Abstract: Systems and methods for accurately measuring changes in biomarker sensitive hydrogel volume and shape due to exposure to various biomarkers include a system for identifying one or more dimensional changes in a biomarker sensitive hydrogel positioned within an in vivo environment. The system includes a biomarker sensitive hydrogel positioned within an in vivo environment and configured to dimensionally change in response to interaction with predefined biomarkers. The system additionally includes an ultrasound transducer for locating and identifying one or more characteristics of the biomarker sensitive hydrogel and a computer system in electrical communication with the ultrasound transducer. The computer system is configured to receive characteristics of the biomarker sensitive hydrogel from the ultrasound transducer and determine dimensional changes of the biomarker sensitive hydrogel based on the received characteristics.

Abstract: The present invention relates to a composition for preventing, alleviating or treating inflammatory diseases, comprising, as an active ingredient, an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, of the present invention, effectively inhibits inflammatory cytokines and inflammatory signaling pathways, thereby effectively alleviating symptoms of inflammatory diseases such as dermatitis. Therefore, the composition according to the present invention may be effectively used for the prevention, alleviation or treatment of inflammatory diseases.

Abstract: One embodiment can provide a system for detecting anomaly for high-dimensional sensor data associated with one or more machines. During operation, the system can obtain sensor data from a set of sensor associated with one or machines, apply data exploration techniques on the sensor data to automatically process sensor data to identify a subset of feature sensors from the available set of feature sensors, apply an unsupervised machine-learning technique to the identified subset of feature sensors and the target sensor to learn a set of pair-wise univariate models, and determine whether and how an anomaly occurs in the operation of the one or more machines based on the set of pair-wise univariate models.

Abstract: The present application relates to a compound of Formula I, or a salt, hydrate or solvate thereof, as defined herein. The present compounds are found to have pharmacological effects, particularly at MRCK. Further provided are pharmaceutical compositions comprising said compounds. The present invention also relates to the use of these compounds as therapeutic agents, in particular, for the treatment and/or prevention of proliferative diseases, such as cancer.

Abstract: A cranial anchor system configured to attach to an opening in a cranium includes an anchor member. The anchor member has a middle anchor portion and a lower anchor portion coupled to and disposed in a downward direction relative to the middle anchor portion. The lower anchor portion has a plurality of contact members, each of which have a leg that extends at least partially in the downward direction, a tab connected to the leg, and a rib disposed between the leg and the tab. The system further includes an outer sheath and an inner sheath disposed within the outer sheath and slidable relative to the outer sheath.

Abstract: The present technology is directed to a kiosk for storing, displaying, and distributing a plurality of baked products. The kiosk may include, for example, a housing defining a chamber therein and configured to receive a plurality of baked products. The kiosk may include one or more sensors configured to analyze the individual baked products to determine one or more baked unit parameters and adjust one or more baking inputs based on the measured parameters.

Abstract: A method of making coated avian egg yolk cores includes providing dried avian egg yolk cores having a diameter of 100 to 1500 micrometers, applying avian egg albumen to the dried avian egg yolk cores to provide the coated avian egg yolk cores, and optionally drying the coated avian egg yolk cores, wherein the ratio of dry avian egg albumen to dried avian egg yolk in the coated avian egg yolk cores is 1:10 to 10:1. Also included are the coated avian egg yolk cores, food and feed additives containing the coated avian egg yolk cores and food and feed compositions containing the coated avian egg yolk cores.

Abstract: A fiber optic cable includes a cable jacket having an outer surface defined by a cable jacket outer diameter JOD and an inner surface defined by a cable jacket inner diameter JID; a plurality N of optical fibers, where N?4, contained within the cable jacket and positioned a distance away from the cable jacket inner diameter, with each optical fiber having a core, a cladding surrounding the core, and at least one coating surrounding the core with the at least one coating having an outer coating diameter less than or equal to about 200 microns and wherein the cable jacket outer diameter JOD is less than or equal to 1 mm.

Abstract: A robot configured for multi-robot pose estimation execute iteratively the primary particle filter and the secondary particle filter independently from each other to update the pose estimations in the primary and the secondary particles. In response to each encounter of the robot with a neighboring robot, the robot receives neighboring particles of a particle filter of the neighboring robot identifying poses and likelihoods of the poses of the neighboring robot and replaces the primary particles of the primary particle filter with the secondary particles fused with the neighboring particles. The robot outputs its pose according to the primary particles of the primary particle filter.

Abstract: The present invention provides a conducting material comprising a carbon-based material selected from a diamond or an insulating diamond-like carbon, having a hydrogen-terminated surface and a layer of tungsten trioxide, rhenium trioxide, or chromium oxide coating said hydrogen-terminated surface. Such conducting materials are useful in the fabrication of electronic components, electrodes, sensors, diodes, field effect transistors, and field emission electron sources.

Abstract: A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the epithelial thickness or gland lumen roundness of the tissue, wherein an increase in epithelial thickness or a decrease in gland lumen roundness indicates the presence of prostate cancer or a prostate cancer field defect.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a BCMA-binding moiety comprising (i) the variable domains of humanized antibody J22.9-ISY, and (ii) a heavy chain constant region comprising a D265C mutation; and (c) a protease-cleavable linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of multiple myeloma.

Abstract: Provided is a method of inhibiting protein kinase C zeta/protein kinase M zeta, including contacting a sample containing an isoform of protein kinase C zeta with a compound of formula: referred to as 1-naphthol-3,6,8-trisulphonic acid, or a pharmaceutically acceptable salt thereof. In some embodiments, contacting the sample with the compound does not inhibit protein kinase C iota/lambda. In a specific example, the sample includes neural tissue, the isoform of protein kinase C zeta is protein kinase M zeta, and inhibiting includes reducing kinase activity and further includes diminishing long-term potentiation. In some embodiment, the method includes inhibiting glucose transport. Also provided is a method of affecting memory, including administering the compounds to a mammalian organism.

Abstract: Provided are methods for increasing insulin sensitivity in subjects. In some embodiments, the method include administering to the subject an effective amount of a composition comprising a lipid bilayer, wherein the lipid bilayer is low in total phosphatidylcholine (PC) or has been treated to reduce total PC.

Abstract: The invention is directed to methods and compositions for treating a disease associated with ventricular enlargement such as 22q11 deletion syndrome (22q11 DS) and schizophrenia (SCZ) by replenishment of decreased levels of miR-382-3p and/or miR-674-3p or inhibition of dopamine receptor Drd1 in ependymal cells.

Abstract: The present invention relates to an intermediate blank connection system for hot-rolled strip headless rolling and a connection method, and belongs to the technical field of intermediate blank connection for strip steel headless rolling. The connection system and the connection method realize matching of an intermediate blank connection device and speed of a unit through a translation drive system. A mounting frame is used to provide support for cutting devices, and the cutting devices are divided into two groups arranged in the mounting frame to achieve clamping of a front slab and a rear slab respectively. Interlaced dovetail cutting edge structures are used to achieve cutting and ensure a good longitudinal stress state. Finally, a certain difference is set in sizes of width directions between cutting edges, to ensure that there is certain extrusion deformation in a process of forming dovetail cutting groove connection, and enhance a connection effect.

Abstract: An aspect of the invention relates to methods and implants comprising acoustic-sensitive material and at least one additional component within said acoustic-sensitive material. In some embodiments, the at least one additional component is one or more of at least one releasable drug within said acoustic-sensitive material and/or a plurality of cells within said acoustic-sensitive material. In some embodiments, the implant comprises a dedicated form, which is provided inside the body of the patient.

Abstract: A production line scheduling method, adapted to a plurality of jobs passing a bottleneck station having at least one manufacturing machine, the jobs respectively correspond to a plurality of job conditions, and the method comprises: performing a plurality of times of a schedule simulation algorithm on the jobs to sequentially establish a plurality of schedule simulation trees, and obtaining a job schedule and a simulated finishing period of each job based on the schedule simulation trees, wherein each schedule simulation tree comprises at least one scheduling route, and each scheduling route is generated from one schedule simulation algorithm; and calculating a plurality of expected feeding times of each job at a plurality of stations comprising the bottleneck station, wherein the schedule simulation algorithm comprises: performing a node expansion step based on at least one node expansion condition and the job conditions to obtain the scheduling route.

Abstract: A method and a device for encoding/decoding images are disclosed. The method for encoding images comprises the steps of: deriving a scan type of a residual signal for a current block according to whether or not the current block is a transform skip block; and applying the scan type to the residual signal for the current block, wherein the transform skip block is a block to which transform for the current block is not applied and is specified on the basis of information indicating whether or not transform for the current block is to be applied.

Abstract: A computer-implemented method of training an autoencoder to recover missing data is provided. The autoencoder includes an encoder for encoding its inputs into a latent space and a decoder for decoding the encodings from the latent space. The method comprises creating a first training set including a valid data set of multiple dimensions, and training the encoder and the decoder in a first training stage using the first training set to reduce a difference between the valid data set provided to the encoder and a data set decoded by the decoder. The method further comprises creating a second training set comprising an invalid data set, and training the encoder in a second training stage using the second training set to reduce a difference between encodings of valid data instances and encodings of their corresponding invalid data instances.