Abstract: The present invention provides an anomaly detection method and apparatus based on a neural network which can be trained on undamaged normal vehicle images and able to detect unknown/unseen vehicle damages of stochastic types and extents from images which are taken in various contexts. The provided method and apparatus are implemented with functional units which are trained to perform the anomaly detection under a GCAN model with a training dataset containing images of undamaged vehicles, intact-vehicle frame images and augmented vehicle frame images of the vehicles.
Type:
Grant
Filed:
September 29, 2020
Date of Patent:
May 10, 2022
Assignee:
Hong Kong Applied Science and Technology Research Institute Company Limited
Abstract: A system for monitoring processing of a fluid receives one or more characteristics of the fluid and uses those characteristics to determine specific gravity of the fluid and a level of processing activity of the fluid. The processor will cause a display device to output a dynamic representation of the specific gravity of the fluid as well as the determined level of processing activity. In some embodiments, the processing activity may include fermentation, as that of a beverage. If so, the dynamic representation of the determined level of processing activity may include a fermentation tank with a dynamically changing cavity. Displayed characteristics of the cavity will change as the determined level of the fermentation increases.
Type:
Grant
Filed:
March 6, 2020
Date of Patent:
May 10, 2022
Assignee:
TZero Research & Development LLC
Inventors:
Stephen M. Wells, Nicholas A. Wells, Eli M. Hughes
Abstract: The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier. A group of the electrode sites may be simultaneously activated to create an activation pattern. The system of the preferred embodiment is preferably designed for deep brain stimulation, and, more specifically, for deep brain stimulation with fine electrode site positioning, selectivity, tunability, and precise activation patterning. The system of the preferred embodiments, however, may be alternatively used in any suitable environment (such as the spinal cord, peripheral nerve, muscle, or any other suitable anatomical location) and for any suitable reason.
Type:
Grant
Filed:
July 17, 2019
Date of Patent:
May 10, 2022
Assignee:
Medtronic Bakken Research Center B.V.
Inventors:
Rio J. Vetter, Daryl R. Kipke, David Pellinen, David J. Anderson, Jamille Farraye Hetke
Abstract: The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like. The present invention also provides assays using transgenic Nestin/Ramp1 rodents, utilizing a CGRP model light aversive behavior model for identifying therapeutically effective anti-CGRP antibodies and fragments thereof having binding specificity for CGRP which inhibit or prevent photophobia in subjects in need thereof. The present invention is specifically directed to methods for identifying therapeutically effective antibodies and fragments thereof having binding specificity for CGRP that may be used to treat CGRP associated disorders such as migraine.
Type:
Grant
Filed:
April 18, 2019
Date of Patent:
May 10, 2022
Assignees:
H. LUNDBECK A/S, THE UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Andrew F. Russo, Eric A. Kaiser, Ana Recober, Adisa Kuburas, Ann C. Raddant, Brian R. Kovacevich, John Latham, Jeffrey T. L. Smith, Leon F. Garcia-Martinez
Abstract: A method is provided for observing structure and function of individual cells in a living human eye, comprising: using an adaptive optics optical coherence tomography (AO-OCT) system to image a volume of a retinal patch including numerous cells of different types, as for example, ganglion cells; using 3D subcellular image registration to correct for eye motion, including digitally dissecting the imaged volume; and using organelle motility inside the cell to increase cell contrast and to measure cell temporal dynamics.
Type:
Grant
Filed:
July 25, 2019
Date of Patent:
May 10, 2022
Assignee:
Indiana University Research and Technology Corporation
Inventors:
Donald Thomas Miller, Zhuolin Liu, Kazuhiro Suzuki, Furu Zhang
Abstract: Described herein are unit oral dose compositions that reduce the severity of heartburn and/or the risk of the occurrence of heartburn in a human in need of taking naproxen sodium for the OTC treatment of acute pain wherein the human is not experiencing heartburn prior to the oral administration of the unit oral dose composition comprising orally administering to the human of a unit oral dose composition comprising (i) naproxen sodium at a dosage from about 100 mg to about 440 mg per unit oral dose composition and (ii) famotidine at a dosage from about 3 mg to about 20 mg per unit oral dose composition, wherein the dissolution rate of famotidine in the unit oral dose composition in said human at a specified time within 45 minutes of administration of said unit oral dose composition to said human is greater than the dissolution rate of naproxen sodium in the unit oral dose composition in said human at the same specified time.
Abstract: A charging-and-discharging device and a charging-and-discharging method are provided. The charging-and-discharging device includes a renewable energy converter, an aluminum battery, a controller and a current converter. The renewable energy converter receives a power from a renewable energy power generation system. The controller is coupled to the renewable energy converter and the aluminum battery, wherein the controller configures a charging-and-discharging power of the aluminum battery, according to a power value of the power, to compensate the power so as to generate a compensated power. The current converter is coupled to the controller, wherein the current converter outputs the compensated power to a power grid after performing DC/AC converting.
Type:
Grant
Filed:
January 21, 2020
Date of Patent:
May 10, 2022
Assignee:
Industrial Technology Research Institute
Abstract: Improved optical interconnects obtained by replacing one or more single core fibers with one or more multicore fibers. In some instances, at least one of the optical fibers is shaped.
Abstract: Disclosed are materials and methods for treating diseases of the mammalian eye, and in particular, Usher syndrome 1B (USH1B). The invention provides AAV-based, dual-vector systems that facilitate the expression of full-length proteins whose coding sequences exceed that of the polynucleotide packaging capacity of an individual AAV vector. In one embodiment, vector systems are provided that include i) a first AAV vector polynucleotide that includes an inverted terminal repeat at each end of the polynucleotide and a suitable promoter followed by a partial coding sequence that encodes an N-terminal portion of a full-length polypeptide; and ii) a second AAV vector polynucleotide that includes an inverted terminal repeat at each end of the polynucleotide and a partial coding sequence that encodes a C-terminal portion of a full-length polypeptide, optionally followed by a polyadenylation (pA) signal sequence.
Type:
Grant
Filed:
February 1, 2019
Date of Patent:
May 10, 2022
Assignee:
University of Florida Research Foundation, Incorporated
Inventors:
Sanford L. Boye, Shannon E. Boye, Frank Dyka, William W. Hauswirth
Abstract: System and methods are provided for producing computed tomography (CT) images. In some aspects, a method includes obtaining medical image data sets acquired using the multiple energies of irradiating radiation and analyzing the medical image data sets for spatial and spectral features. The method also includes comparing the spatial and spectral features of the medical image data sets to identify similarities and using the similarities, weighting the medical image data sets to generate images of the subject having reduced noise compared to images of the subject produced from the medical image data sets without weighting.
Type:
Grant
Filed:
May 8, 2017
Date of Patent:
May 10, 2022
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: According to an aspect of an embodiment, a method for a text classification using multi-task learning executed by a server, the method includes: a step of generating text classification learning data by executing a pre-processing process on raw data collected through a network; a step of learning a category classification in a first classification system preset through a first text classification model using the text classification learning data as an input; a step of learning a category classification in a second classification system preset through a second text classification model using the text classification learning data as an input; and a step of classifying the category in the second classification system by inputting text data received from a user terminal into the second text classification model.
Type:
Grant
Filed:
May 13, 2020
Date of Patent:
May 10, 2022
Assignee:
Korea University Research and Business Foundation
Inventors:
Sang Keun Lee, Kang-Min Kim, Jungho Lee
Abstract: Disclosed herein are embodiments of compositions for gas sensing and sensors utilizing the same. In one embodiment, a composition comprises carbon nanotubes and polymer-coated metal nanoparticles bound to the carbon nanotubes.
Type:
Grant
Filed:
August 18, 2020
Date of Patent:
May 10, 2022
Assignee:
Palo Alto Research Center Incorporated
Inventors:
Gabriel Iftime, Clinton Smith, David Eric Schwartz, Yong Zhang, Vedasri Vedharathinam
Abstract: A distributed system for processing messages includes one or more gateways, sequencers, and compute nodes. The gateway sends a message to the sequencer and the compute node for processing. The sequencer associates the message with an identifier indicating a relative sequence of the message among a plurality of messages. The compute node processes the message to generate a preliminary result, and determines, based on the identifier, whether the compute node processed the message in sequence or out of sequence relative to another message of a plurality of messages. If the compute node determines that the message was received out of sequence, the compute node may process a sequence of messages including the message and at least one preceding message in an appropriate sequence.
Abstract: The present invention is directed to a fatty acid amide of an amino acid, including a stereoisomer and a salt thereof for use in the treatment of a patient suffering from any type of addiction disorder, substance abuse disorder, including any condition and symptom associated therewith and including withdrawal syndrome and relapse addiction during and after a rehabilitation treatment of said patient.
Type:
Grant
Filed:
May 22, 2018
Date of Patent:
May 10, 2022
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
Inventors:
Raphael Mechoulam, Vincenzo Di Marzo, Fabiana Piscitelli, Aron H. Lichtman, Imad M. Damaj, Linda Parker, Rami Yaka
Abstract: The present invention relates to a resource allocation method and apparatus, and a signal transmission method, which are applicable to various technical scenarios of 5G New Radio (NR). A method for operating a communication node for resource allocation in a communication network includes: allocating first data and a first pilot for a first type service to a first block period of a first subframe; allocating second data and a second pilot for a second type service to a second block period overlapping with the first block period; and transmitting the first subframe to another communication node. Here, at least one of the second data and the second pilot is allocated to an area to which the first data is allocated.
Type:
Grant
Filed:
October 31, 2017
Date of Patent:
May 10, 2022
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Ji Hung Kim, Jun Hwan Lee, Jung Hoon Lee, Sung Hyun Moon, Ju Ho Park, Cheul Soon Kim
Abstract: This invention relates to compounds useful as lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family member (LOXL1, LOXL2, LOXL3, LOXL4) inhibitors. In addition there are contemplated pharmaceutical compositions comprising the compounds and the use of the compounds in the treatment of conditions mediated by LOX and LOXL, for example cancer. In particular a LOX inhibitor such as the present compounds may be for use in the treatment of a cancer associated with EGFR. The present invention also contemplates the identification of biomarkers that predict responsiveness to a LOX inhibitor.
Type:
Grant
Filed:
October 12, 2018
Date of Patent:
May 10, 2022
Assignee:
The Institute of Cancer Research: Royal Cancer Hospital
Inventors:
Richard Marais, Caroline Springer, Dan Niculescu-Duvaz, Natalie Miller, Mohammed Aljarah, Alfonso Zambon, Leo Leung, Deborah Smithen, Michael Brown, Haoran Tang
Abstract: Hydrocarbon wells including gas lift valves and methods of providing gas lift in a hydrocarbon well. The hydrocarbon wells include a wellbore extending within a subsurface region and a downhole tubular extending within the wellbore. The downhole tubular defines a tubular conduit, and the wellbore and the downhole tubular define an annular space therebetween. The hydrocarbon wells also include a lift gas supply system configured to provide a lift gas stream to the annular space and a closure material supply system configured to provide a closure material stream to the annular space. The hydrocarbon wells further includes a gas lift valve operatively attached to the downhole tubular. The gas lift valve includes a lift gas injection conduit and an actuation mechanism. The actuation mechanism selectively transitions to a closed state responsive to contact with the closure material. The methods include methods of operating the hydrocarbon wells.
Type:
Grant
Filed:
April 30, 2020
Date of Patent:
May 10, 2022
Assignee:
ExxonMobil Upstream Research Company
Inventors:
David A. Howell, Rosmer Maria Brito Jurado, Federico G. Gallo, Michael C. Romer
Abstract: A laser-produced plasma X-ray system includes a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the liquid metal forms a metal target beam, a circulation pump within the flow system for circulating the liquid metal, a laser pulse emitter configured to transmit a plurality of laser pulses into the chamber via a laser window, focusing optics, located between the emitter and the metal target beam, the focusing optics directing the laser pulses to strike the metal target beam at a target location to form X-ray pulses, and an X-ray window positioned within the chamber to allow the X-ray pulses to exit the chamber.
Type:
Grant
Filed:
December 27, 2017
Date of Patent:
May 10, 2022
Assignees:
Brown University, Research Instruments Corporation
Abstract: A medical intelligent device is for use with a medical jar. The medical jar defines an accommodating space for containing at least one medicine. The medication intelligent device includes a cover and an auxiliary medicine deliver. The cover is detachably mounted on the medical jar. The auxiliary medicine deliver is disposed on the cover and includes a main control chip and a medicine delivery gate electrically connected to the main control chip. The main control chip is used to move the gate between a closed position and an opened position relative to the cover. In the closed position, the medicine delivery gate closes the accommodating space. In the opened position, the medicine delivery gate opens the accommodating space.
Type:
Grant
Filed:
September 28, 2020
Date of Patent:
May 10, 2022
Assignee:
National Applied Research Laboratories
Inventors:
Shaw-Ben Shi, Shu-Hui Hung, Wei-Hua Teng
Abstract: A method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (PBMC) with a third party antigen or antigens in the presence of IL-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of IL-21, IL-15 and IL-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory T-lymphocyte (Tcm) phenotype.
Type:
Grant
Filed:
November 29, 2017
Date of Patent:
May 10, 2022
Assignee:
Yeda Research and Development Co. Ltd.
Inventors:
Yair Reisner, Yaki Eidelstein, Eran Ophir, Assaf Lask, Ran Afik, Noga Or-Geva, Esther Bachar-Lustig