Abstract: Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated GAD autoantigenic peptide, the isolated complex having a structural conformation which enables isolation of a high affinity entity which comprises an antigen binding domain capable of specifically binding to a native conformation of a complex composed of the MHC class II and the type I diabetes-associated GAD autoantigenic peptide; and isolated high affinity entities comprising an antigen binding domain capable of specifically binding the complex, wherein the isolated high affinity entity does not bind to the MHC class II in an absence of the diabetes-associated GAD autoantigenic peptide, wherein the isolated high affinity entity does not bind to the diabetes-associated GAD autoantigenic peptide in an absence of the MHC class II; and methods and kits using same for diagnostic and therapeutic purposes.

Abstract: In some aspects, methods for treating a bacterial infection in a mammalian subject are provided. In some embodiments, a class IIa HDAC inhibitor such as, e.g., a HDAC4 inhibitor, may be used to treat a bacterial infection such as, e.g., anthrax, pertussis, tuberculosis, or cholera.

Abstract: A ToF SPAD based range detecting module is configurable for operation in a first mode to make a distance determination relative to an object within a field of view. The ToF SPAD based range detecting module is further configurable for operation in a second mode to enagage in bi-directional data communication with another apparatus within the field of view.

Abstract: Provided is an isolated population of human pluripotent stem cells comprising at least 50% human pluripotent stem cells characterized by an OCT4+/TRA1-60?/TRA1-81?/SSEA1+/SSEA4? expression signature, and novel methods of generating and maintaining same in a pluripotent, undifferentiated state a suspension culture devoid of cell clumps. Also provided are novel culture media, cell cultures and methods for culturing pluripotent stem cells in a suspension culture or a two-dimensional culture system while maintaining the cells in a proliferative, pluripotent and undifferentiated state. The novel culture media comprise interleukin 11 (IL11) and Ciliay Neurotrophic Factor (CNTF); bFGF at a concentration of at least 50 ng/ml and an IL6RIL6 chimera; or an animal contaminant-free serum replacement and an IL6RIL6 chimera. Also provided are methods for generating lineage-specific cells from the pluripotent stem cells.

Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.

Abstract: A camera module with a fixed near field focus is configured to capture a single image. That single image is segmented by an image divider a number of regions. A focus metric determiner then determines a focus metric for each of the regions. A depth map generator maps the focus metric into a depth value for each of the regions and combines the depth values to generate a depth map.

Abstract: An apparatus includes a camera module configured to generate at least one image and a ToF SPAD based range detecting module configured to generate at least one distance determination to an object within a field of view of the camera module. A processor receives the at least one image from the camera module output and receives the at least one distance determination from the ToF SPAD based range detecting module. This data is processed by the processor to determine a depth map.

Abstract: Provided herein are polymers having the general formula I as defined herein, A-L-B??Formula I as well as crosslinked polymers having the general formula III: B?-L?-A?-A?-L?-B???Formula III and methods of preparing the polymers, wherein A is a dihydroxyphenyl moiety; A?-A? is a pair of crosslinked dihydroxyphenyl moieties; B, B? and B? are each a biopolymer; and L, L? and L? are each a linking moiety. Further provided are crosslinked adhesives prepared from the polymers, methods of generating same by oxidizing a polymer, and uses thereof. Further provided are kits comprising an adhesive and an oxidizing agent.

Abstract: A distance sensing apparatus includes a light source configured to emit polarized light. A light sensitive detector detects light emitted by said light source and reflected from a target. The light sensitive detector is configured to substantially prevent polarized light reflected from a target with a relatively high reflectance from being detected.

Abstract: A ranging apparatus includes an array of light sensitive detectors configured to receive light from a light source which has been reflected by an object. The array includes a number of different zones. Readout circuitry including at least one read out channel is configured to read data output from each of the zones. A processor operates to process the data output to determine position information associated with the object.

Abstract: Provided are printed patterns and objects including, for example, a film or 3D object, which may include one or more nanorods. According to the subject matter provided, the nanorods may reduce or diminish inter-particle interaction in the pattern or object.

Abstract: A ranging apparatus includes a first array with first light sensitive detectors configured to receive light which has been reflected by an object and generate an output. A second array, spaced apart from the first array by a spacing distance, is further included, the second array having second light sensitive detectors. The second array is configurable to either receive light which has been reflected by the object or to be a reference array and generate an output. A processor operates to determine a distance to the object in response to the outputs from the first and the second arrays.

Abstract: The present invention concerns gp19 immunoreactive compositions for E. canis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. canis gp19 are disclosed.

Abstract: Photoluminescence from a sample detector is detected using an array of photo-sensitive detectors. At least one first photo-sensitive detector of the array is provided with a first type of linear polarization filter and at least one second photo-sensitive detector is provided with a second type of linear polarization filter. The first type of linear polarization filter has a plane of polarization which is at angled with respect to a plane of polarization of said second type of polarization filter.

Abstract: A waveguide device is provided. The device comprises a semiconductor waveguide structure and at least one charge storing structure. Said at least one charge storing structure is configured to apply selected electric field on the semiconductor waveguide structure to thereby vary refractive index within said semiconductor waveguide structure. Wherein the charge storing structure comprises a charge trapping layer configured for storing charge carriers configured for selectively generating constant electric field of a predetermined magnitude. The device may be used in optical resonators, interferometer for optical and optoelectronic applications, capable of desirably varying refractive index within the waveguide structure.

Abstract: A neural network is disclosed. The neural network comprises a plurality of optogenetically modified neural cells being three-dimensionally distributed in a hydrogel medium and being disconnected from any solid support having a shear modulus above 1 GPa.

Abstract: A dimensionally stable floor covering, comprising a tufted textile substrate and a reinforcement layer wherein vacuum is used to move adhesive into stitch portions of the yarns and into the back side of the primary backing substrate to provide increased dimensional stability for the entire floor covering. Mixing of reinforcement fibers and adhesive takes place before in situ filtration of the adhesive and fibers. Further, compressed air is injected into the adhesive/fiber composition to provide spaces between the fibers before application of pressure to the composition. The vacuum, mixing, and injection of compressed air assist in preparing the adhesive and fiber composition to be in the preferred condition and position before the application of pressure to the composition.

Abstract: The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. chaffeensis VLPT are disclosed.

Abstract: Rib hook devices, systems, and methods of assembling and using the devices and systems are disclosed. The rib hook device includes a body with a first end and a second end and a rod attachment member coupled to and extending away from the second end of the body. The rib hook system includes at least one rib hook device, a first rod for engaging the at least one rib hook device, and at least one fastener for securing the first rod to the at least one rib hook device. Methods for assembling and using the rib hook devices and systems are also disclosed.

Abstract: The present invention discloses a method for detecting whether cells are infected with human papillomavirus (HPV), and the method includes: (a) capturing a contour of a cell of a cell image, wherein the contour has a contour pixel thereon; (b) identifying a tangent of the contour pixel on the contour to define in relation to the tangent a first side and a second side opposite to the first side, wherein the first side indicates the intracellular region of the cell and the second side indicates the extracellular region of the cell; (c) calculating an optical parameter average of the plurality of pixels on both of the first side and the second side; and (d) determining whether the cell is infected with HPV based on whether the optical parameter average on the first side is smaller than that on the second side.