Abstract: A method of treating a neurological disease (such as autism) in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of microparticles derived from mesenchymal stem cells.

Abstract: Ordered structures composed of a plurality of self-assembled peptide nucleic acid (PNA) monomers, and processes of generating same are provided. The plurality of PNA monomers includes modified PNA monomers which are N-protected PNA monomers and/or which feature at least one aromatic moiety attached to a backbone, a nucleobase and/or a nucleobase linkage unit of the PNA monomer. Tunable photonic crystals formed of the provided ordered structures, uses thereof and articles-of-manufacturing containing same are also provided.

Abstract: The invention provides modulators of human cancer and tumor metastasis in particular. More specifically the present disclosure relates to modulators of SKAI1BC, an antisense long non-coding RNA which was found to be an epigenetic suppressor of the metastasis suppressor gene KAI1/CD82, compositions, methods and uses thereof for decreasing metastasis, invasion and possibly also proliferation of cancer cells.

Abstract: A carbon electrode having a functional moiety that forms a charge-transfer complex with a nitro-containing compound covalently attached to a surface of the electrode, and a process of preparing such an electrode are provided. Also provided are sensing systems integrating the carbon electrode and methods utilizing same for electrochemical detection of nitro-containing compounds.

Abstract: The present invention provides a method and a system based on a multi-gate field effect transistor for sensing molecules in a gas or liquid sample. The said FET transistor comprises dual gate lateral electrodes (and optionally a back gate electrode) located on the two sides of an active region, and a sensing surface on top of the said active region. Appling voltages to the lateral gate electrodes, creates a conductive channel in the active region, wherein the width and the lateral position of the said channel can be controlled. Enhanced sensing sensitivity is achieved by measuring the channels conductivity at a plurality of positions in the lateral direction. The use of an array of the said FTE for electronic nose is also disclosed.

Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.

Abstract: Compounds represented by Formula I are disclosed herein, wherein R, Ra and R1-R14 are as defined herein. Further disclosed are uses and methods utilizing said compounds for use in inhibiting an activity of PERK, and in treating a disease or disorder associated with aggregation-prone proteins, a disease or disorder in which downregulating an unfolded protein response is beneficial, and/or Huntington's disease.

Abstract: Provided are methods of determining a presence or level of soluble mortalin in a body fluid of a subject, and predicting prognosis of a subject diagnosed with cancer (e.g., solid tumor) by determining the presence or level of soluble mortalin in a body fluid of the subject. Also provided are kits for determining presence and/or level of soluble mortalin in a body fluid of the subject and/or predicting prognosis of a subject diagnosed with cancer, comprising at least two distinct antibodies to mortalin directed against different epitopes of said mortalin.

Abstract: Structures for response shaping in frequency and time domain, include an optical response shaper and/or a modulator device with multiple injection. The device comprises a resonator having an enclosed geometric structure, for example a ring or racetrack structure, at least two injecting optical waveguides approaching the resonator to define at least two coupling regions between the resonator and the injecting waveguides, and may define at least two Free Spectral Range states. One or both of the coupling regions has a coupling coefficient selected for a predetermined frequency or time response, and the coupling coefficient or other device parameters may be variable, in some case in real time to render the response programmably variable.

Abstract: A method of detecting an epigenetic DNA modification is described herein, the method comprising: attaching to DNA a labeling agent selective for the DNA modification; contacting an aqueous solution comprising the DNA with at least one addressable region on a surface of a substrate, wherein the addressable region comprises a positively charged substance capable of attaching the DNA to the surface, and the addressable region is surrounded by a hydrophobic region; and determining an amount of labeling agent in the addressable region. Further described herein is a kit comprising a substrate comprising discrete hydrophilic regions separated by a hydrophobic region, and a labeling agent selective for an epigenetic DNA modification; as well as an article of manufacture comprising a substrate comprising a discrete regions separated by a hydrophobic region, a positively charged substance and DNA attached thereto, the DNA comprising such a labeling agent.

Abstract: The present invention provides polypeptides derived from the coronaviruses (CoVs) Spike protein (S) characterized by high affinity and specificity the S receptor and its neutralizing antibodies. The invention further provides compositions and vaccines, and vaccine-based therapies targeting CoVs, and SARS and MERS viruses in particular.

Abstract: Methodologies for labeling the epigenetic modification 5-hydroxymethylcytosine (5hmC) along a DNA molecule, and for determining a presence or a level of this epigenetic modification based on a ratio of fluorescence intensity of a labeled DNA sample to absorption intensity of the DNA sample at 260 nm are disclosed. Related compositions and reagents, and methods of preparing same are also disclosed.

Abstract: A method of processing an input image comprises receiving the input image, storing the image in a memory, and accessing, by an image processor, a computer readable medium storing a trained deep learning network. A first part of the deep learning network has convolutional layers providing low-level features extracted from the input image, and convolutional layers providing a residual image. A second part of the deep learning network has convolutional layers for receiving the low-level features and extracting high-level features based on the low-level features. The method feeds the input image to the trained deep learning network, and applies a transformation to the residual image based on the extracted high-level features.

Abstract: A system for training a quantized neural network dataset, comprising at least one hardware processor adapted to: receive input data comprising a plurality of training input value sets and a plurality of target value sets; in each of a plurality of training iterations: for each layer, comprising a plurality of weight values, of one or more of a plurality of layers of a neural network: compute a set of transformed values by applying to a plurality of layer values one or more emulated non-uniformly quantized transformations by adding to each of the plurality of layer values one or more uniformly distributed random noise values; and compute a plurality of output values; compute a plurality of training output values; and update one or more of the plurality of weight values to decrease a value of a loss function; and output the updated plurality of weight values of the plurality of layers.

Abstract: A method is for the extraction of a phytochemical, e.g., peptide or protein, or a chemical element from a macroalgae, by applying pulsed electric field (PEF)- or continuous electric field (CEF)-treatment to the macroalgae in a solvent, under pressure higher than the ambient pressure. A device and system carry out this method.

Abstract: There is provided a Kramers-Kronig receiver, comprising a reception path; wherein the reception path comprises: a Stokes receiver that is configured to receive a polarization-multiplexed signal and to output a Stokes vector; wherein the polarization-multiplexed signal comprises a first modulated signal, a second modulated signal and a continuous wave signal; wherein the first modulated signal is of a first polarization; wherein the second modulated signal is of a second polarization; wherein the continuous wave signal is of the first modulation or of the second modulation; a set of analog to digital converters that are configured to generate a digital representation of the Stokes vector; and a digital processor that is configured to process the digital representation of the Stokes vector to provide a reconstructed polarization-multiplexed signal, wherein the processing is based on a Kramers-Kronig relationship related to the polarization-multiplexed signal.

Abstract: There is described an integrated antenna for radiating an electromagnetic beam at a wavelength ?, for example, in a range of millimeter and submillimeter waves. The antenna is integrated in a dielectric die having specific dimensions, and is configured as a dense array comprising two or more radiating elements (transmitters). The proposed array is denser than a conventional 1D or 2D array, would such a conventional array be arranged on the same dielectric die with a spacing ?/2 between its neighbouring radiating elements.

Abstract: A method of fabricating a heterostructure system, comprises epitaxially growing a crystalline layer of a first substance on a crystalline base layer by surface catalysis in a solution, wherein the growth is self-terminated once a monolayer of the substance is formed on the base layer.

Abstract: Provided herein is a see-through transparent, stable, safe and (bio)degradable hydrogel-based particulate support medium, made of calcium alginate particles. The calcium alginate particles, or hybrid hydrogel particles, are characterized by a substantially homogeneous average particle size that ranges from 0.1 micrometer to 5 micrometer.

Abstract: Compounds represented by general Formulae I to IV as described herein are disclosed. Further disclosed are composition utilizing the herein disclosed compounds and using the same for the treatment of glycogen storage disorders.