Patents Assigned to Quest Diagnostics
  • Patent number: 9529004
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally are directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: December 27, 2016
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Patent number: 9530635
    Abstract: Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: December 27, 2016
    Assignee: Quest Diagnostics Investments Incoprorated
    Inventors: Beatrisa Boyadzhyan, Karin Thomassian, Anita Dermartirosian, Lou Jambor
  • Publication number: 20160349221
    Abstract: Mass spectrometric methods are described for determining the amount of analyte in a sample collected by a microsampling device. Provided herein are methods directed to quantitating the amount of an analyte in a sample by extracting an analyte from a sample collected by a microsampling device, purifying the sample by liquid chromatography, ionizing the analyte to generate one or more ions detectable by mass spectrometry; and determining the amount of the one or more ions by mass spectrometry. The amount of analyte in the sample is related to the amount of analyte in the patient.
    Type: Application
    Filed: May 27, 2016
    Publication date: December 1, 2016
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Scott Goldman, Mildred Goldman, Leslie Edinboro, Diana Tran, Julia Addiss, Darren Weber, Porus Mistry, Nigel Clarke
  • Patent number: 9506937
    Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: November 29, 2016
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke
  • Publication number: 20160341730
    Abstract: Methods and kits for detecting alternating spatial expression of PTEN and, optionally, SMAD4, CD44, and/or TP53 in colonic tumors are described. The methods and kits are useful for identifying a cancer stem cell (CSC)-like zone within a colonic tumor, identifying an adenoma-adenocarcinoma (Ad-ACA) transition zone in a colorectal cancer (CRC) tumor, identifying a CRC tumor that contains high-grade adenoma and/or early adenocarcinoma regions, identifying CSCs in a CRC tumor, diagnosing a subject with high-grade colon adenoma and/or early adenocarcinoma, and determining the likelihood that a colonic tumor in a subject will undergo invasive transformation if left untreated.
    Type: Application
    Filed: January 27, 2015
    Publication date: November 24, 2016
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Daniel Jones, Kevin J. Arvai, Ya-Hsuan Hsu
  • Patent number: 9481914
    Abstract: The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or more lactobacilli and two or more pathogenic organisms may be detected using PCR analysis of nucleic acid segments corresponding to each target organism. The quantity of the target organisms can then be used to determine a score which is indicative of a diagnosis of bacterial vaginosis.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: November 1, 2016
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Erik P. Johnson, Dale A. Schwab
  • Patent number: 9459267
    Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: October 4, 2016
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Nigel Clarke
  • Publication number: 20160281172
    Abstract: The invention disclosed herein is based on the identification of novel mutations in the JAK2 gene and JAK2 protein. The invention provides compositions and methods useful for diagnosing hematopoietic diseases including, for example, myeloproliferative diseases. The invention also provides compositions and methods useful for determining a prognosis of an individual diagnosed as having a hematopoietic disease.
    Type: Application
    Filed: February 26, 2016
    Publication date: September 29, 2016
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Maher Albitar, Wanlong Ma
  • Publication number: 20160282328
    Abstract: Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Application
    Filed: March 2, 2016
    Publication date: September 29, 2016
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Stephen W. TAYLOR, Michael McPHAUL, Richard E. REITZ, Zhaohui CHEN, Nigel CLARKE
  • Patent number: 9449801
    Abstract: The invention relates to the detection of fatty acids. In a particular aspect, the invention relates to methods for detecting very long chain fatty acids and branched chain fatty acids by mass spectrometry.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: September 20, 2016
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Scott Goldman
  • Publication number: 20160201141
    Abstract: The invention provides methods for determining the prognosis of a patient diagnosed with a leukemia, including B-cell chronic lymphocytic leukemia, by measuring mutations of the WT1 gene in a biological sample. The invention also relates to the diagnosis of leukemia, including B-cell chronic lymphocytic leukemia.
    Type: Application
    Filed: December 10, 2015
    Publication date: July 14, 2016
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Maher Albitar, Wanlong Ma
  • Publication number: 20160160281
    Abstract: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further provided.
    Type: Application
    Filed: December 2, 2015
    Publication date: June 9, 2016
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Matthew J. McGinniss, Arlene M. Buller, Franklin Quan, Mei Peng, Weimin Sun
  • Publication number: 20160160289
    Abstract: The present disclosure relates to methods for the diagnosis and evaluation of neoplastic disorders, particularly non-small cell lung cancer. Assays are described in which patient test samples are analyzed for the presence of one or more specific EML4-ALK fusion genes associated with neoplastic disorders.
    Type: Application
    Filed: October 30, 2015
    Publication date: June 9, 2016
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Heather R. Sanders, Maher Albitar, Aurelia Meloni-Ehrig
  • Publication number: 20160130638
    Abstract: The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or more lactobacilli and two or more pathogenic organisms may be detected using PCR analysis of nucleic acid segments corresponding to each target organism. The quantity of the target organisms can then be used to determine a score which is indicative of a diagnosis of bacterial vaginosis.
    Type: Application
    Filed: October 30, 2015
    Publication date: May 12, 2016
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Erik P. Johnson, Dale A. Schwab
  • Publication number: 20160123985
    Abstract: The present invention provides methods of classifying cluster of differentiation (CD) marker phenotype for hematopoietic cancer cells using multiple circulating cell-free CD markers in bodily fluid. In other aspects, treatment and disease progression of particular hematopoietic cancers can be monitored by measuring the levels of CD and other markers in bodily fluids of a patient.
    Type: Application
    Filed: January 11, 2016
    Publication date: May 5, 2016
    Applicant: Quest Diagnostics Investments Incorporated
    Inventor: Maher Albitar
  • Patent number: 9244084
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally are directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: January 26, 2016
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Patent number: 9234901
    Abstract: Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5?-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: January 12, 2016
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Qibo Jiang, Sum Chan, Richard Reitz
  • Patent number: 9207221
    Abstract: Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: December 8, 2015
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: J. Fred Banks, Peter P. Chou, Noriya M. Matt
  • Publication number: 20150344948
    Abstract: Described herein are methods, compositions and kits directed to amplification of nucleic acids suitable for both next generation sequencing (NGS) and a second round of sequencing as validation, such as Sanger sequencing.
    Type: Application
    Filed: December 27, 2013
    Publication date: December 3, 2015
    Applicant: Quest Diagnostics Investment Incorporated
    Inventors: Heather SANDERS, Hai-Rong LI, Feras HANTASH, Frederic WALDMAN
  • Publication number: 20150315658
    Abstract: Described herein are methods, compositions and kits directed to the detection of gene dysregulations such as those arising from gene fusions and/or chromosomal abnormalities, e.g., translocations, insertions, inversions and deletions. Samples containing dysregulated gene(s) of interest may show independent expression patterns for the 5? and 3? regions of the gene. The methods, compositions and kits are useful for detecting mutations that cause the differential expression of a 5? portion of a target gene relative to the 3? region of the target gene.
    Type: Application
    Filed: April 29, 2015
    Publication date: November 5, 2015
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Heather R. Sanders, Maher Albitar, Aurelia Meloni-Ehrig