit cell includes a second locally resonant unit embedded along the second interface. The second locally resonant unit controls a second phase gradient. The first phase gradient is different from the second phase gradient. The first unit cell and the second unit cell comprise a super cell. The acoustic shield is configured such that a vibrational wave from a first side of the super cell to a second side of the super cell is substantially attenuated.

Abstract: A memory cell is disclosed which includes a semiconductor layer, a first electrode coupled to the semiconductor layer, a second electrode coupled to the semiconductor layer, wherein the first and second electrodes are separated from one another along a first axis and wherein the semiconductor layer extends beyond the first axis along a second axis substantially perpendicular to the first axis, thereby forming a first wing, a third electrode separated from the semiconductor layer by an insulating layer, a first magnetic tunnel junction (MTJ) disposed on the first wing, and a first read electrode coupled to the first MTJ.

Abstract: A method of performing ordered statistics between at least two parties is disclosed which includes identifying a first dataset (xA) by a first node (A), identifying a second dataset (xB) by a second node (B), wherein xB is unknown to A and xA is unknown to B, and wherein A is in communication with B, and wherein A and B are in communication with a server (S), A and B each additively splitting each member of their respective datasets into corresponding shares, sharing the corresponding shares with one another, arranging the corresponding shares according to a mutually agreed predetermined order into corresponding ordered shares, shuffling the ordered shares into shuffled shares, re-splitting the shuffled shares into re-split shuffled shares, and performing an ordered statistical operation on the re-split shuffled shares, wherein the steps of shuffle and re-split is based on additions, subtractions but not multiplication and division.

Abstract: The present application relates generally to a process of manufacturing an optimized packing material comprising chia seed mucilage (CSM), glycerol, and sorbitol, wherein said packaging materials have a good tensile strength (2.005 N/mm2), lower water vapor permeability (1.73×10?9 g×s×Pa/m), a good flexibility (e.g. high elongation at break, 31.729%). The optimum conditions of polyol concentration were 1.3 g of glycerol and 2.0 g of sorbitol per g of CSM. Based on these results, chia seed mucilage can successfully be used to develop biofilms with potential to be used in drug delivery and edible food coating applications. Both the process and the products are within the scope of this application.

Abstract: A system to monitor and control a lyophilization process using a wireless network is disclosed which includes one or more wireless pressure and gas temperature sensors adapted to provide pressure and gas temperature measurements of the ambient environment, a lyophilization chamber, wherein the one or more wireless pressure sensors are distributed in one or more lyophilization vial trays, a vacuum pump, adapted to change the pressure with the lyophilization chamber, a heat exchanger adapted to modify temperature within the lyophilization chamber, and a controller adapted to collect pressure and gas temperature data from the one or more wireless pressure and gas temperature sensors, calculate sublimation rate of a product to be lyophilized using the collected pressure and gas temperature data, and adjust one or both of pressure and temperature within the lyophilization chamber such that the calculated sublimation rate stays within a predetermined envelope.

Abstract: Disclosed herein is a technology for healing bone defects using bioactive silicate glass (BSG) and a 3D osteomimetic composite porous scaffold containing microspheres comprised of poly(lactide-co-glycolide) (PLGA).

Abstract: A single volume soft sensor capable of sensing real-time continuous contact and stretching. A low-cost and an easy method to fabricate such piezoresistive elastomer-based soft sensors for instant interactions is also provided. An electrical impedance tomography (EIT) technique is employed to estimate changes of resistance distribution on the sensor caused by fingertip contact. To compensate for the rebound elasticity of the elastomer and achieve real-time contact sensing, an adaptive baseline update for EIT is utilized. The baseline updates are triggered by fingertip contact and movement detections.

Abstract: A method for processing images of an agricultural field is disclosed that enables accurate phenotype measurements for crops planted in each research plot of the agricultural field. The method comprises receiving a plurality of input images of the agricultural field, calculating and refining object space coordinates for matched key points in the input images and an object space camera pose for each input image, calculating and refining object space center points for the research plots based on a user-defined plot layout, and generating output images of individual research plots that are centered, cropped, orthorectified, and oriented in alignment with planted rows of crops. Based on the output images, accurate phenotype measurements for crops planted in each research plot can be determined.

Abstract: An Anderson localized hyperspectral filter array is disclosed which includes a base layer and a plurality of optical layers deposited on the base layer selected from two or more materials, each material having a refractive index that is different from the other materials of the two or more materials, wherein no consecutively deposited optical layers have the same refractive index, each of the plurality of optical layers having a thickness chosen based on a random number within a predetermined range.