Abstract: Provided is an encoding apparatus for integrally encoding and decoding a speech signal and a audio signal, and may include: an input signal analyzer to analyze a characteristic of an input signal; a stereo encoder to down mix the input signal to a mono signal when the input signal is a stereo signal, and to extract stereo sound image information; a frequency band expander to expand a frequency band of the input signal; a sampling rate converter to convert a sampling rate ; a speech signal encoder to encode the input signal using a speech encoding module when the input signal is a speech characteristics signal; a audio signal encoder to encode the input signal using a audio encoding module when the input signal is a audio characteristic signal; and a bitstream generator to generate a bitstream.

Abstract: Provided are a flexible electronic device including device units, a first etching preventing layer provided on the device units, a conductive line provided on the first etching preventing layer and electrically connected to the device units, a flexible substrate covering the conductive line on the first etching preventing layer and the conductive line, a trench separating the device units and exposing a portion of a bottom surface of the first etching preventing layer and a side surface of each of the device units, and a flexible protective layer conformally covering a bottom surface of each of the device units and an inside of the trench, wherein each of the device units includes a protective substrate, driving parts provided on the protective substrate, and a first encapsulation layer configured to cover the driving parts, and a manufacturing method thereof.

Abstract: A low-jitter digital clock signal generating system which uses optical pulses output from a pulse laser includes a first balanced photodetector that converts first and second optical pulses with a delayed time interval into first and second electrical pulses through first and second photodiodes and outputs first and second modulated pulses generated by allowing the first and second electrical pulses to partially overlap each other, a second balanced photodetector that converts third and fourth optical pulses with the delayed time interval into third and fourth electrical pulses through third and fourth photodiodes, and outputs a second modulated pulse generated by allowing the third and fourth electrical pulses to partially overlap each other, and a capacitor. The capacitor is charged by the first modulated pulse, is discharged by the second modulated pulse, and outputs a voltage according to the charging and discharging as a clock signal.

Abstract: An operation method of a first communication node in a communication system may comprise estimating a channel state between the first communication node and a second communication node based on a pilot signal received from the second communication node; generating a first channel codebook based on the estimated channel state; transmitting information of the first channel codebook to the second communication node; receiving a response indicating whether the first channel codebook is to be used from the second communication node; when the response is an ACK indicating that the first channel codebook is to be used, generating a first secret key by using the first channel codebook; and transmitting data encrypted using the first secret key to the second communication node.

Abstract: A method for an uplink data transmission and user equipment (UE) and a base station using the same are provided. The method for the UE includes: receiving a first message to obtain a dynamic grant; using the dynamic grant to upload a first type data according to the first message; receiving a second message to obtain a configured grant; using the configured grant to upload a second type data according to the second message; cancelling the first type data uploading if the first type data uploading and the second type data uploading are partially or fully overlapping in time and a first priority of the dynamic grant is lower than a second priority of the configured grant; and determining whether to resume the first type data uploading after the end of the second type data uploading.

Abstract: The invention relates to a PSMA-targeting conjugate comprising (a) an amatoxin; (b) a small molecule PSMA-targeting moiety; and (c) optionally a linker linking said amatoxin and said small molecule PSMA-targeting moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Abstract: A method, corresponding system, and computer program product for retrieving relevant documents is disclosed. The method includes running, by a processor, an enhanced query comprising a set of parameters based on which a relevancy of a document is determined. The set of parameters includes one or more of keywords, classification codes, time period, assignees, inventors, authors, and section properties. Thereafter, the processor assigns a score to one or more documents returned in response to running the enhanced query, wherein the score is determined by a scoring algorithm. The scoring algorithm evaluates a degree to which the enhanced query parameters are matched in the at least one document for computing the score. Finally, the processor selects relevant documents from the one or more documents based on the assigned score. The relevant documents are selected based on the assigned score fulfilling one or more predetermined criteria.

Abstract: A resonant tunneling device includes a first two-dimensional semiconductor layer including a first two-dimensional semiconductor material, a first insulating layer on the first two-dimensional semiconductor layer; and a second two-dimensional semiconductor layer on the first insulating layer and including a second two-dimensional semiconductor material of a same kind as the first two-dimensional semiconductor material.

Abstract: It is proposed a tank manufactured from a plastic material. The tank comprises a reinforcement member. The reinforcement member comprises a first portion made of a first material weldable to the plastic material of the tank; and a second portion made of a second material having a tensile stress at break which is three to nine times larger than the tensile stress at yield of the first material. The second portion comprises at least one through-hole, and the first material extends in said at least one through-hole and at opposite sides of said second portion adjacent said at least one through-hole.

Abstract: The present disclosure provides novel heteroaryl compounds of formula (IV). Such compounds are useful for the treatment of cancers.

Abstract: Provided are a carbon isotope analysis device high in partial pressure of carbon dioxide isotope in gas sent into as optical resonator, and high in sensitivity performance and analytical accuracy, and an analysis method by use of the carbon isotope analysis device. A carbon isotope analysis device including a carbon dioxide isotope generator provided with a combustion unit that generates gas containing carbon dioxide isotope from carbon isotope, and a carbon dioxide isotope purifying unit; a spectrometer including an optical resonator having a pair of mirrors, and a photodetector that determines intensity of light transmitted from the optical resonator; a carbon dioxide trap including a cooler for freezing the carbon dioxide isotope, the carbon dioxide trap being disposed between the carbon dioxide isotope generator and the spectrometer; and a light generator.

Abstract: Embodiments of the invention relate to compositions comprising a corrole and optionally a protein, wherein the composition are characterized by improved water solubility. The corrole may be a hydrophobic corrole, according to formula [I]. The protein may be a plasma protein. The plasma protein may be albumin. The compositions may be in nanoparticulate form.

Abstract: A modulating circuit is disclosed which includes a switch, wherein the switch comprises a first terminal, a second terminal, a transistor, wherein the transistor comprises a third terminal, and a fourth terminal, a power converter, wherein the power converter comprises a power input, a multiplexer, wherein the multiplexer comprises an output, and a feedback controller, wherein the feedback controller comprises a first output, a third input, and a fourth input, wherein the power input is coupled to the first terminal, wherein the second terminal is coupled to the fourth terminal, wherein the third terminal is coupled to the first output, wherein the third input is coupled to the fourth terminal, wherein the fourth input is coupled to the output.

Abstract: This invention relates to the production and genotyping of mice lacking both Angiopoietin 1 and Angiopoietin 2. This invention also relates to the use of Tie2 receptor activation for treatment of open angle glaucoma, congenital glaucoma and cystic kidney disease, and more specifically to the use of angiopoietin 1 recombinant proteins, peptides, VE-PTP phosphatase inhibitors, and Tie2-peptomimetics to improve lymphatic drainage in the Schlemm's canal and corneal limbal lymphatic system for open angle glaucoma and congenital glaucoma patients, and to slow and/or reduce the growth of cysts in patients with cystic kidney disease.

Abstract: Provided are a rapid detection method for a condition of landfill leachate polluting groundwater and an application thereof. The rapid detection method includes: carrying out fluorescence detection on groundwater in a specific region of a landfill, and determining whether the groundwater is polluted according to a ratio of fluorescence intensities at specific excitation/emission wavelengths in a specific fluorescence region. The rapid detection method provided by the solution establishes characteristic fluorescence spectrum regions, fluorescence intensities and regular characteristics thereof of organic matters in leachate-polluted groundwater of a landfill in a fluorescence spectrum region, and can achieve the rapid detection of a condition of landfill leachate polluting groundwater by means of a portable fluorescence detector on site. The detection method provided by the solution is characterized by rapid detection, no need of chemical reagents, simple operation, high detection sensitivity and lower cost.

Abstract: A composition of matter comprising an extract of a plurality of seeds of an edible plant of interest is disclosed. Use of the composition and methods of generating same are also disclosed.

Abstract: A plastic vehicle tank defining an interior volume provided to contain liquid and comprising: a. an upper wall; b. a lower wall; c. at least one connecting element joining the upper wall to the lower wall of the plastic vehicle tank, said at least one connecting element being located inside the interior volume provided to contain a liquid, and comprising a structure made of continuous fibers embedded in a matrix.

Abstract: A cell encapsulation device with a suction tube includes a cell encapsulation device for constructing a multicellular structure formed by culturing cells, the cell encapsulation device being provided with a porous membrane on at least one of a top surface and a bottom surface and a frame member at a side surface, and a suction tube having a first tubular member and a second tubular member, in which, a first through hole and a second through hole are formed in an outer circumferential surface of the frame member, the first through hole and the second through hole communicating with one end portion of the first tubular member and one end portion of the second tubular member, respectively, the other end portion of the first tubular member has a connection mechanism to a suction means at the other end portion thereof, and the other end portion of the second tubular member is open to the outside.

Abstract: The present invention relates to use of expression vectors and other compounds in methods to disrupt the LInker of Nucleoskeleton and Cytoskeleton (LINC) complex, uncoupling the nucleus from its linkage to the cytoskeleton, resulting in amelioration of diseases caused by one or more Lmna mutations, so-called laminopathies. More particularly, the invention relates to the expression of dominant negative SUN domain protein and/or dominant negative KASH domain protein to disrupt, for example, the LINC complex in cardiomyocytes for suppressing disease progression in dilated cardiomyopathy (DCM).

Abstract: Provided herein are methods and compositions for treating an eye disorder, for example CORD6. Aspects of the disclosure relate to knocking out an autosomal dominant mutant GUCY2D gene.