Patents Assigned to Quest Diagnostics
  • Patent number: 8603740
    Abstract: The present invention is based on BCR-ABL1 splice variants which result from insertion and/or truncation of the bcr-abl1 transcript and the finding that these variants provide resistance to kinase domain inhibitors such as imatinib, nilotinib and dasatinib.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: December 10, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Wanlong Ma
  • Publication number: 20130316341
    Abstract: Described herein are methods, compositions and kits directed to the detection of gene dysregulations such as those arising from gene fusions and/or chromosomal abnormalities, e.g., translocations, insertions, inversions and deletions. Samples containing dysregulated gene(s) of interest may show independent expression patterns for the 5? and 3? regions of the gene. The methods, compositions and kits are useful for detecting mutations that cause the differential expression of a 5? portion of a target gene relative to the 3? region of the target gene.
    Type: Application
    Filed: March 22, 2013
    Publication date: November 28, 2013
    Applicant: Quest Diagnostics Investments Incorporated
    Inventor: Quest Diagnostics Investments Incorporated
  • Publication number: 20130304501
    Abstract: Embodiments of the invention relate to methods of optimizing the collection of specimens, e.g., of blood, when multiple laboratory tests have been prescribed at one time for a patient. Laboratory tests may use specimens such as blood, drawn, e.g., through venipuncture, and patients may experience greater discomfort, inconvenience, and/or anxiety as more and more blood is collected, and at greater expense. Embodiments of the invention include computer systems configured to optimize the collection of specimens for laboratory tests to reduce the number of specimens that must be collected from a patient for any given set of laboratory tests.
    Type: Application
    Filed: July 24, 2013
    Publication date: November 14, 2013
    Applicant: Quest Diagnostics Investments, Inc.
    Inventor: Jason Lawrence O'Meara
  • Patent number: 8580508
    Abstract: A method is provided for detecting the presence of nucleotides or monitoring nucleotide amplification. It utilizes fluorescence energy transfer by competitive hybridization. Competitive hybridization is achieved by using unequal length complementary probes which have a fluorophore on one probe and a quencher on the other. The fluorophore and quencher are juxtaposed in a manner wherein the proximity of the quencher to the fluorophore produces quenching of the fluorescence of the fluorophore.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: November 12, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Chih-Sheng Chiang, Jose F. Cuan
  • Patent number: 8574915
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: November 5, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • Patent number: 8569689
    Abstract: Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: October 29, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Qibo Jiang, Richard E Reitz, Sum Chan
  • Patent number: 8563922
    Abstract: Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: October 22, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Richard E. Reitz, Amit Ghoshal
  • Patent number: 8557593
    Abstract: The invention relates to the detection of DHA and EPA. In a particular aspect, the invention relates to methods for detecting DHA and EPA by mass spectrometry.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: October 15, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Scott M. Goldman, Julie A. Neidich
  • Patent number: 8546552
    Abstract: Described herein are methods, compositions and kits directed to the detection the 5? portion of TMPRSS2 mRNA for the detection and diagnosis of prostate disease including prostate cancer and benign prostatic hyperplasia.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: October 1, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Heather R. Sanders, Maher Albitar
  • Publication number: 20130236979
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Application
    Filed: April 26, 2013
    Publication date: September 12, 2013
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Publication number: 20130228680
    Abstract: Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample.
    Type: Application
    Filed: March 29, 2013
    Publication date: September 5, 2013
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Richard E Reitz
  • Patent number: 8512948
    Abstract: The invention disclosed herein is based on the identification of novel mutations in the JAK2 gene and JAK2 protein. The invention provides compositions and methods useful for diagnosing hematopoietic diseases including, for example, myeloproliferative diseases. The invention also provides compositions and methods useful for determining a prognosis of an individual diagnosed as having a hematopoietic disease.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: August 20, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Maher Albitar, Wanlong Ma
  • Publication number: 20130206981
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Application
    Filed: March 27, 2013
    Publication date: August 15, 2013
    Applicant: Quest Diagnostics Investment Incorporated
    Inventor: Quest Diagnostics Investments Incorporated
  • Patent number: 8508757
    Abstract: Systems and methods are provided though which a transaction, e.g., in a multi-tier, distributed application may be initiated from a portable or hand-held device, such as a smartphone. A computer system or systems, possibly remote from the device, may approve the transaction, complete it, or both, and the remote computer system or systems may cause a document to be printed, e.g., by a printer physically proximate to the device. Aspects of the invention are illustrated by embodiments in which a drug prescription may be created electronically using a hand-held device. In such an embodiment, the prescription may be transmitted to one or more remote computer systems, such as an application server, for processing. If specified, the remote computer systems may cause a prescription to be printed, e.g., at a printer near the prescriber's location. The prescriber may sign the printed prescription and give it to a patient or pharmacy.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: August 13, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: John Koehl
  • Publication number: 20130203099
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Application
    Filed: April 9, 2013
    Publication date: August 8, 2013
    Applicant: Quest Diagnostics Investments Incorporated
    Inventor: Quest Diagnostics Investments Incorporated
  • Patent number: 8504387
    Abstract: Embodiments of the invention relate to methods of optimizing the collection of specimens, e.g., of blood, when multiple laboratory tests have been prescribed at one time for a patient. Laboratory tests may use specimens such as blood drawn, e.g., through venipuncture, and patients may experience greater discomfort, inconvenience, and/or anxiety as more and more blood is collected, and at greater expense. Embodiments of the invention include computer systems configured to optimize the collection of specimens for laboratory tests to reduce the number of specimens that must be collected from a patient for any given set of laboratory tests.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: August 6, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Jason Lawrence O'Meara
  • Publication number: 20130196869
    Abstract: Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.
    Type: Application
    Filed: December 27, 2012
    Publication date: August 1, 2013
    Applicant: Quest Diagnostics Investments Incorporated
    Inventor: Quest Diagnostics Investments Incorporated
  • Patent number: 8497079
    Abstract: Methods are described for measuring the amount of glucagon in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying glucagon in a sample.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: July 30, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke
  • Patent number: 8497471
    Abstract: Methods are described for measuring the amount of a methylation TPMT enzyme product in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying 6-MMP or isotopically labeled 6-MMP in a test sample utilizing mass spectrometric techniques and for using such methods to determine the activity of TPMT enzyme that is present in a sample.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: July 30, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: William F. Haddon, Nigel J. Clarke
  • Patent number: 8497136
    Abstract: A device and method for detecting the presence of hemoglobin in a biological sample, more particularly, the presence of blood in a fecal sample as an indicator of upper or lower gastrointestinal tract bleeding.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: July 30, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Howard Milne Chandler