Patents Assigned to Research Development
  • Immunoreactive protein orthologs of and
    Patent number: 9645148
    Abstract: The present invention concerns gp36 immunoreactive compositions for E. canis and gp 47 immunoreactive compositions for E. chaffeensis. In particular, epitopes for E. canis gp36 and E. chaffeensis gp 47 are disclosed. In certain embodiments, the immunoreactive compositions comprise tandem repeats having carbohydrate moieties.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: May 9, 2017
    Assignee: Research Development Foundation
    Inventors: Jere W. McBride, Christopher K. Doyle
  • APPARATUS AND METHODS FOR OPTICAL COHERENCE TOMOGRAPHY AND TWO-PHOTON LUMINESCENCE IMAGING
    Publication number: 20170122720
    Abstract: Exemplary embodiments of the present disclosure include a combined catheter-based optical coherence tomography-two-photon luminescence (OCT-TPL) imaging system. Exemplary embodiments further include methods to detect, and further characterize the distribution of cellular components (e.g., macrophage, collagen/elastin fiber, lipid droplet) in thin-cap fibroatheromas with high spatial resolution in vivo.
    Type: Application
    Filed: September 13, 2016
    Publication date: May 4, 2017
    Applicant: Research Development Foundation
    Inventors: Marc FELDMAN, Thomas MILNER, Tianyi WANG, Jennifer WHEDBEE
  • Time to digital converter and applications thereof
    Patent number: 9639063
    Abstract: A time to digital converter includes a sample module operable to sample an input signal at multiple different instances of time. A transition detection module, formed of comparison elements, processes the sampled input signal at successive time instances so as to detect transitions in the input signal in terms of time. An output module generates detected transitions in the input signal on multiple parallel outputs.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: May 2, 2017
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventors: Neale Dutton, Robert K. Henderson, Salvatore Gnecchi
  • Process for the preparation of -iodoamides
    Patent number: 9637462
    Abstract: The present invention provides new stable crystalline N-iodoamides-1-iodo-3,5,5-trimethylhydantoin (1-ITMH) and 3-iodo-4,4-dimethyl-2-oxazolidinone (IDMO). The present invention further provides a process for the preparation of organic iodides using N-iodoamides of this invention and recovery of the amide co-products from waste water.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: May 2, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Gennady Nisnevich, Kseniya Kulbitski, Mark Gandelman, Alexander Artaryan
  • Biomolecular electronic device and process of use
    Patent number: 9629995
    Abstract: Provided is a biological membrane including at least one ring-like polypeptide, where the at least one of the ring-like polypeptide is not a membrane protein, a surface being associated with at least one ring-like polypeptide capable of integration into a cell membrane, an electrode including said surface and electronically and biomedical devices including the electrodes for recording and stimulating cell activity.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: April 25, 2017
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Micha Spira, Oded Shoseyov
  • Electronic devices
    Patent number: 9635162
    Abstract: A mobile communications device includes an antenna, a navigation pad and a signal processor. The antenna, navigation pad, and signal processor cooperate to encode and transmit motion signals from the navigation pad to a computer so that the mobile communications device functions as a pointing device for the computer.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: April 25, 2017
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventor: Jeffrey Raynor
  • Apparatus and methods for identifying and evaluating bright spot indications observed through optical coherence tomography
    Patent number: 9633277
    Abstract: Exemplary embodiments of the present disclosure include apparatus and methods for identifying bright spot indications observed through optical coherence tomography. The indications can be evaluated, for example, to link risk factors or other conditions to clinically relevant outcomes.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: April 25, 2017
    Assignee: Research Development Foundation
    Inventors: Marc D. Feldman, Thomas E. Milner, Jennifer E. Whedbee
  • Methods of killing cells and use of same in prevention and treatment of cancer
    Patent number: 9623109
    Abstract: A method of killing a cell having a mutation in an Adenomatous polyposis coli (APC) gene is disclosed. The method comprises contacting the cell with an inhibitor of Casein kinase I (CKI), the CKI being selected from the group consisting of CKI-alpha and CKI-delta and CKI-epsilon, thereby killing the cell. The method may be used for treating cancers. Pharmaceutical compositions for treatment of cancers are also disclosed.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: April 18, 2017
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yinon Ben-Neriah, Ela Elyada, Ariel Pribluda
  • Exploiting similarity in adjacent slices for compressed sensing MRI
    Patent number: 9619904
    Abstract: A method for reconstructing high signal-to-noise ratio (SNR) magnetic resonance imaging (MRI) slices, including: receiving a thick MRI slice of bodily tissue acquired using a single MRI scan, wherein the thick slice has a high SNR; receiving two thin MRI slices of the bodily tissue acquired using a single MRI scan, wherein each of the two thin MRI slices has a low SNR; and reconstructing multiple high SNR thin slices of the bodily tissue using the thick slice and the two thin slices.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: April 11, 2017
    Assignees: Technion Research & Development Foundation Limited, The Medical Research, Infrastructure and Health Services Fund of the Tel-Aviv Medical Center
    Inventors: Lior Weizman, Yonina Eldar, Dafna Ben Bashat
  • Antioxidant, anti-inflammatory, anti-radiation, metal chelating compounds and uses thereof
    Patent number: 9617301
    Abstract: Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such short peptides in clinical and cosmetic applications are described.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: April 11, 2017
    Assignees: ONEDAY-BIOTECH AND PHARMA LTD., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Josef Mograbi, Daphne Atlas, Shoshana Keynan
  • Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis
    Patent number: 9617347
    Abstract: The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors of LOXL2 expression and activity, such as shRNA targeting LOXL2.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: April 11, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventor: Gera Neufeld
  • Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
    Patent number: 9616112
    Abstract: A composition-of-matter comprising an antibody or antibody fragment including an antigen-binding region capable of specifically binding an antigen-presenting portion of a complex composed of a human antigen-presenting molecule and an antigen derived from a pathogen is disclosed.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: April 11, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Yoram Reiter, Cyril Cohen
  • Aminoglycosides and uses thereof in treating genetic disorders
    Patent number: 9616079
    Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.
    Type: Grant
    Filed: September 27, 2015
    Date of Patent: April 11, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Timor Baasov, Dana Atia-Glikin, Jeyakumar Kandasamy, Valery Belakhov
  • Proximity sensor including a photon emitter, a photon receiver and an opaque structure
    Patent number: 9612330
    Abstract: One or more embodiments are directed to a device comprising: a body having a cavity, an opaque structure, and an aperture in the body that places the cavity in fluid communication with an environment external to the body. A photon emitter is located in the cavity below the aperture and configured to emit photons through the aperture to the environment external to the body. A photon receiver is located in the cavity below the opaque structure of the body and configured to receive photons that are each reflected from both an object that is spaced apart from the body in the environment external to the body and from a surface of the opaque structure.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: April 4, 2017
    Assignees: STMicroelectronics (Grenoble 2) SAS, STMicroelectronics (Research & Development) Limited
    Inventors: Pierre-Jean Parodi-Keravec, Marc Drader
  • NANO CRYSTALLINE CELLULOSE IN CONSTRUCTION APPLICATIONS
    Publication number: 20170088705
    Abstract: Provided are cementitious formulations including nano crystalline cellulose (NCC).
    Type: Application
    Filed: May 20, 2015
    Publication date: March 30, 2017
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Shaul LAPIDOT, Oded SHOSEYOV, Tord GUSTAFSSON, Lea CARMEL-GOREN
  • Query networks evaluation system and method
    Patent number: 9607052
    Abstract: A query network is disclosed, comprising sets of nodes and edges connecting pairs of nodes. The nodes of the query network are associated with edge-defining queries. A method is taught for fully evaluating such a query network. A language is further disclosed for constructing queries. The query network may be used to model a social network, a professional network or the like.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: March 28, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Oded Shmueli, Royi Ronen
  • Vaccines and diagnostics for the
    Patent number: 9605036
    Abstract: The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. chaffeensis VLPT are disclosed.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: March 28, 2017
    Assignee: Research Development Foundation
    Inventors: Jere W. McBride, Tian Luo
  • Immunoreactive glycoprotein GP19
    Patent number: 9605032
    Abstract: The present invention concerns gp19 immunoreactive compositions for E. canis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. canis gp19 are disclosed.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: March 28, 2017
    Assignee: Research Development Foundation
    Inventors: Jere W. McBride, Christopher K. Doyle
  • Immunoreactive glycoprotein GP19 of
    Patent number: 9605033
    Abstract: The present invention concerns gp19 immunoreactive compositions for E. canis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. canis gp19 are disclosed.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: March 28, 2017
    Assignee: Research Development Foundation
    Inventors: Jere W. McBride, Christopher Kuyler Doyle
  • Vaccines and diagnostics for the ehrlichioses
    Patent number: 9605035
    Abstract: The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. chaffeensis VLPT are disclosed.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: March 28, 2017
    Assignee: Research Development Foundation
    Inventors: Jere W. McBride, Tian Luo