Patents Assigned to Quest Diagnostics
  • Patent number: 8916385
    Abstract: Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: December 23, 2014
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: Mildred M. Goldman, Nigel J. Clarke, Richard E. Reitz
  • Patent number: 8916817
    Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: December 23, 2014
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: Changming Yang, Sum Chan
  • Patent number: 8911942
    Abstract: The present invention provides methods of detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. In particular, the present invention provides advanced methods of performing array-based comparative hybridization that allow reproducibility between samples and enhanced sensitivity by using the same detectable label for both test sample and reference sample nucleic acids. Invention methods are useful for the detection or diagnosis of particular disease conditions such as cancer, and detecting predisposition to cancer based on detection of chromosomal or genetic abnormalities and gene expression level. Invention methods are also useful for the detection or diagnosis of hereditary genetic disorders or predisposition thereto, especially in prenatal samples.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: December 16, 2014
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Mansoor S. Mohammed, Natasa Dzidic, Christopher McCaskill, Jaeweon Kim
  • Patent number: 8890061
    Abstract: Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: November 18, 2014
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: J. Fred Banks, Peter P. Chou, Noriya M. Matt
  • Patent number: 8871687
    Abstract: The present invention pertains to a method for determining a sequence of contiguous bases within a polynucleotide, the method relying on single-base primer extension using labeled dideoxynucleotide terminators. The primers are immobilized to solid supports (e.g. microspheres or two-dimensional arrays), allowing for the identification of the labeled terminator incorporated into each primer.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: October 28, 2014
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Charles M. Strom
  • Patent number: 8860972
    Abstract: Systems and methods are provided though which a transaction, e.g., in a multi-tier, distributed application may be initiated from a portable or hand-held device, such as a smartphone. A computer system or systems, possibly remote from the device, may approve the transaction, complete it, or both, and the remote computer system or systems may cause a document to be printed, e.g., by a printer physically proximate to the device. Aspects of the invention are illustrated by embodiments in which a drug prescription may be created electronically using a hand-held device. In such an embodiment, the prescription may be transmitted to one or more remote computer systems, such as an application server, for processing. If specified, the remote computer systems may cause a prescription to be printed, e.g., at a printer near the prescriber's location. The prescriber may sign the printed prescription and give it to a patient or pharmacy.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: October 14, 2014
    Assignee: Quest Diagnostics Investments Inc.
    Inventor: John Koehl
  • Patent number: 8852951
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: October 7, 2014
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Anne Caston-Balderrama, Richard E Reitz
  • Patent number: 8841074
    Abstract: The invention provides compositions and methods for diagnosing a patient as having a myeloproliferative disease by identifying mutations in the MPL gene or gene products.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: September 23, 2014
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Wanlong Ma, Maher Albitar
  • Publication number: 20140242711
    Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Application
    Filed: May 2, 2014
    Publication date: August 28, 2014
    Applicant: Quest Diagnostics Investments Inc.
    Inventors: Changming Yang, Sum Chan
  • Patent number: 8815516
    Abstract: Described herein are methods, compositions and kits directed to the detection of gene dysregulations such as those arising from gene fusions and/or chromosomal abnormalities, e.g., translocations, insertions, inversions and deletions. Samples containing dysregulated gene(s) of interest may show independent expression patterns for the 5? and 3? regions of the gene. The methods, compositions and kits are useful for detecting mutations that cause the differential expression of a 5? portion of a target gene relative to the 3? region of the target gene.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: August 26, 2014
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Heather R. Sanders, Maher Albitar, Aurelia Meloni-Ehrig
  • Publication number: 20140234989
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Application
    Filed: May 1, 2014
    Publication date: August 21, 2014
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Brett HOLMQUIST, Nigel J. CLARKE, Anne Caston-Balderrama, Richard E. Reitz
  • Patent number: 8779355
    Abstract: Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: July 15, 2014
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: Beatrisa Boyadzhyan, Karin Thomassian, Anita Dermartirosian, Lou Jambor
  • Publication number: 20140178870
    Abstract: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further provided.
    Type: Application
    Filed: April 29, 2013
    Publication date: June 26, 2014
    Applicant: Quest Diagnostics Investments Incorporated
    Inventor: Quest Diagnostics Investments Incorporated
  • Publication number: 20140175275
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Application
    Filed: February 26, 2014
    Publication date: June 26, 2014
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • Publication number: 20140179010
    Abstract: Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.
    Type: Application
    Filed: February 26, 2014
    Publication date: June 26, 2014
    Applicant: Quest Diagnostics Investments, Inc.
    Inventors: J. Fred BANKS, Peter P. CHOU, Noriya M. MATT
  • Patent number: 8759754
    Abstract: Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: June 24, 2014
    Assignee: Quest Diagnostics Investments Inc.
    Inventors: Qibo Jiang, Richard E Reitz, Sum Chan
  • Patent number: 8753825
    Abstract: Methods for detecting invasive trophoblast antigen (ITA) in biological samples comprise screening the samples for ITA using antibodies that bind to the ITA. The methods are useful to detect pregnancy, trophoblastic diseases, and Down's syndrome in fetuses of pregnant women. Some methods include screening the samples with a plurality of capture antibodies that specifically bind ITA. Chemiluminescent immunoassays are disclosed. The methods may be practiced with the diagnostic kits of the invention.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: June 17, 2014
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Murugan R. Pandian, Julie Y. Yu
  • Patent number: 8753817
    Abstract: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further provided.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: June 17, 2014
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Weimin Sun, Matthew J. McGinniss, Donghui Huang, Arlene Buller, Raymond Fenwick, Mei Peng, Franklin Quan
  • Publication number: 20140162371
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Application
    Filed: February 14, 2014
    Publication date: June 12, 2014
    Applicant: Quest Diagnostics Investments Incoporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Patent number: 8748810
    Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: June 10, 2014
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: Changming Yang, Sum Chan