Abstract: Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.

Abstract: Disclosed is an RNA aptamer, a synthetic oligonucleotide of 2?-fluoro-modified A, U, and C nucleotides, with improved stability compared to its unmodified counterpart. Like the unmodified aptamer, however, the modified version is a potent glutamate receptor antagonist. Additionally, the RNA aptamers described herein are water soluble by nature, and generally exhibit nano- to micromolar potency making them potential therapeutic agents for the treatment of neurological disorders involving glutamate receptor activity.

Abstract: A method for detecting a foreign object between a transmission pad and a reception pad for wireless power transfer (WPT) may comprise steps of performing a zero phase angle (ZPA) control for a power transfer converter included in or connected to the transmission pad; detecting a characteristic parameter with respect to at least one of an input current and a switching frequency of the power transfer converter; and determining whether or not a foreign object exists between the transmission pad and the reception pad according to whether the characteristic parameter with respect to at least one of the input current and the switching frequency deviates from an allowable range.

Abstract: Compositions including combinations of class I histone deacetylase (HDAC) inhibitors and programmed cell death protein 1 (PD-1) inhibitors for enhancing antitumor activity are disclosed. Further disclosed are methods of administering these compositions as immunotherapies for suppressing regulatory T cells in renal cell carcinoma.

Abstract: Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations containing them. Also provided are methods of preparing and using the disclosed capsid-protein-mutated rAAV constructs in a variety of diagnostic and therapeutic modalities, including, inter alia, as mammalian cell-targeting delivery agents, and as human gene therapy vectors. Also disclosed are large-scale production methods for capsid-modified rAAV expression vectors, viral particles, and infectious virions having improved transduction efficiencies over those of the corresponding, un-modified, rAAV vectors, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications.

Abstract: A computer-implemented method for determining rock and fluid parameters of a subsurface region from measured seismic reflection data, said method including: generating, with a computer, a geophysical data volume by combining a plurality of angle stacks obtained from the measured seismic reflection data and geophysical property data obtained from a full wavefield inversion of the measured seismic reflection data; for each point of the geophysical data volume, determining, with a computer, a petrophysical model that is a probability of a rock state based on initial values of the rock and fluid parameters and the geophysical data volume; iteratively determining, using a computer, updated values for the rock and fluid parameters, wherein the iteratively determining includes determining a petrophysical parameter estimate for the rock and fluid parameters from the petrophysical model as constrained by the geophysical data volume and the initial values of the rock and fluid parameters, minimizing a misfit between th

Abstract: The present invention separates radiation from an object by a polarization filter 3 into polarized light beams, causes one of the beams to enter a spectrum analyzer 7 through a first optical path, causes the other to enter the spectrum analyzer 7 through a second optical path, and measures the two-color ratio, while causes radiation of a blackbody 2 placed in a vacuum ultralow temperature thermostatic chamber 1 in a quasi-thermal equilibrium state at an ultralow temperature in vacuo to enter the polarization filter 3 through a third optical path, separates the radiation into polarized light beams, causes the beams to each enter the same optical paths as the respective optical paths for the radiation of the object, causes the beams to enter the spectrum analyzer 7, measures the two-color ratio, and accurately obtains the temperature of the object on the basis of these two two-color ratios.

Abstract: Disclosed herein are an in-network caching apparatus and method. The in-network caching method using the in-network caching apparatus includes receiving content from a second node in response to a request from a first node; checking a Conditional Leave Copy Everywhere (CLCE) replication condition depending on a number of requests for the content; checking a priority condition based on a result value of a priority function for the content; checking a partition depending on the number of requests for the content; performing a cache replacement operation for the content depending on a result of checking the partition for the content; and transmitting the content to the first node.

Abstract: A drug containing, as an active ingredient, a compound represented by ALK inhibitors such as brigatinib, AP26113-analog, and AZD3463 has been found to be effective against a non-small cell lung cancer having a point mutation at C797S in EGFR which has acquired a resistance to chemotherapy agents. Further, the drug used in combination with an anti-EGFR antibody demonstrates a notable suppression effect on the tumor growth. The drug has a potential to be a therapeutic agent effective against a non-small cell lung cancer which is resistant to gefitinib, a first generation therapeutic agent and osimertinib, a third generation therapeutic agent.

Abstract: An embodiment method of operating an imaging device including a sensor array including a plurality of pixels, includes: capturing a first low-spatial resolution frame using a subset of the plurality of pixels of the sensor array; generating, using a processor coupled to the sensor array, a first depth map using raw pixel values of the first low-spatial resolution frame; capturing a second low-spatial resolution frame using the subset of the plurality of pixels of the sensor array; generating, using the processor, a second depth map using raw pixel values of the second low-spatial resolution frame; and determining whether an object has moved in a field of view of the imaging device based on a comparison of the first depth map to the second depth map.

Abstract: A method and an apparatus for random access in a mobile communication system are provided. A terminal receives a synchronization signal block, obtains beam index information from the received synchronization signal block, and transmits a preamble message occupying a plurality of preamble resources including a preamble resource corresponding to the beam index information to a base station. A random access resource includes a plurality of preamble resources, and the synchronization signal block is specified for one beam and corresponds to one preamble resource of the random access resource.

Abstract: Provided herein are topical formulations containing copper ions and methods of treating inflammatory, microbial, and arthritic conditions in various areas of the body using such formulations. Methods of treating osteoarthritis using topical copper ion treatments are provided. Methods of treating and preventing microbial infections using copper ion treatments are further provided, including methods of preventing biofilm. A topical treatment in its basic form comprises a biocompatible copper ion solution or suspension obtained by leaching of the copper ions from copper metal. The copper ion solution or suspension is combined with various carriers to form the copper ion treatment including creams, gels, lotions, foams, pastes, tampons, solutions, suppositories, body wipes, wound dressings, skin patches, and suture material. Methods of making the copper ion solution or suspension from solid copper metal in a biocompatible solution are also provided.

Abstract: Uses of expanded cord blood hematopoietic stem/progenitor cells (HSPC) are described. Examples include to reduce transplant rejection, to induce immune tolerance, to reduce total parenteral nutrition (TPN) feeding, opioid use, mucositis, and hospitalization following a medical procedure and to reduce graft versus host disease (GVHD) following an allogeneic transplant.

Abstract: The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to FAD to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor.

Abstract: Status of a payload and a shipping container is tracked and monitored by a tracking module which receives at least one signal from one or more sensors; determines a rate of change over time for the signal(s) and sensor(s); compares, in real-time, memory-stored rate-of-change thresholds corresponding to a payload type to the determined rate(s) of change; and, responsive to the comparison indicating a current or impending violation of a payload handling condition, powers up a wireless communications interface, communicates a digital report to a remote computing system, and powers down the wireless communications interface upon completion of the communicating of the report, while continuing to monitor the sensor(s).

Abstract: Robotic gripper fingers are disclosed. A gripper assembly includes a first finger defining a first object engagement face and a second finger defining a second object engagement face. The first object engagement face of the first finger opposes the second object engagement face of the second finger. The gripper assembly also includes at least one actuator in communication with the first finger that is configured to actuate the first finger relative to the second finger. The gripper assembly includes at least one first sensor facing outward from the first object engagement face. The at least one first sensor is configured to detect objects to be manipulated by actuating the first finger relative to the second finger.

Abstract: The present application relates to novel nucleoside derivatives of formula (I) as claimed in claim 1, pharmaceutical compositions comprising the compounds, processes of preparation thereof, and methods of use thereof for treating cancer.

Abstract: Embodiments of an optical adhesive are provided. The optical adhesive includes about 20% to about 60% by volume of first monomers. The first monomers have at least two acrylate or methacrylate groups. The optical adhesive also includes about 40% to about 80% by volume of second monomers. The second monomers have at least one fluorine atom and at least one acrylate or methacrylate group. The optical adhesive has a refractive index of from about 1.40 to about 1.55, and in the temperature range of about 10° C. to about 85° C., the refractive index of the optical adhesive has a thermal drift dn/dT of less than about ?4×10?4/° C. Embodiments of a mechanical joint between two optical fiber segments using the optical adhesive and embodiments of a method for joining two optical fiber segments are also provided.