Abstract: A polymeric nanoparticle is disclosed which comprises: (i) at least one disease-associated antigen which is capable of producing a T-cell response, wherein the disease-associated antigen is encapsulated in the nanoparticle; (ii) at least one adjuvant; and (iii) a dendritic cell targeting moiety which is attached to the outer surface of the nanoparticle. Use of the nanoparticle for treating diseases associated with abnormal cell growth or an infection is also disclosed.

Abstract: A modulator comprises one or more resonators. Each resonator has a light confining closed loop structure, such as a ring structure, and two, three or more electrodes associated with the light-confining structure, and may be a micro-resonator. An optical signal is modulated by a digital signal using the resonator. The procedure comprises obtaining the digital signal, mapping the signal using a mapping function to produce a transformed digital signal, the transformed digital signal being selected to produce, say linear, output from the resonator, inputting the transformed digital signal via electrodes onto the resonator; and modulating the optical signal via coupling from the resonator. Suitable mapping produces 16 QAM and other modulation schemes.

Abstract: Compositions comprising self-assembled hydrogel particles formed of short peptides which comprise one or more aromatic amino acid residue(s) in an inverted emulsion are disclosed. Such hydrogel particles which encapsulate an active agent and uses thereof in therapeutic and diagnostic applications are also disclosed.

Abstract: A method of detecting a target within a population of molecules comprising: contacting a plurality of labeled probe molecules with the population of molecules potentially containing a target of the probe molecules; acquiring a probe specific signal emitted by said labeled probe molecules that bound to said target together with a background signal; preferentially modulating said probe specific signal by at least one of modulating said acquisition and modulating an emission of said probe specific signal; and detecting said probe specific signal over said background signal using said preferential modulation.

Abstract: A sensing element comprises a transistor having a gate electrode, a source electrode, a gate electrode and a semiconductor nanostructure connecting between the source and the gate electrodes. The semiconductor nanostructure is modified by a functional moiety covalently attached thereto. A voltage source is connected to the gate electrode. A controller controls a gate voltage applied by the voltage source to the gate electrode such as to reverse a redox reaction occurring when the moiety contacts a redox reactive agent.

Abstract: This invention is directed to nanocomposite comprising biodegradable polymers and inorganic nanoparticles or nanotubes, methods of preparation and uses thereof.

Abstract: Resistive heating elements are embedded in a shape memory polymer actuator. Sensing elements are associated with the resistive heating elements. The sensing elements sense changes in the resistive heating elements and correlate the changes with deformation of the shape memory polymer actuator.

Abstract: Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.

Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.

Abstract: A method of processing an image is disclosed. The method comprises decomposing the image into a plurality of channels, each being characterized by a different depth-of-field, and accessing a computer readable medium storing an in-focus dictionary defined over a plurality of dictionary atoms, and an out-of-focus dictionary defined over a plurality of sets of dictionary atoms, each set corresponding to a different out-of-focus condition. The method also comprises computing one or more sparse representations of the decomposed image over the dictionaries.

Abstract: Methods of inducing bradycardia (slowing a heart rate) in a subject in need thereof, treating a medical condition in which inducing bradycardia (slowing a heart rate) is desirable or beneficial in a subject in need thereof and/or treating a medical condition associated with cardiac arrhythmia, are provided. The methods are effected by blocking SK4 channel in SAN cell of the subject and/or by administering to the subject a therapeutically effective amount of a blocker of an SK4 channel. A method of identifying candidate compounds for treating an arrhythmic cardiac disorder, by identifying compounds that reduce a pacing rate of the SAN cells is also provided.

Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which emit light in the near-infrared (NIR) region and are therefore useful for in vivo imaging, as well as compositions and uses thereof.

Abstract: Described herein are methods of enhancing formation and/or growth of an adventitious root in a plant and/or plant tissue, and/or for promoting grafting unification, enhancing fruit size and/or reducing flowering in a plant. The method comprises contacting at least a portion of the plant and/or plant tissue with a compound having Formula I: wherein X, Y and R1-R7 are as defined herein. Further described are compositions for enhancing formation and/or growth of an adventitious root in a plant and/or plant tissue, and/or for promoting grafting unification, enhancing fruit size and/or reducing flowering in a plant, comprising the abovementioned compound and a horticulturally acceptable carrier. Novel compounds having Formula I are also described herein.

Abstract: Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.

Abstract: There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output.

Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.

Abstract: A spherical particle comprising decellularized omentum being between 1 nM-300 ?M in diameter is disclosed. In some embodiments, the particle comprises biological cells. In other embodiments, the particle comprises a biomolecule. Uses of the particles are also disclosed.

Abstract: A T cell expressing an FC gamma receptor is provided. Accordingly there is provided a T cell genetically engineered to express a first polypeptide comprising an amino acid sequence of an Fc receptor common ? chain (FcR?), said amino acid sequence is capable of transmitting an activating signal; and a second polypeptide comprising an extracellular ligand-binding domain of an Fc? receptor capable of binding an Fc ligand and an amino acid sequence capable of recruiting said first polypeptide such that upon binding of said Fc ligand to said extracellular ligand-binding domain of said Fc? receptor said activating signal is transmitted.

Abstract: Self-assembled structures formed of a plurality of cyclic peptides which are in association with metal ions is provided. The cyclic peptides are each of from 2 to 6 amino acid residues, and two or more of the amino acid residues are each independently an aromatic amino acid residue. The self-assembled structures exhibit photoluminescence and can be used or incorporated in light emitting systems.

Abstract: Computerized method and system for estimating a rain attribute on microwave communications, the estimation being carried out by: obtaining quantized minimum and maximum levels of received signals and transmitted signals over a microwave link during a period; subtracting the quantized maximum level of received signals from the quantized minimum level of transmitted signals to provide a minimal attenuation value; subtracting the quantized minimal level of received signals from the quantized maximal level of transmitted signals to provide a maximal attenuation value; calculating an attenuation difference related to the period by subtracting the minimal attenuation value from the maximal attenuation value; calculating a bias compensated attenuation difference based on the attenuation difference, and bias value related to the microwave link; and calculating the rain attribute, including the average rain during the period, based on the bias compensated attenuation difference.