Abstract: Disclosed are methods for identifying the core regulatory circuitry or cell identity program of a cell or tissue, and related methods of diagnoses, screening, and treatment involving the core regulatory circuitry and/or cell identity programs identified using the methods.

Abstract: A block copolymer is provided. The block copolymer includes a first block including repeat units represented by formula (I), and a second block connected to the first block and including repeat units represented by formula (II) or (III). The disclosure also provides a method for preparing the block copolymer and a thin film structure including the same.

Abstract: Tin oxide film on a semiconductor substrate is etched selectively in a presence of silicon (Si), carbon (C), or a carbon-containing material (e.g., photoresist) by exposing the substrate to a process gas comprising hydrogen (H2) and a hydrocarbon. The hydrocarbon significantly improves the etch selectivity. In some embodiments an apparatus for processing a semiconductor substrate includes a process chamber configured for housing the semiconductor substrate and a controller having program instructions on a non-transitory medium for causing selective etching of a tin oxide layer on a substrate in a presence of silicon, carbon, or a carbon-containing material by exposing the substrate to a plasma formed in a process gas that includes H2 and a hydrocarbon.

Abstract: The microfluidic chip can comprise at least one multichamber flow assembly that can comprise a plurality of microchannels. The plurality of microchannels can comprise a first microchannel that includes: a first inlet; a first outlet; and a first chamber fluidly connected to the first inlet and the first outlet. The plurality of microchannels can comprise a second microchannel that includes: a second inlet; a second outlet; and a second chamber fluidly connected to the second inlet and the second outlet. The multichamber flow assembly can comprise a porous biocompatible membrane oriented along a longitudinal interface between the first microchannel and the second microchannel, wherein the porous biocompatible membrane is permeable for movement of biomolecules from the first chamber to the second chamber through the porous biocompatible membrane.

Abstract: Disclosed are compositions and methods for targeted treatment of TAG-72-expressing cancers. In particular, affinity maturated single chain variable fragment (scFv) antibodies that bind TAG-72 on cancer cells are disclosed.

Abstract: Systems, methods, and other embodiments described herein relate to generating depth estimates of an environment depicted in a monocular image. In one embodiment, a method includes identifying semantic features in the monocular image according to a semantic model. The method includes injecting the semantic features into a depth model using pixel-adaptive convolutions. The method includes generating a depth map from the monocular image using the depth model that is guided by the semantic features. The pixel-adaptive convolutions are integrated into a decoder of the depth model. The method includes providing the depth map as the depth estimates for the monocular image.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

Abstract: A method for preparing an anti-bacterial and anti-ultraviolet multifunctional chemical fiber includes: dissolving several soluble metal salts and a polymer complexing dispersant into water to prepare an aqueous solution; adding into a polymer monomer; reacting under microwave or hydrothermal action to obtain a polymer monomer containing multifunctional nano oxides; adding the polymer monomer with other monomer, catalyst, initiator, stabilizer, and the like into a polymerization reactor; and carrying out esterification, polycondensation or copolymerization to obtain a polymer melt, and carrying out spinning or ribbon casting and granule cutting to obtain an anti-bacterial and anti-ultraviolet multifunctional chemical fiber or masterbatch chips.

Abstract: Hydrocarbon composition plays vital role in fuel quality. For gasoline/motor spirit applications the hydrocarbon should have more octane-possessing molecules from the groups of aromatics, naphthenics and isoparaffins, while n-paraffins are not preferred due to their poor octane. Among the high-octane groups, again aromatics occupy the top but not more than 35 vol % aromatics can be mixed in gasoline for engine applications to avoid harmful emission, But there is no single process that addresses so far the issue of co-producing all the desired hydrocarbon components in a single process. Thus, it is interesting to have a single once-through process working on single catalyst system to produce mixture of all three high-octane molecules namely, aromatics, naphthenics and isoparaffins directly from low-value, low-octane n-paraffin feed. Herein, we report a novel single-step catalytic process for the simultaneous production of aromatics, naphthenics and isoparaffins for gasoline and petrochemical applications.

Abstract: A method is provided for using twisted acenes, and more particularly to configurationally stable twisted acenes that are imbedded into the structure of [7]helicene at the fulcrum ring to form useable material structures. The helicene propagates its chiral nature into the acene, while acting as a locking mechanism to thermal racemization. These doubly-helical compounds are part of a new homologous series of polycyclic aromatic hydrocarbons, namely the [7]helitwistacenes. Such [7]helitwistacenes have utility as materials suitable for forming a circularly polarized organic light emitting diode (CP-OLED) for direct emission of circularly polarized (CP) light for the fabrication of high efficiency electronic displays.

Abstract: A bone screw may be insertable into a bone, and may have a proximal member, a distal member with bone-engaging threads, wherein the distal member is configured to slidably engage the proximal member such that a variable-length cavity is defined within the proximal member and the distal member, and a tension member residing at least partially within the variable-length cavity. The tension member may have a proximal end coupled to the proximal member and a distal end coupled to the distal member such that, in response to motion of the distal member away from the proximal member, the tension member elongates and urges the distal member to move toward the proximal member. The proximal member and the distal member may be interconnected to share bending loads at a bending transmission feature.

Abstract: A long-range wireless network extends the battery life of the most remote end devices by forming pairs with a relayer end device that relays data from the remote end device to a gateway. The battery life of the relayer is reduced to extend the battery life of the remote end device. An analysis server selects pairs of end devices that have a difference in battery levels above a threshold, and require less transmission energy from the remote end device to the relayer than to the gateway. Energy or path losses are estimated based on geographic locations of end devices and terrain or obstacles. Redundant pairs from a remote end device are eliminated by selecting the relayer requiring the lowest transmission energy. A new configuration is sent to the remote end device. New configurations with higher Spreading Factors (SF) compensate for pairs with larger path losses to the relayer.

Abstract: A method for scene reconstruction includes generating a depth estimate and a first pose estimate from a current image. The method also includes generating a second pose estimate based on the current image and one or more previous images in a sequence of images. The method further includes generating a warped image by warping each pixel in the current image based on the depth estimate, the first pose estimate, and the second pose estimate. The method still further includes controlling an action of an agent based on the second warped image.

Abstract: A training system and method of object detection model is disclosed. The training system includes an object detection model and a loss calculation module. The object detection model is configured to generate an output image according to an input image. The loss calculation module, coupled to the object detection model, is configured to calculate a total classification loss value according to the output image and a solution image, calculate a loss value according to the total classification loss value, and transmit the loss value to the object detection model. The total classification loss value is calculated according to a number of classification losses corresponding to a number of object types. Each classification loss corresponding to each object type is calculated according to a first parameter, a second parameter and a third parameter.

Abstract: The invention provides a process for the preparation of bismuth oxyhalide, comprising a precipitation of bismuth oxyhalide in an acidic aqueous medium in the presence of a reducing agent. Also provided are bismuth oxyhalide compounds doped with elemental bismuth Bi(0). The use of Bi(0)doped-bismuth oxyhalide as photocatalysts in water purification is also described.

Abstract: Systems and methods for generating and/or deploying an accurate, interactive, screener web page are provided. A method may include receiving a modular framework question including a subject field that is initialized in an empty state. The method may include filling the empty subject field with a subject text to create a completed question. The method may include transmitting the completed question as part of the interactive screener web page to a survey participant; receiving, as input to the interactive screener web page, a response to the completed question; generating, in real-time, a response score based on the response; and routing the survey participant to an on-line survey when the response score satisfies a predetermined threshold response score, and routing the survey participant away from the on-line survey when the response score fails to satisfy the predetermined threshold response score.

Abstract: Disclosed is a power optical transmission route and spectrum allocation method based on an elastic optical network, including: determining a set of alternative routes among nodes of a power communication network according to power communication topology; coloring the routes for classification, determining a total number of colors allocated, and determining the coloring of the set of alternative routes according to a hop count of route nodes and the total number of colors of spectrums; proportionally classifying the spectrums into blocks according to the total number of colors allocated and the number of route classes allocated to each color; selecting an optimal solution from the set of alternative routes by comprehensively considering a switching hop count and a network-wide risk balance value, to determine a route to execute service allocation; and determining positions of spectrum blocks according to the route selected and the allocated colors, to complete spectrum allocation.

Abstract: Microfluidic devices and nanobiosensors comprising a magnetic nanoparticle attached to a reporter molecule via a release unit for microfluidic-based detection of a target analyte in a biological sample. The nanobiosensors can be magnetically manipulated or guided through the microfluidics channels for incubation with the biological sample, concentration of the nanobiosensors, and detection of target analytes, without having to pump the entire initial sample through a microfluidic channel of the microfluidic device. The magnetic nanoparticles are separated from the reporter molecules before detection and can be re-used.