Abstract: This invention relates to novel protein transduction domains (PTDs) derived from secretory leukocyte protease inhibitor (SLPI). SLPI-derived PTDs are able to deliver cargo moieties in vivo and in vitro into the cytoplasm and nucleus of a host cell. The invention also relates to a transduction complex comprising one or more SLPI-derived PTDs linked or fused to one or more cargo moieties, which may comprise, for example, proteins, nucleic acids, lipids, carbohydrates, small molecules and other chemical compounds. The invention also relates to the manufacture of SLPI-derived PTDs, complexes comprising them; compositions comprising SLPI-derived PTDs or complexes; and utilization of SLPI-derived PTDs or complexes comprising them for therapeutic, diagnostic and research methods involving delivery of heterologous molecules across cellular membranes, and especially, across nuclear membranes.

Abstract: The invention provides compositions with low toxicity and high bioavailability for treating cancer or for inhibiting the development of cancer

Abstract: Disclosed in this specification is a method for aligning nanostructures. A substrate is coated with a liquid solution comprising particles. Before the solution is cured, circularly-polarized light is applied to the substrate to induce a magnetic field in the particles. A low strength magnetic field is then applied. The induced magnetic field of the particles aligns with the applied magnetic field. The solution is permitted to cure while simultaneously exposed to both the circularly-polarized light and the applied magnetic field. The resulting composite retains the particle alignment.

Abstract: The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.

Abstract: An electrode assembly includes a substantially porous element configured to be coupled to an electrode for delivery of electrical current to a patient in a neurostimulation procedure. The substantially porous material defining a contact surface, of which at least a portion contacts the patient during the neurostimulation procedure. A first insulating member is coupled to the substantially porous element and exposed at the contact surface to prevent a portion of the contact surface from contacting the patient to deliver the electrical current during the neurostimulation procedure.

Abstract: Method and apparatus for storing heat in industrial systems where large sources of stored energy are called upon to meet a work load, storing the heat content of a hot working fluid by using the hot working fluid as a heat transfer fluid in vapor form and depositing its heat content on a heat storage medium and then removing the cooled and condensed liquid phase of that heat transfer fluid, and when hot working fluid again is needed, the liquid heat transfer fluid is returned to the heated storage medium and is reheated as it passes through the hot storage medium and then is returned to the working system to be used as a hot working fluid.

Abstract: This disclosure describes unique single stranded DNA templates having a characteristic sequence and secondary structure. The DNA templates disclosed herein are useful for making small RNA molecules through promoterless transcription by a mammalian RNA polymerase, and can serve as an effective vector for producing small RNA molecules of interest in vitro, in situ and in vivo in mammalian cells.

Abstract: The present invention relates to a method for enhancing arginase activity in a damaged or injured cell. In other aspects, the invention provides a method for treating a disorder that can be treated by enhancing arginase activity in a human in need thereof, the method comprising administering to the human an effective amount of a compound that enhances arginase activity. Such disorders include ischemia, hypoxia, neurodegenerative disease or condition, stroke or trauma of the nervous system. In yet another aspect, the invention provides methods for promoting regeneration of a neural cell in a human in need thereof.

Abstract: Disclosed in this specification is a method for coating a substrate to prevent dewetting. A suspension of nanoparticles is deposited onto the substrate to produce a nanoparticle layer. The nanoparticle layer is then coated with a monomer. The monomer polymerizes on the nanoparticle layer to produce a polymeric layer.

Abstract: The invention relates to curcumin derivatives having the formula I: wherein: Z represents: H3CO A represents —CH2—CH2— or —CH?CH—; L represents —C(O)—(NH)n1—R—(NH)n2—C(O)—; R represents a saturated or unsaturated, branched or unbranched hydrocarbyl chain having a minimum of 3 carbon atoms in the chain; wherein the maximum number of carbon atoms in the chain is 24; and wherein the carbon atoms of the chain can be replaced by at least one heteroatom, wherein the heteroatoms are independently —O— or —NH2—, with the proviso that each heteroatom is separated from each other heteroatom by at least two carbon atoms; n1 and n2 independently represent 0 or 1; and Y represents an antibody that binds specifically to a target antigen of a tumor cell. The invention further relates to methods of method of inhibiting the growth of tumors in a human by administering an effective amount of the curcumin derivative, and to methods of producing the curcumin derivative.

Abstract: The present invention teaches how to change the skin color perception, mainly the facial color from red, blue or yellow to white appearance, using quantum and optical principles. By selecting the right size and material of particles compounded in cosmetic preparations and applying the preparations to the skin, the scattering and/or emission from micro- and nanoparticles can provide a complementary color or in proximity to that complementary color of the skin color. The mixture of the color provided by the particles and the reflected color from the skin will whiten the skin or make inconspicuous of the hyperchromic portion of the skin. The invention can also be used for other applications in which the particles can be applied to a surface or blended into a material, such as, for example, automobile paint, house paint, glass color and nail polish.

Abstract: The subject matter disclosed in this specification pertains to the transfer of compounds of interest into a target biological cell. Specifically, discrete particles that are surrounded in three dimensions with phospholipid bilayers are provided wherein the compound of interest (e.g.) a protein are free to laterally move within the bilayer. The particles may be embedded within a hydrogel matrix. In some embodiments, stem cells are co-cultured in the hydrogel matrix to facilitate the absorption of the compound of interest.

Abstract: Disclosed in this specification is a high capacity compact gel documentation system for documenting different types of electrophoresis gels or other translucent objects using ultraviolet light. The system includes a base with a scanning surface having a transparent bottom surface. A light source is connected to a conveying mechanism, disposed below the transparent bottom surface, to move the light source over the length of the transparent bottom surface. An image capture device receives a reflected image and provides it to a microprocessor. Moreover, separate interchangeable filters allow for documentation of UV and white light gel captures, alleviating the need for separate transilluminators and hoods with filters and cameras.

Abstract: The present invention is directed to convertible nucleosides and polymer supported convertible nucleosides for use in SNAr displacement reactions. The convertible nucleosides can be used to synthesize numerous substituted purine and pyrimidine derivatives.

Abstract: The invention relates to novel curcumin derivatives in which one or two of the phenolic groups have been modified.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for developing transcranial electrical stimulation protocols are disclosed. In one aspect, a method includes forming a first array of electrodes and optimizing a plurality of electrode parameters within the first array of electrodes to achieve a desired physiological response; identifying one or more electrodes within the optimized first array that have relatively low current compared to the remaining electrodes in the first array; removing the identified low current electrodes from the first array to form a second array of electrodes, wherein the number of electrodes in the second array is less than the number of electrodes in the first array and optimizing a plurality of electrode parameters with the second array of electrodes to achieve a desired physiological response.

Abstract: The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.

Abstract: The present invention is directed to providing antimicrobial compositions consisting of a polymeric material and, embedded therein, an antimicrobial compound. The antimicrobial compound contains at least one quaternary ammonium group, at least one hydrocarbon chain comprising a minimum of 10 carbon atoms and a maximum of 24 carbon atoms, and one or more anions to balance the charge of the quaternary ammonium groups. The invention is also directed to a method of making antimicrobial compositions containing an antimicrobial compound embedded in a polymeric material.

Abstract: A method for producing an adsorbent, having the steps of combining a first sludge and a second material to form a mixture, thermally drying the mixture, and pyrolizing the mixture using at least four temperature zones wherein each temperature zone is set between about 600° C. and 1,100° C. The first sludge is a municipal sludge or an industrial sludge, and the second material is a compost material or one of municipal sludge or industrial sludge differing from the first sludge. The compost material is at least one of tobacco waste, waste paper and wood char, or a combination thereof. Further, the drying can happen in two stages. Each stage can include two separate temperatures.

Abstract: A nickel-zinc battery includes a battery housing, a nickel oxide positive electrode supported in the battery housing, a metal substrate negative electrode supported in the battery housing, a spacer disposed between the positive and negative electrodes, an electrolyte contained within the battery housing and a means for circulating electrolyte in fluid communication with the housing for circulating the electrolyte between the positive and negative electrodes. The electrolyte contains zinc and the metal substrate is adapted for deposition of the zinc during charging of the battery. The spacer maintains the positive electrode in a spaced relationship apart from the negative electrode.