Abstract: A method for evaluating a treatment for a brain condition, including: extracting one or more microstate parameter values from at least one EEG signal that was measured after the treatment; and evaluating at least one parameter of the treatment based on the one or more microstate parameter values.

Abstract: Provided herein are methods and systems for applying an ensemble comprising a plurality of neural network based decoders trained using actively selected training samples for decoding error correction encoded codewords which are also encoded for error detection before transmitted over transmission channels subject to interference. In particular, each of the neural network based decoders is associated with only a limited size region of the distribution space of the error correction code where the distribution space is partitioned based on error detection values computed for the encoded codewords. As such each of the decoders is specialized for decoding encoded codewords mapped to its limited size associated region. During run-time a received encoded codeword may be mapped to one of the regions and may be fed accordingly to one of the neural network based decoders of the ensemble which is associated with the mapped region.

Abstract: Structures for response shaping in frequency and time domain, include an optical response shaper and/or a modulator device with multiple injection. The device comprises a resonator having an enclosed geometric structure, for example a ring or racetrack structure, at least two injecting optical waveguides approaching the resonator to define at least two coupling regions between the resonator and the injecting waveguides, and may define at least two Free Spectral Range states. One or both of the coupling regions has a coupling coefficient selected for a predetermined frequency or time response, and the coupling coefficient or other device parameters may be variable, in some case in real time to render the response programmably variable.

Abstract: Provided herein are methods and systems for applying active learning to train neural network based decoders to decode error correction codes transmitted over transmission channels subject to interference. The decoder may be trained using training samples actively by mapping a distribution of a large pool of samples and selecting samples estimated to most contribute to the training, specifically to exclude high SNR samples expected to be correctly decoded and low SNR samples which are potentially un-decodable. Further presented are ensembles of neural network based decoders applied to decode error correction codes. Each of the decoders of the ensemble is actively learned and trained using samples mapped into a respective region of the training samples distribution and is therefore optimized for the respective region. In runtime, the received code may be directed to one or more of the ensemble's decoders according to the region into which the received code is mapped.

Abstract: A system featuring a substrate and a multiplicity of nanostructures arranged on the substrate is provided. At least one portion of the nanostructures feature a capturing moiety covalently attached to a surface thereof and at least another portion of the nanostructures, which can be the same or different from the first portion, feature a light-activatable moiety covalently attached to a surface thereof. The capturing moiety is such that selectively interacts with an analyte, and the light-activatable moiety generates, upon exposure to light, a reactive moiety that interferes with an interaction of the capturing moiety and the analyte. Further provided are systems featuring a substrate and a multiplicity of nanostructures aligned generally vertically to the substrate, at least a portion of these nanostructures being branched nanostructures. Uses of the systems in extracting, and optionally identifying, the analyte from a sample are also provided.

Abstract: A method for robust state manipulation in quantum information processing comprises evanescently coupling a first waveguide to a second waveguide, the first and second waveguide having different geometries respectively; and providing waveguide geometries such that their coupling is detuned, the detuning being a function of the geometries, the detuned coupling thereby providing reliable population transfer between the first and second waveguides that is robust to fabrication and other errors. The method may be used to provide a quantum optical coupler.

Abstract: The present invention provides a method and a system based on a multi-gate field effect transistor for sensing molecules in a gas or liquid sample. The said FET transistor comprises dual gate lateral electrodes (and optionally a back gate electrode) located on the two sides of an active region, and a sensing surface on top of the said active region. Appling voltages to the lateral gate electrodes, creates a conductive channel in the active region, wherein the width and the lateral position of the said channel can be controlled. Enhanced sensing sensitivity is achieved by measuring the channels conductivity at a plurality of positions in the lateral direction. The use of an array of the said FTE for electronic nose is also disclosed.

Abstract: Methodologies for labeling the epigenetic modification 5-hydroxymethyl-cytosine (5hmC) along a DNA molecule, and for determining a presence or a level of this epigenetic modification based on a ratio of fluorescence intensity of a labeled DNA sample to absorption intensity of the DNA sample at 260 nm are disclosed. Related compositions and reagents, and methods of preparing same are also disclosed.

Abstract: An illustrative embodiment includes a method for solving a dynamical system. The method comprises: obtaining multidimensional snapshots representing respective discrete solutions of the dynamical system; storing the multidimensional snapshots within a snapshot tensor having an order of at least three; generating a basis for at least a subspace of a state space of the dynamical system at least in part by performing a decomposition of the snapshot tensor; deriving a reduced order model at least in part by using the basis to project the dynamical system from the state space onto the subspace; and solving the reduced order model of the dynamical system.

Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.

Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

Abstract: A system for frequency conversion, comprises a laser source and a harmonic generation crystal. The laser source is configured to produce optical pulse energy of less than 100 ?J. The harmonic generation crystal comprises a structure characterized by a nonlinear susceptibility, and a crystal grating period which adiabatically varies along the longitudinal direction in a manner that the crystal grating period is inversely proportional to a crystal grating function of a coordinate z measured along the longitudinal direction.

Abstract: A method of mapping transverse relaxation in a magnetic resonance (MR) scan data, comprises receiving a multi-echo spin-echo MR scan protocol comprising a plurality of MR imaging parameters, and for each echo of the multi-echo spin-echo MR scan protocol: generating, based on the parameters, a simulated echo modulation curve using a set of refocusing coherence pathways, for each of a plurality of predetermined transverse relaxation times; calculating, for each transverse relaxation time, diffusion attenuation based on a respective subset of the refocusing coherence pathways; and correcting the echo modulation curve using the diffusion attenuation. The method can also comprise comparing the scan data to the corrected echo modulation curve for each of at least a portion of the transverse relaxation values, and generating a displayed output comprising a map of transverse relaxation based on the comparison.

Abstract: Methods of inducing bradycardia (slowing a heart rate) in a subject in need thereof, treating a medical condition in which inducing bradycardia (slowing a heart rate) is desirable or beneficial in a subject in need thereof and/or treating a medical condition associated with cardiac arrhythmia, are provided. The methods are effected by blocking SK4 channel in SAN cell of the subject and/or by administering to the subject a therapeutically effective amount of a blocker of an SK4 channel. A method of identifying candidate compounds for treating an arrhythmic cardiac disorder, by identifying compounds that reduce a pacing rate of the SAN cells is also provided.

Abstract: There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output.

Abstract: A method of fetal genotyping, comprises receiving maternal genomic DNA (gDNA) data, maternal cell-free DNA (cfDNA) data, and paternal gDNA data of a pair parenting to a fetus. The data are analyzed to identify a first set of sites at which the parents are homozygous for different alleles, and a second set at which at least one of the parents has a mutation. For each site of the first set, a probability that a respective portion of the maternal cfDNA data is derived from the fetus is determined. Each site of the second set is classified according to the determined probabilities as being either fetal or maternal to genotype the fetus.

Abstract: Provided are methods of determining a presence or level of soluble mortalin in a body fluid of a subject, and predicting prognosis of a subject diagnosed with cancer (e.g., solid tumor) by determining the presence or level of soluble mortalin in a body fluid of the subject. Also provided are kits for determining presence and/or level of soluble mortalin in a body fluid of the subject and/or predicting prognosis of a subject diagnosed with cancer, comprising at least two distinct antibodies to mortalin directed against different epitopes of said mortalin.

Abstract: The present invention provides cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives, capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition; as well as compositions thereof and methods of use.

Abstract: The present invention relates to a method for total chemical synthesis of 9-cis-?-carotene (9CBC), and further provides stable formulations thereof.

Abstract: In a system for converting digital data into a modulated optical signal, an electrically controllable device having M actuating electrodes provides an optical signal that is modulated in response to binary voltages applied to the actuating electrodes. A digital-to-digital converter provides a mapping of input data words to binary actuation vectors of M bits and supplies the binary actuation vectors as M bits of binary actuation voltages to the M actuating electrodes, where M is larger than the number of bits in each input data word. The digital-to-digital converter maps each digital input data word to a binary actuation vector by selecting a binary actuation vector from a subset of binary actuation vectors available to represent each of the input data words.