Abstract: The present disclosure relates to PKC activators and combinations thereof. The disclosure further relates to compositions, kits, uses, and methods thereof.

Abstract: In one embodiment, a plasma processing device may include a dielectric window, a vacuum chamber, an energy source, and at least one air amplifier. The dielectric window may include a plasma exposed surface and an air exposed surface. The vacuum chamber and the plasma exposed surface of the dielectric window can cooperate to enclose a plasma processing gas. The energy source can transmit electromagnetic energy through the dielectric window and form an elevated temperature region in the dielectric window. The at least one air amplifier can be in fluid communication with the dielectric window. The at least one air amplifier can operate at a back pressure of at least about 1 in-H2O and can provide at least about 30 cfm of air.

Abstract: Chlorotoxin variants, chlorotoxin variant conjugates, compositions that include the chlorotoxin variants or conjugates, and methods for using the chlorotoxin variants, conjugates, and compositions.

Abstract: First-aid systems including an ultra compact first-aid pouch configured to fit behind the ballistic plates of a protective vest are disclosed. In this configuration, the first-aid kit is protected from shrapnel and tearing, is easily locatable and removable and does not affect the user's freedom of movement. When the first-aid pouch is removed from its protected location, it presents the first-aid equipment in a logical and easily viewable manner.

Abstract: Disclosed is a plasma sterilizer apparatus for a pipe and, more particularly, to a plasma sterilizer apparatus for a pipe, which can be easily mounted on a pipe and effectively sterilize harmful microorganisms contained in water or raw materials flowing through a pipe. A plasma sterilizer apparatus for a pipe comprises: a first connection member connected to one side of a pipe; a second connection member connected to the other side of the pipe; a first electrode mounting member disposed in contact with the first connection member; a second electrode mounting member disposed in contact with the second connecting member; a first electrode member provided on the first electrode mounting member; and a second electrode member provided on the second electrode mounting member.

Abstract: A method for providing adaptive localized notification in a vehicle compartment is presented. The method includes detecting a location of an event in a spatial environment adjacent to a first vehicle. The method also includes identifying a notification output device of multiple notification output devices that corresponds to the location of the event. The method further includes outputting, in the vehicle compartment via the notification output device, a notification that is localized to correspond to the location of the event.

Abstract: The present invention relates to a method for selectively separating propylene carbonate by adding water to reaction products comprising a polyether carbonate polyol and propylene carbonate, which are generated from a polymerization reaction of propylene oxide and carbon dioxide under a double metal cyanide (DMC) catalyst, wherein an economical and effective separation of propylene carbonate can be achieved.

Abstract: An apparatus and method are provided for computed tomography (CT) imaging to reduce truncation artifacts due to a part of an imaged object being outside the scanner field of view (FOV) for at least some views of a CT scan. After initial determining extrapolation widths to extend the projection data to fill a truncation region, the extrapolation widths are combined into a padding map and smoothed to improve uniformity and remove jagged edges. Then a hybrid material model fits the measured projection data nearest the truncation region to extrapolate projection data filling the truncation region. Smoothing the padding map is improved by the insight that in general smaller extrapolation widths are more accurate and trustworthy. Further, practical applications often include multiple inhomogeneous materials. Thus, the hybrid material model provides a better approximation than single material models, and more accurate fitting is achieved.

Abstract: Provided are LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.

Abstract: Described herein is a chelator for radiolabels (e.g., 89Zr) for targeted PET imaging that is an alternative to DFO. In certain embodiments, the chelator for 89Zr is the ligand, 3,4,3-(LI-1,2-HOPO) (“HOPO”), which exhibits equal or superior stability compared to DFO in chemical and biological assays across a period of several days in vivo. As shown in FIG. 1, the HOPO is an octadentate chelator that stabilizes chelation of radiolabels (e.g., 89Zr). A bifunctional ligand comprising p-SCN-Bn-HOPO is shown in FIG. 4 and FIG. 5. Such a bifunctional ligand can eliminate (e.g., 89Zr) loss from the chelate in vivo and reduce uptake in bone and non-target tissue. Therefore, the bifunctional HOPO ligand can facilitate safer and improved PET imaging with radiolabeled antibodies.

Abstract: Systems and methods providing low-density parity-check (LDPC) decoder configurations capable of decoding multiple code blocks in parallel are described. Parallel LDPC decoders of embodiments can be reconfigured to simultaneously decode multiple codewords with reconfigurable size. In operation of embodiments of a parallel LDPC decoder, a plurality of active portions of the decoder logic are configured for parallel processing of a plurality of code blocks, wherein each active region processes a respective code block. The decoder logic active portions of embodiments are provided using a reconfigurable segmented scalable cyclic shifter supporting multiple instruction, multiple data (MIMD), wherein multiple individual different data shifts are implemented with respect to a plurality of code blocks in an instance of data shifting operation.

Abstract: A gas injector for a substrate processing system includes a first injector housing including a base portion defining a first gas flow channel; a projecting portion extending from the base portion; and a second gas flow channel extending through the base portion and the projecting portion. The gas injector includes a second injector housing including a first cavity including a first opening, a second opening and a first plurality of gas through holes arranged around the second opening. The first gas flow channel communicates with the first plurality of gas through holes. The second injector housing includes a second cavity that includes a second plurality of gas through holes and that extends from the second opening of the first cavity. The second gas flow channel communicates with the second plurality of gas through holes. Gas in the first and second gas flow channels flows into a processing chamber without mixing.

Abstract: An electrodialytic battery system comprises an electrodialysis apparatus having first and second reservoirs, wherein concentration of an input solution in the first reservoir increases and concentration of the input solution decreases in the second reservoir during an operation mode. A first redox-active electrolyte chamber comprises a first electrode and a first solution of a first redox-active electrolyte material and has a reversible redox reaction with the first electrolyte material to drive an ion into the first reservoir. A second redox-active electrolyte chamber comprises a second electrode and a second solution of a redox-active electrolyte material and has a reversible redox reaction with the second electrolyte material to accept an ion from the second reservoir. A first type of membrane is disposed between the first and second reservoirs, and a second type of membrane, different from the first type, is disposed between the respective electrode chambers and reservoirs.

Abstract: A method of obtaining an in-memory vector-based dot product is disclosed, which includes providing a matrix of memory cells having M rows, each memory cell in each row holding a value and having dedicated read transistors T1 and T2, where T1 is controlled by the value held in the associated memory cell and T2 is controlled by a row-dedicated source (vin) for each row, the combination of the T1 and T2 transistors for each cell selectively (i) couple a reference voltage with a column-dedicated read bit line (RBL) for each column for an in-memory vector-based dot product operation or (ii) couple ground with the column-dedicated read bit line (RBL) for each column for a memory read operation, where total resistance of the read transistors (R) for each cell in each row is based on Rmax/2(M-1), . . . Rmax, where Rmax is the resistance of the least significant cell in each row.

Abstract: The present disclosure provides a pharmaceutical composition for treating or alleviating an autoimmune disease and/or complication thereof and/or nephritis, including: an effective amount of an extract of a plant belonging to Rutaceae as an effective ingredient for treating or alleviating the autoimmune disease and/or complication thereof and/or nephritis, wherein the autoimmune disease is selected from a group consisting of lupus erythematosus, psoriasis, psoriatic arthritis, ankylosing spondylitis, rheumatoid arthritis, juvenile idiopathic arthritis, Crohn's disease and ulcerative colitis (UC).

Abstract: As disclosed herein, stapled peptides targeting the interaction interface between proteins that maintain the integrity of Wiskott-Aldrich syndrome protein family member 3 (WASF3) leads to destabilization of WASF3 and suppression of invasion. Disclosed are stapled peptides that inhibit the binding of Cytoplasmic FMR1-interacting protein 1 (CYFIP1) to either WASF3 or NCK-associated protein (NCKAP1). Also disclosed are methods for treating or suppressing invasion and metastasis of a cancer in a subject that involve administering to the subject a therapeutically effective amount of a stapled peptide disclosed herein.

Abstract: An ink composition for photonic sintering and a method or producing the ink composition, the ink composition includes: metal nanoparticles comprising a first metal satisfying interaction formula 1; an organic non-aqueous binder; and a non-aqueous solvent. Interaction formula 1 is A1/A2?0.2, where A1/A2 is a ratio, in the x-ray photoelectron spectrum on the surface of the first metal, in which first metal 2p3/2 peak area of the oxide of the first metal (A1) is divided by first metal 2p3/2 peak area of the first metal (A2).

Abstract: The invention relates to a pressure vessel system comprising a pressure vessel for storing a gas under pressure, at a potential leakage interface of the pressure vessel, one or more gas sensitive parts configured to undergo a modification when the gas passes along the potential leakage interface; said leakage interface being an interface within the pressure vessel; and one or more detection modules configured to detect a modification of the one or more gas sensitive parts. The invention also relates to a connection assembly comprising a first connection part and a second connection part, said first and second connection part being configured to realize a gas tight connection; one or more gas sensitive parts arranged at a connection interface between the first connection part and the second connection part, and one or more detection modules configured to detect a modification of the one or more gas sensitive parts.

Abstract: System, methods, and other embodiments described herein relate to conditionally generating custom images by sampling latent space of a generator. In one embodiment, a method includes, in response to receiving a request to generate a custom image, generating a component instruction by translating a description about requested characteristics for the object instance into a vector that identifies a portion of a latent space within a respective generator. The method includes computing the object instance by controlling the respective one of the generators according to the component instruction to produce the object instance. The respective one of the generators being configured to generate objects within a semantic object class. The method includes generating the custom image from at least the object instance to produce the custom image from the description as a photorealistic image approximating a real image corresponding to the description.

Abstract: Embodiments of the invention are directed compositions and devices that include a spatially-variant lattice (SVL), such as spatially variant photonic crystals (SVPC), as well as methods for making and using the same. In particular, the compositions and devices include SVPCs that are configured for manipulating the path and/or properties of electromagnetic radiation flowing through the SVPC in a variety of ways.