Abstract: A method of fabricating a substrate having a through via includes: providing a carrier board having a release layer thereon; attaching the substrate onto the carrier board via the release layer; applying a light beam to the substrate to form a first blind hole in the substrate, wherein the first blind hole penetrates a first surface and a second surface of the substrate; performing an enlargement process on the first blind hole to form a second blind hole; forming a through via in the second blind hole; and performing a de-bonding process to release the substrate having a through via from the carrier board.

Abstract: Disclosed are a wireless device capable of being self-powered and an operating method thereof. The wireless device includes an energy harvesting module that generates electrical energy based on energy supplied from an outside, a power management module that generates a voltage based on the electrical energy provided from the energy harvesting module, a user input interface that includes at least one input device sensing an input of a user, and a communication module that transfers a command corresponding to the at least one input device to the outside based on the voltage provided from the power management module, in response to that the at least one input device is accessed by the user.

Abstract: The disclosure provides rAAV particles comprising a new capsid variant, AAV44.9(E531D). The disclosure also provides rAAV particles comprising AAV44.9(E531D) for treatment of the eye, including treatment of retinal disorders. In particular embodiments, the disclosure provides rAAV particles comprising an AAV44.9(E531D) capsid that exhibits enhanced lateral spread after subretinal injection to a fovea of the subject, wherein detachment of the fovea is minimized. The disclosure further provides rAAV particles comprising an AAV44.9(E531D) capsid and a polynucleotide encoding a heterologous nucleic acid sequence. Methods of treatment comprising administering rAAV particles to a mammal in need thereof, and methods of transducing photoreceptor and RPE cells with rAAV particles, are also provided.

Abstract: Provided are an apparatus and method for experiencing an augmented reality (AR)-based screen sports match which enable even a child, an elderly person, and a person with a disability to easily and safely experience a ball sports match, such as tennis, badminton, or squash, as a screen sports match without using a wearable marker or sensor, a wearable display, an actual ball, and an actual tool.

Abstract: Methods for treating MPS III diseases are disclosed. The methods involve administering a therapeutically effective amount of a composition comprising ambroxol to a subject with the disease. Also disclosed are pharmaceuticals suitable for treating MPS III diseases.

Abstract: A bio-resin composition, a bio-resin composite, and a bio-foam material are provided. The bio-resin composition includes a polymer matrix, a toughener, and an antistatic agent. The weight ratio of the polymer matrix to the toughener is between 90:10 and 60:40. Based on the total weight of the polymer matrix and the toughener, the content of the antistatic agent is between 1% and 10%.

Abstract: The invention relates to methods for eliciting an immune response to an immunogen, and in particular, to such methods using polymersomes as carriers for the immunogen.

Abstract: A power transmission system for driving a robot joint includes a driving part including a first driving unit and a second driving unit, a first force transmission part including a first sheath formed to have a predetermined length, flexibility, and a hollow shape and a first wire which is inserted into the first sheath and of which one end is fixed to a joint of a robot and the other end is connected to the first driving unit, and a second force transmission part including a second sheath formed to have a predetermined length, flexibility, and a hollow shape and a second wire which is inserted into the second sheath and of which one end is fixed to the joint of the robot and the other end is connected to the second driving unit.

Abstract: An energy trading method and system based on a dynamic price and demand of renewable energy are disclosed. The energy trading method includes receiving, from an energy consumer, demand information including a demand for energy required by the energy consumer, determining a amount of generation of an energy provider that is required to satisfy the demand from the energy consumer based on the demand information, determining a generation price to be paid by the energy consumer to purchase energy based on the amount of generation, and determining an energy trading with the energy consumer based on the generation price. The energy provider provides energy to the energy consumer according to the energy trading.

Abstract: The present disclosure relates to a system for reminding a person to perform an activity. The system comprise a robot configured to carry out different behaviors, wherein the activity and its corresponding trigger condition are set by a user and the system selects, from the different behaviors, a first behavior assigned to the activity, senses the person, determines, based on the sensors information, whether or not the activity is performed by the person in accordance with the trigger condition. The robot carries out the selected behavior if the activity is not performed by the person in accordance with the trigger condition, wherein after or during the selected behavior is carried out, an activity of the person is determined based on the information derived from the sensors to select a second behavior from the different behaviors.

Abstract: Disclosed is a quantum key distribution system using an RFI (reference frame independent) QKD (quantum key distribution) protocol, which includes a first signal processing circuit that generates transmission basis information and transmission bit information, a quantum channel transmitter that generates a single photon or coherent light, and modulates the single photon or the coherent light based on the transmission basis information and the transmission bit information to generate a quantum signal, a quantum channel receiver that receives the quantum signal through a quantum channel and detects reception bit information from the quantum signal based on reception basis information, and a second signal processing circuit that generates the reception basis information, transmits the reception basis information to the first signal processing circuit through a public channel, and receives the transmission basis information from the first signal processing circuit through the public channel.

Abstract: The present disclosure provides novel heteroaryl compounds of formula (VII). Such compounds are useful for the treatment of cancers.

Abstract: Provided herein are methods and compositions for determining T-cell differentiation by comparing the methylation status of T cells relative to a T cell methylation index and using this determination to identify or isolate populations of T cells having desired T cell multipotency. Further, the present methods and compositions can be used to monitor or treat symptoms of chronic infections, autoimmune diseases, and cancer.

Abstract: A flexible guide for a rotating resonator mechanism, in particular of a horological movement, the guide including a fixed support, an element that is capable of moving relative to the fixed support, at least one main flexible blade allowing the movable element to move relative to the fixed support by bending the one or more main flexible blades via a rotary motion about a centre of rotation, the flexible guide being arranged substantially in one plane, and includes at least one translation table joined to one end of the main flexible blade, the main flexible blade and the translation table forming a pair connected to the fixed support, to the movable element, or to an intermediate movable part, such that the translation table is configured to move in translation at least in part under the effect of the bending of the main flexible blade.

Abstract: A biodegradable material and a method for preparing a biodegradable material are provided. The biodegradable material includes a continuous phase and a dispersed phase. The continuous phase includes a polyester, and the dispersed phase includes a modified saccharide oligomer. In particular, the weight ratio of the modified saccharide oligomer to the polyester is from 3:97 to 30:70. The dispersed phase has a maximum diameter of 100 nm to 900 nm.

Abstract: The present disclosure relates to a system for continuously sharing behavioral states of a creature. The system comprises a robot configured to carry out different behaviors, at least one sensing means for automatically sensing the creature, a determining means for continuously determining the state of the creature based on information derived from the at least one sensing means and a selecting means for selecting, from the different behaviors, a behavior that is assigned to the determined state, wherein the robot is configured to carry out the selected behavior.

Abstract: System and methods for predictive application streaming are provided. The system may execute an application and, concurrently, the system may while load data blocks not stored on the device using a construct of superblocks. The system may detect an access event caused by an application accessing a data block in a memory. The system may determine, in response to the access event, a superblock comprising a plurality of blocks that are historically accessed within the same execution time window as the block. The system may forecast, based on the superblock and a machine learning model, superblocks to be accessed by the application that are not stored in the memory. The system may download the superblocks from a remote endpoint accessible via a network.

Abstract: The presently disclosed subject matter provides methods and compositions for enhancing immune responses toward tumor and pathogen antigens. It relates to fusion polypeptide that can be expressed in cells (e.g., immunoresponsive cells comprising an antigen-recognizing receptor) to improve the activity and/or efficiency of the cells. In certain embodiments, the fusion polypeptide comprises an extracellular domain and a transmembrane domain of a co-stimulatory ligand, and an intracellular domain of a co-stimulatory molecule.

Abstract: The present disclosure describes methods, devices, and non-transitory computer readable storage medium for recognizing a human action using a graph convolutional network (GCN). The method includes obtaining, by a device, a plurality of joint poses. The device includes a memory storing instructions and a processor in communication with the memory. The method also includes normalizing, by the device, the plurality of joint poses to obtained a plurality of normalized joint poses; extracting, by the device, a plurality of rough features using a modified spatial-temporal GCN (ST-GCN) from the plurality of normalized joint poses; reducing, by the device, a feature dimension of the plurality of rough features to obtain a plurality of dimension-shrunk features; refining, by the device, the plurality of dimension-shrunk features based on a self-attention model to obtain a plurality of refined features; and recognizing, by the device, a human action based on the plurality of refined features.

Abstract: System, methods, and other embodiments described herein relate to improving the estimation of battery life. In one embodiment, a method includes measuring electrochemical data of a battery cell associated with an electrochemical reaction triggered by a test during a diagnostic cycle. The method also includes determining a feature associated with the degradation of the battery cell from the electrochemical data. The method also includes predicting an end-of-life (EOL) of the battery cell by using the feature in a machine learning (ML) model.