Abstract: The present disclosure generally relates to a composition matter and a method for cancer treatment comprising albumin (alb) coated tannic acid-Fe nanoparticles (NPs) with a therapeutic compound, and one or more diluents, excipients or carriers. In particular, the present invention provides a treatment by enhancing antitumor immunity using tannic acid-based nanoparticles containing a therapeutic cancer treatment that can induce immunogenic cell death (ICD). The method disclosed herein provides a potential solution to the immunotoxicity accompanying the ICD cancer immunotherapy by intratumoral or intravenous administration of a nanocapsule formulation of carfilzomib (CFZ), an ICD-inducing proteasome inhibitor, using interfacial supramolecular assembly of tannic acid (TA) and iron, supplemented with albumin coating for better metabolic stability.

Abstract: A method of determining a model for pixel power consumption for each pixel in a display of a device displaying each color in a color space is disclosed which includes establishing a color space for the display, decomposing the color space into a plurality of subgrids, measuring the pixel power associated with a selected set of colors in each subgrid of the plurality of subgrids, establishing a pixel power model for each subgrid of the plurality of subgrids by applying a function to the power values at the selected set of colors in that subgrid, and deriving a piecewise pixel power model for the entire color space which includes pixel power models for the plurality of subgrids.

Abstract: The invention generally relates to high-throughput label-free enzymatic bioassays using desorption electrospray ionization-mass spectrometry (DESI-MS).

Abstract: The present invention relates to a low-cost, thermally reversible valve for paper-fluidic diagnostic devices. In particular, this invention demonstrates a tunable valve mechanism fabricated by wax-ink printing and localized heating via thin-film resistors to sequentially release liquids through a cellulose or nitrocellulose membrane. The wax-ink valve can obstruct fluid flow for a sustained time and are thermally actuated to release a controlled amount of liquid past the valve. This integrated paper-fluidic diagnostic assay device requires minimal user involvement, can be easily manufactured and tuned to meet various fluid delivery timing and incubation needs.

Abstract: The present disclosure relates to a novel tetrazole azasydnone, a method of making the novel tetrazole azasydnone, and a method of using the novel tetrazole azasydnone as a primary explosive. In one aspect, the novel tetrazole azasydnone has a structure of formula I: wherein A? represents a cation with a 1+ charge.

Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.

Abstract: A flow measurement apparatus comprising an elongated mounting stem having an inner stem cavity, the mounting stem configured to be mounted in an area of flow to be measured. A probe housing is mounted to an outer surface of the mounting stem and positioned on an upstream side of the mounting stem. The probe housing has a first hole near a center point of the housing and a second, third and fourth hole positioned near the perimeter of the housing. A fifth hole is located on a downstream side of the mounting stem. At least five pressure sensors and a plurality of pressure tapping tubes connecting the holes to the corresponding pressure sensors are included.

Abstract: A method of determining a model for pixel power consumption for each pixel in a display of a device displaying each color in a color space is disclosed which includes establishing a color space for the display, decomposing the color space into a plurality of subgrids, measuring the pixel power associated with a selected set of colors in each subgrid of the plurality of subgrids, establishing a pixel power model for each subgrid of the plurality of subgrids by applying a function to the power values at the selected set of colors in that subgrid, and deriving a piecewise pixel power model for the entire color space which includes pixel power models for the plurality of subgrids.

Abstract: Systems and methods for wireless stimulation of biological tissue (e.g. nerves, muscle tissue, etc.) and, in one exemplary implementation, to therapy for glaucoma based on the wireless administration of energy to the eye of a mammalian subject (e.g. human, rodent, etc.) to reduce an elevated intraocular pressure (IOP) involving the use of a multi-coil wireless power transfer assembly. The multi-coil wireless power transfer assembly may be used alone or in combination with a stimulation coil that can be implanted in the eye of a mammalian subject or within a contact lens worn by a mammalian subject.

Abstract: An optical sensor system, comprising refractory plasmonic elements that can withstand temperatures exceeding 2500° C. in chemically aggressive and harsh environments that impose stress, strain and vibrations. A plasmonic metamaterial or metasurface, engineered to have a specific spectral and angular response, exhibits optical reflection characteristics that are altered by varying physical environmental conditions including but not limited to temperature, surface chemistry or elastic stress, strain and other types of mechanical load. The metamaterial or metasurface comprises a set of ultra-thin structured layers with a total thickness of less than tens of microns that can be deployed onto surfaces of devices operating in harsh environmental conditions. The top interface of the metamaterial or metasurface is illuminated with a light source, either through free space or via an optical fiber, and the reflected signal is detected employing remote detectors.

Abstract: A lyophilization method for lyophilizing products inside one or more vials within a lyophilization chamber is disclosed which includes humidifying a charge gas to a predetermined relative humidity, cooling shelves in the lyophilization chamber to a predetermined temperature, pressurizing the chamber with the humidified charge gas to a pressurization threshold to thereby achieving a target relative humidity level within the lyophilization chamber, and suddenly releasing pressure within the lyophilization chamber until a depressurization threshold is reached in a short time interval up to about 4 seconds, during the depressurization, product inside one or more vials nucleate.

Abstract: The present disclosure relates to compositions and methods of carbonic anhydrase IX inhibitors. The present disclosure also relates to targeting conjugates of carbonic anhydrase IX inhibitors. The present disclosure also relates to the use of targeting conjugates of carbonic anhydrase IX inhibitors in methods of treating disease and for imaging of disease.

Abstract: Systems and techniques for wireless implantable devices, for example implantable biomedical devices employed for biomodulation. Some embodiments include a biomodulation system including a non-implantable assembly including a source for wireless power transfer and a data communications system, an implantable assembly including a power management module configured to continuously generate one or more operating voltage for the implantable assembly using wireless power transfer from the non-implantable assembly, a control module operably connected to at least one communication channel and at least one stimulation output, the control module including a processor unit to process information sensed via the at least one communication channel and, upon determining a condition exists, to generate an output to trigger the generation of a stimulus.

Abstract: A MXene support for a noble metal that forms a catalyst having active sites comprising single metal-layer nanostructures. The catalyst is stable under conditions for methane conversion to higher hydrocarbons and provides reduced coke formation. The results show a supported metal catalyst using the MXene where Pt atoms form one or more layers of atoms on the surface of the Mo2TiC2Tx support after it is reduced at 750° C. The catalyst shows high selectivity for C2-hydrocarbons with reduced coke formation, which can cost effectively convert methane into other valuable products.

Abstract: A fluorescent oxygen sensing ink includes at least one organic solvent, at least one polymer binder disposed in the organic solvent, and an oxygen-sensitive fluorescent dye disposed in the organic solvent. The oxygen-sensitive fluorescent dye and the at least one polymer can interact to form a moisture-resistant film. The fluorescent oxygen sensing ink can be incorporated into an oxygen sensing wound dressing.

Abstract: A method of generating a three-dimensional (3D) structure model from a two-dimensional (2D) drawing file, which includes one or more illustrations of a structure, using a data processing device includes importing the 2D drawing file to the data processing device, converting the 2D drawing file into a raster graphics file, converting the raster graphics file into a vector graphics file, extracting one or more graphical projections representative of the structure from the vector graphics file, converting the one or more projections into a tagged data graphics file, forming a 3D structure model representative of the structure by connecting the plurality of cartesian points of the tagged data graphics file, and generating an electronic output file including the 3D structure model.

Abstract: System and methods for OCR sensing with a suction-line accumulator are provided. The accumulator may include a sensor configured to detect the level of oil. The accumulator may further include a valve which opens when oil is at a high-level and closes when oil is at a low-level. The accumulator may measure a mass flow rate of oil in the vapor compression cycle system based on an amount of time taken to fill a portion of the accumulator. The accumulator may further determine an oil circulation ratio based on the measured time taken to fill the portion of the accumulator. The smart accumulator may output the oil circulation ratio.

Abstract: The invention related to single photon emission systems based on nano-diamonds. Single-photon sources have a broad range of applications in quantum communication, quantum computing and quantum metrology.

Abstract: Nanoassembly methods for producing quasi-3D plasmonic films with periodic nanoarrays of nano-sized surface features. A sacrificial layer is deposited on a surface of a donor substrate having periodic nanoarrays of nanopattern features formed thereon. A plasmon film is deposited onto the sacrificial layer and a dielectric spacer is deposited on the plasmon film. The donor substrate having the sacrificial layer, plasmon film, and dielectric spacer thereon is immersed in a bath of etchant to selectively remove the sacrificial layer such that the plasmon film and the dielectric spacer thereon adhere to the surface of the donor substrate. The dielectric spacer and the plasmon film are mechanically separated from the donor substrate to define a quasi-three dimensional (3D) plasmonic film having periodic nanoarrays of nano-sized surface features defined by the nanopattern features of the donor substrate surface. The quasi-3D plasmonic film is then applied to a receiver substrate.

Abstract: The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging drugs for cancers.